Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMC 1728102)

Published in Gut on November 01, 2000

Authors

D M Keefe1, J Brealey, G J Goland, A G Cummins

Author Affiliations

1: Department of Gastroenterology, Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia. dkeefe@mail.rah.sa.gov.au

Articles citing this

Biomarkers for radiation-induced small bowel epithelial damage: an emerging role for plasma Citrulline. World J Gastroenterol (2007) 1.34

Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol (2010) 1.33

Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies. Support Care Cancer (2006) 1.16

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer (2006) 1.10

Emerging evidence on the pathobiology of mucositis. Support Care Cancer (2013) 0.99

Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats. Dig Dis Sci (2002) 0.99

Emerging evidence on the pathobiology of mucositis. Support Care Cancer (2013) 0.97

Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro. Dig Dis Sci (2008) 0.96

Measuring mucosal damage induced by cytotoxic therapy. Support Care Cancer (2004) 0.95

Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis. Chemother Res Pract (2012) 0.95

Irreversible electroporation on the small intestine. Br J Cancer (2012) 0.95

Gastrointestinal mucositis: a new biological model. Support Care Cancer (2003) 0.92

Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report. Support Care Cancer (2008) 0.91

Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis. Am J Physiol Gastrointest Liver Physiol (2009) 0.90

Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat. PLoS One (2012) 0.89

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation. World J Gastroenterol (2014) 0.88

5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells. Br J Pharmacol (2013) 0.87

Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis. Clin Exp Immunol (2010) 0.87

Dairy milk fat augments paclitaxel therapy to suppress tumour metastasis in mice, and protects against the side-effects of chemotherapy. Clin Exp Metastasis (2011) 0.87

Irinotecan disrupts tight junction proteins within the gut : implications for chemotherapy-induced gut toxicity. Cancer Biol Ther (2013) 0.85

Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells. Cell Death Differ (2012) 0.84

Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats. Dig Dis Sci (2008) 0.83

Serum-derived bovine immunoglobulin/protein isolate in the alleviation of chemotherapy-induced mucositis. Support Care Cancer (2015) 0.83

The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study. BMC Cancer (2013) 0.83

Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil. Cancer Biol Ther (2014) 0.83

Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury. Dig Dis Sci (2005) 0.81

Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma. J Histochem Cytochem (2009) 0.81

Interaction between host cells and microbes in chemotherapy-induced mucositis. Nutrients (2013) 0.81

Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells. PLoS One (2015) 0.80

A diet containing whey protein, glutamine, and TGFbeta modulates gut protein metabolism during chemotherapy-induced mucositis in rats. Dig Dis Sci (2009) 0.80

Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. Radiat Res (2016) 0.80

Alimentary tract mucositis in cancer patients: impact of terminology and assessment on research and clinical practice. Support Care Cancer (2006) 0.80

In vivo effects of immunomodulators in a murine model of Fluorouracil-induced mucositis. Curr Ther Res Clin Exp (2011) 0.79

Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model. Nutrients (2013) 0.79

Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art. Exp Biol Med (Maywood) (2015) 0.79

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol Commun (2016) 0.78

Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy. Onco Targets Ther (2016) 0.78

Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments. Front Pharmacol (2016) 0.78

Effects of Continuing Adjuvant S-1 for 1 Year on the Prognosis of Gastric Cancer Patients: Results from a Prospective Single Center Study. J Gastric Cancer (2015) 0.77

Role of p53 in Anticancer Drug Treatment- and Radiation-Induced Injury in Normal Small Intestine. Cancer Biol Med (2012) 0.77

Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Support Care Cancer (2015) 0.77

How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions. Pathogens (2016) 0.77

Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis. Mol Cancer (2014) 0.77

New pathways for alimentary mucositis. J Oncol (2008) 0.77

Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis. Gut Microbes (2016) 0.76

Pro-Tumoral Inflammatory Myeloid Cells as Emerging Therapeutic Targets. Int J Mol Sci (2016) 0.76

Chronic low vitamin intake potentiates cisplatin-induced intestinal epithelial cell apoptosis in WNIN rats. World J Gastroenterol (2006) 0.76

Innate Lymphoid Cells in Graft-Versus-Host Disease. Am J Transplant (2015) 0.76

The nature of small intestinal mucositis: a video-capsule endoscopy study. Support Care Cancer (2008) 0.76

Escherichia coli Nissle 1917-derived factors reduce cell death and late apoptosis and increase transepithelial electrical resistance in a model of 5-fluorouracil-induced intestinal epithelial cell damage. Cancer Biol Ther (2014) 0.75

The Effects of Irreversible Electroporation on the Colon in a Porcine Model. PLoS One (2016) 0.75

The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. PLoS One (2014) 0.75

Differential effects of cyclosporin and etanercept treatment on various pathologic parameters in a murine model of irradiation-induced mucositis. Curr Ther Res Clin Exp (2012) 0.75

Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons. Front Physiol (2017) 0.75

Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Int J Mol Sci (2017) 0.75

Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice. Braz J Med Biol Res (2015) 0.75

Enteral feeding and its impact on the gut immune system and intestinal mucosal barrier. Prz Gastroenterol (2015) 0.75

Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa. PLoS One (2017) 0.75

Risk factors for Clostridium difficile infection in hemato-oncological patients: A case control study in 144 patients. Sci Rep (2016) 0.75

Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer. Front Pharmacol (2017) 0.75

