PubRank

J Trepel

Author PubWeight™ 38.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem 2000 2.24
2 Metastasis-associated differences in gene expression in a murine model of osteosarcoma. Cancer Res 2001 2.10
3 p53 inhibits hypoxia-inducible factor-stimulated transcription. J Biol Chem 1998 1.94
4 Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res 1996 1.82
5 p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem 1996 1.70
6 Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. Mol Cell Biol 1996 1.61
7 Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer Res 1992 1.50
8 Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res 1996 1.48
9 A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion. Oncogene 2007 1.48
10 Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol 2000 1.41
11 A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells. Oncogene 1997 1.36
12 Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. Cancer Res 2001 1.27
13 Human monoclonal antibody directed against an envelope glycoprotein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A 1986 1.24
14 Taxol induction of p21WAF1 and p53 requires c-raf-1. Cancer Res 1995 1.20
15 A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells. J Immunol 1992 1.19
16 Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions. FASEB J 2001 1.17
17 Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition. Br J Cancer 2007 1.02
18 Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-1-integrin. Clin Exp Metastasis 1996 1.01
19 Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli. Cell Death Differ 2001 1.00
20 The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase. Mol Genet Metab 1999 1.00
21 In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome. Oncogene 1998 0.91
22 Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors. Biochem Pharmacol 2000 0.90
23 Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21(waf1/cip1). Prostate 1998 0.89
24 Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1. Biochem Biophys Res Commun 1998 0.83
25 Effect of interferons on protein synthesis in human lymphocytes: enhanced synthesis of eight specific peptides in T cells and activation-dependent inhibition of overall protein synthesis. J Immunol 1982 0.82
26 Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1. J Cell Physiol 1999 0.81
27 Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells. Cell Growth Differ 1994 0.80
28 Nuclear beta-catenin displays GSK-3beta- and APC-independent proteasome sensitivity in melanoma cells. Biochim Biophys Acta 2000 0.79
29 Gastrin-releasing peptide and other autocrine growth factors in lung cancer: pathogenetic and treatment implications. Important Adv Oncol 1988 0.78
30 Modulation of prion protein structural integrity by geldanamycin. Glycobiology 2003 0.78
31 Melanoma cell lines contain a proteasome-sensitive, nuclear cytoskeleton-associated pool of beta-catenin. Ann N Y Acad Sci 1999 0.76
32 Rapid turnover and impaired cell-surface expression of the human folate receptor in mouse L(tk-) fibroblasts, a cell line defective in glycosylphosphatidylinositol tail synthesis. Arch Biochem Biophys 1995 0.76
33 Antigrowth factor strategies. Cancer 1993 0.75