Cell adhesion molecules in the normal and cancerous mammary gland.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMID 10887494)

Published in J Mammary Gland Biol Neoplasia on April 01, 1996

Authors

D Alford1, J Taylor-Papadimitriou

Author Affiliations

1: Epithelial Cell Biology Laboratory, Imperial Cancer Research Fund, London, U.K.

Articles citing this

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol (1997) 10.61

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell (2014) 4.44

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13

Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia (1999) 2.77

The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol (1996) 1.88

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol (2004) 1.56

Tissue architecture: the ultimate regulator of epithelial function? Philos Trans R Soc Lond B Biol Sci (1998) 1.40

AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. Mol Biol Cell (2000) 1.30

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J Mammary Gland Biol Neoplasia (1998) 1.30

Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells. J Cell Sci (2003) 1.27

Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle. PLoS One (2012) 1.13

Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones. Endocr Relat Cancer (2000) 1.06

Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro. Proc Natl Acad Sci U S A (2004) 0.88

Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells. Mol Cell Biol (1996) 0.87

Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells. Clin Exp Metastasis (2011) 0.85

Articles by these authors

(truncated to the top 100)

Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein. Proc Natl Acad Sci U S A (1981) 3.99

Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J Cancer (1981) 3.90

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem (1990) 3.70

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J Biol Chem (1988) 3.19

Use of monoclonal antibodies for the histopathological diagnosis of human malignancy. J Clin Pathol (1982) 2.69

Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells. J Immunol (1983) 2.59

Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Lancet (1982) 2.51

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem (1999) 2.09

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res (1987) 1.99

The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM. Nature (1987) 1.88

Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci (1994) 1.85

Effects of SV40 transformation on the cytoskeleton and behavioural properties of human keratinocytes. Cell Differ (1982) 1.81

Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions. Lancet (1982) 1.76

Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. J Biol Chem (1997) 1.72

Monoclonal antibodies in the analysis of fibronectin isoforms generated by alternative splicing of mRNA precursors in normal and transformed human cells. J Cell Biol (1987) 1.68

Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium. Proc Natl Acad Sci U S A (1987) 1.64

Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus. Proc Natl Acad Sci U S A (1991) 1.63

The prognostic significance of two epithelial membrane antigens expressed by human mammary carcinomas. Int J Cancer (1984) 1.61

Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours. Int J Cancer (1985) 1.57

Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. Proc Natl Acad Sci U S A (1994) 1.53

Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth. Nature (1978) 1.52

Growth requirements of human mammary epithelial cells in culture. Int J Cancer (1977) 1.49

Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells. J Biol Chem (1996) 1.48

A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int J Cancer (1989) 1.46

O-linked glycosylation in the mammary gland: changes that occur during malignancy. J Mammary Gland Biol Neoplasia (2001) 1.43

Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res (1991) 1.41

Immunocytochemical staining of cells in pleural and peritoneal effusions with a panel of monoclonal antibodies. J Clin Pathol (1983) 1.41

Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms. Cancer Res (1986) 1.39

Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. J Biol Chem (1998) 1.34

A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes. Int J Cancer (1989) 1.34

Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells. Eur J Biochem (1995) 1.31

Collagen-induced morphogenesis and expression of the alpha 2-integrin subunit is inhibited in c-erbB2-transfected human mammary epithelial cells. Oncogene (1993) 1.29

The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. J Biol Chem (2000) 1.26

Analysis of the tissue-specific promoter of the MUC1 gene. J Biol Chem (1993) 1.25

An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. Glycobiology (1999) 1.23

Structure and biology of a carcinoma-associated mucin, MUC1. Am Rev Respir Dis (1991) 1.23

Production of PDGF-like growth factor by breast cancer cell lines. Int J Cancer (1985) 1.23

Detection of the tumour-associated antigens recognized by the monoclonal antibodies HMFG-1 and 2 in serum from patients with breast cancer. Int J Cancer (1984) 1.23

Response to epidermal growth factors of cultured human mammary epithelial cells from benign tumours. Nature (1977) 1.21

Establishment and characterization of SV40-transformed human breast epithelial cell lines. Cancer Res (1982) 1.20

Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals. Biochem Biophys Res Commun (1992) 1.18

Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells. J Cell Physiol (1980) 1.17

The prognostic value of the monoclonal antibodies HMFG1 and HMFG2 in breast cancer. Br J Cancer (1985) 1.17

Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. Immunology (1999) 1.16

The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. J Biol Chem (2000) 1.15

Differential expression of keratin 19 in normal human epithelial tissues revealed by monospecific monoclonal antibodies. Histochem J (1986) 1.15

A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins. J Cell Sci (1985) 1.13

Effect of modification of carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product. Epithelial Cell Biol (1993) 1.13

Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit. Biochem Biophys Res Commun (1990) 1.10

Keratin 19 expression in the adult and developing human mammary gland. Histochem J (1990) 1.09

The differential diagnosis of routinely processed anaplastic tumors using monoclonal antibodies. Am J Clin Pathol (1984) 1.09

Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res (1992) 1.07

bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells. J Cell Biol (1995) 1.06

