Published in Neuroreport on June 26, 2000
Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nat Commun (2015) 1.57
Neural circuitry of stress-induced insomnia in rats. J Neurosci (2008) 1.32
Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats. Psychopharmacology (Berl) (2010) 1.14
Role of orexin/hypocretin in dependence and addiction. Brain Res (2009) 1.12
Orexin, stress, and anxiety/panic states. Prog Brain Res (2012) 1.11
Tobacco addiction and the dysregulation of brain stress systems. Neurosci Biobehav Rev (2012) 1.09
A major role for perifornical orexin neurons in the control of glucose metabolism in rats. Diabetes (2009) 1.08
Hypocretin/orexin in arousal and stress. Brain Res (2009) 1.03
Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci (2013) 1.01
Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. Endocrinology (2011) 1.00
A neuropeptide-centric view of psychostimulant addiction. Br J Pharmacol (2008) 0.97
Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior. Physiol Behav (2013) 0.91
Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamus. J Physiol (2002) 0.89
Hypocretins and the neurobiology of sleep-wake mechanisms. Prog Brain Res (2012) 0.87
Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal. PLoS One (2012) 0.87
Hypocretin (orexin) neuromodulation of stress and reward pathways. Curr Opin Neurobiol (2014) 0.87
The hypocretin/orexin system. J R Soc Med (2002) 0.84
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship. Front Behav Neurosci (2012) 0.83
The role of the glucocorticoids in developing resilience to stress and addiction. Front Psychiatry (2013) 0.82
Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiol Rev (2017) 0.81
The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area. Neurosci Lett (2011) 0.81
Fos expression in arousal and reward areas of the brain in grass rats following induced wakefulness. Physiol Behav (2011) 0.81
Effects of rapid eye movement sleep deprivation on hypocretin neurons in the hypothalamus of a rat model of depression. Neuropeptides (2007) 0.80
State-dependent control of lumbar motoneurons by the hypocretinergic system. Exp Neurol (2009) 0.80
Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats. Front Behav Neurosci (2014) 0.80
Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans. Psychopharmacology (Berl) (2014) 0.79
Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats. J Gastroenterol (2011) 0.79
Circadian rhythm disruption by a novel running wheel: roles of exercise and arousal in blockade of the luteinizing hormone surge. Physiol Behav (2014) 0.79
The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress. Physiol Behav (2012) 0.79
Expression patterns of corticotropin-releasing factor, arginine vasopressin, histidine decarboxylase, melanin-concentrating hormone, and orexin genes in the human hypothalamus. J Comp Neurol (2010) 0.79
The role of the lateral hypothalamus and orexin in ingestive behavior: a model for the translation of past experience and sensed deficits into motivated behaviors. Front Syst Neurosci (2014) 0.78
Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis. Front Neural Circuits (2016) 0.78
Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states. Front Syst Neurosci (2015) 0.77
Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference. Front Behav Neurosci (2013) 0.77
Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy. Front Behav Neurosci (2013) 0.77
Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance. Horm Behav (2010) 0.77
The Role of Orexin Signaling in the Ventral Tegmental Area and Central Amygdala in Modulating Binge-like Ethanol Drinking Behavior. Alcohol Clin Exp Res (2017) 0.76
Orexin expression in different prostate histopathologic examinations: Can it be a marker for prostate cancer? A preliminary result. Turk J Urol (2013) 0.75
The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). PLoS One (2014) 0.75
Peripherally administered orexin improves survival of mice with endotoxin shock. Elife (2016) 0.75
Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats. J Gastroenterol (2007) 0.75
Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control. Front Neurosci (2017) 0.75
Antistress effects of Kampo medicine "Yokukansan" via regulation of orexin secretion. Neuropsychiatr Dis Treat (2017) 0.75
Neuroendocrine, Autonomic, and Metabolic Responses to an Orexin Antagonist, Suvorexant, in Psychiatric Patients with Insomnia. Innov Clin Neurosci (2017) 0.75
Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (1999) 17.72
Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01
