Published in Gut on December 01, 2000
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev (2014) 1.57
Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut (2001) 1.29
Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. J Physiol (2004) 1.20
Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J Cell Mol Med (2008) 1.18
Cyclooxygenase expression during Helicobacter pylori infection in Mongolian gerbils. Dig Dis Sci (2003) 0.93
Endogenous cyclo-oxygenase activity regulates mouse gastric surface pH. J Physiol (2002) 0.93
Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in rats: possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity. BMC Complement Altern Med (2013) 0.93
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity. Infect Immun (2001) 0.91
Host factors are important in determining clinical outcomes of Helicobacter pylori infection. J Gastroenterol (2006) 0.91
The role of cyclooxygenase in gastric mucosal protection. Dig Dis Sci (2005) 0.89
Cyclooxygenase 1 is required for pH control at the mouse gastric surface. Gut (2004) 0.88
Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo. Exp Physiol (2007) 0.88
Short-term celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. World J Gastroenterol (2009) 0.82
The probiotic mixture VSL#3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor. PLoS One (2013) 0.82
Khaya senegalensis inhibits piroxicam mediated gastro-toxicity in wistar rats. Avicenna J Phytomed (2014) 0.81
Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo. Mol Cancer (2009) 0.80
Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage. PLoS One (2015) 0.78
Differential Cytotoxicity but Augmented IFN-γ Secretion by NK Cells after Interaction with Monocytes from Humans, and Those from Wild Type and Myeloid-Specific COX-2 Knockout Mice. Front Immunol (2015) 0.78
COX-2 Gene Promoter Methylation in Patients Infected with Helicobacter Pylori. Clin Med Insights Gastroenterol (2013) 0.77
JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. Oncotarget (2016) 0.77
Model-based prediction of the acute and long-term safety profile of naproxen in rats. Br J Pharmacol (2015) 0.77
Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. Dig Dis Sci (2004) 0.76
Recombinant Human Epidermal Growth Factor Alleviates Gastric Antral Ulcer Induced by Naproxen: A Non-steroidal Anti Inflammatory Drug. Gastroenterology Res (2010) 0.76
Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis. World J Gastroenterol (2013) 0.76
NSAID-induced antral ulcers are associated with distinct changes in mucosal gene expression. Aliment Pharmacol Ther (2009) 0.75
Peroxisome proliferator-activated receptor gamma activation counters the detrimental effect of Helicobacter pylori lipopolysaccharide on gastric mucin synthesis. Inflammopharmacology (2003) 0.75
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer (CORM-2) accelerates the healing of pre-existing gastric ulcers. Br J Pharmacol (2017) 0.75
Evaluation of anti-inflammatory, analgesic activities, and side effects of some pyrazole derivatives. Inflammopharmacology (2016) 0.75
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol (1971) 37.53
Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology (1979) 5.73
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem (1990) 3.34
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res (1995) 2.74
Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A (1998) 2.71
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology (1997) 2.67
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest (1994) 2.55
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology (1998) 2.46
Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett (1993) 2.41
Towards a better aspirin. Nature (1994) 2.20
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology (1981) 2.13
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology (1996) 1.92
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest (1994) 1.89
Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem (1995) 1.82
Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am J Physiol (1997) 1.70
Myofibroblasts in human granulation tissue. Hum Pathol (1974) 1.68
A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem (1996) 1.61
Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells. Clin Exp Immunol (1997) 1.46
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol (1998) 1.44
Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharmacol Exp Ther (1995) 1.37
Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. Biochem Biophys Res Commun (1992) 1.25
Separation of the impairment of haemostasis by aspirin from mucosal injury in the human stomach. Clin Sci (Lond) (1991) 1.13
Selective inhibition of cyclooxygenase 2. Biochem Pharmacol (1994) 1.06
Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch Biochem Biophys (1993) 1.04
Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut (1993) 1.03
Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem J (1995) 1.02
Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. Prostaglandins Leukot Essent Fatty Acids (1998) 0.99
Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br J Pharmacol (1998) 0.95
Inhibition of acid secretion in isolated canine parietal cells by prostaglandins. J Pharmacol Exp Ther (1982) 0.95
