Published in Nucleosides Nucleotides Nucleic Acids on January 25, 2001
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Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus. J Virol Methods (1987) 2.10
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J Biol Chem (1989) 1.89
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem (2000) 1.85
Molecular dipstick test for diagnosis of sleeping sickness. J Clin Microbiol (2006) 1.84
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc Natl Acad Sci U S A (1989) 1.74
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Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem Biophys Res Commun (1987) 1.67
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Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. VI. The binding and cleavage of substrates containing nucleotide analogs. Nucleic Acids Res (1985) 1.40
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Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2', 3'-dideoxyguanosine in vitro. Biochem Biophys Res Commun (1987) 1.27
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The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding. Nucleic Acids Res (1993) 1.20
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine. Biochem Biophys Res Commun (1986) 1.19
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability. Nucleic Acids Res (1992) 1.16
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry (1997) 1.13
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. J Med Chem (1988) 1.12
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins (1998) 1.11
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Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem (1994) 1.10
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Proc Natl Acad Sci U S A (1991) 1.09
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Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides. Nucleic Acids Res (1991) 1.05
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Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J Med Chem (1986) 1.01
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro. Biochem Biophys Res Commun (1987) 1.00
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus. J Biol Chem (1991) 0.99
Incorporation of 2'-amido-nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates. Nucleic Acids Res (1995) 0.99
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Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. EcoRII endonuclease cleavage of substrates with repeated natural and modified recognition sites. FEBS Lett (1984) 0.98
Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J Mol Biol (1999) 0.97
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(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity. Nucleosides Nucleotides Nucleic Acids (2001) 0.94
An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside. Nucleic Acids Res (1995) 0.92
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Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. J Med Chem (1995) 0.91
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Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1. J Med Chem (1996) 0.89
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Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Biochem Pharmacol (1988) 0.89
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Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. V. Study of single-strand cleavages. Nucleic Acids Res (1985) 0.87
Processive cleavage of concatemer DNA duplexes by Eco RII restriction endonuclease. Mol Biol Rep (1985) 0.87
[Characteristics of a plasmid bearing a gene of a restriction modification type II system--the SsoII isoschizomer]. Mol Biol (Mosk) (1998) 0.87
Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30. Eur J Biochem (1997) 0.86
RNA as a target for drug design, the example of Tat-TAR interaction. Curr Top Med Chem (2002) 0.86
Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides. Chemistry (2000) 0.86
Resolution of aristeromycin enantiomers. J Med Chem (1985) 0.86
Antimalarial antisense activity of hexitol nucleic acids. Parasitol Res (1999) 0.85
The role of modifications in oligonucleotides in sequence recognition by MvaI restriction endonuclease. Eur J Biochem (1988) 0.85
Modified substrates as probes for studying uracil-DNA glycosylase. Gene (1995) 0.85
Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA. Biochem Pharmacol (2000) 0.85
Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine. Antiviral Res (1992) 0.84
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3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues. J Med Chem (1989) 0.83
[Interaction of EcoRII restriction and modification enzyme with synthetic DNA fragments. IV. DNA duplexes with phosphoamide and pyrophosphate internucleotide bonds--the substrates for the study of single-strand breaks]. Mol Biol (Mosk) (1986) 0.83
The interaction of DNA duplexes containing 2-aminopurine with restriction endonucleases EcoRII and SsoII. Nucleic Acids Res (1995) 0.83
Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine. Antiviral Res (1989) 0.83
[Synthesis and properties of DNA-duplexes, containing 9-(1'-hydroxy-2'-(hydroxymethyl)ethoxy)methylguanine]. Bioorg Khim (1991) 0.83
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. J Med Chem (2000) 0.82
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Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides. J Med Chem (1989) 0.82
Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides. Biochem Biophys Res Commun (1995) 0.81
Thermodynamic characterization of the partially unfolded state of Ca(2+)-loaded bovine alpha-lactalbumin: evidence that partial unfolding can precede Ca2+ release. Biochemistry (1996) 0.81
Cleavage of synthetic substrates containing non-nucleotide inserts by restriction endonucleases. Change in the cleavage specificity of endonuclease SsoII. Nucleic Acids Res (1992) 0.81
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents. Biochem Pharmacol (1989) 0.81
Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids. Nucleic Acids Res (2007) 0.81
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues. J Med Chem (1993) 0.81
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides. J Med Chem (1993) 0.81
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines. J Med Chem (1990) 0.81