Published in J Gen Physiol on September 01, 2000
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol (2002) 5.18
Gating mechanism of BK (Slo1) channels: so near, yet so far. J Gen Physiol (2003) 2.31
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site. J Gen Physiol (2001) 2.24
Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol (2001) 2.15
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proc Natl Acad Sci U S A (2003) 1.99
Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity. J Gen Physiol (2002) 1.98
Differential effects of beta 1 and beta 2 subunits on BK channel activity. J Gen Physiol (2005) 1.88
Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing. J Gen Physiol (2004) 1.82
Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81
Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity is enhanced by its beta1 subunit. J Gen Physiol (2005) 1.79
Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. J Clin Invest (2003) 1.79
BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A (2012) 1.71
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension. J Clin Invest (2004) 1.70
Mechanism of beta4 subunit modulation of BK channels. J Gen Physiol (2006) 1.54
Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels. J Gen Physiol (2002) 1.45
Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+. Proc Natl Acad Sci U S A (2002) 1.41
Intra- and intersubunit cooperativity in activation of BK channels by Ca2+. J Gen Physiol (2006) 1.39
Defining the BK channel domains required for beta1-subunit modulation. Proc Natl Acad Sci U S A (2006) 1.38
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel. J Gen Physiol (2006) 1.33
K+ channels in apoptosis. J Membr Biol (2006) 1.29
An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol (2006) 1.26
Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage. J Gen Physiol (2008) 1.26
Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. J Gen Physiol (2001) 1.25
Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A (2003) 1.23
Heterogeneity in function of small artery smooth muscle BKCa: involvement of the beta1-subunit. J Physiol (2009) 1.21
Hair cells--beyond the transducer. J Membr Biol (2006) 1.20
Stimulatory action of internal protons on Slo1 BK channels. Biophys J (2003) 1.19
Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J Urol (2009) 1.19
A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) (2013) 1.17
Modulation of BK channel voltage gating by different auxiliary β subunits. Proc Natl Acad Sci U S A (2012) 1.17
Ethanol modulates BKCa channels by acting as an adjuvant of calcium. Mol Pharmacol (2008) 1.14
Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Biophys J (2004) 1.13
The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction. FEBS Lett (2009) 1.12
Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. J Gen Physiol (2001) 1.12
Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling. FEBS Lett (2010) 1.10
{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia. J Physiol (2009) 1.08
Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. J Physiol (2010) 1.07
Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms. Proc Natl Acad Sci U S A (2003) 1.05
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J (2008) 1.04
Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol (2007) 1.04
Potentiation of large conductance, Ca2+-activated K+ (BK) channels by alpha5beta1 integrin activation in arteriolar smooth muscle. J Physiol (2008) 1.04
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Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla. J Physiol (2003) 1.02
Measuring the influence of the BKCa {beta}1 subunit on Ca2+ binding to the BKCa channel. J Gen Physiol (2009) 1.02
The BK channel: a vital link between cellular calcium and electrical signaling. Protein Cell (2012) 1.01
Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel. Biophys J (2005) 1.00
Interleukin-4 activates large-conductance, calcium-activated potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol (2008) 0.98
Pregnancy upregulates large-conductance Ca(2+)-activated K(+) channel activity and attenuates myogenic tone in uterine arteries. Hypertension (2011) 0.98
Dynamic regulation of β1 subunit trafficking controls vascular contractility. Proc Natl Acad Sci U S A (2014) 0.98
Intersubunit coupling in the pore of BK channels. J Biol Chem (2009) 0.97
Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries. Hypertension (2012) 0.97
Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys J (2002) 0.96
An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate. J Gen Physiol (2011) 0.96
Subunit-specific effect of the voltage sensor domain on Ca2+ sensitivity of BK channels. Biophys J (2008) 0.96
The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension. J Clin Invest (2004) 0.95
