Published in Circulation on January 02, 2001
Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A (2001) 2.14
Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Fail Rev (2005) 2.10
Thin filament mutations: developing an integrative approach to a complex disorder. Circ Res (2011) 1.55
Modifier genes for hypertrophic cardiomyopathy. Curr Opin Cardiol (2002) 1.47
Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations. J Am Coll Cardiol (2014) 1.47
Genetic testing for inherited cardiac disease. Nat Rev Cardiol (2013) 1.20
Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation. J Physiol (2008) 1.11
Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations. Biophys J (2011) 1.08
Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes? J Biol Chem (2008) 1.06
Regulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assays. Biophys J (2003) 1.01
Molecular genetics and pathogenesis of hypertrophic cardiomyopathy. Minerva Med (2001) 1.00
Facilitated cross-bridge interactions with thin filaments by familial hypertrophic cardiomyopathy mutations in α-tropomyosin. J Biomed Biotechnol (2011) 0.90
Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin. Biochem Biophys Res Commun (2011) 0.89
Coarctation of the aorta and mild to moderate developmental delay in a child with a de novo deletion of chromosome 15(q21.1q22.2). BMC Med Genet (2006) 0.85
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium. J Muscle Res Cell Motil (2013) 0.83
On predictors of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol (2003) 0.83
Calcium-dependent interaction sites of tropomyosin on reconstituted muscle thin filaments with bound Myosin heads as studied by site-directed spin-labeling. Biophys J (2013) 0.76
Investigating the effects of resveratrol on chronically ischemic myocardium in a swine model of metabolic syndrome: a proteomics analysis. J Med Food (2015) 0.76
Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118). J Biol Chem (2013) 0.75
Molecular biology of heart disease. World J Cardiol (2011) 0.75
Novel proteins associated with human dilated cardiomyopathy: selective reduction in α(1A)-adrenergic receptors and increased desensitization proteins. J Recept Signal Transduct Res (2013) 0.75
Cardiomyopathy classification: ongoing debate in the genomics era. Biochem Res Int (2012) 0.75
Over-Expression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of the Troponin-T in Drosophila Indirect Flight Muscles. G3 (Bethesda) (2017) 0.75
A One Health Approach to Hypertrophic Cardiomyopathy. Yale J Biol Med (2017) 0.75
A controlled trial of teaching critical appraisal of the clinical literature to medical students. JAMA (1987) 14.20
Regulation of contraction in striated muscle. Physiol Rev (2000) 9.40
Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge. Circulation (1987) 5.73
Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med (1985) 5.09
Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res (1996) 4.75
Identification of a genetic locus for familial atrial fibrillation. N Engl J Med (1997) 4.66
Second dose of measles, mumps, and rubella vaccine: questionnaire survey of health professionals. BMJ (2001) 4.50
Determining optimal therapy--randomized trials in individual patients. N Engl J Med (1986) 4.49
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med (2001) 4.46
Reversal of the cross-bridge force-generating transition by photogeneration of phosphate in rabbit psoas muscle fibres. J Physiol (1992) 4.34
Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. N Engl J Med (1998) 4.29
Synthesis of the yeast cell wall and its regulation. Annu Rev Biochem (1982) 4.26
Do sick newborn infants benefit from participation in a randomized clinical trial? J Pediatr (1999) 3.98
Comparison of percutaneous and surgical tracheostomies. Chest (1996) 3.56
Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair. Am J Hum Genet (1988) 3.41
WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases. Cell Mol Life Sci (2001) 3.38
A clinician's guide for conducting randomized trials in individual patients. CMAJ (1988) 3.35
Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation (2001) 3.33
Verifying quality and safety in health informatics services. BMJ (2001) 3.31
The effect of phosphate and calcium on force generation in glycerinated rabbit skeletal muscle fibers. A steady-state and transient kinetic study. J Biol Chem (1990) 3.29
Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation (2001) 3.21
Mutations in the lactose operon caused by bacteriophage Mu. J Mol Biol (1972) 3.17
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. Nat Genet (1996) 3.02
The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology (1994) 2.95
Ipsilateral breast tumor recurrence postlumpectomy is predictive of subsequent mortality: results from a randomized trial. Investigators of the Ontario Clinical Oncology Group. Int J Radiat Oncol Biol Phys (1994) 2.86
Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol (1982) 2.84
The molecular genetic basis for hypertrophic cardiomyopathy. J Mol Cell Cardiol (2001) 2.83
Energetic aspects of muscle contraction. Monogr Physiol Soc (1985) 2.78
A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. Heparin-Aspirin Reperfusion Trial (HART) Investigators. N Engl J Med (1990) 2.73
The kinetics of actin nucleation and polymerization. J Biol Chem (1983) 2.70
A standard heparin nomogram for the management of heparin therapy. Arch Intern Med (1991) 2.69
It's time for a change to a troponin standard. Circulation (2000) 2.69
Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation. Circulation (1992) 2.67
The impact of socioeconomic status on health functioning as assessed by the SF-36 questionnaire: the Whitehall II Study. Am J Public Health (1997) 2.65