The influence of neoadjuvant chemotherapy on gastric cancer patients' postoperative infectious complications: What is the negative role played by the intestinal barrier dysfunction? Oncotarget (2017) 0.75

Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice. Toxicol Rep (2015) 0.75

Articles cited by this

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17

An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells. J Pathol (1975) 1.83

Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells (1997) 1.78

Peritz' F test: basic program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput Biol Med (1984) 1.78

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents. Br J Cancer (1987) 1.74

Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br J Cancer (1983) 1.72

Apoptosis and the dilemma of cancer chemotherapy. Blood (1997) 1.71

Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. II. Electron microscopic observations. Gastroenterology (1962) 1.57

Chemotherapeutic alteration of small intestinal morphology and function: a progress report. J Clin Gastroenterol (1979) 1.54

Quantitative histological study of enteropathy associated with HIV infection. Gut (1990) 1.35

Response of the rat small-intestine epithelium to methotrexate. Gut (1980) 1.26

The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. Cancer Res (1998) 1.17

Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) (1997) 1.14

Functional and structural changes of the human proximal small intestine after cytotoxic therapy. J Clin Pathol (1985) 1.01

Light and scanning electron microscopic observations of the effects of sublethal doses of methotrexate on the rat small intestine. Anat Rec (1978) 0.91

Necrosis and apoptosis in the gastrointestinal tract. Gut (1995) 0.88

Gastrointestinal toxicity of chemotherapeutic agents. Semin Oncol (1982) 0.86

Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology. J Clin Pathol (1990) 0.84

Articles by these authors

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut (2001) 4.91

Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) (1997) 1.14

Fluid replacement after appendicectomy or cholecystectomy. A comparison of oral glucose-electrolyte solution with intravenous fluids. J R Coll Surg Edinb (1987) 1.13

Transforming growth factor-beta levels in maternal milk and expression in postnatal rat duodenum and ileum. Pediatr Res (1998) 1.05

Suppression of rejection of Nippostrongylus brasiliensis in iron and protein deficient rats: effect of syngeneic lymphocyte transfer. Gut (1978) 0.97

Histopathology in giardiasis: a correlation with diarrhoea. Aust N Z J Med (1978) 0.94

Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. Immunol Cell Biol (1994) 0.91

Comparison of culture, histopathology and urease testing for the diagnosis of Helicobacter pylori gastritis and susceptibility to amoxycillin, clarithromycin, metronidazole and tetracycline. Pathology (1998) 0.86

Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the rat. Clin Exp Med (2005) 0.83

Effect of iron and protein deficiency on the expulsion of Nippostrongylus brasiliensis from the small intestine of the rat. Gut (1977) 0.83

Epithelial growth of the small intestine in human infants. J Pediatr Gastroenterol Nutr (1998) 0.82

The interactive role of mucosal T lymphocytes in intestinal growth, development and enteropathy. J Gastroenterol Hepatol (1993) 0.82

Gastrointestinal: celiac disease. J Gastroenterol Hepatol (2001) 0.81

Deficiency of invariant natural killer T cells in coeliac disease. Gut (2006) 0.81

Activation of the gut-associated lymphoid tissue with expression of interleukin-2 receptors that peaks during weaning in the rat. J Pediatr Gastroenterol Nutr (1999) 0.81

Lymphocyte activation as measured by interleukin-2 receptor expression to gluten fraction 111 in coeliac disease. Immunol Cell Biol (1990) 0.80

Renal potassium adaptation in the rat: role of glucocorticoids and aldosterone. Am J Physiol (1984) 0.79

Intestinal mucosal mast cells in rats with graft-versus-host reaction. Adv Exp Med Biol (1987) 0.79

Dependence of epithelial growth of the small intestine on T-cell activation during weaning in the rat. Gastroenterology (1996) 0.79

The effect of methionine and protein deficiency in delaying expulsion of Nippostrongylus brasiliensis in the rat. Am J Clin Nutr (1986) 0.78

Proliferative activity in the proximal and distal colon of the rat after fasting and refeeding. Immunol Cell Biol (1988) 0.77

Development of ulcerative colitis despite long-term immunosuppression with cyclosporin and azathioprine in an Australian Aborigine. J Gastroenterol Hepatol (2002) 0.76

Roles of mucosal mast cells in intestinal cell-mediated immunity. Ann Allergy (1987) 0.76

Zinc deficiency is associated with suppression of colonocyte proliferation in the distal large bowel of rats. Biol Trace Elem Res (1988) 0.76

Phenotype and activation of milk-derived and peripheral blood lymphocytes from normal and coeliac subjects. Immunol Cell Biol (1991) 0.76

A randomized controlled trial to determine the effects of humidified carbon dioxide insufflation during thoracoscopy. Surg Endosc (1999) 0.76

Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress. Chemotherapy (2013) 0.75

Reversible nutritional myopathy with myotonia in the protein-deficient rat given methionine. Aust J Exp Biol Med Sci (1985) 0.75

Blood loss during Nippostrongylus brasiliensis infection in the rat. Parasitology (1986) 0.75

Neonatal gut development and epidermal growth factor. Gastroenterology (1989) 0.75

The response of the small intestine of the protein-deficient rat to infection with Nippostrongylus brasiliensis. Int J Parasitol (1987) 0.75

Images of interest. Gastrointestinal: Behçet's disease. J Gastroenterol Hepatol (2000) 0.75

Cyproheptadine and mineralocorticoid effector mechanisms. J Clin Endocrinol Metab (1983) 0.75