Published in Oncogene on May 15, 2000
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J Natl Cancer Inst (2009) 2.30
Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance. Mol Cancer Ther (2008) 1.65
Retracted Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Retrovirology (2006) 1.60
Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med (2004) 1.44
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One (2011) 1.31
Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. J Virol (2007) 1.18
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. Blood (2007) 1.17
Cellular network entropy as the energy potential in Waddington's differentiation landscape. Sci Rep (2013) 1.12
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia. PLoS One (2010) 1.08
Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock. PLoS One (2010) 1.07
Opposing cytokine-specific effects of all trans-retinoic acid on the activation and expression of signal transducer and activator of transcription (STAT)-1 in THP-1 cells. Immunology (2002) 1.06
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood (2010) 1.04
Suppressors of cytokine signaling in health and disease. Pediatr Nephrol (2005) 1.02
Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC Cell Biol (2004) 1.01
STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells. Carcinogenesis (2014) 1.01
The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia (2011) 1.01
Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses. PLoS One (2009) 0.98
Critical role of STAT3 in melanoma metastasis through anoikis resistance. Oncotarget (2014) 0.98
Bone marrow stroma-mediated resistance to FLT3 inhibitors in FLT3-ITD AML is mediated by persistent activation of extracellular regulated kinase. Br J Haematol (2013) 0.95
PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Am J Pathol (2010) 0.95
TYK2 is a key regulator of the surveillance of B lymphoid tumors. J Clin Invest (2004) 0.95
Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification. Cancer Res (2010) 0.93
Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter. Int J Cancer (2012) 0.88
Transcriptional regulation of the major HIV-1 coreceptor, CXCR4, by the kappa opioid receptor. J Leukoc Biol (2011) 0.83
Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia. Blood Cancer J (2013) 0.83
Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res (2014) 0.82
STAT5-mediated self-renewal of normal hematopoietic and leukemic stem cells. JAKSTAT (2012) 0.81
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood (2014) 0.81
STAT3 is Overactivated in Gastric Cancer Stem-Like Cells. Cell J (2016) 0.79
Sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma B₁₆F₁₀ cell line. Mar Drugs (2011) 0.79
Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo. Oncotarget (2016) 0.78
Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTEN-glioblastoma in vivo. Oncotarget (2016) 0.75
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2. Cell Death Dis (2016) 0.75
CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts. Oncotarget (2016) 0.75
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol (2000) 6.05
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol Cell Biol (2000) 3.93
STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J Biol Chem (1996) 2.10
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol (1995) 1.92
Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell (2001) 1.88
The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis. J Immunol (1989) 1.63
Eosinophil cationic protein and immunoglobulin levels in bronchoalveolar lavage fluid obtained from patients with chronic eosinophilic pneumonia. Eur Respir J (1996) 1.53
Eosinophil chemotactic activity in bronchoalveolar lavage from idiopathic pulmonary fibrosis is dependent on cytokine priming of eosinophils. Eur Respir J (1998) 1.48
Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signal (1998) 1.42
Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions. Proc Natl Acad Sci U S A (1992) 1.39
Trauma: the role of the innate immune system. World J Emerg Surg (2006) 1.37
Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. Clin Exp Immunol (2008) 1.30
STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. Blood (1999) 1.29
Systemic inflammation in chronic obstructive pulmonary disease. Eur Respir J Suppl (2003) 1.28
STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells. Mol Cell Biol Res Commun (2000) 1.24
Relative contributions of human types 1 and 2 T-helper cell-derived eosinophilotrophic cytokines to development of eosinophilia. Blood (1993) 1.17
Platelet and fibrin deposition at the damaged vessel wall: cooperative substrates for neutrophil adhesion under flow conditions. Blood (1997) 1.17
Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. Biochem J (1998) 1.17
Systemic inflammation in COPD visualised by gene profiling in peripheral blood neutrophils. Thorax (2005) 1.16
RANTES- and interleukin-8-induced responses in normal human eosinophils: effects of priming with interleukin-5. Blood (1994) 1.11
Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3. Blood (1991) 1.11
Differential activation of human basophils by anti-IgE and formyl-methionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways. Eur J Immunol (1991) 1.10
Regulation of p21rac activation in human neutrophils. Blood (1999) 1.09
Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. J Allergy Clin Immunol (1993) 1.06
Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family. Cytokine Growth Factor Rev (2001) 1.06
Activation of the STAT3/acute phase response factor transcription factor by interleukin-5. J Biol Chem (1995) 1.05
Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science (2001) 1.04
Continuous cell activation is necessary for stable interaction of complement receptor type 3 with its counter-structure in the aggregation response of human neutrophils. Eur J Immunol (1990) 1.03
Activation of the small GTPase rap1 in human neutrophils. Blood (1998) 1.01
Eosinophils do respond to fMLP. Blood (1987) 1.01
Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation. Arterioscler Thromb Vasc Biol (2003) 1.00
Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5. Blood (1998) 0.99
In vivo priming of platelet-activating factor-induced eosinophil chemotaxis in allergic asthmatic individuals. Blood (1992) 0.98