Differential effect of interferon on DNA synthesis, 2-deoxyglucose uptake and ornithine decarboxylase activity in 3T3 cells stimulated by polypeptide growth factors and tumor promotors. J Cell Physiol (1980) 1.06

On cysteine and cystine peptides. V. S-trityl and S-diphenylmethyl-cysteine and -cysteine peptides. J Chem Soc Perkin 1 (1970) 1.04

The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells. J Biol Chem (1996) 1.04

A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer. Br J Cancer (1996) 1.03

The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine. Cancer Immunol Immunother (1996) 1.02

Biology and natural history of breast cancer. Int J Cancer Suppl (1990) 1.00

Some properties of cells cultured from early-lactation human milk. J Natl Cancer Inst (1977) 0.99

Primary human breast carcinomas transplantable in the nude mouse. J Natl Cancer Inst (1979) 0.99

Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells. Int J Cancer (1987) 0.98

The product of the human MUC1 gene when secreted by mouse cells transfected with the full-length cDNA lacks the cytoplasmic tail. Biochem Biophys Res Commun (1992) 0.98

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model. Br J Cancer (2009) 0.98

Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter. J Biol Chem (1996) 0.98

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels. J Cell Sci (1998) 0.98

Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition. J Mol Biol (1998) 0.97

Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. Int J Cancer (1978) 0.95

Identification of three non-VNTR MUC1-derived HLA-A*0201-restricted T-cell epitopes that induce protective anti-tumor immunity in HLA-A2/K(b)-transgenic mice. Int J Cancer (2001) 0.95

Modulation of phenotype in cultures of human milk epithelial cells and its relation to the expression of a membrane antigen. Cell Differ (1983) 0.95

The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24. Ann Hum Genet (1987) 0.94

Collagen-induced rapid morphogenesis of human mammary epithelial cells: the role of the alpha 2 beta 1 integrin. J Cell Sci (1992) 0.94

Selective contact-dependent cell communication. Nature (1977) 0.94

The value of immunohistochemical markers in the diagnosis of cervical neoplasia. Br J Obstet Gynaecol (1984) 0.93

Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer. Br J Cancer (2013) 0.92

Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice. Eur J Cancer (1980) 0.92

Monoclonal antibodies that distinguish between human cellular and plasma fibronectin. Mol Biol Med (1984) 0.91

Inhibitory effect of interferon on cellular DNA synthesis: modulation by pure mitogenic factors. J Interferon Res (1981) 0.90

Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells. J Cell Sci (1987) 0.90

Selective inhibition by interferon of serum-stimulated biochemical events in 3T3 cells. Biochem Biophys Res Commun (1979) 0.90

Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells. Eur J Cancer Clin Oncol (1986) 0.90

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity. J Biol Chem (1991) 0.89

A transfected sialyltransferase that is elevated in breast cancer and localizes to the medial/trans-Golgi apparatus inhibits the development of core-2-based O-glycans. J Cell Biol (1997) 0.89

Ovarian cancer: diagnosis using 123I monoclonal antibody in comparison with surgical findings. Nucl Med Commun (1984) 0.89

Morphogenetic and proliferative responses to heregulin of mammary epithelial cells in vitro are dependent on HER2 and HER3 and differ from the responses to HER2 homodimerisation or hepatocyte growth factor. Int J Oncol (2000) 0.88

Immunity to murine breast cancer cells modified to express MUC-1, a human breast cancer antigen, in transgenic mice tolerant to human MUC-1. Cancer Res (2000) 0.88

Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free medium. J Biotechnol (2004) 0.88

Morphological differentiation of hybrids of human mammary epithelial cell lines is dominant and correlates with the pattern of expression of intermediate filaments. Exp Cell Res (1991) 0.88

Monoclonal antibodies to epithelial membrane antigen and human milk fat globule mucin define epitopes expressed on other molecules. Lancet (1985) 0.88

Carbohydrate recognition on MUC1-expressing targets enhances cytotoxicity of a T cell subpopulation. Scand J Immunol (1997) 0.87

Studies of clonal cell lines developed from primary breast cancers indicate that the ability to undergo morphogenesis in vitro is lost early in malignancy. Int J Cancer (1992) 0.87

Effect of interferon on some aspects of transformation by polyoma virus. Nat New Biol (1971) 0.87

Radioimmunodiagnosis of ovarian cancer using 123I-labelled, tumor-associated monoclonal antibodies. Cancer Detect Prev (1984) 0.87

Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells. Mol Cell Biol (1996) 0.87

Mouse ST6Gal sialyltransferase gene expression during mammary gland lactation. Glycobiology (2001) 0.87

Monoclonal antibodies that distinguish between subspecies of human interferon-alpha and that detect interferon oligomers. J Immunol (1984) 0.87

An immunohistological study of benign and malignant skin tumours: epithelial aspects. Histopathology (1984) 0.87

Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. Cancer Immunol Immunother (1993) 0.87

Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells. Int J Cancer (1996) 0.86

Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies. Br J Obstet Gynaecol (1983) 0.86