Published in J Clin Invest on March 01, 1975
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest (1985) 4.38
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest (1981) 3.34
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest (1987) 2.81
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest (1987) 2.36
Retracted Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes. J Clin Invest (1979) 1.94
Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol (2010) 1.92
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity. J Clin Invest (1986) 1.67
In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus. J Clin Invest (1983) 1.50
Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. J Clin Invest (1995) 1.29
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. J Clin Invest (1984) 1.13
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes. J Clin Invest (1987) 1.07
Diabetes mellitus: The epidemic of the century. World J Diabetes (2015) 1.06
Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status. West J Med (1985) 1.00
Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes. J Clin Invest (1986) 0.95
Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. J Clin Invest (1990) 0.89
Hyperglucagonemia and insulin-mediated glucose metabolism. J Clin Invest (1987) 0.86
Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes. Vasc Health Risk Manag (2007) 0.82
The metabolic syndrome. J R Soc Med (2006) 0.80
Differential roles of splanchnic and peripheral tissues in the pathogenesis of impaired glucose tolerance. J Clin Invest (1984) 0.79
Insulin resistance: from bit player to centre stage. CMAJ (2011) 0.76
Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design. Trials (2016) 0.75
Relation of insulin resistance with social-demographics, adiposity and behavioral factors in non-diabetic adult Canadians. J Diabetes Metab Disord (2016) 0.75
The chronic cardiovascular risk factor syndrome (syndrome X): mechanisms and implications for atherogenesis. Postgrad Med J (1991) 0.75
Antidiabetic and gastric emptying inhibitory effect of herbal Melia azedarach leaf extract in rodent models of diabetes type 2 mellitus. J Exp Pharmacol (2017) 0.75
Syndrome X: what's old, what's new, what's etiologic? J Clin Invest (1993) 0.75
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (1963) 16.71
Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab (1971) 5.20
Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest (1970) 4.74
Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic. Diabetes (1960) 2.93
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest (1970) 2.68
Some current controversies in diabetes research. Diabetes (1965) 1.92
CRITICAL FACTORS IN EXCESSIVE SERUM-INSULIN RESPONSE TO GLUCOSE. OBESITY IN MATURITY-ONSET DIABETES AND GROWTH HORMONE IN ACROMEGALY. Lancet (1965) 1.88
The significance and interpretation of mildly abnormal oral glucose tolerance. Diabetologia (1971) 1.31
Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes (1968) 1.21
Automated colorimetric determination of free fatty acids in biologic fluids. Clin Chem (1967) 1.10
Serial postprandial plasma insulin levels in 117 subjects with and without diabetes. Diabetes (1973) 1.06
Excessive serum insulin response to oral glucose in obesity and mild diabetes. Study of 501 patients. Diabetes (1970) 0.99
Diurnal serum growth hormone levels in poorly and well-controlled juvenile diabetics. Diabetes (1971) 0.95
Is there a delay in the plasma insulin response of patients with chemical diabetes mellitus? Diabetes (1971) 0.93
Insulin patterns in equivocal glucose tolerance tests (chemical diabetes). Diabetes (1973) 0.93
Comparison of the effects of metabolic acidosis and acute uremia on carbohydrate tolerance. Diabetes (1972) 0.90
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Insulin resistance and cigarette smoking. Lancet (1992) 4.10
Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology (1995) 3.91
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (1998) 3.41
Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest (1981) 3.34
Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab (2001) 3.31
Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes (1996) 3.21
Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest (1980) 3.10
Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA (1991) 3.01
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest (1987) 2.81
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia (2007) 2.71
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest (1970) 2.68
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest (2000) 2.67
Coronary artery disease in Chinese males without hypercholesterolaemia. J Intern Med (1990) 2.54
A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism (2000) 2.49
The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease. Ann Neurol (1993) 2.48
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem (1987) 2.48
The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes (1985) 2.46
Fructose-induced insulin resistance and hypertension in rats. Hypertension (1987) 2.43
Effects of a quick-release form of bromocriptine (Ergoset) on fasting and postprandial plasma glucose, insulin, lipid, and lipoprotein concentrations in obese nondiabetic hyperinsulinemic women. Diabetes Care (1997) 2.40
LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective. Diabetes (1981) 2.40
Relationship between several surrogate estimates of insulin resistance and quantification of insulin-mediated glucose disposal in 490 healthy nondiabetic volunteers. Diabetes Care (2000) 2.22
Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab (1998) 2.21
The insulin receptor: its role in insulin resistance of obesity and diabetes. Diabetes (1976) 2.15
Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med (1976) 2.13