Bilirubin is an antioxidant of possible physiological importance. Science (1987) 11.26
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature (1997) 6.73
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (1998) 6.69
Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest (1998) 4.94
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology (2000) 4.27
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc Natl Acad Sci U S A (1997) 3.53
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49
Purification and properties of an enzyme, zymolyase, which lyses viable yeast cells. Arch Biochem Biophys (1972) 3.12
Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94
Laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor dissection. Surg Endosc (2007) 2.77
cDNA cloning, sequence, and expression of carbonic anhydrase in Chlamydomonas reinhardtii: regulation by environmental CO2 concentration. Proc Natl Acad Sci U S A (1990) 2.71
Comparison of the uptake of nitrate and ammonium by rice seedlings: influences of light, temperature, oxygen concentration, exogenous sucrose, and metabolic inhibitors. Plant Physiol (1978) 2.50
High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan. Gut (1999) 2.46
Combination therapy with fluconazole and flucytosine for cryptococcal meningitis in Ugandan patients with AIDS. Clin Infect Dis (1998) 2.40
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. J Thromb Haemost (2006) 2.40
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A (1999) 2.39
Cerebral arteriovenous malformations: factors influencing the surgical difficulty and outcome. Neurosurgery (1991) 2.36
A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature (1990) 2.29
Amnestic people with Alzheimer's disease who remembered the Kobe earthquake. Br J Psychiatry (1998) 2.26
Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain. Nature (1995) 2.20
Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc Natl Acad Sci U S A (1995) 2.19
Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type). Biochem Biophys Res Commun (1983) 2.16
Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun (2001) 2.13
Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. J Physiol (2000) 2.11
Comparative evaluation of 99mTc-MIBI and 99mTc-HMDP scintimammography for the diagnosis of breast cancer and its axillary metastases. Eur J Nucl Med (2001) 2.09
Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity. Int J Tuberc Lung Dis (2000) 2.07
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell (1998) 2.07
A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J Bacteriol (1983) 2.06
Subcutaneous release of trigger thumb and fingers in 210 fingers. J Hand Surg Br (1990) 2.05
Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci U S A (1988) 2.04
Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut (2005) 2.02
Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjögren's syndrome. Gastroenterology (1996) 2.01
Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma. Ann Allergy Asthma Immunol (2000) 1.99
Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. Am J Physiol (1991) 1.98
Escherichia coli gene that controls sensitivity to alkylating agents. J Bacteriol (1978) 1.96
Electrical properties of the epidermal stratum corneum. Med Biol Eng (1976) 1.94
Comparison of unitary displacements and forces between 2 cardiac myosin isoforms by the optical trap technique: molecular basis for cardiac adaptation. Circ Res (1998) 1.94
Inhibition of macrophage migration by muramyl peptides. Infect Immun (1979) 1.91
Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. J Bacteriol (1991) 1.91
Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol (2000) 1.89
Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis (1997) 1.87
Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation (2001) 1.86
Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium. Am J Ophthalmol (1988) 1.81
Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.79
Structure of the gene encoding beta-1,3-glucanase A1 of Bacillus circulans WL-12. Gene (1990) 1.79
Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Neurology (2005) 1.78
Cloning and sequence analysis of the gbpC gene encoding a novel glucan-binding protein of Streptococcus mutans. Infect Immun (1997) 1.75
Daily physical activity levels in preadolescent boys related to VO2max and lactate threshold. Eur J Appl Physiol Occup Physiol (1986) 1.75
Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. J Immunol (2001) 1.74
OPC-41061, a highly potent human vasopressin V2-receptor antagonist: pharmacological profile and aquaretic effect by single and multiple oral dosing in rats. J Pharmacol Exp Ther (1998) 1.74
