Structural insights into microtubule function.

Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol (2006) 3.63

Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56

Mechanisms of Taxol resistance related to microtubules. Oncogene (2003) 3.16

Microtubule assembly dynamics at the nanoscale. Curr Biol (2007) 3.02

High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis. Cell (2014) 2.71

Function of dynein and dynactin in herpes simplex virus capsid transport. Mol Biol Cell (2002) 2.61

Mechanochemical model of microtubule structure and self-assembly kinetics. Biophys J (2005) 2.31

Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25

The role of HDAC6 in cancer. J Biomed Biotechnol (2010) 1.77

Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem (2008) 1.73

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. EMBO J (2010) 1.72

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci U S A (2002) 1.64

Phospholipase d activation correlates with microtubule reorganization in living plant cells. Plant Cell (2003) 1.49

Bending dynamics of fluctuating biopolymers probed by automated high-resolution filament tracking. Biophys J (2007) 1.49

Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2010) 1.46

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion. PLoS One (2013) 1.46

The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Genes Dev (2002) 1.45

Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition. Proc Natl Acad Sci U S A (2010) 1.45

Herpesvirus interactions with the host cytoskeleton. J Virol (2008) 1.43

Mitochondria, the Cell Cycle, and the Origin of Sex via a Syncytial Eukaryote Common Ancestor. Genome Biol Evol (2016) 1.43

Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation. J Cell Biol (2011) 1.40

A fourth component of the fission yeast gamma-tubulin complex, Alp16, is required for cytoplasmic microtubule integrity and becomes indispensable when gamma-tubulin function is compromised. Mol Biol Cell (2002) 1.38

Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol Biol Cell (2004) 1.34

Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J Biol Chem (2009) 1.34

Controlling RNA self-assembly to form filaments. Nucleic Acids Res (2006) 1.33

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res (2005) 1.28

Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res (2010) 1.23

The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly. Mol Biol Cell (2006) 1.21

Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK. Mol Biol Cell (2005) 1.18

Microtubules and their role in cellular stress in cancer. Front Oncol (2014) 1.15

Drosophila spermiogenesis: Big things come from little packages. Spermatogenesis (2012) 1.15

Microtubules in bacteria: Ancient tubulins build a five-protofilament homolog of the eukaryotic cytoskeleton. PLoS Biol (2011) 1.14

Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol (2009) 1.12

Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization. Am J Respir Cell Mol Biol (2012) 1.11

TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. Proc Natl Acad Sci U S A (2003) 1.09

Initiation of hepatitis C virus infection requires the dynamic microtubule network: role of the viral nucleocapsid protein. J Biol Chem (2009) 1.09

Diversity of TITAN functions in Arabidopsis seed development. Plant Physiol (2002) 1.06

Classically activated macrophages use stable microtubules for matrix metalloproteinase-9 (MMP-9) secretion. J Biol Chem (2012) 1.04

Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice. J Cell Biol (2003) 1.00

Review series: The functions and consequences of force at kinetochores. J Cell Biol (2013) 1.00

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis (2011) 0.99

Crystal structure of the GABA(A)-receptor-associated protein, GABARAP. EMBO Rep (2002) 0.98

The mechanisms of microtubule catastrophe and rescue: implications from analysis of a dimer-scale computational model. Mol Biol Cell (2011) 0.98

Archaeal origin of tubulin. Biol Direct (2012) 0.97

Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells. Vet Microbiol (2009) 0.95

Gravity-induced modifications to development in hypocotyls of Arabidopsis tubulin mutants. Plant Physiol (2009) 0.95

Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Dev Biol (2010) 0.94

Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly. Mol Biol Cell (2013) 0.92

Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea. Biol Direct (2010) 0.91

PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Mol Endocrinol (2012) 0.90

Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J (2013) 0.90

Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer. Biochemistry (2008) 0.90

Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies. J Theor Biol (2008) 0.89

A small heat shock/alpha-crystallin protein from encysted Artemia embryos suppresses tubulin denaturation. Cell Stress Chaperones (2003) 0.89

Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function. Mol Biol Cell (2007) 0.88

Proteasomes are a target of the anti-tumour drug vinblastine. Biochem J (2001) 0.87

