Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMID 11069776)

Published in J Cell Sci on December 01, 2000

Authors

E Genersch1, K Hayess, Y Neuenfeld, H Haller

Author Affiliations

1: Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Wiltberg Strasse 50, Germany. elke.genersch@medkem.lu.se

Articles citing this

Matrix metalloproteinase control of capillary morphogenesis. Crit Rev Eukaryot Gene Expr (2008) 1.32

TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci (2005) 1.30

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032. Neoplasia (2011) 1.26

Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve. Brain Behav Immun (2006) 1.26

Understanding signaling cascades in melanoma. Photochem Photobiol (2007) 1.10

The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease. Respir Res (2001) 1.08

TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene (2010) 1.06

Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation. Mol Biol Cell (2003) 1.05

Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One (2009) 0.95

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer. PLoS One (2015) 0.90

A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders. Front Cell Neurosci (2015) 0.90

Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity. J Biol Chem (2009) 0.89

Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media. Exp Mol Med (2009) 0.87

Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo. PLoS One (2014) 0.86

Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression. BMC Cancer (2011) 0.84

Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. BMB Rep (2013) 0.83

Recognition of Streptococcus pneumoniae and muramyl dipeptide by NOD2 results in potent induction of MMP-9, which can be controlled by lipopolysaccharide stimulation. Infect Immun (2014) 0.83

Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated protein94 (Grp94)-IgG complexes. J Cell Mol Med (2011) 0.82

MMP9 processing of HSPB1 regulates tumor progression. PLoS One (2014) 0.82

Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation. Oncotarget (2016) 0.81

Nicotinic receptor signaling in nonexcitable epithelial cells: paradigm shifting from ion current to kinase cascade. Focus on "Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases". Am J Physiol Cell Physiol (2010) 0.79

Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-α-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-κB pathway. Oncol Lett (2012) 0.79

Blockade of Ets-1 attenuates epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells. Am J Physiol Heart Circ Physiol (2015) 0.78

Cell type-specific release of matrix-metallo-proteinase-9 by bacterial chemoattractant in human blood phagocytic leukocytes. Int J Clin Exp Med (2011) 0.78

Correlation of circulating MMP-9 with white blood cell count in humans: effect of smoking. PLoS One (2013) 0.78

Stages of the Inflammatory Response in Pathology and Tissue Repair after Intracerebral Hemorrhage. Semin Neurol (2016) 0.77

A Role for the Cavin-3/Matrix Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype. Cancer Growth Metastasis (2014) 0.77

Okadaic acid induces matrix metalloproteinase-9 expression in fibroblasts: crosstalk between protein phosphatase inhibition and β-adrenoceptor signalling. Br J Pharmacol (2012) 0.77

Vastatin, an Endogenous Antiangiogenesis Polypeptide That Is Lost in Hepatocellular Carcinoma, Effectively Inhibits Tumor Metastasis. Mol Ther (2016) 0.76

Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells. World J Gastroenterol (2015) 0.75

Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage. Mol Brain (2017) 0.75

Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells. Sci Rep (2015) 0.75

Role of Klotho in migration and proliferation of human dermal microvascular endothelial cells. Microvasc Res (2016) 0.75

Endothelial Response to Glucocorticoids in Inflammatory Diseases. Front Immunol (2016) 0.75

Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complement Altern Med (2013) 0.75

Articles by these authors

(truncated to the top 100)

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science (2001) 8.53

Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest (1999) 3.28

Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure. Circ Res (2000) 2.76

AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation (2000) 2.57

Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Mol Cell Biol (1999) 2.27

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J Biol Chem (1994) 2.25

Infiltrates in protocol biopsies from renal allografts. Am J Transplant (2007) 2.24

Serum leptin and ghrelin correlate with disease activity in ANCA-associated vasculitis. Rheumatology (Oxford) (2008) 2.11

NF-kappaB inhibition ameliorates angiotensin II-induced inflammatory damage in rats. Hypertension (2000) 2.06

Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. FEBS Lett (1997) 2.03

Use of Doppler ultrasonography to predict the outcome of therapy for renal-artery stenosis. N Engl J Med (2001) 2.00

Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells. Circ Res (2001) 1.88

Ignition of calcium sparks in arterial and cardiac muscle through caveolae. Circ Res (2000) 1.71

Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. J Cell Biol (2000) 1.56

Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure. Eur J Clin Invest (2003) 1.49

Increased number of alveolar macrophages expressing adhesion molecules of the leukocyte adhesion molecule family in smoking subjects. Association with cell-binding ability and superoxide anion production. Am Rev Respir Dis (1992) 1.49

Right-sided chest pain at the onset of haemodialysis. Nephrol Dial Transplant (2001) 1.44

The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course. Am J Transplant (2010) 1.43

The tell-tale urinary chloride. Nephrol Dial Transplant (2001) 1.39

Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients. Am J Transplant (2011) 1.36

Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils. Kidney Int (1998) 1.34

Hypertension-induced end-organ damage : A new transgenic approach to an old problem. Hypertension (1999) 1.32

Monocyte infiltration and adhesion molecules in a rat model of high human renin hypertension. Hypertension (1999) 1.30

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo. Kidney Int (2006) 1.23

Trauma involving the proximal tibial epiphysis. Arch Orthop Trauma Surg (1991) 1.23

Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat Genet (1996) 1.22

From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model. FASEB J (1997) 1.21

Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment: a randomised controlled 52-week efficacy and safety study. Int J Clin Pract (2011) 1.20

L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells. FASEB J (1998) 1.20

Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury. Hypertension (2001) 1.19

The Diabetes Intervention Study (DIS): a cooperative multi-intervention trial with newly manifested type II diabetics: preliminary results. Monogr Atheroscler (1985) 1.15

Lymphatic neoangiogenesis in human renal allografts: results from sequential protocol biopsies. Am J Transplant (2007) 1.13

Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin. Curr Biol (2000) 1.13

Protein kinase calpha targeting is regulated by temporal and spatial changes in intracellular free calcium concentration [Ca(2+)](i). FASEB J (2000) 1.13

Anti-endothelial cell antibodies in Takayasu arteritis. Circulation (1996) 1.13

Saxagliptin improves glycaemic control and is well tolerated in patients with type 2 diabetes mellitus and renal impairment. Diabetes Obes Metab (2011) 1.13

K+ currents in human coronary artery vascular smooth muscle cells. Circ Res (1996) 1.12

Diagnostic role of endothelial microparticles in vasculitis. Rheumatology (Oxford) (2008) 1.12

The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem (1998) 1.11

Blood pressure-independent effects in rats with human renin and angiotensinogen genes. Hypertension (2000) 1.10

High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha. Circ Res (1997) 1.10

Vertebral osteomyelitis and endocarditis of a pacemaker lead due to Granulicatella (Abiotrophia) adiacens. Infection (2002) 1.09

Angiotensin II (AT(1)) receptor blockade reduces vascular tissue factor in angiotensin II-induced cardiac vasculopathy. Am J Pathol (2000) 1.08

Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage. Hypertension (2000) 1.07

Hydrogen peroxide, potassium currents, and membrane potential in human endothelial cells. Circulation (1999) 1.06

Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function. Kidney Int (2001) 1.06

Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C. Neuroreport (2000) 1.05

Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats. Kidney Int (1999) 1.05

Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res (2000) 1.03

Amelioration of angiotensin II-induced cardiac injury by a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor. Circulation (2001) 1.03

Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effects. Kidney Int (2000) 1.03

[Epidermiology and associated risk factors of hyperlipoproteinemia]. Z Gesamte Inn Med (1977) 1.02

Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage. FASEB J (2001) 1.02

Cyclosporin A protects against angiotensin II-induced end-organ damage in double transgenic rats harboring human renin and angiotensinogen genes. Hypertension (2000) 1.02

Antiendothelial cell antibodies in thromboangiitis obliterans. Am J Med Sci (1998) 1.01

Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation (1999) 1.01

Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact. Circulation (2000) 1.00

Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. J Biol Chem (1997) 1.00

The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus. Ann Rheum Dis (2008) 0.99

Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Brain Res (2001) 0.98

Course and relevance of arteriovenous fistulas after renal transplant biopsies. Am J Transplant (2008) 0.96

Thyrotropin-releasing hormone induces opposite effects on Ca2+ channel currents in pituitary cells by two pathways. Proc Natl Acad Sci U S A (1991) 0.96

Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest. J Cell Sci (2000) 0.96

Protocol biopsies in renal transplantation: insights into patient management and pathogenesis. Am J Transplant (2007) 0.96

Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice. Diabetologia (2009) 0.95

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase. J Biol Chem (1992) 0.95

Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study. Diabetologia (2009) 0.95

Severe relapse of Wegener's granulomatosis during the early postpartum period. Ann Rheum Dis (2006) 0.95

Regulation of spontaneous transient outward potassium currents in human coronary arteries. Circulation (1997) 0.94

Genetic roots of the red deer (Cervus elaphus) population in Eastern Switzerland. J Hered (2004) 0.94

Efficiency of high-flux hemodialysis in the treatment of valproic acid intoxication. J Toxicol Clin Toxicol (2003) 0.93

Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol (2001) 0.93

Autosomal dominant hypertension and brachydactyly in a Turkish kindred resembles essential hypertension. Hypertension (1996) 0.92

Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition. Am J Hypertens (2001) 0.92

ICAM-1 antisense oligodesoxynucleotides prevent reperfusion injury and enhance immediate graft function in renal transplantation. Kidney Int (1998) 0.91

Endothelial cell dysfunction and arterial wall hypertrophy are associated with disturbed carbohydrate metabolism in patients at risk for cardiovascular disease. Arterioscler Thromb Vasc Biol (1999) 0.91

Erythropoietin and progression of CKD. Kidney Int Suppl (2007) 0.91

Calcium-activated potassium channels and nitrate-induced vasodilation in human coronary arteries. J Pharmacol Exp Ther (1998) 0.91

Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction. J Biol Chem (2000) 0.91

beta(1)-Subunit of BK channels regulates arterial wall[Ca(2+)] and diameter in mouse cerebral arteries. J Appl Physiol (1985) (2001) 0.91

Calcium antagonists ameliorate ischemia-induced endothelial cell permeability by inhibiting protein kinase C. Circulation (1999) 0.91

Effect of water and bicarbonate loading in patients with chronic renal failure. Clin Nephrol (1997) 0.90

Pituitary adenylate-cyclase-activating peptides relax human coronary arteries by activating K(ATP) and K(Ca) channels in smooth muscle cells. J Vasc Res (1997) 0.90

Protein kinase C bound to the Golgi apparatus supports the formation of constitutive transport vesicles. Biochem J (1996) 0.90

Endometrial stromal sarcoma arising in extrauterine endometriosis: a case report. Eur J Gynaecol Oncol (2005) 0.90

Calcium sparks in human coronary artery smooth muscle cells resolved by confocal imaging. J Hypertens (2000) 0.89

Blood pressure telemonitoring is useful to achieve blood pressure control in inadequately treated patients with arterial hypertension. J Hum Hypertens (2011) 0.89

Conversion of Goodpasture's syndrome into membranous glomerulonephritis. Nephrol Dial Transplant (2001) 0.89

Elevation of serum CXCL13 in SLE as well as in sepsis. Lupus (2010) 0.89

Extracellular matrix regulates apoptosis in human neutrophils. Kidney Int (1999) 0.88

Chlamydia pneumoniae DNA in non-coronary atherosclerotic plaques and circulating leukocytes. J Lab Clin Med (2000) 0.88

Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding. Clin Nephrol (2004) 0.88

Ischemia-reperfusion injury in renal transplantation is independent of the immunologic background. Kidney Int (2000) 0.88

Effects of p-chlorophenoxyisobutyric acid (CPIB) on the human liver. Atherosclerosis (1980) 0.88

Superoxide anion release induced by platelet-activating factor is increased in human alveolar macrophages from smokers. Eur Respir J (1992) 0.87

CXCL13 as a new biomarker of systemic lupus erythematosus and lupus nephritis - from bench to bedside? Clin Exp Immunol (2015) 0.87

Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J Biol Chem (1999) 0.87

Calcium ions as efficient cofactor of polycation-mediated gene transfer. Biochim Biophys Acta (1999) 0.87

Urokinase activates the Jak/Stat signal transduction pathway in human vascular endothelial cells. Arterioscler Thromb Vasc Biol (1999) 0.87

The adipocyte volume in human adipose tissue: II. Observations in diabetes mellitus, primary hyperlipoproteinemia and weight reduction. Int J Obes (1978) 0.87