Published in Invest Ophthalmol Vis Sci on July 01, 2000
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol (2007) 3.86
The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci U S A (2002) 2.18
The bisretinoids of retinal pigment epithelium. Prog Retin Eye Res (2011) 2.02
Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation. Invest Ophthalmol Vis Sci (2008) 1.96
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci (2011) 1.78
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci U S A (2004) 1.74
Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res (2009) 1.69
The susceptibility of the retina to photochemical damage from visible light. Prog Retin Eye Res (2011) 1.67
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem (2008) 1.61
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem (2008) 1.51
Retinal pigment epithelium lipofuscin proteomics. Mol Cell Proteomics (2008) 1.50
[Vitamins and trace elements in age-related macular degeneration. Current recommendations, based on the results of the AREDS study]. Ophthalmologe (2002) 1.43
How much blue light should an IOL transmit? Br J Ophthalmol (2003) 1.41
ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Invest Ophthalmol Vis Sci (2005) 1.40
Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease. Invest Ophthalmol Vis Sci (2011) 1.37
Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration. Br J Ophthalmol (2005) 1.27
Spectroscopic and morphological studies of human retinal lipofuscin granules. Proc Natl Acad Sci U S A (2003) 1.23
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS One (2013) 1.22
Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci (2013) 1.22
Age and disease-related structural changes in the retinal pigment epithelium. Clin Ophthalmol (2008) 1.19
Keypathophysiologic pathways in age-related macular disease. Graefes Arch Clin Exp Ophthalmol (2004) 1.13
A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration. Hum Mol Genet (2011) 1.09
Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol (2005) 1.05
Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. Mol Aspects Med (2012) 1.03
Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci (2010) 1.02
A2E accumulation influences retinal microglial activation and complement regulation. Neurobiol Aging (2012) 1.01
Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids. Trans Am Ophthalmol Soc (2002) 0.95
Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A (2010) 0.95
Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology. Invest Ophthalmol Vis Sci (2013) 0.94
Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. Elife (2016) 0.93
Retinal phototoxicity in a novel murine model of intraocular lens implantation. Mol Vis (2009) 0.92
Accumulation of A2-E in mitochondrial membranes of cultured RPE cells. Graefes Arch Clin Exp Ophthalmol (2006) 0.88
Why study rod cell death in retinal degenerations and how? Doc Ophthalmol (2003) 0.88
Ageing of the retinal pigment epithelium: implications for transplantation. Graefes Arch Clin Exp Ophthalmol (2003) 0.87
Studying melanin and lipofuscin in RPE cell culture models. Exp Eye Res (2014) 0.86
Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light. Apoptosis (2009) 0.86
Light damage in Abca4 and Rpe65rd12 mice. Invest Ophthalmol Vis Sci (2014) 0.84
Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype. J Biol Chem (2014) 0.84
Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions. PLoS One (2013) 0.83
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage. J Mol Med (Berl) (2015) 0.83
AcrySof Natural filter decreases blue light-induced apoptosis in human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol (2008) 0.82
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci U S A (2014) 0.82
Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem (2015) 0.81
Widespread choroidal thickening and abnormal midperipheral fundus autofluorescence characterize exudative age-related macular degeneration with choroidal vascular hyperpermeability. Clin Ophthalmol (2015) 0.81
Metabolic constraints on the recovery of sensitivity after visual pigment bleaching in retinal rods. J Gen Physiol (2009) 0.80
Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells. Acta Ophthalmol (2013) 0.80
Macular pigment density at the site of altered fundus autofluorescence. Graefes Arch Clin Exp Ophthalmol (2010) 0.79
Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 0.79
[RPE transplantation: the challenges and the future]. Ophthalmologe (2004) 0.78
Role of autofluorescence in inflammatory/infective diseases of the retina and choroid. J Ophthalmol (2014) 0.78
Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage. J Biol Chem (2015) 0.78
[cSLO digital fundus autofluorescence imaging]. Ophthalmologe (2005) 0.77
Photic injury to cultured RPE varies among individual cells in proportion to their endogenous lipofuscin content as modulated by their melanosome content. Invest Ophthalmol Vis Sci (2014) 0.76
Light filtering in a retinal pigment epithelial cell culture model. Optom Vis Sci (2011) 0.76
Anthocyanin can arrest the cone photoreceptor degeneration and act as a novel treatment for retinitis pigmentosa. Int J Ophthalmol (2016) 0.76
Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT. Graefes Arch Clin Exp Ophthalmol (2015) 0.75
Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo. PLoS One (2016) 0.75
Fundus autofluorescence applications in retinal imaging. Indian J Ophthalmol (2015) 0.75
Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. Proc Natl Acad Sci U S A (2017) 0.75
The Minnesota Grading System using fundus autofluorescence of eye bank eyes: a correlation to age-related macular degeneration (an AOS thesis). Trans Am Ophthalmol Soc (2008) 0.75
The Barthel ADL Index: a reliability study. Int Disabil Stud (1988) 9.20
Parental monitoring: association with adolescents' risk behaviors. Pediatrics (2001) 4.15
Suicide within 12 months of contact with mental health services: national clinical survey. BMJ (1999) 3.61
Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med (1999) 3.49
Using telemedicine for termination of pregnancy with mifepristone and misoprostol in settings where there is no access to safe services. BJOG (2008) 3.40
Oxidative damage and age-related macular degeneration. Mol Vis (1999) 2.97
Retracted Enterocolitis in children with developmental disorders. Am J Gastroenterol (2000) 2.70
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res (1999) 2.69
Use of free-access minerals. Vet Rec (1992) 2.65
Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials. Br J Ophthalmol (2009) 2.60
A prospective study of psychological distress and sexual risk behavior among black adolescent females. Pediatrics (2001) 2.48
Failure of regional blockade for caesarean section. Int J Obstet Anesth (2002) 2.17
Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci (1999) 2.12
Long-term mortality after first psychiatric admission. Br J Psychiatry (1997) 2.06
Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab. Eye (Lond) (2011) 2.05
Mutations in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) and adult vitelliform macular dystrophy but not age-related macular degeneration. Eur J Hum Genet (2000) 2.02
Depression, suicide, and the national service framework. BMJ (2001) 2.02
Intravitreal bevacizumab for choroidal neovascularisation associated with pseudoxanthoma elasticum. Br J Ophthalmol (2008) 1.97
Macular full-thickness and lamellar holes in association with type 2 idiopathic macular telangiectasia. Eye (Lond) (2008) 1.96
Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2004) 1.86
Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus. Gut (2006) 1.78
Ethnic differences in satisfaction with mental health services among representative people with psychosis in south London: PRiSM study 4. Br J Psychiatry (1997) 1.78
Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species. J Biol Chem (1995) 1.74
Mental disorder and clinical care in people convicted of homicide: national clinical survey. BMJ (1999) 1.71
Purification and properties of L(+)-lactate dehydrogenase from potato tubers. Biochem J (1972) 1.70
Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci (2001) 1.70
Cost effectiveness of an outpatient multidisciplinary pulmonary rehabilitation programme. Thorax (2001) 1.67
Identification and characterization of a two-component sensor-kinase and response-regulator system (DcuS-DcuR) controlling gene expression in response to C4-dicarboxylates in Escherichia coli. J Bacteriol (1999) 1.64
Bioterrorism preparedness and response: use of information technologies and decision support systems. Evid Rep Technol Assess (Summ) (2002) 1.61
[Bilateral acute syphilitic posterior placoid chorioretinopathy--angiographic and autofluorescence characteristics]. Ophthalmologe (1999) 1.59
Cognitive-behavioral group therapy versus phenelzine in social phobia: long-term outcome. Depress Anxiety (1999) 1.59
[Anti-VEGF therapy of neovascular age-related macular degeneration: therapeutic strategies status December 2012]. Klin Monbl Augenheilkd (2013) 1.58
Reminiscence therapy for dementia. Cochrane Database Syst Rev (2005) 1.57
Tools for monitoring the effectiveness of district maternity referral systems. Health Policy Plan (2001) 1.54
Koch's or Crohn's--or something else? Int J Clin Pract (1997) 1.54
Single night studies in obstructive sleep apnea. Sleep (1991) 1.52
Genetic alterations in 'normal' luminal and myoepithelial cells of the breast. J Pathol (1999) 1.50
Accuracy of hepatocellular carcinoma detection on multidetector CT in a transplant liver population with explant liver correlation. Clin Radiol (2011) 1.50
Comparison of liver transplantation outcomes from adult split liver and circulatory death donors. Br J Surg (2012) 1.49
Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis Cartilage (2008) 1.49
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J (2004) 1.48
Fatal acute fulminant liver failure due to clozapine: a case report and review of clozapine-induced hepatotoxicity. Gastroenterology (1997) 1.44
[Vitamins and trace elements in age-related macular degeneration. Current recommendations, based on the results of the AREDS study]. Ophthalmologe (2002) 1.43
Analysis of rewarming curves in Raynaud's phenomenon of various aetiologies. J Hand Surg Eur Vol (2009) 1.43
Congenital joint laxity and dwarfism in calves. Vet Rec (2000) 1.40
[Trends in inpatient treatment in ophthalmology in Germany]. Ophthalmologe (2013) 1.38
Video-assisted structured teaching to improve aseptic technique during neuraxial block. Br J Anaesth (2013) 1.38
