Published in Biophys Chem on December 15, 2000
Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. Biochemistry (2008) 1.26
Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci U S A (2010) 1.02
Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? J Mol Biol (2015) 0.95
Systemic amyloidosis: a challenge for the rheumatologist. Nat Rev Rheumatol (2010) 0.94
Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophys J (2006) 0.91
Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses. J Biol Chem (2009) 0.82
Uncovering the Mechanism of Aggregation of Human Transthyretin. J Biol Chem (2015) 0.82
Highly anomalous energetics of protein cold denaturation linked to folding-unfolding kinetics. PLoS One (2011) 0.80
Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.78
Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites. J Biol Chem (2015) 0.78
Cooperative stabilization of transthyretin by clusterin and diflunisal. Biochemistry (2014) 0.76
A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation. Int J Mol Sci (2016) 0.75
Recombinant Newcastle disease virus as a vaccine vector. J Virol (2001) 2.67
Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin). J Clin Invest (1984) 2.41
Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates. Am J Pathol (2001) 1.91
Thermal versus guanidine-induced unfolding of ubiquitin. An analysis in terms of the contributions from charge-charge interactions to protein stability. Biochemistry (1999) 1.83
Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants. J Biol Chem (2001) 1.70
Engineering a thermostable protein via optimization of charge-charge interactions on the protein surface. Biochemistry (1999) 1.67
Calorimetrically determined dynamics of complex unfolding transitions in proteins. Annu Rev Biophys Biophys Chem (1990) 1.64
Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1. Amyloid (1999) 1.59
Overexpression of clusterin in human breast carcinoma. Am J Pathol (2000) 1.56
The tetrameric protein transthyretin dissociates to a non-native monomer in solution. A novel model for amyloidogenesis. J Biol Chem (1999) 1.46
A Danish kindred with familial amyloid cardiomyopathy revisited: identification of a mutant transthyretin-methionine111 variant in serum from patients and carriers. Am J Med (1992) 1.45
Serine hydroxymethyltransferase from Escherichia coli: purification and properties. J Bacteriol (1985) 1.40
Lower kinetic limit to protein thermal stability: a proposal regarding protein stability in vivo and its relation with misfolding diseases. Proteins (2000) 1.37
Molecular phylogeny of Cyprinidae inferred from cytochrome b DNA sequences. Mol Phylogenet Evol (1998) 1.36
Identification of highly transformable wheat genotypes for mass production of fertile transgenic plants. Genome (2002) 1.35
Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis. Endocrine (1997) 1.27
Presence of an abnormal transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy. Trans Assoc Am Physicians (1983) 1.24
The molecular basis of cooperativity in protein folding. Thermodynamic dissection of interdomain interactions in phosphoglycerate kinase. Biochemistry (1992) 1.23
The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils. J Biol Chem (1998) 1.22
Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP). Biochemistry (1991) 1.21
Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. J Neurosci (2001) 1.20
Kinetic study on the irreversible thermal denaturation of yeast phosphoglycerate kinase. Biochemistry (1991) 1.18
Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. J Mol Biol (2002) 1.18
pH corrections and protein ionization in water/guanidinium chloride. Biophys J (2001) 1.18
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine. Anal Biochem (1986) 1.14
Prenatal diagnosis of familial amyloidotic polyneuropathy: evidence for an early expression of the associated transthyretin methionine 30. Hum Genet (1990) 1.12
Structure of Met30 variant of transthyretin and its amyloidogenic implications. EMBO J (1993) 1.12
A new mutation causing familial amyloidotic polyneuropathy. Biochem Biophys Res Commun (1989) 1.11
Studies on plasma transthyretin (prealbumin) in familial amyloidotic polyneuropathy, Portuguese type. J Lab Clin Med (1983) 1.10
Geographical distribution of TTR met30 carriers in northern Sweden: discrepancy between carrier frequency and prevalence rate. J Med Genet (1994) 1.10
Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Lab Invest (2000) 1.10
A model-independent, nonlinear extrapolation procedure for the characterization of protein folding energetics from solvent-denaturation data. Biochemistry (1996) 1.09
Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity. FEBS Lett (2008) 1.09
Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy. Am J Pathol (1997) 1.07
Cold denaturation of ubiquitin. Biochim Biophys Acta (1999) 1.06
Production of transgenic tropical maize with cryIAb and cryIAc genes via microprojectile bombardment of immature embryos. Theor Appl Genet (1999) 1.06
Analysis of differential scanning calorimetry data for proteins. Criteria of validity of one-step mechanism of irreversible protein denaturation. Biophys Chem (1997) 1.05
Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A (1999) 1.04
Biochemical marker in familial amyloidotic polyneuropathy, Portuguese type. Family studies on the transthyretin (prealbumin)-methionine-30 variant. J Clin Invest (1985) 1.04
Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis. Am J Pathol (2000) 1.03
The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution. FEBS Lett (1997) 1.03
Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor. J Biol Chem (2001) 1.02
Transthyretin in high density lipoproteins: association with apolipoprotein A-I. J Lipid Res (2000) 1.02
Review: TTR amyloidosis-structural features leading to protein aggregation and their implications on therapeutic strategies. J Struct Biol (2000) 1.01