Modulation of host microtubule dynamics by pathogenic bacteria. Biomol Concepts (2012) 0.87

Septin 7 is required for orderly meiosis in mouse oocytes. Cell Cycle (2012) 0.85

HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion. PLoS One (2013) 0.84

GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. J Biol Chem (2008) 0.84

Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis. Semin Cell Dev Biol (2016) 0.84

Microtubule disruption in keratinocytes induces cell-cell adhesion through activation of endogenous E-cadherin. Mol Biol Cell (2001) 0.84

Bacterial tubulin distinct loop sequences and primitive assembly properties support its origin from a eukaryotic tubulin ancestor. J Biol Chem (2011) 0.84

Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. Mol Cancer Ther (2011) 0.84

Lysine post-translational modifications and the cytoskeleton. Essays Biochem (2012) 0.84

Oryzalin bodies: in addition to its anti-microtubule properties, the dinitroaniline herbicide oryzalin causes nodulation of the endoplasmic reticulum. Protoplasma (2009) 0.83

Chromosome segregation in plant meiosis. Front Plant Sci (2014) 0.83

Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study. Phys Chem Chem Phys (2013) 0.83

Fragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin. BMC Genomics (2014) 0.83

Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PLoS One (2011) 0.82

Influenza virus A/Beijing/501/2009(H1N1) NS1 interacts with β-tubulin and induces disruption of the microtubule network and apoptosis on A549 cells. PLoS One (2012) 0.82

RCB20, an experimental benzimidazole derivative, affects tubulin expression and induces gross anatomical changes in Taenia crassiceps cysticerci. Parasitol Res (2013) 0.81

Targeting Alp7/TACC to the spindle pole body is essential for mitotic spindle assembly in fission yeast. FEBS Lett (2014) 0.81

Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease. Antimicrob Agents Chemother (2015) 0.81

Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrob Agents Chemother (2010) 0.81

Mitogen-activated protein/extracellular signal-regulated kinase kinase 1act/tubulin interaction is an important determinant of mitotic stability in cultured HT1080 human fibrosarcoma cells. Cancer Res (2010) 0.80

Spatial control of microtubule length and lifetime by opposing stabilizing and destabilizing functions of Kinesin-8. Curr Biol (2014) 0.80

Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone. Int J Mol Sci (2015) 0.80

Cellular morphogenesis in silico. Biophys J (2009) 0.79

Interactions of prion protein with intracellular proteins: so many partners and no consequences? Cell Mol Neurobiol (2009) 0.79

Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9). BMC Genomics (2008) 0.79

Microtubule- and dynein-dependent nuclear trafficking of rhesus rhadinovirus in rhesus fibroblasts. J Virol (2011) 0.79

MAP65-1a positively regulates H2O2 amplification and enhances brassinosteroid-induced antioxidant defence in maize. J Exp Bot (2013) 0.79

Regulation of centriolar satellite integrity and its physiology. Cell Mol Life Sci (2016) 0.78

Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi's Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens (2012) 0.78

Structural and functional characterization of the α-tubulin acetyltransferase MEC-17. J Mol Biol (2014) 0.78

Effect of calcium on electrical energy transfer by microtubules. J Biol Phys (2008) 0.78

Emergent properties of composite semiflexible biopolymer networks. Bioarchitecture (2014) 0.78

Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4. Clin Proteomics (2011) 0.78

F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis. Oncotarget (2016) 0.78

Microtubule plus-end tracking proteins in neuronal development. Cell Mol Life Sci (2016) 0.77

Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer. Cell Death Dis (2016) 0.77

An electron microscopy journey in the study of microtubule structure and dynamics. Protein Sci (2015) 0.77

MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition. Sci Rep (2015) 0.77

Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. J Med Chem (2013) 0.77

Cryo-EM studies of microtubule structural intermediates and kinetochore-microtubule interactions. Methods Cell Biol (2010) 0.77

Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues. PLoS One (2014) 0.77

In vitro study on the alterations of brain tubulin structure and assembly affected by magnetite nanoparticles. J Biol Inorg Chem (2013) 0.77

Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3. J Phys Chem B (2015) 0.77

CoMFA, HQSAR and molecular docking studies of butitaxel analogues with beta-tubulin. J Mol Model (2004) 0.76