Mechanisms of insulin resistance in aging. J Clin Invest (1983) 2.00
Role of insulin in endogenous hypertriglyceridemia. J Clin Invest (1967) 2.00
Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1987) 1.96
Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest (1974) 1.92
Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care (1992) 1.92
Effect of metformin on carbohydrate and lipoprotein metabolism in NIDDM patients. Diabetes Care (1990) 1.90
Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test. Diabetologia (1994) 1.87
In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest (1986) 1.87
Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med (1974) 1.84
Kinetics of triglyceride turnover of very low density lipoproteins of human plasma. J Clin Invest (1965) 1.83
Insulin resistance in pulmonary arterial hypertension. Eur Respir J (2008) 1.80
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem (1994) 1.79
Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor. Mol Cell Biol (1984) 1.76
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J Clin Invest (1987) 1.76
The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest (1976) 1.75
Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J Biol Chem (1996) 1.74
Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem (1996) 1.71
Insulin treatment reverses the insulin resistance of type II diabetes mellitus. Diabetes Care (1983) 1.71
Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J Clin Invest (1976) 1.66
Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation. J Biol Chem (1995) 1.65
Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics (2004) 1.65
Effects of low-fat, high-carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. Am J Clin Nutr (1997) 1.62
Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes (1996) 1.60
Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest (1975) 1.59
Rationale of the diet-heart statement of the American Heart Association. Report of the Nutrition Committee. Circulation (1993) 1.58
G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes. Mol Cell Biol (1999) 1.58
Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes (1990) 1.54
Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism (1998) 1.54
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol (2001) 1.53
Insulin binding to isolated human adipocytes. Diabetes (1974) 1.53
Effects of fasting on insulin binding, glucose transport, and glucose oxidation in isolated rat adipocytes: relationships between insulin receptors and insulin action. J Clin Invest (1976) 1.52
Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1985) 1.51
Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes. Biochem J (1978) 1.51
Effects of age and obesity on insulin binding to isolated adipocytes. Endocrinology (1975) 1.50
Effects of streptozotocin-induced diabetes on insulin binding, glucose transport, and intracellular glucose metabolism in isolated rat adipocytes. Diabetes (1979) 1.50
Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivity. Diabetes (1977) 1.49
Further evidence for a central role of adipose tissue in the antihyperglycemic effect of metformin. Diabetes Care (1998) 1.49
Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J Clin Invest (1988) 1.49
Effects of sleep deprivation on cognitive ability and skills of pediatrics residents. Acad Med (1989) 1.48
From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia (1997) 1.46
Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes (1994) 1.46
Resistance to insulin-stimulated-glucose uptake in patients with hypertension. J Clin Endocrinol Metab (1988) 1.46
Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med (1996) 1.45
Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling. J Biol Chem (1996) 1.45
Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care (1994) 1.44
Low-dose combined therapy with fluvastatin and cholestyramine in hyperlipidemic patients. Ann Intern Med (1994) 1.44
Much ado about (almost) nothing. Diabetes Care (1997) 1.43
Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem (1994) 1.43
Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes. Am J Med (1981) 1.43
Enhanced glucose utilization during prolonged glucose clamp studies. Diabetes (1981) 1.42
Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation. J Biol Chem (1979) 1.42
Insulin resistance and cigarette smoking. Lancet (1992) 1.42
Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes (1986) 1.41
Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance. J Biol Chem (1987) 1.41
Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab (1987) 1.40
Relation between dietary vitamin intake and resistance to insulin-mediated glucose disposal in healthy volunteers. Am J Clin Nutr (1996) 1.40
Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and insulin concentrations. J Intern Med (1992) 1.39
Coronary heart disease in the absence of hypercholesterolaemia. J Intern Med (1990) 1.39
Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity (Silver Spring) (2009) 1.39
Evidence for recycling of insulin receptors in isolated rat adipocytes. J Biol Chem (1981) 1.38
Insulin delivery rate into plasma in normal and diabetic subjects. J Clin Invest (1968) 1.38
Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol (1982) 1.38
Decreased insulin binding to lymphocytes from diabetic subjects. J Clin Invest (1974) 1.37
The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. J Biol Chem (2000) 1.35
A quantitative ultrastructural study of microtubule content and secretory granule accumulation in parathyroid glands of phosphate- and colchicine-treated rats. J Clin Invest (1975) 1.35
beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem (2001) 1.35
Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. J Clin Endocrinol Metab (1979) 1.34