Published in Mol Biochem Parasitol on December 01, 2000
Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library. EMBO J (2002) 1.73
Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. Mol Biol Cell (2003) 1.53
Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. Parasit Vectors (2010) 1.22
The development of Trypanosoma brucei within the tsetse fly midgut observed using green fluorescent trypanosomes. Kinetoplastid Biol Dis (2003) 1.18
Apoptotic markers in protozoan parasites. Parasit Vectors (2010) 1.16
Tsetse EP protein protects the fly midgut from trypanosome establishment. PLoS Pathog (2010) 1.09
Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens. Infect Immun (2005) 1.05
Defects in the N-linked oligosaccharide biosynthetic pathway in a Trypanosoma brucei glycosylation mutant. Eukaryot Cell (2004) 0.94
Structural characterization and epitope mapping of the glutamic acid/alanine-rich protein from Trypanosoma congolense: defining assembly on the parasite cell surface. J Biol Chem (2011) 0.88
Trypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expression. Exp Parasitol (2009) 0.79
Affinity is an important determinant of the anti-trypanosome activity of nanobodies. PLoS Negl Trop Dis (2012) 0.79
Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity. PLoS Negl Trop Dis (2015) 0.76
Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models. PLoS Pathog (2016) 0.75
Characterization of an African trypanosome mutant refractory to lectin-induced death. Biochem Biophys Rep (2015) 0.75
Enzymatic synthesis of deoxyribonucleic acid. XXVI. Physical and chemical studies of a homogeneous deoxyribonucleic acid polymerase. J Biol Chem (1969) 10.45
Bent helical structure in kinetoplast DNA. Proc Natl Acad Sci U S A (1982) 6.43
Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem (2000) 4.96
The origins of a new Trypanosoma brucei rhodesiense sleeping sickness outbreak in eastern Uganda. Lancet (2001) 3.42
A homogeneous type II DNA topoisomerase from HeLa cell nuclei. J Biol Chem (1981) 3.07
Expression of a polypeptide containing a dipeptide repeat is confined to the insect stage of Trypanosoma brucei. Nature (1987) 2.86
The molecular biology of trypanosomes. Annu Rev Biochem (1982) 2.81
Enzymatic synthesis of deoxyribonucleic acid. XXX. Binding of triphosphates to deoxyribonucleic acid polymerase. J Biol Chem (1969) 2.80
Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein. Proc Natl Acad Sci U S A (1985) 2.67
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei. J Cell Biol (1989) 2.60
A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein. Cell (1989) 2.56
A burgeoning epidemic of sleeping sickness in Uganda. Lancet (2005) 2.44
Visualization of the bent helix in kinetoplast DNA by electron microscopy. Cell (1986) 2.31
Specific labeling of 3' termini with T4 DNA polymerase. Methods Enzymol (1980) 2.30
The insect endosymbiont Sodalis glossinidius utilizes a type III secretion system for cell invasion. Proc Natl Acad Sci U S A (2001) 2.26
Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases. Trop Med Int Health (2005) 2.26
The 3'-terminal nucleotide sequences of T7 DNA. J Mol Biol (1972) 2.25
The structure and replication of kinetoplast DNA. Annu Rev Microbiol (1995) 2.16
Procyclin: an unusual immunodominant glycoprotein surface antigen from the procyclic stage of African trypanosomes. Mol Biochem Parasitol (1988) 2.01
Analysis of nucleotide sequences at 3' termini of duplex deoxyribonucleic acid with the use of the T4 deoxyribonucleic acid polymerase. J Biol Chem (1971) 2.00
Ribonucleotides associated with a gap in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. J Biol Chem (1986) 1.97
The 3'-terminal nucleotide sequences of bacteriophage lambda DNA. Proc Natl Acad Sci U S A (1973) 1.92
Replication of kinetoplast DNA in trypanosomes. Annu Rev Microbiol (1988) 1.91
A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem (2001) 1.88
Fatty acid remodeling: a novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell (1990) 1.83
Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein. J Cell Biol (1986) 1.83
Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proc Natl Acad Sci U S A (1990) 1.81
Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters. EMBO J (1990) 1.79
Identification of a glycolipid precursor of the Trypanosoma brucei variant surface glycoprotein. J Biol Chem (1986) 1.75
Elements in the 3' untranslated region of procyclin mRNA regulate expression in insect forms of Trypanosoma brucei by modulating RNA stability and translation. Mol Cell Biol (1997) 1.73
The replication of kinetoplast DNA networks in Crithidia fasciculata. Cell (1978) 1.72
Physical characterization of a kinetoplast DNA fragment with unusual properties. J Biol Chem (1984) 1.71
In situ hybridization to the Crithidia fasciculata kinetoplast reveals two antipodal sites involved in kinetoplast DNA replication. Cell (1992) 1.71
Biosynthesis of glycosyl phosphatidylinositol membrane anchors. J Biol Chem (1990) 1.70
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine. J Biol Chem (1989) 1.70
A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein. J Biol Chem (1986) 1.67
A highly bent fragment of Crithidia fasciculata kinetoplast DNA. J Biol Chem (1986) 1.66
Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin. J Cell Biol (1997) 1.63
A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia. Genes Dev (2000) 1.63
RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA. EMBO J (2001) 1.62
Putative genes of a variant-specific antigen gene transcription unit in Trypanosoma brucei. Mol Cell Biol (1988) 1.59
Free minicircles of kinetoplast DNA in Crithidia fasciculata. J Biol Chem (1979) 1.59
A bent helix in kinetoplast DNA. Cold Spring Harb Symp Quant Biol (1983) 1.55
The effect of template secondary structure on vaccinia DNA polymerase. J Biol Chem (1979) 1.55
