J P Klein

Author PubWeight™ 149.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med 1999 5.82
2 IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol 1997 4.52
3 Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and International Bone Marrow Transplant Registry Working Committee on Alternative Donor and Stem Cell Sources. N Engl J Med 2000 3.19
4 Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol 1997 2.79
5 Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation. IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow Transplantation (EBMT). Blood 2000 2.40
6 Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release. J Immunol 1995 1.89
7 Testing for centre effects in multi-centre survival studies: a Monte Carlo comparison of fixed and random effects tests. Stat Med 1999 1.88
8 High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America. J Clin Oncol 1997 1.75
9 Treatment for acute myelocytic leukemia with allogeneic bone marrow transplantation following preparation with BuCy2. Blood 1991 1.72
10 Capsular polysaccharide types 5 and 8 of Staphylococcus aureus bind specifically to human epithelial (KB) cells, endothelial cells, and monocytes and induce release of cytokines. Infect Immun 1995 1.72
11 Promotion of intestinal carcinogenesis by Streptococcus bovis. Carcinogenesis 2000 1.71
12 Combination drug therapy of seropositive rheumatoid arthritis. J Rheumatol 1995 1.62
13 Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant. Bone Marrow Transplant 2004 1.55
14 Factors correlated with progression-free survival after high-dose chemotherapy and hematopoietic stem cell transplantation for metastatic breast cancer. JAMA 1999 1.49
15 Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 1987 1.48
16 Reflex prolongation of stage I of expiration. Pflugers Arch 1986 1.45
17 The extent of primary melanoma excision. A re-evaluation--how wide is wide? Ann Surg 1983 1.45
18 Bone marrow transplantation for Fanconi anemia. Blood 1995 1.42
19 High-dose chemotherapy and autologous stem-cell transplantation for ovarian cancer: an autologous blood and marrow transplant registry report. Ann Intern Med 2000 1.42
20 Results of transplanting bone marrow from genetically identical twins into patients with aplastic anemia. Ann Intern Med 1997 1.41
21 [Endo-urological drainage in urinary outflow obstruction caused by cancer]. Ned Tijdschr Geneeskd 1994 1.40
22 Common antigens of streptococcal and non-streptococcal oral bacteria: immunochemical studies of extracellular and cell-wall-associated antigens from Streptococcus sanguis, Streptococcus mutans, Lactobacillus salivarius, and Actinomyces viscosus. Infect Immun 1981 1.38
23 Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: A randomized, multicenter, double-blind trial. J Clin Oncol 2000 1.37
24 Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia. J Clin Oncol 2000 1.36
25 Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program. Blood 2001 1.34
26 Conservation of salivary glycoprotein-interacting and human immunoglobulin G-cross-reactive domains of antigen I/II in oral streptococci. Infect Immun 1994 1.33
27 Allogeneic bone marrow transplantation for low-grade lymphoma. Blood 1998 1.29
28 Purification and characterization of a saliva-interacting cell-wall protein from Streptococcus mutans serotype f by using monoclonal-antibody immunoaffinity chromatography. Biochem J 1985 1.28
29 Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Transplant 1998 1.25
30 Bone marrow transplants from HLA-identical siblings in advanced Hodgkin's disease. J Clin Oncol 1996 1.22
31 T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities. Blood 2000 1.19
32 The role of frailty models and accelerated failure time models in describing heterogeneity due to omitted covariates. Stat Med 1997 1.18
33 Blood group A and B antigens are strongly expressed on platelets of some individuals. Blood 2000 1.17
34 Estimating leukemia-free survival after allografting for chronic myeloid leukemia: a new method that takes into account patients who relapse and are restored to complete remission. Blood 2000 1.17
35 Estimation of variance in Cox's regression model with shared gamma frailties. Biometrics 1997 1.17
36 Cytokine production by human epithelial and endothelial cells following exposure to oral viridans streptococci involves lectin interactions between bacteria and cell surface receptors. Infect Immun 1996 1.12
37 Recovery of peripheral chemoreceptor function after denervation in ponies. J Appl Physiol Respir Environ Exerc Physiol 1980 1.11
