R A Kohanski

Author PubWeight™ 35.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism-based design of a protein kinase inhibitor. Nat Struct Biol 2001 2.13
2 Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes. J Biol Chem 1984 1.62
3 Homogeneous functional insulin receptor from 3T3-L1 adipocytes. Purification using N alpha B1-(biotinyl-epsilon-aminocaproyl)insulin and avidin-sepharose. J Biol Chem 1985 1.20
4 Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. J Biol Chem 1996 1.18
5 Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity. J Biol Chem 1997 1.16
6 Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes. J Biol Chem 1986 1.16
7 Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK(1) cells. J Biol Chem 2000 1.14
8 Stat5 is a physiological substrate of the insulin receptor. Proc Natl Acad Sci U S A 1997 1.08
9 Monovalent avidin affinity columns. Methods Enzymol 1990 1.04
10 Effect of phenylarsine oxide on insulin-dependent protein phosphorylation and glucose transport in 3T3-L1 adipocytes. J Biol Chem 1987 1.04
11 Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the "immunoproteasome". J Biol Chem 1998 1.03
12 Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. J Biol Chem 2000 1.02
13 The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. Nucleic Acids Res 1999 0.99
14 Identification and partial purification of the insulin-responsive glucose transporter from 3T3-L1 adipocytes. Biochim Biophys Acta 1986 0.93
15 Kinetic evidence for activating and non-activating components of autophosphorylation of the insulin receptor protein kinase. Biochem Biophys Res Commun 1986 0.91
16 A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo. Diabetes 2001 0.91
17 Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expression. Mol Cell Biol 1995 0.91
18 Activation of the insulin receptor's kinase domain changes the rate-determining step of substrate phosphorylation. Biochemistry 2001 0.90
19 Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain. J Biol Chem 2001 0.90
20 Cis-autophosphorylation of juxtamembrane tyrosines in the insulin receptor kinase domain. Biochemistry 1997 0.87
21 Binding of insulin to solubilized insulin receptor from human placenta. Evidence for a single class of noninteracting binding sites. J Biol Chem 1983 0.86
22 Conformational changes in the activation loop of the insulin receptor's kinase domain. Protein Sci 1999 0.86
23 Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome. Metabolism 1994 0.85
24 A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo. Mol Cell Biol 1998 0.85
25 Phosphorylation of myosin regulatory light chains by the molluscan twitchin kinase. Eur J Biochem 1995 0.83
26 Autophosphorylation dependent destabilization of the insulin receptor kinase domain: tryptophan-1175 reports changes in the catalytic cleft. Biochemistry 1999 0.83
27 Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a nonprocessive mode of degradation. Biochemistry 1999 0.82
28 Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. J Biol Chem 2000 0.82
29 Partial activation of the insulin receptor kinase domain by juxtamembrane autophosphorylation. Biochemistry 1998 0.81
30 A simple quantitative assay of 125I-labeled alpha-bungarotoxin binding to soluble and membrane-bound acetylcholine receptor protein. Anal Biochem 1977 0.80
31 Environments of the four tryptophans in the extracellular domain of human tissue factor: comparison of results from absorption and fluorescence difference spectra of tryptophan replacement mutants with the crystal structure of the wild-type protein. Biophys J 1995 0.80
32 Post-translational processing and activation of insulin and EGF proreceptors. Biochimie 1986 0.79
33 Receptor affinity chromatography. Ann N Y Acad Sci 1985 0.78
34 Posttranslational processing of the insulin proreceptor. Curr Top Cell Regul 1985 0.76
35 Conformational states of the insulin receptor. Biochem Biophys Res Commun 1988 0.76
36 A tyrosine kinase assay using reverse-phase high-performance liquid chromatography. Anal Biochem 1997 0.76
37 Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor. Mol Cell Biol 2001 0.75
38 Phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase. Biochem Biophys Res Commun 1997 0.75
39 The native alpha 2 beta 2 tetramer is the only subunit structure of the insulin receptor in intact cells and purified receptor preparations. Arch Biochem Biophys 1991 0.75