The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

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Published in Ann N Y Acad Sci on January 01, 2000

Authors

M G Spillantini1, M Goedert

Author Affiliations

1: Department of Neurology and Brain Repair Centre, University of Cambridge, Cambridge, UK. mgs11@cam.ac.uk

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Alpha-synuclein in Lewy bodies. Nature (1997) 20.83

Neurodegenerative tauopathies. Annu Rev Neurosci (2001) 9.53

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci U S A (1998) 8.41

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A (1998) 6.13

Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol (1999) 4.98

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci U S A (2000) 3.86

Identification of two distinct synucleins from human brain. FEBS Lett (1994) 3.61

Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron (1993) 3.45

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett (1998) 3.26

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J Neurosci Res (1994) 3.26

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. EMBO J (1992) 3.04

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem Biol (1998) 2.73

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J (1997) 2.60

The mas oncogene encodes an angiotensin receptor. Nature (1988) 2.53

Tau protein pathology in neurodegenerative diseases. Trends Neurosci (1998) 2.37

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J Biol Chem (1998) 2.32

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett (1998) 2.26

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Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP. Proc Natl Acad Sci U S A (1996) 1.94

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol (2000) 1.92

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ (1998) 1.92

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments. Proc Natl Acad Sci U S A (1997) 1.89

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin. FEBS Lett (1999) 1.88

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Effect of SB 203580 on the activity of c-Raf in vitro and in vivo. Oncogene (1999) 1.86

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis (2000) 1.84

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. Exp Neurol (1994) 1.84

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr Biol (1999) 1.81

Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Lett (1998) 1.79

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J (1995) 1.77

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Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J Biol Chem (1995) 1.70

A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto) Ann Neurol (2000) 1.65

Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J Biol Chem (1999) 1.50

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. J Neuropathol Exp Neurol (1999) 1.49

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBS Lett (1992) 1.45

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J (2000) 1.44

Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein. Neurosci Lett (1999) 1.42

Abnormal tau-containing filaments in neurodegenerative diseases. J Struct Biol (2000) 1.42

Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. Proc Natl Acad Sci U S A (1990) 1.42

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. Acta Neuropathol (1996) 1.39

Tau pathology in a family with dementia and a P301L mutation in tau. J Neuropathol Exp Neurol (1999) 1.38

SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett (1996) 1.37

Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation. J Biol Chem (1997) 1.30

Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci Lett (2000) 1.27

Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment. Acta Neuropathol (1996) 1.27

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. Proc Natl Acad Sci U S A (1990) 1.22

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease. FEBS Lett (1992) 1.21

FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10. FEBS Lett (1999) 1.19

Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci (1983) 1.18

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells. Neurosci Lett (1995) 1.18

Assembly of Alzheimer-like filaments from full-length tau protein. FEBS Lett (1994) 1.18

Lewy body diseases and multiple system atrophy as alpha-synucleinopathies. Mol Psychiatry (1998) 1.17

Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics. Nucleic Acids Res (2000) 1.17

Dopamine, norepinephrine and serotonin production by an intestinal carcinoid tumor. Cancer (1980) 1.16

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. FEBS Lett (1996) 1.16

Alternative splicing of synaptotagmins involving transmembrane exon skipping. FEBS Lett (1999) 1.15

Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits. J Neuropathol Exp Neurol (1999) 1.12

Expression of APP in transgenic mice: a comparison of neuron-specific promoters. Neurobiol Aging (1996) 1.12

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section. Brain Res (1985) 1.10

Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature (1984) 1.09

SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK). FEBS Lett (1997) 1.08

Familial Parkinson's disease. The awakening of alpha-synuclein. Nature (1997) 1.07

Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Mol Cell Neurosci (2001) 1.07

Invited review: Prion-like transmission and spreading of tau pathology. Neuropathol Appl Neurobiol (2015) 1.05

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356. Biochem J (1996) 1.04

Tau gene mutation K257T causes a tauopathy similar to Pick's disease. J Neuropathol Exp Neurol (2000) 1.04

The repeat region of microtubule-associated protein tau forms part of the core of the paired helical filament of Alzheimer's disease. Ann Med (1989) 1.04

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease. Brain Res (1986) 1.01

A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. Ann Neurol (2000) 1.00

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease. Brain Res Mol Brain Res (1996) 1.00

Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Neurogenetics (2000) 1.00

Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain. FEBS Lett (1995) 0.99

Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17. Am J Hum Genet (1997) 0.99

Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics (1995) 0.98

The regional distribution and chromatographic characterisation of neurotensin-like immunoreactivity in the rat central nervous system. J Neurochem (1982) 0.98

Requirement of nerve growth factor for development of substance P-containing sensory neurones. Nature (1980) 0.98

Pick's disease associated with the novel Tau gene mutation K369I. Ann Neurol (2001) 0.97

Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia. Brain Res (1978) 0.96

The nature of the substance P-containing nerve fibres in taste papillae of the rat tongue. Neuroscience (1982) 0.95

Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia. Proc Natl Acad Sci U S A (1984) 0.95

Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices. Brain Res (1984) 0.93

Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells. Br J Pharmacol (1997) 0.92

Molecular structure of microtubule-associated protein 2b and 2c from rat brain. J Biol Chem (1990) 0.90

Neurotensin in human small cell lung carcinoma. Br J Cancer (1984) 0.90

Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. Acta Neuropathol (1997) 0.88

Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Nature (1984) 0.88

Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Ann N Y Acad Sci (1996) 0.88

Cathepsin D displays in vitro beta-secretase-like specificity. Brain Res (1997) 0.87

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci Lett (1994) 0.86

Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord. Exp Neurol (1993) 0.86

The natural osmolyte trimethylamine N-oxide (TMAO) restores the ability of mutant tau to promote microtubule assembly. FEBS Lett (2000) 0.84

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neurosci Lett (1995) 0.84

Use of a heat-stable microtubule-associated protein class-specific antibody to investigate the mechanism of microtubule binding. J Biol Chem (1991) 0.84

The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease. Biochem Pharmacol (1984) 0.83

Phosphorylation of tau by cyclic-AMP-dependent protein kinase. Dementia (1994) 0.83