'In vitro' amyloid fibril formation from transthyretin: the influence of ions and the amyloidogenicity of TTR variants. Biochim Biophys Acta (1996) 1.01
Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model. FASEB J (2006) 1.00
Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain. Neuroscience (2004) 0.99
Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. J Mol Biol (2001) 0.97
Effect of Zn2+ on the thermal denaturation of carboxypeptidase B. Biochemistry (1991) 0.96
Transthyretin Leu 68 in a form of cardiac amyloidosis. Basic Res Cardiol (1992) 0.96
Heat capacity analysis of oxidized Escherichia coli thioredoxin fragments (1--73, 74--108) and their noncovalent complex. Evidence for the burial of apolar surface in protein unfolded states. Eur J Biochem (2001) 0.95
Evidence for the role of megalin in renal uptake of transthyretin. J Biol Chem (2000) 0.95
Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin. Eur J Biochem (1997) 0.95
Genetic expression of a transthyretin mutation in typical and late-onset Portuguese families with familial amyloidotic polyneuropathy. Neurology (1986) 0.95
Haplotype analysis of familial amyloidotic polyneuropathy. Evidence for multiple origins of the Val----Met mutation most common to the disease. Hum Genet (1989) 0.94
Thyroxine binding in a TTR Met 119 kindred. J Clin Endocrinol Metab (1993) 0.93
Proteins of Newcastle disease virus envelope: interaction between the outer hemagglutinin-neuraminidase glycoprotein and the inner non-glycosylated matrix protein. Biochim Biophys Acta (1989) 0.93
Thyroid hormone metabolism in a transthyretin-null mouse strain. J Biol Chem (1994) 0.93
Vitreous amyloidosis after liver transplantation in patients with familial amyloid polyneuropathy: ocular synthesis of mutant transthyretin. Amyloid (2000) 0.93
Thyroid hormone distribution in the mouse brain: the role of transthyretin. Neuroscience (2002) 0.93
Thermodynamics and dynamics of histidine-binding protein, the water-soluble receptor of histidine permease. Implications for the transport of high and low affinity ligands. Eur J Biochem (2000) 0.92
Acidic pH enhancement of the fusion of Newcastle disease virus with cultured cells. Virology (1999) 0.92
Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M. Biochem Biophys Res Commun (2000) 0.92
An osmolyte effect on the heat capacity change for protein folding. Biochemistry (1995) 0.92
Domain structure and function of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem (1994) 0.92
Search for intermediate structures in transthyretin fibrillogenesis: soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils. J Mol Biol (2000) 0.92
Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy. J Neurochem (2006) 0.91
Simultaneous detection of anti-C1q and anti-double stranded DNA autoantibodies in lupus nephritis: predictive value for renal flares. Lupus (2010) 0.91
Family studies of the genetic abnormality in transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy. Ann N Y Acad Sci (1984) 0.91
Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice. Am J Physiol (1997) 0.90
The low-affinity Ca2(+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction. Proc Natl Acad Sci U S A (1990) 0.90
17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway. Cell Mol Neurobiol (2009) 0.90
Thermally induced conformational changes in horseradish peroxidase. Eur J Biochem (2001) 0.89
Sero-epidemiological survey of influenza C virus infection in Spain. Eur J Epidemiol (1994) 0.89
Thermal and pH-induced conformational changes of a beta-sheet protein monitored by infrared spectroscopy. Biochemistry (1999) 0.89
Native hydrogen bonds in a molten globule: the apoflavodoxin thermal intermediate. J Mol Biol (2001) 0.89
Immunoassay for transthyretin variants associated with amyloid neuropathy. Scand J Immunol (1993) 0.89
Onset in the seventh decade and lack of symptoms in heterozygotes for the TTRMet30 mutation in hereditary amyloid neuropathy-type I (Portuguese, Andrade). Am J Med Genet (1987) 0.89
Prediction of relapse by day 100 BCR-ABL quantification after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia (2006) 0.89
Non-typhi Salmonella bacteraemia. Infection (1990) 0.88
Fractionation and characterization of the immunosuppressive substance in crude extracellular products released by Streptococcus intermedius. J Clin Invest (1981) 0.88
Differential scanning calorimetric study of the thermal stability of xylanase from Streptomyces halstedii JM8. Biochemistry (1994) 0.88
Discrimination of peripheral polyneuropathies caused by TTR variant or diabetes in the same pedigree through protein studies. Adv Neurol (1988) 0.88
Irreversible thermal denaturation of Torpedo californica acetylcholinesterase. Protein Sci (1995) 0.88
Structure of the Val122Ile variant transthyretin - a cardiomyopathic mutant. Acta Crystallogr D Biol Crystallogr (1996) 0.88
Permanent genetic resources added to Molecular Ecology Resources Database 1 February 2013-31 March 2013. Mol Ecol Resour (2013) 0.88
The Impact of type 2 diabetes on mortality in end-stage renal disease patients differs between genders. Nephron Clin Pract (2009) 0.87
Transthyretin Ser 6 gene frequency in individuals without amyloidosis. Hum Genet (1995) 0.87
Are there equilibrium intermediate states in the urea-induced unfolding of hen egg-white lysozyme? Biochemistry (1997) 0.86
Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding. Biochemistry (1992) 0.86
Transthyretin is up-regulated by sex hormones in mice liver. Mol Cell Biochem (2008) 0.86
Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model. Endocrinology (2000) 0.86
The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage. J Biol Chem (2000) 0.86
Two partially unfolded states of Torpedo californica acetylcholinesterase. Protein Sci (1996) 0.85