Published in JAMA on August 16, 2000
Randomized Investigation of Chest Pain Diagnostic Strategies | NCT01035047
Early Risk Stratification in ED Chest Pain Patients | NCT02364271
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Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome. J Am Coll Cardiol (2010) 5.70
Prognostic indices for older adults: a systematic review. JAMA (2012) 5.70
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45
The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov (2008) 2.90
Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation (2010) 2.89
Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis. Lancet (2009) 2.81
Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial. JACC Cardiovasc Imaging (2011) 2.15
New advances in the management of acute coronary syndromes: 1. Matching treatment to risk. CMAJ (2001) 2.12
Safety and efficiency of emergency department assessment of chest discomfort. CMAJ (2004) 2.09
Risk stratification and therapeutic decision making in acute coronary syndromes. JAMA (2000) 1.99
British Cardiac Society Working Group on the definition of myocardial infarction. Heart (2004) 1.97
Was it a heart attack? BMJ (2002) 1.95
A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study. Eur Heart J (2010) 1.90
Chest pain in the emergency room: value of the HEART score. Neth Heart J (2008) 1.83
Predictors of outcome and the lack of effect of percutaneous coronary intervention across the risk strata in patients with persistent total occlusion after myocardial infarction: Results from the OAT (Occluded Artery Trial) study. JACC Cardiovasc Interv (2008) 1.63
Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database. Circ Cardiovasc Qual Outcomes (2015) 1.62
A simple score to predict the outcome of severe malaria in adults. Clin Infect Dis (2010) 1.54
Limitations of risk score models in patients with acute chest pain. Am J Emerg Med (2009) 1.53
Risk score to predict serious bleeding in stable outpatients with or at risk of atherothrombosis. Eur Heart J (2010) 1.53
Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients. Am Heart J (2005) 1.48
Renal outcomes associated with invasive versus conservative management of acute coronary syndrome: propensity matched cohort study. BMJ (2013) 1.46
Use of multidetector computed tomography for the assessment of acute chest pain: a consensus statement of the North American Society of Cardiac Imaging and the European Society of Cardiac Radiology. Int J Cardiovasc Imaging (2007) 1.46
Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients. Pharmacoepidemiol Drug Saf (2008) 1.45
Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute. J Am Soc Echocardiogr (2009) 1.45
Emergency department and office-based evaluation of patients with chest pain. Mayo Clin Proc (2010) 1.44
Dealing with heterogeneity of treatment effects: is the literature up to the challenge? Trials (2009) 1.44
The diagnostic value of clinical symptoms in women and men presenting with chest pain at the emergency department, a prospective cohort study. PLoS One (2015) 1.40
Prediction of mortality among emergency medical admissions. Emerg Med J (2006) 1.39
Role of cardiac computed tomography and magnetic resonance imaging in the evaluation of acute chest pain in the emergency department. Int J Cardiovasc Imaging (2007) 1.39
Evaluation of the accuracy of smartphone medical calculation apps. J Med Internet Res (2014) 1.39
Acute coronary syndromes: diagnosis and management, part I. Mayo Clin Proc (2009) 1.38
Reduction in observation unit length of stay with coronary computed tomography angiography depends on time of emergency department presentation. Acad Emerg Med (2013) 1.37
Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute. JACC Cardiovasc Imaging (2009) 1.30
Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med (2010) 1.27
Acute coronary syndrome: unstable angina and non-ST segment elevation myocardial infarction. BMJ (2003) 1.21
Determinants of health after hospital discharge: rationale and design of the Vanderbilt Inpatient Cohort Study (VICS). BMC Health Serv Res (2014) 1.17
Diagnostic accuracy of the TIMI risk score in patients with chest pain in the emergency department: a meta-analysis. CMAJ (2010) 1.14
Changes in clinical profile, treatment, and mortality in patients hospitalised for acute myocardial infarction between 1985 and 2008. PLoS One (2011) 1.14
Monitoring guideline adherence in the management of acute coronary syndrome in hospitals: design of a multicentre study. Neth Heart J (2014) 1.14
Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation (2010) 1.07
One-year health status outcomes of unstable angina versus myocardial infarction: a prospective, observational cohort study of ACS survivors. BMC Cardiovasc Disord (2007) 1.07
Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial. Trials (2012) 1.06