38 Protoplast and cytoplasmic membrane preparations from Streptococcus sanguis and Streptococcus mutans. J Gen Microbiol 1983 1.10
39 Complete nucleotide sequence of the sr gene from Streptococcus mutans OMZ 175. FEMS Microbiol Lett 1990 1.09
40 Activation of human monocytes by Streptococcus mutans serotype f polysaccharide: immunoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production. Infect Immun 1991 1.09
41 T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation. Blood 1999 1.08
42 Protective effect of vaccination with a combination of recombinant surface antigen 1 and interleukin-12 against toxoplasmosis in mice. Infect Immun 1998 1.07
43 Results of compression-plating of closed Galeazzi fractures. J Bone Joint Surg Am 1985 1.07
44 Cloning of the saliva-interacting protein gene from Streptococcus mutans. J Bacteriol 1987 1.07
45 NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci. Cell Microbiol 2001 1.05
46 Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. Bone Marrow Transplant 2011 1.04
47 Common antigens of streptococcal and nonstreptococcal oral bacteria: characterization of wall-associated protein and comparison with extracellular protein antigen. Infect Immun 1983 1.03
48 Respiratory modulation of sympathetic activity. J Auton Nerv Syst 1985 1.03
49 Bone marrow transplantation for severe aplastic anemia: has outcome improved? Blood 1997 1.03
50 Ultrasound and cholangiography for the diagnosis of biliary complications after orthotopic liver transplantation: a comparative study. J Clin Ultrasound 1996 1.02
51 The N-terminal half part of the oral streptococcal antigen I/IIf contains two distinct binding domains. FEMS Microbiol Lett 1997 1.02
52 Autotransplants for Hodgkin's disease in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry. J Clin Oncol 1999 1.02
53 Multi-state models and outcome prediction in bone marrow transplantation. Stat Med 2001 1.01
54 Identification and preliminary characterization of saliva-interacting surface antigens of Streptococcus mutans by immunoblotting, ligand blotting, and immunoprecipitation. Infect Immun 1984 1.01
55 Effect of peripheral chemoreceptor denervation on acclimatization of goats during hypoxia. J Appl Physiol Respir Environ Exerc Physiol 1981 1.00
56 Influence of protective isolation on outcome of allogeneic bone marrow transplantation for leukemia. Bone Marrow Transplant 1998 0.99
57 Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myelogenous leukemia in first remission. Bone Marrow Transplant 1995 0.99
58 Confidence bands for the difference of two survival curves under proportional hazards model. Lifetime Data Anal 2001 0.98
59 Statistical methods for dependent competing risks. Lifetime Data Anal 1995 0.98
60 Effects of long-term cryopreservation on hematopoietic progenitor cells in umbilical cord blood. Bone Marrow Transplant 1999 0.98
61 Wisconsin healthcare ethics committees. Camb Q Healthc Ethics 1997 0.98
62 Human IgG and Streptococcus mutans SR protein contain cross-reactive epitopes. J Immunol 1989 0.97
63 Induction of nitric oxide production by polyosides from the cell walls of Streptococcus mutans OMZ 175, a gram-positive bacterium, in the rat aorta. Infect Immun 1997 0.96
64 A biomechanical analysis of the vertebral and rib deformities in structural scoliosis. Eur Spine J 1999 0.96
65 Binding of Streptococcus mutans SR protein to human monocytes: production of tumor necrosis factor, interleukin 1, and interleukin 6. Infect Immun 1994 0.95
66 Local and systemic immune response to orally administered liposome-associated soluble S. mutans cell wall antigens. Immunology 1985 0.95
67 The neutralization of interferons by antibody. II. Neutralizing antibody unitage and its relationship to bioassay sensitivity: the tenfold reduction unit. J Interferon Cytokine Res 2001 0.94
68 Serum and salivary antibody responses in rats orally immunized with Streptococcus mutans carbohydrate protein conjugate associated with liposomes. Infect Immun 1986 0.94
69 Purification and characterization of the expression product of the sr gene of Streptococcus mutans OMZ 175. Microb Pathog 1989 0.94
70 A biological marker model for predicting disease transitions. Biometrics 1984 0.93
71 High probability of long-term survival in 2-year survivors of autologous hematopoietic cell transplantation for AML in first or second CR. Bone Marrow Transplant 2010 0.92
72 Expression and functional properties of the Streptococcus intermedius surface protein antigen I/II. Infect Immun 2001 0.91
