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D Kioussis

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991 8.31
2 Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A 1991 5.52
3 "Infectious" transplantation tolerance. Science 1993 4.98
4 Unexpected relationships between four large deletions in the human beta-globin gene cluster. Cell 1983 3.57
5 Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice. Cell 1989 3.48
6 The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J Biol Chem 1981 3.26
7 Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity 1995 3.18
8 Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods 1995 2.86
9 Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature 1984 2.83
10 Locus control region function and heterochromatin-induced position effect variegation. Science 1996 2.42
11 Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. J Exp Med 1998 2.31
12 The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development 2000 2.22
13 The structure of the human CD2 gene and its expression in transgenic mice. EMBO J 1988 2.00
14 Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster. Nucleic Acids Res 1986 1.90
15 Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 1993 1.87
16 Embryonic expression and cloning of the murine GATA-3 gene. Development 1994 1.84
17 Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev 1994 1.80
18 The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med 1996 1.56
19 Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 1991 1.54
20 The level of CD8 expression can determine the outcome of thymic selection. Cell 1992 1.53
21 Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc Natl Acad Sci U S A 1992 1.52
22 The presence of intervening sequences in the alpha-fetoprotein gene of the mouse. J Biol Chem 1979 1.50
23 Random activation of a transgene under the control of a hybrid hCD2 locus control region/Ig enhancer regulatory element. EMBO J 1995 1.49
24 Expression and rescuing of a cloned human tumour necrosis factor gene using an EBV-based shuttle cosmid vector. EMBO J 1987 1.48
25 Bad can act as a key regulator of T cell apoptosis and T cell development. J Exp Med 1999 1.46
26 Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression. Eur J Immunol 1991 1.41
27 Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner. Nat Genet 1999 1.40
28 Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. Immunity 2000 1.33
29 The AXH module: an independently folded domain common to ataxin-1 and HBP1. FEBS Lett 2003 1.29
30 Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes. J Immunol 1993 1.27
31 A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 1997 1.26
32 Differential expression of human globin genes introduced in K562 cells. EMBO J 1985 1.25
33 Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice. J Immunol 1994 1.23
34 Construction and cloning of rat albumin structural gene sequences. Proc Natl Acad Sci U S A 1979 1.17
35 A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor beta chain genes in synovial lymphocytes. Scand J Immunol 1987 1.13
36 Complex lymphoid and epithelial thymic tumours in Thy1-myc transgenic mice. Nature 1989 1.13
37 Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity 1998 1.13
38 Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J 1999 1.12
39 Glucocorticoids attenuate T cell receptor signaling. J Exp Med 2001 1.10
40 Elimination of the immunogenicity of therapeutic antibodies. J Immunol 1999 1.08
41 Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest 1998 1.07
42 A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J Immunol 1997 1.06
43 Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity. Immunity 1994 1.05
44 The action of Bax and bcl-2 on T cell selection. J Exp Med 1998 1.04
45 T cell deletion follows chronic antigen specific T cell activation in vivo. Int Immunol 1993 1.00
46 Expression in vivo of CD45RA, CD45RB and CD44 on T cell receptor-transgenic CD8+ T cells following immunization. Eur J Immunol 1995 0.99
47 Locus control regions and epigenetic chromatin modifiers. Curr Opin Genet Dev 2000 0.99
48 T-cell lymphomas in v-Myb transgenic mice. Oncogene 1996 0.99
49 Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction. J Biol Chem 1978 0.99
50 Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc Natl Acad Sci U S A 1994 0.97
51 Multiple sites of post-activation CD8+ T cell disposal. Eur J Immunol 1997 0.97
52 Deletion analysis of the human CD2 gene locus control region in transgenic mice. Nucleic Acids Res 1991 0.97
53 Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur J Immunol 1994 0.97
54 Tracing and characterization of the low-avidity self-specific T cell repertoire. Eur J Immunol 2000 0.97
55 The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selection. Immunity 2001 0.97
56 Two non-allelic human interferon alpha genes with identical coding regions. EMBO J 1984 0.96
57 Molecular cloning of developmentally regulated, low-abundance mRNA sequences from embryonic muscle. Proc Natl Acad Sci U S A 1980 0.96
58 Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection. Int Immunol 1996 0.95
59 Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes. Cell Death Differ 2009 0.94
60 A self-reactive T cell population that is not subject to negative selection. Int Immunol 1992 0.93
61 TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL. Oncogene 2007 0.93
62 Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes. Proc Natl Acad Sci U S A 1998 0.93
63 T cell activation results in physical modification of the mouse CD8 beta chain. J Immunol 1994 0.92
64 Inhibition of thymocyte negative selection by T cell receptor antagonist peptides. Eur J Immunol 1996 0.92
65 Human CD4 restores normal T cell development and function in mice deficient in murine CD4. J Exp Med 1994 0.91
66 Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production. J Immunol 1991 0.91
67 Human bcr-abl gene has a lethal effect on embryogenesis. Transgenic Res 1991 0.90
68 Interactions with multiple peptide ligands determine the fate of developing thymocytes. Proc Natl Acad Sci U S A 1998 0.89
69 Tumor size at the time of adoptive transfer determines whether tumor rejection occurs. Eur J Immunol 2000 0.88
70 Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation. Dev Immunol 1996 0.88
71 Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J Biol Chem 1992 0.87
72 Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice. J Immunol 1998 0.87
73 Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunol 1995 0.87
74 Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex. Proc Natl Acad Sci U S A 1991 0.86
75 Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice. Eur J Immunol 1996 0.84
76 Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes. J Immunol 2000 0.83
77 Structure and expression of the human globin genes and murine histocompatibility antigen genes. Cold Spring Harb Symp Quant Biol 1983 0.82
78 In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells. Eur J Immunol 1993 0.82
79 Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection. Eur J Immunol 2000 0.81
80 The agonist-antagonist balance in positive selection. Immunol Today 1997 0.81
81 Elevated Bcl-2 is not a causal event in the positive selection of T cells. Eur J Immunol 2001 0.80
82 In vitro positive selection of alpha beta TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone. Int Immunol 1997 0.79
83 T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model. Int Immunol 1993 0.77
84 Functional analysis of the human neurofilament light chain gene promoter. Nucleic Acids Res 1993 0.76
85 Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. J Cell Sci 1996 0.76
86 Human CD2 is functional in CD2 transgenic mice. Immunology 1991 0.75
87 Transgenic mice carrying the guinea-pig alpha-lactalbumin gene transcribe milk protein genes in their sebaceous glands during lactation. Biochem J 1991 0.75
88 Signaling in primary thymocytes after presentation of altered peptide ligands by antigen-presenting cells or MHC-peptide tetramers. Cold Spring Harb Symp Quant Biol 1999 0.75
89 Identification of the thymic stromal populations which participate in the negative selection of double positive thymocytes. Folia Med (Plovdiv) 1995 0.75
90 The programmed cell death of an immature thymocyte cell line transgenic for an alpha beta TCR and the c-myc proto-oncogene. Dev Immunol 1996 0.75
91 DNA sequences required for regulated expression of the human beta-globin gene. Prog Clin Biol Res 1985 0.75
92 Structure-function relationships of the human T lymphocyte CD2 antigen. Cold Spring Harb Symp Quant Biol 1989 0.75
93 Th cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions. J Immunol 1999 0.75