Regulation of mesangial cell cyclooxygenase synthesis by cytokines and glucocorticoids. Am J Physiol (1992) 0.93
Prostaglandin protection of human isolated gastric glands against indomethacin and ethanol injury. Evidence for direct cellular action of prostaglandin. J Clin Invest (1988) 0.92
Localization of prostaglandin endoperoxide synthase-1 to the endoplasmic reticulum and nuclear envelope is independent of its C-terminal tetrapeptide-PTEL. Arch Biochem Biophys (1995) 0.87
Prostaglandin production by intact isolated gastric parietal cells. Eur J Pharmacol (1980) 0.84
Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells. J Pharmacol Exp Ther (1993) 0.82
Plasticity of myofibroblasts appearing in granulation tissues after acetic acid treatment. Effect of bFGF. Dig Dis Sci (1995) 0.81
Prostaglandin E2 and [14C]arachidonic acid release by carbachol in the isolated canine parietal cell. J Pharmacol Exp Ther (1987) 0.81
Expression of cyclooxygenase 1 and 2 by human gastric endothelial cells. Gut (1999) 0.80
E2 prostaglandins modulate cell proliferation in the small intestinal epithelium of the rat. Digestion (1992) 0.80
[Isolated human gastric mucosa cells--studies on physiologic and pharmacologic regulatory mechanisms]. Klin Wochenschr (1986) 0.80
Nature and time-course of piroxicam-induced injury to human gastric mucosa. Aliment Pharmacol Ther (1989) 0.79
Prostaglandin E2 output by isolated rat gastric parietal cells and non-parietal epithelial cells. Prostaglandins (1988) 0.78
Effect of sofalcone on localization of 15-hydroxyprostaglandin dehydrogenase, an enzyme that metabolizes prostaglandin E2, in rat gastric mucosa: an immunohistochemical study. J Clin Gastroenterol (1992) 0.78
Roles of muscularis mucosae and myofibroblasts in the healing process of acetic acid-induced ulcer. J Clin Gastroenterol (1990) 0.77
The effects of acid secretagogues on protective agents of gastric cells from adult rabbits in vitro. J Clin Gastroenterol (1992) 0.77
Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody. J Clin Pathol (1995) 0.77
Concern Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med (2000) 29.03
A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med (1998) 3.96
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol (2001) 3.35
Asia Pacific consensus recommendations for colorectal cancer screening. Gut (2008) 3.19
Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ (1992) 3.17
Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease, or treatment? Gastroenterology (1985) 3.12
Mild cervical dyskaryosis: safety of cytological surveillance. Lancet (1992) 3.09
Liver biopsy: blind or guided? BMJ (1994) 2.86
Coronary heart disease in Western Collaborative Group Study. Final follow-up experience of 8 1/2 years. JAMA (1975) 2.84
Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia (2000) 2.84
Identification of polyphosphate-accumulating organisms and design of 16S rRNA-directed probes for their detection and quantitation. Appl Environ Microbiol (2000) 2.57
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med (1996) 2.37
Prevalence of human papillomavirus type 16 DNA sequences in cervical intraepithelial neoplasia and invasive carcinoma of the cervix. Br J Obstet Gynaecol (1985) 2.28
Persisting mortality in diabetic ketoacidosis. Diabet Med (1993) 2.28
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet (1993) 2.20
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A (1997) 2.12
Audit of outcome of long-term enteral nutrition by percutaneous endoscopic gastrostomy. Lancet (1993) 2.10
Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J Biol Chem (1993) 2.07
Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease. Gut (1989) 2.06
Withdrawing low risk women from cervical screening programmes: mathematical modelling study. BMJ (1999) 2.03
Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection. BMJ (1994) 1.99
Randomised controlled trial of azathioprine withdrawal in ulcerative colitis. BMJ (1992) 1.94
Prescribing in the UK. Lancet (2001) 1.93
Journals should see original protocols for clinical trials. BMJ (2001) 1.88
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations. Gut (2006) 1.87
Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum. Clin Chem (1995) 1.75
Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders. Drugs (1998) 1.74
Current views on cervical intraepithelial neoplasia. J Clin Pathol (1991) 1.72
Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am J Physiol (1997) 1.70
Histological and immunocytochemical study of cervical intraepithelial neoplasia (CIN) with associated HPV 6 and HPV 16 infections. J Clin Pathol (1986) 1.70
3-Aminopropyltriethoxysilane (APES): a new advance in section adhesion. J Clin Pathol (1987) 1.70
Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori. J Clin Microbiol (1999) 1.69
Social adjustment after rehabilitation: a two year follow-up of patients with severe head injury. Psychol Med (1980) 1.68
Effect of cigarette smoking on cervical epithelial immunity: a mechanism for neoplastic change? Lancet (1988) 1.66
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature (1989) 1.64
Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction. Circulation (2000) 1.63
Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration. Gastroenterology (1997) 1.59
High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut (1991) 1.58