The kinetics of magnesium adenosine triphosphate cleavage in skinned muscle fibres of the rabbit. J Physiol (1984) 2.64
Reliability of a Standardized Mini-Mental State Examination compared with the traditional Mini-Mental State Examination. Am J Psychiatry (1991) 2.61
Desmin mutation responsible for idiopathic dilated cardiomyopathy. Circulation (1999) 2.59
Activation heat, activation metabolism and tension-related heat in frog semitendinosus muscles. J Physiol (1972) 2.59
Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature (1990) 2.46
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. J Mol Biol (2000) 2.43
Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death. Lancet (1993) 2.38
Echocardiography-guided ethanol septal reduction for hypertrophic obstructive cardiomyopathy. Circulation (1998) 2.37
APOE modifies the association between Aβ load and cognition in cognitively normal older adults. Neurology (2011) 2.35
Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. Circulation (1991) 2.33
Skeletal muscle energetics and metabolism. Annu Rev Physiol (1978) 2.33
Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy. Circulation (2001) 2.25
Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2001) 2.23
Novel proteins with binding specificity for DNA CTG repeats and RNA CUG repeats: implications for myotonic dystrophy. Hum Mol Genet (1996) 2.23
A transgenic rabbit model for human hypertrophic cardiomyopathy. J Clin Invest (1999) 2.19
Electrocardiographic and clinical criteria for recognition of acute myocardial infarction based on analysis of 3,697 patients. Am J Cardiol (1983) 2.18
Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol (2012) 2.17
A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP-specific antibodies protect mice against bacterial challenge. Infect Immun (1996) 2.13
Development and implementation of guidelines for family practice: lessons from The Netherlands. J Fam Pract (1995) 2.11
Diagnostic marker cooperative study for the diagnosis of myocardial infarction. Circulation (1999) 2.09
Membrane fusion activity of tick-borne encephalitis virus and recombinant subviral particles in a liposomal model system. Virology (2000) 2.09
The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature (1999) 2.08
Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study. Circulation (2000) 2.05
Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy. J Clin Invest (1993) 2.04
Short and long term prognosis of acute myocardial infarction since introduction of thrombolysis. BMJ (1993) 2.03
Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. Circulation (1990) 2.01
Isolation and sequence analysis of a full-length cDNA for human M creatine kinase. Biochem Biophys Res Commun (1986) 1.96
Changes in monoamine concentrations in mouse brain associated with ethanol dependence and withdrawal. Br J Pharmacol (1974) 1.94
Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. Proc Natl Acad Sci U S A (1989) 1.90
Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy. J Am Coll Cardiol (1993) 1.89
Integrated patient records: another move towards quality for patients? Qual Health Care (1993) 1.88
Does breastfeeding at six months predict cognitive development? Aust N Z J Public Health (1998) 1.87
Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst (1996) 1.86
Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue. Psychosom Med (2000) 1.80
Familial colloid cyst of the third ventricle: case report and review of associated conditions. Neurosurgery (1996) 1.79
An improved basis for enzymatic estimation of infarct size. Circulation (1975) 1.77
Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Clin Invest (1995) 1.75
The influence of location and extent of myocardial infarction on long-term ventricular dysrhythmia and mortality. Circulation (1979) 1.75
Characterization of cry genes in a Mexican Bacillus thuringiensis strain collection. Appl Environ Microbiol (1998) 1.74
ABC of child abuse. Child sexual abuse--II. BMJ (1989) 1.72
Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation (2000) 1.72
Regulation of the cross-bridge transition from a weakly to strongly bound state in skinned rabbit muscle fibers. Am J Physiol (1995) 1.71
Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation (2000) 1.70
Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A (1995) 1.70
Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology (2011) 1.70
Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease'. J Neurol Neurosurg Psychiatry (2011) 1.69
Segmented k-space fast cardiac imaging using an echo-train readout. Magn Reson Med (1999) 1.69
Electrocardiographic diagnosis of myocardial infarction in the presence of complete left bundle branch block. Am Heart J (1988) 1.69
Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation (1991) 1.68
Postprandial plasma bile acid responses in normal weight and obese subjects. Ann Clin Biochem (2010) 1.67
Effects of nifedipine on myocardial perfusion and ischemic injury in dogs. Circ Res (1978) 1.67
The struggle to diagnose UTI in children under two in primary care. Fam Pract (1997) 1.65
Deleterious effects of methylprednisolone in patients with myocardial infarction. Circulation (1976) 1.65
Kinetics of force generation and phosphate release in skinned rabbit soleus muscle fibers. Am J Physiol (1992) 1.65
Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. J Clin Invest (1990) 1.64
Derivation of protein-specific pair potentials based on weak sequence fragment similarity. Proteins (2000) 1.63
Early diagnosis of acute myocardial infarction based on assay for subforms of creatine kinase-MB. Circulation (1990) 1.61
Depression and substance use in minority middle-school students. Am J Public Health (2001) 1.61