Setting the stage for molecular dissection of the regulatory components of BK channels. J Gen Physiol (2002) 0.95
Function and regulation of large conductance Ca(2+)-activated K+ channel in vascular smooth muscle cells. Drug Discov Today (2012) 0.95
Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels. J Gen Physiol (2005) 0.95
Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice. Diabetes (2012) 0.95
Linking exponential components to kinetic states in Markov models for single-channel gating. J Gen Physiol (2008) 0.95
Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains. Biophys J (2007) 0.92
Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1. J Neurosci (2010) 0.92
The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating. J Gen Physiol (2005) 0.92
Single-channel biophysical and pharmacological characterizations of native human large-conductance calcium-activated potassium channels in freshly isolated detrusor smooth muscle cells. Pflugers Arch (2013) 0.91
The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating. J Neurosci (2013) 0.89
Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2011) 0.89
MiRP3 acts as an accessory subunit with the BK potassium channel. Am J Physiol Renal Physiol (2008) 0.89
Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits. Front Physiol (2014) 0.88
Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. J Gen Physiol (2008) 0.88
Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. Am J Physiol Heart Circ Physiol (2014) 0.88
Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol (2012) 0.83
Functional link between muscarinic receptors and large-conductance Ca2+ -activated K+ channels in freshly isolated human detrusor smooth muscle cells. Pflugers Arch (2014) 0.83
Kinetic gating mechanisms for BK channels: when complexity leads to simplicity. J Gen Physiol (2001) 0.83
The beta1 subunit enhances oxidative regulation of large-conductance calcium-activated K+ channels. J Gen Physiol (2004) 0.83
Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels. J Biol Chem (2014) 0.82
Hill coefficients of a polymodal Monod-Wyman-Changeux model for ion channel gating. Biophys J (2010) 0.82
The β1-subunit of the MaxiK channel associates with the thromboxane A2 receptor and reduces thromboxane A2 functional effects. J Biol Chem (2012) 0.82
Smooth muscle BK channel activity influences blood pressure independent of vascular tone in mice. J Physiol (2014) 0.81
Both transmembrane domains of BK β1 subunits are essential to confer the normal phenotype of β1-containing BK channels. PLoS One (2014) 0.81
Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytes. J Membr Biol (2003) 0.81
Epigenetic upregulation of large-conductance Ca2+-activated K+ channel expression in uterine vascular adaptation to pregnancy. Hypertension (2014) 0.80
BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating. Pflugers Arch (2013) 0.79
Potassium transport in the maturing kidney. Pediatr Nephrol (2007) 0.79
Smooth muscle relaxation and activation of the large conductance Ca(++)-activated K+ (BK(Ca)) channel by novel oestrogens. Br J Pharmacol (2013) 0.79
BK channel news: full coverage on the calcium bowl. J Gen Physiol (2004) 0.79
Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels. PLoS One (2013) 0.78
Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle. PLoS One (2015) 0.78
Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits. Int Rev Neurobiol (2016) 0.78
Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.78
Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells. Am J Physiol Lung Cell Mol Physiol (2009) 0.78
Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications. J Physiol (2016) 0.78
Knockout of the BK β2 subunit reveals the importance of accessorizing your channel. J Gen Physiol (2014) 0.77
Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels. Proc Natl Acad Sci U S A (2015) 0.77
Mg2+-dependent regulation of BK channels: importance of electrostatics. J Gen Physiol (2008) 0.77
Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation. Am J Physiol Cell Physiol (2009) 0.76
Monitoring transient Ca2+ dynamics with large-conductance Ca2+-dependent K+ channels at active zones in frog saccular hair cells. Neuroscience (2009) 0.76
High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Pregnancy Reprograms Large-Conductance Ca(2+)-Activated K(+) Channel in Uterine Arteries: Roles of Ten-Eleven Translocation Methylcytosine Dioxygenase 1-Mediated Active Demethylation. Hypertension (2017) 0.75
Alcohol modulation of BK channel gating depends on β subunit composition. J Gen Physiol (2016) 0.75
Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. J Biol Chem (2014) 0.75
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