Published in Immunity on August 01, 2000
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35
IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med (2011) 3.29
ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med (2002) 2.92
Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol (2011) 2.44
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. J Exp Med (2005) 2.00
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol (2009) 1.73
IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol Res (2009) 1.68
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. PLoS Pathog (2013) 1.59
IRF8 regulates B-cell lineage specification, commitment, and differentiation. Blood (2008) 1.53
Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood (2014) 1.47
Retracted TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937. Genes Dev (2001) 1.46
Multiple cis regulatory elements control RANTES promoter activity in alveolar epithelial cells infected with respiratory syncytial virus. J Virol (2001) 1.45
Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood (2005) 1.44
Microglia development and function. Annu Rev Immunol (2014) 1.41
Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria. PLoS Pathog (2006) 1.40
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Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nat Commun (2011) 1.23
IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J Immunol (2010) 1.22
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood (2012) 1.19
Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood (2013) 1.16
Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages. Proc Natl Acad Sci U S A (2005) 1.14
IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. Cell Rep (2012) 1.12
The interferon signaling network and transcription factor C/EBP-beta. Cell Mol Immunol (2007) 1.12
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Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol (2004) 1.06
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Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. J Exp Med (2009) 1.03
Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element. Mol Cell Biol (2002) 1.03
Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol (2015) 1.03
Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells. Proc Natl Acad Sci U S A (2012) 1.02
IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PLoS One (2012) 1.00
IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment. Neoplasia (2012) 0.99
Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med (2013) 0.98
Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain. Nat Commun (2014) 0.96
IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation. J Immunol (2015) 0.96
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res (2011) 0.96
The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study. PLoS One (2011) 0.96
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Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS One (2011) 0.95
A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes Dev (2015) 0.94
Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Exp Hematol (2010) 0.93
Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments. Immunol Res (2009) 0.93
Innate antiviral response: role in HIV-1 infection. Viruses (2011) 0.93
Molecular control of monocyte development. Cell Immunol (2014) 0.92
Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol (2016) 0.91
Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood (2012) 0.90
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med (2016) 0.87
Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells. J Immunol (2011) 0.86
ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines. Blood (2009) 0.84
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation. Blood (2014) 0.82
A role for IRF8 in B cell anergy. J Immunol (2013) 0.82
Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells. Cell Death Dis (2014) 0.82
Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol Rev (2014) 0.81
Transcription factor IRF8 controls Th1-like regulatory T-cell function. Cell Mol Immunol (2015) 0.81
Interferon regulatory factor 8 mediates tumor-induced inhibition of antigen processing and presentation by dendritic cells. Cancer Immunol Immunother (2008) 0.81
Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation. Biochem J (2001) 0.81
Discovering sparse transcription factor codes for cell states and state transitions during development. Elife (2017) 0.80
Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling. Leukemia (2014) 0.80
Regulation and consequences of monocytosis. Immunol Rev (2014) 0.79
Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. J Immunol (2013) 0.79
Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice. PLoS One (2013) 0.79
Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS One (2012) 0.79
Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem (2014) 0.79
Relevance of Interferon Regulatory Factor-8 Expression in Myeloid-Tumor Interactions. J Interferon Cytokine Res (2016) 0.79
The prognostic significance of IRF8 transcripts in adult patients with acute myeloid leukemia. PLoS One (2013) 0.78
Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells. J Immunol (2015) 0.77
The Interferon Consensus Sequence Binding Protein (Icsbp/Irf8) Is Required for Termination of Emergency Granulopoiesis. J Biol Chem (2015) 0.76
Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development. Cell Death Dis (2016) 0.76
Mechanisms overseeing myeloid-derived suppressor cell production in neoplastic disease. Cancer Immunol Immunother (2017) 0.76
Death-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β. J Biol Chem (2016) 0.75
Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members. J Biol Chem (2016) 0.75
An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs. BMC Bioinformatics (2010) 0.75
Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations. Springerplus (2016) 0.75
Transcriptional determination and functional specificity of myeloid cells: making sense of diversity. Nat Rev Immunol (2017) 0.75
SETD1B activates iNOS expression in myeloid-derived suppressor cells. Cancer Res (2017) 0.75
Inhibition of IRF8 Negatively Regulates Macrophage Function and Impairs Cutaneous Wound Healing. Inflammation (2016) 0.75
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