| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women.
|
Lancet
|
2009
|
13.51
|
|
2
|
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group.
|
N Engl J Med
|
1997
|
6.23
|
|
3
|
Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group.
|
Lancet
|
2000
|
5.03
|
|
4
|
Vidarabine versus acyclovir therapy in herpes simplex encephalitis.
|
N Engl J Med
|
1986
|
4.37
|
|
5
|
Drug-associated hospital admissions in older medical patients.
|
J Am Geriatr Soc
|
1988
|
2.82
|
|
6
|
Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers.
|
Lancet
|
1975
|
2.61
|
|
7
|
Patient-initiated, twice-daily oral famciclovir for early recurrent genital herpes. A randomized, double-blind multicenter trial. Canadian Famciclovir Study Group.
|
JAMA
|
1996
|
1.89
|
|
8
|
Severe lithium intoxication: management without dialysis and report of a possible teratogenic effect of lithium.
|
Can Med Assoc J
|
1971
|
1.54
|
|
9
|
Distribution and removal of human serum albumin-technetium 99m instilled intranasally.
|
Br J Clin Pharmacol
|
1976
|
1.52
|
|
10
|
Prospects for control of herpes simplex virus disease through immunization.
|
Clin Infect Dis
|
2000
|
1.51
|
|
11
|
Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea.
|
Clin Infect Dis
|
1997
|
1.51
|
|
12
|
Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in women aged 15-25 years with and without serological evidence of previous exposure to HPV-16/18.
|
Int J Cancer
|
2011
|
1.41
|
|
13
|
Intracerebroventricular and intraperitoneal disodium phosphonoacetate treatment of herpes simplex virus type I experimental encephalitis in rats.
|
J Infect Dis
|
1979
|
1.27
|
|
14
|
Influenza immunization: knowledge, attitude and behaviour of health care workers.
|
Can J Infect Control
|
1994
|
1.20
|
|
15
|
Oseltamivir: a clinical and pharmacological perspective.
|
Expert Opin Pharmacother
|
2001
|
1.15
|
|
16
|
Treatment of wounds from animals suspected of carrying neurotropic viruses.
|
Br Med J
|
1975
|
1.14
|
|
17
|
Immunization with a human diploid cell strain of rabies virus vaccine: two-year results.
|
J Infect Dis
|
1978
|
1.09
|
|
18
|
Amantadine kinetics in healthy young subjects after long-term dosing.
|
Clin Pharmacol Ther
|
1979
|
1.08
|
|
19
|
Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.
|
Antimicrob Agents Chemother
|
1985
|
1.04
|
|
20
|
Human diploid cell strain rabies vaccine. Rapid prophylactic immunisation of volunteers with small doses.
|
Lancet
|
1976
|
1.04
|
|
21
|
Prospective, randomized, comparative trials in the therapy for intraabdominal and female genital tract infections.
|
Rev Infect Dis
|
1984
|
1.04
|
|
22
|
Remission of progressive multifocal leukoencephalopathy following splenectomy and antiretroviral therapy in a patient with HIV infection.
|
N Engl J Med
|
1997
|
1.04
|
|
23
|
Lithium intoxication.
|
Can Med Assoc J
|
1972
|
1.02
|
|
24
|
An outbreak of methicillin resistant Staphylococcus aureus on a burn unit: potential role of contaminated hydrotherapy equipment.
|
Burns
|
2001
|
1.00
|
|
25
|
Determinants of rifabutin-associated uveitis in patients treated with rifabutin, clarithromycin, and ethambutol for Mycobacterium avium complex bacteremia: a multivariate analysis. Canadian HIV Trials Network Protocol 010 Study Group.
|
J Infect Dis
|
1998
|
0.98
|
|
26
|
Amantadine kinetics in healthy elderly men: implications for influenza prevention.
|
Clin Pharmacol Ther
|
1985
|
0.92
|
|
27
|
Randomized, double-blind, placebo-controlled, clinic-initiated, Canadian multicenter trial of topical edoxudine 3.0% cream in the treatment of recurrent genital herpes. Canadian Cooperative Study Group.
|
J Infect Dis
|
1991
|
0.91
|
|
28
|
Naturally acquired serum rabies neutralizing antibody in a Canadian Inuit population.
|
Arctic Med Res
|
1988
|
0.90
|
|
29
|
Clinical course of recurrent genital herpes and treatment with foscarnet cream: results of a Canadian multicenter trial.
|
J Infect Dis
|
1987
|
0.90
|
|
30
|
Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine.
|
Clin Pharmacol Ther
|
1993
|
0.90
|
|
31
|
Aging and heavy drug use: a prescription survey in Manitoba.
|
J Chronic Dis
|
1983
|
0.90
|
|
32
|
Evaluation of a human diploid cell strain rabies vaccine: final report of a three year study of pre-exposure immunization.
|
J Hyg (Lond)
|
1982
|
0.90
|
|
33
|
Comparative bioavailability of acyclovir from oral valacyclovir and acyclovir in patients treated for recurrent genital herpes simplex virus infection.
|
Can J Clin Pharmacol
|
2001
|
0.84
|
|
34
|
Vitamin A and risk of HIV-1 seroconversion among Kenyan men with genital ulcers.
|
AIDS
|
2001
|
0.84
|
|
35
|
Potential of influenza vaccine and amantadine to prevent influenza A illness in Canadian forces personnel 1980-1983.
|
Mil Med
|
1986
|
0.83
|
|
36
|
Prescribing patterns for older heavy drug users living in the community.