73 [Presence of virus in cariogenic bacteria in dental plaque]. J Biol Buccale 1973 0.91
74 Massive creatine kinase elevations with quetiapine: report of two cases. Pharmacopsychiatry 2006 0.90
75 Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier's disease: more evidence for non-mesodermal tumor predisposition in multiple enchondromatosis. Skeletal Radiol 1998 0.90
76 Production of cytokines by monocytes, epithelial and endothelial cells activated by Streptococcus bovis. Cytokine 2000 0.90
77 Depression of ventilation by dopamine in goats--effects of carotid body excision. Respir Physiol 1980 0.89
78 Immunogenicity of polysaccharides conjugated to peptides containing T- and B-cell epitopes. Infect Immun 1994 0.89
79 Fissure caries in gnotobiotic rats infected with Actinomyces naeslundii and Actinomyces israelii. Helv Odontol Acta 1973 0.89
80 Mononuclear cell analysis of muscle biopsies in prednisone- and azathioprine-treated Duchenne muscular dystrophy. Neurology 1993 0.89
81 Antibody specificity and antigen characterization of rat monoclonal antibodies against Streptococcus mutans cell wall-associated protein antigens. Infect Immun 1985 0.88
82 Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation. The Acute Lymphoblastic Leukemia Working Committee. Ann Intern Med 1995 0.88
83 Survival with bone marrow transplantation versus hydroxyurea or interferon for chronic myelogenous leukemia. The German CML Study Group. Blood 1998 0.88
84 Purification and partial characterization of rat macrophage Fc receptor and binding factor for IgA. Biochim Biophys Acta 1990 0.88
85 Toxoplasma gondii-induced foetal resorption in mice involves interferon-gamma-induced apoptosis and spiral artery dilation at the maternofoetal interface. Int J Parasitol 2008 0.88
86 The A and the extended V N-terminal regions of streptococcal protein I/IIf mediate the production of tumour necrosis factor alpha in the monocyte cell line THP-1. Mol Microbiol 1998 0.87
87 Risk factors for hepatic veno-occlusive disease following HLA-identical sibling bone marrow transplants for leukemia. Bone Marrow Transplant 1996 0.87
88 Purification and some properties of free and cell-associated dextransucrase from Streptococcus sanguis. Biochimie 1976 0.87
89 Biomechanical implications of the negative heel rocker sole shoe: gait kinematics and kinetics. Gait Posture 2005 0.87
90 Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent. Parassitologia 1997 0.86
91 Protein I/II of oral viridans streptococci increases expression of adhesion molecules on endothelial cells and promotes transendothelial migration of neutrophils in vitro. Cell Immunol 1998 0.86
92 Involvement of alpha5beta1 integrins in interleukin 8 production induced by oral viridans streptococcal protein I/IIf in cultured endothelial cells. Cell Microbiol 1999 0.86
93 Economic analyses of bone marrow and blood stem cell transplantation for leukemias and lymphoma: what do we know? Bone Marrow Transplant 1998 0.86
94 Epitope mapping of Streptococcus mutans SR protein and human IgG cross-reactive determinants, by using recombinant proteins and synthetic peptides. J Immunol 1992 0.86
95 Dental caries in gnotobiotic rats immunized with purified glucosyltransferase from Streptococcus sanguis. Arch Oral Biol 1978 0.85
96 Diphenylhydantoin intoxication associated with hyperglycemia. J Pediatr 1966 0.85
97 Detection of BCR/ABL RNA transcripts using the polymerase chain reaction is highly predictive for relapse in patients transplanted with unrelated marrow grafts for chronic myelogenous leukaemia. Br J Haematol 1997 0.85
98 Lactate dehydrogenase from Streptococcus mutans: purification, characterization, and crossed antigenicity with lactate dehydrogenases from Lactobacillus casei, Actinomyces viscosus, and Streptococcus sanguis. Infect Immun 1985 0.84
99 Regression analysis of mean quality-adjusted survival time based on pseudo-observations. Stat Med 2009 0.84
100 Molecular characterization of the gene sr of the saliva interacting protein from Streptococcus mutans OMZ175. Arch Oral Biol 1990 0.84
101 [Epidemiologic development of AIDS in Austria]. Wien Klin Wochenschr 1993 0.83
102 A 40-kilodalton cell wall protein-coding sequence upstream of the sr gene of Streptococcus mutans OMZ175 (serotype f). Infect Immun 1991 0.83
103 Chemotherapy versus transplants for acute myelogenous leukemia in second remission. Leukemia 1996 0.83
104 Anti-IgG antibodies in rheumatic diseases cross-react with Streptococcus mutans SR antigen. Clin Exp Immunol 1991 0.83
