Published in Eur J Hum Genet on October 01, 2000
FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71
The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet (2006) 3.93
Genetic influence on human lifespan and longevity. Hum Genet (2006) 3.27
Genetic signatures of exceptional longevity in humans. PLoS One (2012) 3.20
Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci U S A (2002) 2.96
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet (2007) 2.51
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37
A populationwide coalescent analysis of Icelandic matrilineal and patrilineal genealogies: evidence for a faster evolutionary rate of mtDNA lineages than Y chromosomes. Am J Hum Genet (2003) 1.84
A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol (2009) 1.81
No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc Natl Acad Sci U S A (2005) 1.66
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. Proc Natl Acad Sci U S A (2003) 1.60
Genetics of healthy aging and longevity. Hum Genet (2013) 1.50
Selection against variants in the genome associated with educational attainment. Proc Natl Acad Sci U S A (2017) 1.38
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell (2013) 1.33
Survival of parents and siblings of supercentenarians. J Gerontol A Biol Sci Med Sci (2007) 1.32
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) (2011) 1.26
Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci (2011) 1.16
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
The epidemiology of longevity and exceptional survival. Epidemiol Rev (2013) 1.09
Endophenotypes in normal brain morphology and Alzheimer's disease: a review. Neuroscience (2009) 1.02
Large common deletions associate with mortality at old age. Hum Mol Genet (2011) 0.96
Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics (2007) 0.93
Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity". J Gerontol A Biol Sci Med Sci (2015) 0.93
Apolipoprotein E and familial longevity. Neurobiol Aging (2012) 0.93
Genetic variation in healthy oldest-old. PLoS One (2009) 0.92
Cognitive function in families with exceptional survival. Neurobiol Aging (2011) 0.91
The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians. Eur J Hum Genet (2011) 0.91
Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E. PLoS One (2010) 0.90
Contemporary human genetic strategies in aging research. Ageing Res Rev (2010) 0.89
Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. PLoS One (2014) 0.89
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS One (2010) 0.89
Longevity and correlated frailty in multigenerational families. J Gerontol A Biol Sci Med Sci (2006) 0.88
Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits. Mech Ageing Dev (2011) 0.88
Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun Ageing (2012) 0.87
Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality? Hum Genet (2013) 0.85
Association of healthy aging with parental longevity. Age (Dordr) (2012) 0.84
The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms. Biomed Res Int (2014) 0.84
Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc (2011) 0.84
A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci. PLoS One (2012) 0.83
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data. Ann Epidemiol (2015) 0.83
Positive attitude towards life and emotional expression as personality phenotypes for centenarians. Aging (Albany NY) (2012) 0.83
Genomics for disease treatment and prevention. Psychiatr Clin North Am (2010) 0.81
Bitter taste receptor polymorphisms and human aging. PLoS One (2012) 0.79
Epigenetic memory of longevity in Caenorhabditis elegans. Worm (2012) 0.79
FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis. Sci Rep (2015) 0.78
The Genomic Basis of Postponed Senescence in Drosophila melanogaster. PLoS One (2015) 0.78
New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people? World J Hepatol (2013) 0.77
Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects. Age (Dordr) (2011) 0.76
Disease load at conception predicts survival in later epidemics in a historical French-Canadian cohort, suggesting functional trans-generational effects in humans. PLoS One (2014) 0.75
Heritability of a skeletal biomarker of biological aging. Biogerontology (2007) 0.75
The impact of parental investment on lifetime reproductive success in Iceland. PeerJ (2017) 0.75
Familial Risk for Exceptional Longevity. N Am Actuar J (2015) 0.75
MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping. Age (Dordr) (2012) 0.75
Sleeping at the century mark. Sleep (2010) 0.75
The influence of gender on inheritance of exceptional longevity. Aging (Albany NY) (2015) 0.75
Allegro, a new computer program for multipoint linkage analysis. Nat Genet (2000) 14.00
Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet (1999) 3.95
Protection of privacy by third-party encryption in genetic research in Iceland. Eur J Hum Genet (2000) 3.49
Familial aggregation of Parkinson's disease in Iceland. N Engl J Med (2000) 2.41
The mutation rate in the human mtDNA control region. Am J Hum Genet (2000) 2.40
mtDNA and the origin of the Icelanders: deciphering signals of recent population history. Am J Hum Genet (2000) 2.23
Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. Am J Hum Genet (2000) 2.22
Ethics of population genomics research. Nature (1999) 2.20
The Icelandic Healthcare Database and informed consent. N Engl J Med (2000) 2.14
Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet (1997) 1.87
mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry. Am J Hum Genet (2001) 1.81
Genetic evidence for a family-based Scandinavian settlement of Shetland and Orkney during the Viking periods. Heredity (Edinb) (2005) 1.59
A reassessment of genetic diversity in Icelanders: strong evidence from multiple loci for relative homogeneity caused by genetic drift. Ann Hum Genet (2003) 1.43
Using quality measures to facilitate allele calling in high-throughput genotyping. Genome Res (1999) 1.36
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet (1999) 1.35
Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Mol Psychiatry (2004) 1.32
Importance sampling. I. Computing multimodel p values in linkage analysis. Am J Hum Genet (1992) 1.31
Sequential imputation and multipoint linkage analysis. Genet Epidemiol (1993) 1.28
The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. J Cell Biol (1990) 1.19
A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet (2001) 1.17
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry (2011) 1.08
A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. Arthritis Rheum (2001) 1.02
Validation of the deCODE Migraine Questionnaire (DMQ3) for use in genetic studies. Eur J Neurol (2006) 1.01
A common biological basis of obesity and nicotine addiction. Transl Psychiatry (2013) 1.01
Expression of the oligodendrocyte-myelin glycoprotein by neurons in the mouse central nervous system. J Neurochem (1998) 1.00
The inheritance of rheumatoid arthritis in Iceland. Arthritis Rheum (2001) 0.96
The inheritance of hip osteoarthritis in Iceland. Arthritis Rheum (2000) 0.96
The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. J Biol Chem (1991) 0.94
Two large glycosylated polypeptides found in myelinating oligodendrocytes but not in myelin. Proc Natl Acad Sci U S A (1986) 0.92
Diabetes, dependence, asymptotics, selection and significance. Nat Genet (1997) 0.92
Neuregulin 1 in schizophrenia: out of Iceland. Mol Psychiatry (2003) 0.91
The OMgp gene, a second growth suppressor within the NF1 gene. Oncogene (1998) 0.89
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. Neurology (2001) 0.88
The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor. J Biol Chem (1998) 0.87
Binding of hexabrachions to heparin and DNA. J Biol Chem (1989) 0.86
Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3. J Immunol Methods (2000) 0.83
CDKN2A mutations and melanoma risk in the Icelandic population. J Med Genet (2008) 0.82
HLA class II alleles and haplotypes in Icelandic Type I diabetic patients: comparison of Icelandic and Norwegian populations. Diabetologia (2002) 0.78
Genome-wide linkage screen of a consanguineous multiple sclerosis kinship. Mult Scler (2003) 0.77
Immunohistochemical staining of cells in the brain of a patient with acquired immune deficiency syndrome (AIDS) with a monoclonal antibody to visna virus. Acta Neuropathol (1987) 0.76
Genetic homogeneity of Icelanders. Nat Genet (2000) 0.75
A 70-kd polypeptide secreted by human peripheral blood mononuclear cells that suppresses proliferation of a human glioblastoma cell line. Ann N Y Acad Sci (1988) 0.75
Health care and privacy. An interview with Kari Stefansson, founder and CEO of deCODE Genetics in Reykjavik, Iceland. EMBO Rep (2001) 0.75
Linkage analysis with adjustment for covariates: a method combining peeling with Gibbs sampling. Cytogenet Cell Genet (1992) 0.75