Studies on ficin. I. Its isolation and characterization. Biochemistry (1968) 1.54
Decatenation of kinetoplast DNA by topoisomerases. J Biol Chem (1980) 1.54
Enzymatic synthesis of deoxyribonucleic acid. XXXI. Binding of deoxyribonucleic acid to deoxyribonucleic acid polymerase. J Biol Chem (1969) 1.53
Purification and properties of the deoxyribonucleic acid polymerase induced by vaccinia virus. J Biol Chem (1979) 1.52
A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei. Proc Natl Acad Sci U S A (1994) 1.52
Duplication and transcription of procyclin genes in Trypanosoma brucei. Nucleic Acids Res (1989) 1.52
Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria. J Biol Chem (1989) 1.51
A glycan-phosphatidylinositol-specific phospholipase D in human serum. Science (1987) 1.50
The attachment of minicircles to kinetoplast DNA networks during replication. Cell (1993) 1.49
The kinetics of maturation of trypanosome infections in tsetse. Parasitology (1995) 1.48
2.9 A resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei. J Mol Biol (1990) 1.48
Assessing the patterns of health-seeking behaviour and awareness among sleeping-sickness patients in eastern Uganda. Ann Trop Med Parasitol (2004) 1.48
Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: a dual role for polypyrimidine tracts in trypanosomes? Nucleic Acids Res (1994) 1.47
Human African trypanosomiasis: Epidemiology and control. Adv Parasitol (2006) 1.47
Accurate polyadenylation of procyclin mRNAs in Trypanosoma brucei is determined by pyrimidine-rich elements in the intergenic regions. Mol Cell Biol (1994) 1.45
Antioxidants promote establishment of trypanosome infections in tsetse. Parasitology (2007) 1.43
The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly. Proc Natl Acad Sci U S A (2001) 1.41
The immunochemical structure and surface arrangement of Leishmania donovani lipophosphoglycan determined using monoclonal antibodies. Mol Biochem Parasitol (1989) 1.40
Reanalyzing the 1900-1920 sleeping sickness epidemic in Uganda. Emerg Infect Dis (2004) 1.39
A gap at a unique location in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. J Biol Chem (1985) 1.37
The absence of supercoiling in kinetoplast DNA minicircles. EMBO J (1993) 1.37
Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates. J Cell Biol (2001) 1.35
Minisatellite marker analysis of Trypanosoma brucei: reconciliation of clonal, panmictic, and epidemic population genetic structures. Proc Natl Acad Sci U S A (2000) 1.33
Intermediates in the replication of kinetoplast DNA minicircles. J Biol Chem (1985) 1.32
Heterogeneity of minicircles in kinetoplast DNA of Leishmania tarentolae. J Mol Biol (1980) 1.32
Contributions of the procyclin 3' untranslated region and coding region to the regulation of expression in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol (1997) 1.32
Gapped Minicircles. A novel replication intermediate of kinetoplast DNA. J Biol Chem (1984) 1.31
Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues. J Mol Biol (1991) 1.31
Intramitochondrial localization of universal minicircle sequence-binding protein, a trypanosomatid protein that binds kinetoplast minicircle replication origins. J Cell Biol (2001) 1.31
Replication of kinetoplast DNA maxicircles. Cell (1984) 1.30
The endosymbionts of tsetse flies: manipulating host-parasite interactions. Int J Parasitol (2001) 1.28
cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei. Proc Natl Acad Sci U S A (1988) 1.28
The structure of replicating kinetoplast DNA networks. J Cell Biol (1993) 1.26
The procyclin repertoire of Trypanosoma brucei. Identification and structural characterization of the Glu-Pro-rich polypeptides. J Biol Chem (1999) 1.25
The topology of the kinetoplast DNA network. Cell (1995) 1.23
Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors. Science (2000) 1.23
Epidemiological relationships of Trypanosoma brucei stocks from south east Uganda: evidence for different population structures in human infective and non-human infective isolates. Parasitology (1994) 1.22
The origins, dynamics and generation of Trypanosoma brucei rhodesiense epidemics in East Africa. Parasitol Today (1996) 1.22
An analog of myristic acid with selective toxicity for African trypanosomes. Science (1991) 1.22
The replication mechanism of kinetoplast DNA networks in several trypanosomatid species. J Cell Sci (1998) 1.21
Glossina fuscipes fuscipes in the trypanosomiasis endemic areas of south eastern Uganda: apparent density, trypanosome infection rates and host feeding preferences. Acta Trop (2006) 1.21
'GPEET' procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427. Biochem J (1997) 1.20
The distribution of dust mite allergen in the houses of patients with asthma. Am Rev Respir Dis (1981) 1.20
Biosynthesis of a variant surface glycoprotein of Trypanosoma brucei. Processing of the glycolipid membrane anchor and N-linked oligosaccharides. J Biol Chem (1988) 1.19
Kinetoplast DNA replication: mechanistic differences between Trypanosoma brucei and Crithidia fasciculata. J Cell Biol (1994) 1.18
Unravelling the procyclin coat of Trypanosoma brucei. Mol Biochem Parasitol (1998) 1.17
Unlocking the secrets of trypanosome kinetoplast DNA network replication. Protist (2001) 1.17
Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei. J Mol Biol (2001) 1.17
Two distinct forms of surface antigen gene rearrangement in Trypanosoma brucei. Nature (1982) 1.16
DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect Immun (2001) 1.15
Presence of a bent helix in fragments of kinetoplast DNA minicircles from several trypanosomatid species. Mol Biochem Parasitol (1984) 1.15
A mitochondrial DNA primase from the trypanosomatid Crithidia fasciculata. J Biol Chem (1997) 1.14
The use of transgenic Trypanosoma brucei to identify compounds inducing the differentiation of bloodstream forms to procyclic forms. Mol Biochem Parasitol (1999) 1.14