Association is not the same as accuracy. Arq Bras Cardiol (2014) 1.06
FRISC score for selection of patients for an early invasive treatment strategy in unstable coronary artery disease. Heart (2005) 1.04
Identification of modifiable and nonmodifiable risk factors for neurologic deterioration after acute ischemic stroke. J Stroke Cerebrovasc Dis (2012) 1.02
The prognostic significance of a fragmented QRS complex after primary percutaneous coronary intervention. Heart Vessels (2011) 1.00
Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events. Am Heart J (2010) 0.99
Risk score to stratify children with suspected serious bacterial infection: observational cohort study. Arch Dis Child (2011) 0.99
Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial. Eur Heart J (2008) 0.99
Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome. Heart (2006) 0.99
Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores. PLoS One (2009) 0.99
Is primary angioplasty for some as good as primary angioplasty for all? J Gen Intern Med (2002) 0.98
Short-term outcomes of acute myocardial infarction in patients with acute kidney injury: a report from the national cardiovascular data registry. Circulation (2011) 0.98
Pretest probability assessment derived from attribute matching. BMC Med Inform Decis Mak (2005) 0.98
Utility of admission cardiac troponin and "Ischemia Modified Albumin" measurements for rapid evaluation and rule out of suspected acute myocardial infarction in the emergency department. Emerg Med J (2006) 0.97
The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology. Eur Heart J (2014) 0.97
Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction. J Mol Cell Cardiol (2014) 0.96
A study to derive a clinical decision rule for triage of emergency department patients with chest pain: design and methodology. BMC Emerg Med (2008) 0.94
Percutaneous coronary intervention in the elderly. Nat Rev Cardiol (2010) 0.93
TIMI risk score accurately risk stratifies patients with undifferentiated chest pain presenting to an emergency department. Heart (2006) 0.93
Risk scores for patients with chest pain: evaluation in the emergency department. Curr Cardiol Rev (2011) 0.93
Risk stratification of patients with acute chest pain and normal troponin concentrations. Heart (2005) 0.93
Central obesity and cardiovascular outcomes in patients with acute coronary syndrome: observations from the MERLIN-TIMI 36 trial. Heart (2011) 0.93
Age-related alteration of risk profile, inflammatory response, and angiographic findings in patients with acute coronary syndrome. Clin Med Cardiol (2009) 0.93
Lipoprotein-associated phospholipase A2 for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach: the North Wuerttemberg and Berlin Infarction Study-II (NOBIS-II). Clin Res Cardiol (2007) 0.92
B-type natriuretic peptide and high sensitive C-reactive protein predict 2-year all cause mortality in chest pain patients: a prospective observational study from Salta, Argentina. BMC Cardiovasc Disord (2011) 0.92
Should patients with acute coronary disease be stratified for management according to their risk? Derivation, external validation and outcomes using the updated GRACE risk score. BMJ Open (2014) 0.92
Emergency department observation units and the older patient. Clin Geriatr Med (2013) 0.91
Performance and efficacy of 320-row computed tomography coronary angiography in patients presenting with acute chest pain: results from a clinical registry. Int J Cardiovasc Imaging (2011) 0.91
Use of multidetector computed tomography for the assessment of acute chest pain: a consensus statement of the North American Society of Cardiac Imaging and the European Society of Cardiac Radiology. Eur Radiol (2007) 0.90
Clinical risk stratification in the emergency department predicts long-term cardiovascular outcomes in a population-based cohort presenting with acute chest pain: primary results of the Olmsted county chest pain study. Medicine (Baltimore) (2009) 0.90
The impact of the HEART risk score in the early assessment of patients with acute chest pain: design of a stepped wedge, cluster randomised trial. BMC Cardiovasc Disord (2013) 0.90
Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department. Circ Cardiovasc Imaging (2011) 0.89
Atherosclerotic risk factors and their association with hospital mortality among patients with first myocardial infarction (from the National Registry of Myocardial Infarction). Am J Cardiol (2012) 0.89
Identifying cardiac syncope based on clinical history: a literature-based model tested in four independent datasets. PLoS One (2013) 0.89
Modern risk stratification in coronary heart disease. J Med Life (2011) 0.88
B-type natriuretic peptide as a predictor of anterior wall location in patients with non-ST-elevation myocardial infarction. Clinics (Sao Paulo) (2011) 0.88
Wellens syndrome. CMAJ (2016) 0.88
Acute coronary syndromes without ST segment elevation. BMJ (2007) 0.88