Phase II study of weekly intravenous and intraperitoneal paclitaxel combined with S-1 for advanced gastric cancer with peritoneal metastasis. Ann Oncol (2009) 1.73
Conformational rigidity of specific pyrimidine residues in tRNA arises from posttranscriptional modifications that enhance steric interaction between the base and the 2'-hydroxyl group. Biochemistry (1992) 1.73
Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma. Anal Biochem (1988) 1.73
Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion. Eye (Lond) (2006) 1.73
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72
Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons. Science (1995) 1.70
Inactivation of the cholinesterase gene by Alu insertion: possible mechanism for human gene transposition. Proc Natl Acad Sci U S A (1991) 1.69
Biochemical and immunological characterization of the DNA binding protein (RBP-J kappa) to mouse J kappa recombination signal sequence. J Biochem (1992) 1.69
UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging Cell (2005) 1.68
Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology (1999) 1.67
Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol (1999) 1.67
Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography. Anal Biochem (1987) 1.67
Risk factors for cerebral hemorrhage and cerebral infarction in a Japanese rural community. Stroke (1982) 1.67
Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium. Proc Natl Acad Sci U S A (2000) 1.67
Recent advances in the transition-metal-catalyzed regioselective approaches to polysubstituted benzene derivatives. Chem Rev (2000) 1.66
Ultrasonographic characteristics of thyroid nodules: prediction of malignancy. Arch Surg (2001) 1.65
Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun (2001) 1.64
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans. J Gen Microbiol (1993) 1.61
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem (2000) 1.61
Retrovirus long terminal repeats activate expression of coding sequences for the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A (1982) 1.61
Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30). Clin Genet (1991) 1.60
Lysis of viable yeast cells by enzymes of Arthrobacter luteus. Arch Biochem Biophys (1971) 1.59
The Drosophila mus101 gene, which links DNA repair, replication and condensation of heterochromatin in mitosis, encodes a protein with seven BRCA1 C-terminus domains. Genetics (2000) 1.58
Molecular analysis of non-syndromic preaxial polydactyly: preaxial polydactyly type-IV and preaxial polydactyly type-I. Clin Genet (2005) 1.58
Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. Infect Immun (1997) 1.57
Odontogenic cyst giving rise to an adenomatoid odontogenic tumor: report of a case with peculiar features. J Oral Maxillofac Surg (1992) 1.56
Voiding dysfunction in patients with human T-lymphotropic virus type-1-associated myelopathy (HAM). Paraplegia (1989) 1.55
Single-mode spontaneous emission from a single quantum dot in a three-dimensional microcavity. Phys Rev Lett (2001) 1.55
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infect Immun (1994) 1.54
Behavioral-independent features of complex heartbeat dynamics. Phys Rev Lett (2001) 1.54
High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocr J (2001) 1.53
Inhibition of macrophage migration by synthetic muramyl dipeptide. Biochem Biophys Res Commun (1978) 1.53
Systematic study of gene expression and transcription organization in the gntZ-ywaA region of the Bacillus subtilis genome. Microbiology (2000) 1.52
A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration. Neurology (1999) 1.52
Suppression of tumor necrosis factor-alpha production and neutrophil infiltration during ischemia-reperfusion injury of the liver after heat shock preconditioning. J Hepatol (2001) 1.50
Phosphorylation-dependent power output of transgenic flies: an integrated study. Biophys J (1997) 1.50
Viability of an Escherichia coli pgsA null mutant lacking detectable phosphatidylglycerol and cardiolipin. J Bacteriol (2000) 1.50
Supernumerary head of biceps brachii and branching pattern of the musculocutaneus nerve in Japanese. Surg Radiol Anat (1992) 1.50
Automatic construction of knowledge base from biological papers. Proc Int Conf Intell Syst Mol Biol (1997) 1.48
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment. Nucleic Acids Res (1989) 1.48
Neuroprotective mechanism of bromocriptine. Lancet (1995) 1.48
Rapid prediction of rifampin susceptibility of Mycobacterium tuberculosis. Am J Respir Crit Care Med (1997) 1.47