|
DICP
|
1991
|
0.82
|
|
37
|
Prophylactic amantadine dose and plasma concentration-effect relationships in healthy adults.
|
Clin Pharmacol Ther
|
1985
|
0.82
|
|
38
|
Human diploid-cell-culture vaccine for rabies prophylaxis.
|
Can Med Assoc J
|
1979
|
0.82
|
|
39
|
Double-blind trial of perioperative intravenous metronidazole prophylaxis for abdominal and vaginal hysterectomy.
|
Surgery
|
1983
|
0.81
|
|
40
|
Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis.
|
Infection
|
1987
|
0.81
|
|
41
|
Frequency of changing enteral alimentation bags and tubing, and adverse clinical outcomes in patients in a long term care facility.
|
Can J Infect Control
|
1993
|
0.81
|
|
42
|
A placebo-controlled dose-finding study with bambuterol in elderly patients with asthma.
|
Chest
|
1993
|
0.80
|
|
43
|
Efficacy and safety of foscarnet for recurrent orolabial herpes: a multicentre randomized double-blind study.
|
CMAJ
|
1988
|
0.80
|
|
44
|
Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects.
|
Br J Clin Pharmacol
|
1995
|
0.78
|
|
45
|
Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2.
|
Can J Physiol Pharmacol
|
1999
|
0.78
|
|
46
|
Pseudomonas folliculitis in a resort whirlpool.
|
Can Med Assoc J
|
1982
|
0.78
|
|
47
|
Efficacy and safety of famciclovir for treating mucocutaneous herpes simplex infection in HIV-infected individuals. Collaborative Famciclovir HIV Study Group.
|
AIDS
|
2000
|
0.78
|
|
48
|
Respiratory failure in a man with bone and lung lesions.
|
Hosp Pract (1995)
|
1998
|
0.77
|
|
49
|
Neonatal herpes simplex virus infection in Manitoba, 1980 to 1986, and implications for preventive strategies.
|
Pediatr Infect Dis J
|
1988
|
0.77
|
|
50
|
Immunologic studies in subjects with a serum sickness-like illness after immunization with human diploid cell rabies vaccine.
|
J Allergy Clin Immunol
|
1987
|
0.77
|
|
51
|
Topical undecylenic acid for herpes simplex labialis: a multicenter, placebo-controlled trial.
|
J Infect Dis
|
1997
|
0.76
|
|
52
|
Stress-induced reactivation of latent herpes simplex virus infection in rat lumbar dorsal root ganglia.
|
J Psychosom Res
|
1993
|
0.76
|
|
53
|
Dermacase. Herpes simplex virus.
|
Can Fam Physician
|
2001
|
0.75
|
|
54
|
Fatal diphtheria in an older woman.
|
Can Med Assoc J
|
1985
|
0.75
|
|
55
|
Use of antiviral prophylaxis in influenza outbreaks in long term care facilities.
|
Can J Infect Dis
|
2000
|
0.75
|
|
56
|
Double-blind trial of perioperative intravenous metronidazole prophylaxis for abdominal hysterectomy.
|
Can Med Assoc J
|
1982
|
0.75
|
|
57
|
Enprofylline disposition in the presence and absence of amoxycillin or erythromycin.
|
Br J Clin Pharmacol
|
1987
|
0.75
|
|
58
|
Partial characterization of alpha 1-acid glycoprotein isolated from mouse serum.
|
Comp Biochem Physiol B
|
1987
|
0.75
|
|
59
|
Pharmacokinetic disposition of loracarbef in healthy young men and women at steady state.
|
J Clin Pharmacol
|
1994
|
0.75
|
|
60
|
Effect of a polynucleotide interferon inducer of fungal origin on experimental rhinovirus infection in humans.
|
J Infect Dis
|
1978
|
0.75
|
|
61
|
Pharmacokinetics and pharmacodynamics of bambuterol, a long-acting bronchodilator pro-drug of terbutaline, in young and elderly patients with asthma.
|
Clin Pharmacol Ther
|
1992
|
0.75
|
|
62
|
Effect of acute experimental influenza A virus pneumonia on concentration of alpha 1-acid glycoprotein in mouse serum.
|
Inflammation
|
1989
|
0.75
|
|
63
|
Amantadine prophylaxis during an institutional outbreak of type A influenza.
|
Arch Intern Med
|
1987
|
0.75
|
|
64
|
Rabies vaccines.
|
Nurs Times
|
1976
|
0.75
|
|
65
|
Slow release theophylline disposition and effect in elderly patients with chronic obstructive lung disease: influence of dose formulation and institutionalization.
|
Biopharm Drug Dispos
|
1989
|
0.75
|
|
66
|
Nadolol antihypertensive effect and disposition in young and elderly adults with mild to moderate essential hypertension.
|
Clin Pharmacol Ther
|
1989
|
0.75
|
|
67
|
Percutaneous feeding tube changes in long-term-care facility patients.
|
Infect Control Hosp Epidemiol
|
1996
|
0.75
|
|
68
|
Characterization of acute and latent herpes simplex virus infection of dorsal root ganglia in rats.
|
Lab Anim
|
1991
|
0.75
|
|
69
|
Immunohistological characterisation of acute herpes simplex virus infection of lumbar dorsal root ganglia in the rat.
|
J Med Microbiol
|
1993
|
0.75
|
|
70
|
In vitro reactivation of latent herpes simplex virus by the demethylating compound hexamethylene-bis-acetamide.
|
J Virol Methods
|
1992
|
0.75
|
|
71
|
Long-term captopril in young and old patients with mild hypertension.
|
J Clin Pharmacol
|
1991
|
0.75
|