Estimating the long-term impact of a prophylactic human papillomavirus 16/18 vaccine on the burden of cervical cancer in the UK. Br J Cancer (2006) 1.57
Rectal mucosal plasma cells in inflammatory bowel disease. Gut (1983) 1.56
T-lymphocyte populations in normal and coeliac small intestinal mucosa defined by monoclonal antibodies. Gut (1986) 1.56
The stem cells of small intestinal crypts: where are they? Cell Prolif (2009) 1.55
A review of evaluative studies of computer-based learning in nursing education. Nurse Educ Today (2001) 1.54
Enhanced synthesis of neutrophil-activating peptide-1/interleukin-8 in active ulcerative colitis. Clin Sci (Lond) (1992) 1.53
Chemical components separation with botulinum toxin A: a novel technique to improve primary fascial closure rates of the open abdomen. Hernia (2012) 1.52
Meta-analysis: the diagnostic yield of chromoendoscopy for detecting dysplasia in patients with colonic inflammatory bowel disease. Aliment Pharmacol Ther (2010) 1.48
DNA adducts in different tissues of smokers and non-smokers. Int J Cancer (1990) 1.48
Narrow band imaging for characterization of high grade dysplasia and specialized intestinal metaplasia in Barrett's esophagus: a meta-analysis. Endoscopy (2010) 1.44
Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3. Am J Physiol (1999) 1.42
Ileo-caecal ulceration associated with the use of diclofenac slow release. Aliment Pharmacol Ther (1993) 1.40
Social adjustment after closed head injury: a further follow-up seven years after injury. J Neurol Neurosurg Psychiatry (1985) 1.39
Monoclonal antigranulocyte antibody imaging in inflammatory bowel disease: a preliminary report. Nucl Med Commun (1992) 1.39
Current differences in referral patterns for pulmonary endarterectomy in the UK. Eur Respir J (2008) 1.39
Bayesian analysis of pentaquark signals from CLAS data. Phys Rev Lett (2008) 1.39
Somatostatin in treatment of haematemesis and melaena. Lancet (1985) 1.39
Cytological status and lesion size: a further dimension in cervical intraepithelial neoplasia. Br J Obstet Gynaecol (1989) 1.38
Evaluation of diagnostic peritoneal lavage in stable patients with gunshot wounds to the abdomen. Arch Surg (1997) 1.38
The Prader-Willi syndrome with a 15/15 translocation. Case report and review of the literature. J Med Genet (1976) 1.38
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. Gut (1983) 1.37
Measurement of two- and three-nucleon short-range correlation probabilities in nuclei. Phys Rev Lett (2006) 1.37
Prostaglandins and ulcerative colitis. Gut (1984) 1.36
Resolution of hyperparathyroidism, renal osteodystrophy and metastatic calcification after renal homotransplantation. N Engl J Med (1968) 1.36
Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Aliment Pharmacol Ther (2002) 1.35
An irritable bowel syndrome-specific symptom questionnaire: development and validation. Scand J Gastroenterol (2003) 1.34
Inhibition of prostaglandin synthetase in human rectal mucosa. Gut (1983) 1.32
Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther (2005) 1.32
Paneth cells: their role in innate immunity and inflammatory disease. Gut (2005) 1.32
Intravenous omeprazole rapidly raises intragastric pH. Gut (1985) 1.31
High definition colonoscopy vs. standard video endoscopy for the detection of colonic polyps: a meta-analysis. Endoscopy (2011) 1.30
Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut (1992) 1.30
Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am J Physiol Cell Physiol (2002) 1.30
Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele. J Clin Microbiol (1999) 1.28
Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding? Aliment Pharmacol Ther (2005) 1.27
Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer. Gut (1986) 1.27
Expression and regulation of antimicrobial peptides in the gastrointestinal tract. J Leukoc Biol (2003) 1.26
Novel endoscopic observation in Barrett's oesophagus using high resolution magnification endoscopy and narrow band imaging. Aliment Pharmacol Ther (2007) 1.25
Narrow-band imaging with magnification in Barrett's esophagus: validation of a simplified grading system of mucosal morphology patterns against histology. Endoscopy (2008) 1.24
Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination. Curr Microbiol (1999) 1.23
Potential role of epithelial cell-derived histone H1 proteins in innate antimicrobial defense in the human gastrointestinal tract. Infect Immun (1998) 1.22
Investigations: how to get from guidelines to protocols. BMJ (1991) 1.22
Viruses and cervical cancer. BMJ (1991) 1.21
Characterization of antigen-presenting activity of intestinal mononuclear cells isolated from normal and inflammatory bowel disease colon and ileum. Immunology (1988) 1.21
Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. Gut (1983) 1.21
Interleukin-8 and inducible nitric oxide synthase mRNA levels in inflammatory bowel disease at first presentation. J Pathol (1997) 1.21
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut (1998) 1.20
Gastro-oesophageal candidiasis. Gut (1982) 1.20
The effect of lower-extremity position on cerebrospinal fluid pressures. Acad Emerg Med (2001) 1.19
Recent advances in Clostridium difficile-associated disease. Gut (2008) 1.19
Subpopulations of Langerhans' cells in cervical neoplasia. Br J Obstet Gynaecol (1987) 1.19