The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils. Injury (2007) 0.98
Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics. Am J Respir Crit Care Med (1994) 0.98
Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. Oncogene (1995) 0.98
Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor. Oncogene (1999) 0.98
Neutrophil adhesion to fibrinogen and fibrin under flow conditions is diminished by activation and L-selectin shedding. Blood (1997) 0.97
Mechanisms involved in eosinophil migration. Platelet-activating factor-induced chemotaxis and interleukin-5-induced chemokinesis are mediated by different signals. J Leukoc Biol (1996) 0.95
Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases. J Biol Chem (1997) 0.94
Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils. J Leukoc Biol (1999) 0.94
Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett (1999) 0.94
Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor. Oncogene (1999) 0.93
NADPH:O2 oxidoreductase of human eosinophils in the cell-free system. FEBS Lett (1990) 0.93
Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha. Blood (1995) 0.91
Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1β synthesis by human neutrophils. Eur Respir J (2010) 0.90
Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. Pharmacol Res Commun (1986) 0.90
Cytokine-mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members. FEBS Lett (2000) 0.89
Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood (2000) 0.89
Cytokine priming of the respiratory burst in human eosinophils is Ca2+ independent and accompanied by induction of tyrosine kinase activity. J Leukoc Biol (1993) 0.89
Human platelets secrete chemotactic activity for eosinophils. Blood (1993) 0.88
Platelet-dependent primary hemostasis promotes selectin- and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions. Blood (1996) 0.88
P-selectin and MAC-1 mediate monocyte rolling and adhesion to ECM-bound platelets under flow conditions. J Leukoc Biol (1998) 0.88
Growth hormone induces expression of c-jun and jun B oncogenes and employs a protein kinase C signal transduction pathway for the induction of c-fos oncogene expression. J Mol Endocrinol (1991) 0.88
The role of transcription factor PU.1 in the activity of the intronic enhancer of the eosinophil-derived neurotoxin (RNS2) gene. Blood (1998) 0.88
Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am J Respir Cell Mol Biol (1993) 0.87
Effects of nedocromil sodium on in vitro induced migration, activation, and mediator release from human granulocytes. J Allergy Clin Immunol (1993) 0.87
C/EBP regulates the promoter of the eosinophil-derived neurotoxin/RNS2 gene in human eosinophilic cells. J Leukoc Biol (1999) 0.86
Altered AP-1/ATF complexes in adenovirus-E1-transformed cells due to EIA-dependent induction of ATF3. Oncogene (1996) 0.86
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils. J Immunol (1998) 0.86
Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions. Thromb Haemost (1998) 0.86
Characterization of eosinophil adhesion to TNF-alpha-activated endothelium under flow conditions: alpha 4 integrins mediate initial attachment, and E-selectin mediates rolling. J Immunol (1999) 0.86
Characteristics of hexokinase, pyruvate kinase, and glucose-6-phosphate dehydrogenase during adult and neonatal reticulocyte maturation. Am J Hematol (1985) 0.86
Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils. Blood (1996) 0.86
Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophils. Biochem J (1997) 0.86
Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. J Biol Chem (1999) 0.85
Identification of cytokine-regulated genes in human leukocytes in vivo. J Allergy Clin Immunol (2000) 0.85
Platelet-activating factor (PAF) acts as an intercellular messenger in the changes of cytosolic free Ca2+ in human neutrophils induced by opsonized particles. FEBS Lett (1989) 0.85
Down modulation of L-Selectin expression on eosinophils recovered from bronchoalveolar lavage fluid after allergen provocation. Clin Exp Allergy (1993) 0.85
Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. J Invest Dermatol (1993) 0.84
NF-kappa B/Rel family members regulating the ICAM-1 promoter in monocytic THP-1 cells. Immunobiology (1997) 0.84
Biomarkers of therapy responsiveness in asthma: pitfalls and promises. Clin Exp Allergy (2011) 0.83
Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells. FEBS Lett (1999) 0.83
Granulocyte signal transduction and priming: cause without effect? Immunol Lett (1997) 0.83
A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor beta c gene. J Immunol (1999) 0.83
Signal transduction in eosinophils. Clin Exp Allergy (1996) 0.83
Differential mechanisms in the stimulus-secretion coupling in human basophils: evidence for a protein-kinase-C-dependent and a protein-kinase-C-independent route. Agents Actions (1990) 0.83
Activation of a functionally distinct 80-kDa STAT5 isoform by IL-5 and GM-CSF in human eosinophils and neutrophils. Mol Cell Biol Res Commun (1999) 0.83
Epidermal growth factor-induced cell rounding is sensitive to simulated microgravity. Aviat Space Environ Med (1991) 0.82
Phosphorylation of nuclear protein is an early event in TGF beta 1 action. Biochem Biophys Res Commun (1991) 0.82
Epidermal growth factor and bombesin differ strikingly in the induction of early responses in Swiss 3T3 cells. J Cell Physiol (1990) 0.82
Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. Biochem Biophys Res Commun (1988) 0.82
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction. Oncogene (1997) 0.82
Release of platelet-activating factor is important for the respiratory burst induced in human eosinophils by opsonized particles. Blood (1992) 0.82
Coding sequence of a ferredoxin gene from Anabaena variabilis ATCC 29413. Nucleic Acids Res (1986) 0.82
Acute-phase concentrations of soluble fibrinogen inhibit neutrophil adhesion under flow conditions in vitro through interactions with ICAM-1 and MAC-1 (CD11b/CD18). J Thromb Haemost (2013) 0.81
Cooperation between Fc gamma receptor II and complement receptor type 3 during activation of platelet-activating factor release by cytokine-primed human eosinophils. J Immunol (1994) 0.81
Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge. Clin Exp Allergy (1997) 0.81