105 Hemoglobin affinity for oxygen during short-term exhaustive exercise. J Appl Physiol Respir Environ Exerc Physiol 1980 0.83
106 TNF-alpha release by monocytic THP-1 cells through cross-linking of the extended V-region of the oral streptococcal protein I/II. J Leukoc Biol 2000 0.82
107 Common antigens of streptococcal and non-streptococcal oral bacteria: isolation and biochemical characterization of the extracellular protein antigen. J Gen Microbiol 1982 0.82
108 Report from the International Bone Marrow Transplant Registry and Autologous Blood and Marrow Transplant Registry - North America. Clin Transpl 1995 0.82
109 Is the severity of knee osteoarthritis on magnetic resonance imaging associated with outcome of exercise therapy? Arthritis Care Res (Hoboken) 2014 0.81
110 [Ultrastructural study of IgA in human dental plaque]. J Biol Buccale 1974 0.81
111 Mucosal immunogenicity of polysaccharides conjugated to a peptide or multiple-antigen peptide containing T- and B-cell epitopes. Infect Immun 1995 0.81
112 A comparison of several methods of estimating the survival function when there is extreme right censoring. Biometrics 1985 0.81
113 HLA-identical sibling bone marrow transplants vs chemotherapy for acute myelogenous leukemia in first remission. Leukemia 1996 0.80
114 Ultrastructural location of Streptococcus mutans and Streptococcus sanguis antigens in carious human dentine. J Biol Buccale 1981 0.80
115 Drug resistance rates of Mycobacterium tuberculosis strains in Austria between 1995 and 1998 and molecular typing of multidrug-resistant isolates. The Austrian Drug Resistant Tuberculosis Study Group. Epidemiol Infect 2000 0.80
116 The effect of graft purging with 4-hydroperoxycyclophosphamide in autologous bone marrow transplantation for acute myelogenous leukemia. Exp Hematol 2001 0.80
117 Report from the International Bone Marrow Transplant Registry and the Autologous Blood and Marrow Transplant Registry--North America. Clin Transpl 1994 0.79
118 Radiation-free preparation for allogeneic bone marrow transplantation in adults with acute lymphoblastic leukemia. J Clin Oncol 1992 0.79
119 Local response in rat to liposome-associated Streptococcus mutans polysaccharide-protein conjugate. Vaccine 1987 0.79
120 Immunoelectrophoretic study of cell surface antigens from different Streptococcus mutans serotypes and Streptococcus sanguis. J Biol Buccale 1985 0.78
121 Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes. Eur J Immunol 1999 0.78
122 Preparation for marrow transplantation in Hodgkin's and non-Hodgkin's lymphoma using Bu/CY. Bone Marrow Transplant 1993 0.78
123 Controlled trial of orally administered immunoglobulin following bone marrow transplantation. Bone Marrow Transplant 1994 0.78
124 Allogeneic bone marrow transplantation for leukemia using chemotherapy as conditioning: 6-year results of a single institution trial. Transplant Proc 1991 0.77
125 Regulation of PaCO2 and ventilation in humans inspiring low levels of CO2. J Appl Physiol Respir Environ Exerc Physiol 1982 0.77
126 [Extracellular polysaccharides and caries activity in a gnotobiotic system for lysogenic and cured streptococci]. J Biol Buccale 1975 0.77
127 Immunolabelling of SR protein and serotype polysaccharide in Streptococcus mutans. J Gen Microbiol 1990 0.77
128 Desferrioxamine enhances the effects of gamma radiation on clonogenic survival and the formation of chromosomal aberrations in endothelial cells. Radiat Res 1998 0.77
129 Survival differences in Austrian patients with the acquired immunodeficiency syndrome. Eur J Epidemiol 1995 0.76
130 Immunogenic properties of the glucosyltransferase from Streptococcus sanguis OMZ 9: kinetic study of inhibition by antibodies. Infect Immun 1978 0.76
131 Ventilatory response to inspired CO2 in normal and carotid body-denervated ponies. J Appl Physiol Respir Environ Exerc Physiol 1982 0.76
132 Effect of elevated PICO2 on metabolic rate in humans and ponies. J Appl Physiol Respir Environ Exerc Physiol 1982 0.76
133 Inhibition of glucosyltransferase by human salivary immunoglobulin A. Infect Immun 1977 0.76
134 Induction of NO production by polyosides from the wall of Streptococcus mutans OMZ175 in the rat aorta. Adv Exp Med Biol 1997 0.76
135 Complete bipartition of the atlas in the Klippel-Feil syndrome. A radiologically illustrated case report. Surg Radiol Anat 1997 0.76
136 Biomechanics of the double rocker sole shoe: gait kinematics and kinetics. Conf Proc IEEE Eng Med Biol Soc 2004 0.75