Effects of oral zinc supplementation on serum, hair and sweat zinc levels in 7 subjects. Sci Total Environ (1985) 1.38
Eighteen-month follow-up of intravitreal bevacizumab in type 2 idiopathic macular telangiectasia. Br J Ophthalmol (2008) 1.38
Correct condom application among African-American adolescent females: the relationship to perceived self-efficacy and the association to confirmed STDs. J Adolesc Health (2001) 1.34
An immunomagnetic separation method using superparamagnetic (MACS) beads for large-scale purification of human mammary luminal and myoepithelial cells. Epithelial Cell Biol (1994) 1.34
SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. J Med Genet (2009) 1.32
Impact of dermoscopy and short-term sequential digital dermoscopy imaging for the management of pigmented lesions in primary care: a sequential intervention trial. Br J Dermatol (2009) 1.32
In vitro secondary MLR. I. Kinetics of proliferation and specificity of in vitro primed responder cells. J Immunol (1977) 1.29
Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Bone Marrow Transplant (2012) 1.28
Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration. Br J Ophthalmol (2005) 1.27
Preparation of the mammalian organ of Corti for scanning electron microscopy. J Microsc (1987) 1.27
Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. J Med Genet (1998) 1.27
Impaired functional capacity is associated with all-cause mortality after major elective intra-abdominal surgery. Br J Anaesth (2010) 1.25
Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient. Bone Marrow Transplant (2004) 1.21
Comparison of peak flow gauge and peak flow meter. Thorax (1975) 1.21
Massive proliferation of lens epithelial remnants after Nd-YAG laser capsulotomy. Br J Ophthalmol (1995) 1.20
[Intravitreal bevacizumab for neovascular age-related macular degeneration]. Ophthalmologe (2006) 1.20
[Bevacizumab for treatment of macular edema secondary to retinal vein occlusion]. Ophthalmologe (2006) 1.19
Phenelzine vs atenolol in social phobia. A placebo-controlled comparison. Arch Gen Psychiatry (1992) 1.19
Buying 'legal' recreational drugs does not mean that you are not breaking the law. QJM (2010) 1.19
Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br J Cancer (2004) 1.17
Management of sickle cell disease. Postgrad Med J (1987) 1.17
Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients. J Med Genet (1999) 1.16
Multispecies coexistence of trees in tropical forests: spatial signals of topographic niche differentiation increase with environmental heterogeneity. Proc Biol Sci (2013) 1.15
Discrete arcs of increased fundus autofluorescence in retinal dystrophies and functional correlate on microperimetry. Eye (Lond) (2008) 1.14
Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie (2004) 1.13
A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization. Exp Eye Res (1996) 1.13
Modelling the natural history of geographic atrophy in patients with age-related macular degeneration. Ophthalmic Epidemiol (2005) 1.11
Defining and labelling 'healthy' and 'unhealthy' food. Public Health Nutr (2008) 1.11
A comparison of 'abruptly stopping' with 'tailing off' oral corticosteroids in acute asthma. Respir Med (1995) 1.10
Diurnal variations in human corneal thickness. Br J Ophthalmol (1996) 1.10
Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells. Free Radic Biol Med (2001) 1.10
A controlled family history study of prepubertal major depressive disorder. Arch Gen Psychiatry (1989) 1.09
Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus. Circulation (2000) 1.09
Paragonimiasis in the United States. A report of nine cases in Hmong immigrants. Chest (1982) 1.09
Characterisation of severe rod-cone dystrophy in a consanguineous family with a splice site mutation in the MERTK gene. Br J Ophthalmol (2009) 1.08
Hamstrings vs. patella tendon for anterior cruciate ligament reconstruction: a randomised controlled trial. Knee (2001) 1.08
Improvement in quality of life of children with acute Crohn's disease does not parallel mucosal healing after treatment with exclusive enteral nutrition. Aliment Pharmacol Ther (2004) 1.07
The photoreactivity of the retinal age pigment lipofuscin. J Biol Chem (1999) 1.07
Comparative in-vitro activity of five fluoroquinolones against mycobacteria. J Antimicrob Chemother (1987) 1.07
Perioperative goal-directed haemodynamic treatment and the equity of differing modalities. Br J Anaesth (2013) 1.07
Reality orientation for dementia: a systematic review of the evidence of effectiveness from randomized controlled trials. Gerontologist (2000) 1.07
Multiple mechanisms are implicated in the generation of 5q35 microdeletions in Sotos syndrome. J Med Genet (2005) 1.06
Marrow transplantation from unrelated donors for patients with severe aplastic anemia who have failed immunosuppressive therapy. Biol Blood Marrow Transplant (1999) 1.06
Retinal and choroidal microangiopathies: therapeutic opportunities. Microvasc Res (2007) 1.06
Retinitis pigmentosa: a preliminary report on tissue culture studies of retinal pigment epithelial cells from eight affected human eyes. Exp Eye Res (1983) 1.05
Pharmacokinetics of R 82913 in patients with AIDS or AIDS-related complex. Lancet (1991) 1.05
Three dimensional analysis of microaneurysms in the human diabetic retina. J Anat (1999) 1.03
Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene (2012) 1.03