Use of alternative methodologies for evaluation of composite end points in trials of therapies for critical limb ischemia. Am Heart J (2012) 0.88
Impact of minimising door-to-balloon times in ST-elevation myocardial infarction to less than 30 min on outcome: an analysis over an 8-year period in a tertiary care centre. Clin Res Cardiol (2010) 0.88
Novel QCA methodologies and angiographic scores. Int J Cardiovasc Imaging (2011) 0.88
Discrepancies between the medical record and the reports of patients with acute coronary syndrome regarding important aspects of the medical history. BMC Health Serv Res (2012) 0.87
Validation of the GRACE score for prognosis in Indian patients with acute coronary syndromes. Indian Heart J (2012) 0.87
Are patients with non-ST elevation myocardial infarction undertreated? BMC Cardiovasc Disord (2007) 0.87
The absence of coronary artery calcification does not rule out the presence of significant coronary artery disease in Asian patients with acute chest pain. Int J Cardiovasc Imaging (2011) 0.87
Dynamic TIMI risk score for STEMI. J Am Heart Assoc (2013) 0.87
Percutaneous coronary intervention in the elderly. Ulster Med J (2007) 0.86
Determining optimal population rates of cardiac catheterization: a phantom alternative? CMAJ (2005) 0.86
Cumulative risk assessment in unstable angina: clinical, electrocardiographic, autonomic, and biochemical markers. Heart (2003) 0.86
Whole-chest 64-MDCT of emergency department patients with nonspecific chest pain: Radiation dose and coronary artery image quality with prospective ECG triggering versus retrospective ECG gating. AJR Am J Roentgenol (2009) 0.86
Prognostic significance of multiple-detector computed tomography in conjunction with TIMI risk score for patients with non-ST elevation acute coronary syndrome. Heart Vessels (2008) 0.86
New horizons of acute myocardial infarction: from the Korea Acute Myocardial Infarction Registry. J Korean Med Sci (2013) 0.85
Cholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome. Acad Emerg Med (2012) 0.85
Relationship between obesity and N-terminal brain natriuretic Peptide level as a prognostic value after acute myocardial infarction. Korean Circ J (2010) 0.85
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med (1996) 23.76
Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med (1992) 18.74
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation (1990) 9.74
Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med (2001) 9.31
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation (1996) 9.00
Reducing the frequency of errors in medicine using information technology. J Am Med Inform Assoc (2001) 8.37
Factors influencing infarct size following experimental coronary artery occlusions. Circulation (1971) 7.04
Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med (1996) 6.92
The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation (1982) 5.56
The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med (2001) 5.50
Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS Pilot Study. ROXIS Study Group. Lancet (1997) 5.44
TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation (2000) 5.15
Determinants of HIV-1 shedding in the genital tract of women. Lancet (2001) 5.10
Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol (1985) 4.61
TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation (1996) 4.41
Myocardial infarct size and ventricular function in rats. Circ Res (1979) 4.33
Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J Clin Invest (1965) 4.23
Myocardial reperfusion: a double-edged sword? J Clin Invest (1985) 4.12
A trial of two strategies to modify the test-ordering behavior of medical residents. N Engl J Med (1980) 3.98
Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res (1966) 3.95
Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators. Circulation (1999) 3.90
Idiopathic hypertrophic subaortic stenosis. Clinical analysis of 126 patients with emphasis on the natural history. Circulation (1968) 3.82
Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol (1971) 3.68
Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation (2000) 3.66
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev (1996) 3.49
Aortic stenosis. Circulation (1968) 3.49
Viruses as precipitants of asthmatic attacks in children. JAMA (1974) 3.30
Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. The Care Investigators. Circulation (1999) 3.26
Defective cardiac parasympathetic control in patients with heart disease. N Engl J Med (1971) 3.24
Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators. Circulation (1998) 3.19
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet (2009) 3.13
Acute coronary syndrome without ST elevation: implementation of new guidelines. Lancet (2001) 3.07
Mechanism of action of calcium-channel-blocking agents. N Engl J Med (1982) 2.99
Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med (1988) 2.98
Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation (2000) 2.93
Correlates of certification in family medicine in the billing patterns of Ontario general practitioners. CMAJ (1989) 2.91
A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy. Lancet (2001) 2.78
Retention of women enrolled in a prospective study of human immunodeficiency virus infection: impact of race, unstable housing, and use of human immunodeficiency virus therapy. Am J Epidemiol (2001) 2.77
Do the results of randomized clinical trials of cardiovascular drugs influence medical practice? The SAVE Investigators. N Engl J Med (1992) 2.72
Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators. Circulation (1997) 2.64
Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial. Circulation (1999) 2.59
The use of SI units in reporting results obtained in hospital laboratories. J Clin Pathol (1974) 2.55
Population health and health care use: an information system for policy makers. Milbank Q (1996) 2.54
Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium. J Clin Invest (1967) 2.51
VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial. Circulation (2000) 2.47
Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol (1991) 2.40
Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology (2010) 2.38
Unstable angina: an etiologic approach to management. Circulation (1998) 2.31
The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation (1965) 2.30
Oxygen consumption of the heart. Newer concepts of its multifactoral determination. Am J Cardiol (1968) 2.29
Coronary-artery surgery at the crossroads. N Engl J Med (1977) 2.28
Reduction of experimental myocardial infarct size by corticosteroid administration. J Clin Invest (1973) 2.28
Geographic variation in patient and hospital characteristics, management, and clinical outcomes in ST-elevation myocardial infarction treated with fibrinolysis. Results from InTIME-II. Eur Heart J (2001) 2.28
Randomised trial of fish oil for prevention of restenosis after coronary angioplasty. Lancet (1989) 2.28
Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res (1985) 2.23
Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med (1998) 2.22
Physicians certified in family medicine. What are they doing 8 to 10 years later? Can Fam Physician (2001) 2.21
Coronary-artery spasm. N Engl J Med (1978) 2.20
Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. N Engl J Med (1980) 2.20
Rhinovirus and influenza type A infections as precipitants of asthma. Am Rev Respir Dis (1976) 2.20
Reversible ischemic left ventricular dysfunction: evidence for the "hibernating myocardium". J Am Coll Cardiol (1986) 2.20
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. Ann Intern Med (1980) 2.19
Precordial S-T segment elevation mapping: an atraumatic method for assessing alterations in the extent of myocardial ischemic injury. The effects of pharmacologic and hemodynamic interventions. Am J Cardiol (1972) 2.19
Radial artery harvesting for coronary bypass operations: neurologic complications and their potential mechanisms. J Thorac Cardiovasc Surg (2001) 2.18
What do outpatients value most in their anesthesia care? Can J Anaesth (2001) 2.18
Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) Study Group. Circulation (1999) 2.16
Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole. Circulation (1971) 2.15
Association of race and gender with HIV-1 RNA levels and immunologic progression. J Acquir Immune Defic Syndr (2000) 2.13
Velocity of contraction as a determinant of myocardial oxygen consumption. Am J Physiol (1965) 2.11
Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion. Circulation (1972) 2.10
Greater frequency of viral respiratory infections in asthmatic children as compared with their nonasthmatic siblings. J Pediatr (1974) 2.09
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity. Am J Med (1969) 2.09
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part I: Basic and clinical electrophysiologic effects. Ann Intern Med (1980) 2.08
Mortality related to cardiac catheterization and angiography. Cathet Cardiovasc Diagn (1982) 2.08
Application of the TIMI risk score for ST-elevation MI in the National Registry of Myocardial Infarction 3. JAMA (2001) 2.07
Plastic surgery of the face in Byzantium in the fourth century. Plast Reconstr Surg (1998) 2.06
Female and Male Physicians: Different Practice Profiles: Will increasing numbers of female GPs affect practice patterns of the future? Can Fam Physician (1991) 2.05
The diabetes epidemic in Australia: prevalence, patterns and the public health. Med J Aust (1995) 2.03
Hemodynamic assessment of amrinone. A new inotropic agent. N Engl J Med (1978) 2.03
Sex differences in management and outcome after acute myocardial infarction in the 1990s: A prospective observational community-based study. Israeli Thrombolytic Survey Group. Circulation (2000) 2.02