137 Immunological study of lactate dehydrogenase from Streptococcus mutans and evidence of common antigenic domains with lactate dehydrogenases from lactic bacteria. Infect Immun 1986 0.75
138 Life events and burnout. J Psychol 1981 0.75
139 Modelling covariate adjusted mortality relative to a standard population. Stat Med 1999 0.75
140 [What are the complementary preoperative examinations to be performed in children of ASA class 1?]. Ann Fr Anesth Reanim 1989 0.75
141 Glucose and sucrose effects in the culture media on Streptococcus sanguis OMZ 9 glucosyltransferase inhibition by anti-glucosyltransferase antibodies. J Biol Buccale 1980 0.75
142 [Therapy considered or the medication in a mirror]. Evol Psychiatr (Paris) 1971 0.75
143 [Application possibilities of modern thermography--first experience with the new Tomey TG 1000]. Klin Monbl Augenheilkd 2011 0.75
144 Tax Equity and Fiscal Responsibility Act of 1982: its impact on employee benefits. Employee Relat Law J 1983 0.75
145 [Our experience with pulsed oxygen and general anesthesia in direct suspension laryngoscopy]. Ann Otolaryngol Chir Cervicofac 1976 0.75
146 Urinary tract injuries in multiply-injured patients: a rational guideline for the initial assessment. Injury 1991 0.75
147 [Diagnosis of affective disorders in DSM-5: changes and controversies]. Fortschr Neurol Psychiatr 2014 0.75
148 Managed care: effects on the physician-patient relationship. Camb Q Healthc Ethics 2000 0.75
149 Factors affecting neutrophil and platelet reconstitution following T cell-depleted bone marrow transplantation: differential effects of growth factor type and role of CD34(+) cell dose. Bone Marrow Transplant 2001 0.75
150 Protein I/II from oral viridans streptococci modulates expression of E-selectin, ICAM-1 and VCAM-1, and promotes transendothelial migration of neutrophils in vitro. Adv Exp Med Biol 1997 0.75
151 The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase. Blood 2001 0.75
152 A Psychometric Evaluation of the German Version of the Quick Inventory of Depressive Symptomatology (QIDS-SR16) in Outpatients with Depression. Fortschr Neurol Psychiatr 2015 0.75
153 [Adolescence, or the impossible encounter]. Neuropsychiatr Enfance Adolesc 1984 0.75
154 [The natural environment of the child]. Soins 1976 0.75
155 Infant tuberculosis in Austria--trend reversal since 1990? Infection 1998 0.75
156 [Resource use and financing of guideline-adherent psychotherapeutic inpatient care]. Nervenarzt 2015 0.75
157 [Decisional consequences of systematic preoperative complementary examinations in young, ASA class I adults]. Ann Fr Anesth Reanim 1989 0.75
158 Augmented compressional therapy. Am Correct Ther J 1972 0.75
159 Survival of patients with chronic myelogenous leukaemia relapsing after bone marrow transplantation: comparison with patients receiving conventional chemotherapy. Br J Haematol 1997 0.75
160 Soluble and insoluble proteins of normal human mature enamel. Arch Oral Biol 1982 0.75
161 Kinematic analysis of upper extremity joint motion in children using posterior walkers. Conf Proc IEEE Eng Med Biol Soc 2004 0.75
162 Health-care benefits for employees age 65-70. Employee Relat Law J 1983 0.75
163 [Value of jet ventilation during otorhinolaryngologic endoscopies practiced under general anesthesia]. Ann Anesthesiol Fr 1976 0.75
164 Current developments in employee benefits. Amending qualified plans for tax reform. Employee Relat Law J 1989 0.75
165 [In vitro methods for the study of potentialities for dental plaque inhibition]. J Biol Buccale 1973 0.75
166 Effect of short-term interferon therapy on the outcome of subsequent HLA-identical sibling bone marrow transplantation for chronic myelogenous leukemia: an analysis from the international bone marrow transplant registry. Blood 2000 0.75
167 [Study of buccal aerobic bacteria in children with many caries and without caries]. Rev Odontostomatol (Paris) 1973 0.75
168 [Atypical genesis of anterior ischemic optic neuropathy]. Ophthalmologe 2015 0.75
169 Immunolocalization of Streptococcus mutans sr gene product in recombinant Escherichia coli. Oral Microbiol Immunol 1989 0.75
170 [Ocular cicatricial pemphigoid - state of the art in clinic and therapy for a problematic disease]. Klin Monbl Augenheilkd 2013 0.75
171 Injuries of the lateral ankle ligaments: classification with tenography and arthrography. Radiology 1989 0.75
172 Ultrastructural localization of immunoglobulins in carious human dentine. Arch Oral Biol 1981 0.75