Brain dopamine and obesity.

The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) (2006) 9.18

Can food be addictive? Public health and policy implications. Addiction (2011) 6.27

Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci (2010) 5.98

Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev (2007) 5.22

Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science (2008) 4.94

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci (2011) 4.88

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl) (2007) 4.73

Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci (2008) 3.48

Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci (2010) 3.48

Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study. J Abnorm Psychol (2008) 3.20

Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr (2008) 3.02

'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiol Behav (2009) 2.94

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage (2008) 2.86

The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res (2010) 2.68

Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav Neurosci (2007) 2.38

Food reinforcement and eating: a multilevel analysis. Psychol Bull (2007) 2.32

Neural correlates of food addiction. Arch Gen Psychiatry (2011) 2.30

Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation. Proc Natl Acad Sci U S A (2009) 2.27

Obesity and the brain: how convincing is the addiction model? Nat Rev Neurosci (2012) 2.26

Neuroimaging and obesity: current knowledge and future directions. Obes Rev (2011) 2.23

Reward mechanisms in obesity: new insights and future directions. Neuron (2011) 2.21

Dissociable Effects of Serotonin and Dopamine on the Valuation of Harm in Moral Decision Making. Curr Biol (2015) 2.21

Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4. Neuroimage (2010) 2.18

Obesity and addiction: neurobiological overlaps. Obes Rev (2012) 1.99

Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB J (2008) 1.99

The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology (Berl) (2012) 1.96

Weight gain is associated with reduced striatal response to palatable food. J Neurosci (2010) 1.94

Inverse association between BMI and prefrontal metabolic activity in healthy adults. Obesity (Silver Spring) (2008) 1.92

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci (2008) 1.90

An examination of the food addiction construct in obese patients with binge eating disorder. Int J Eat Disord (2011) 1.88

Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol (2008) 1.84

Youth at risk for obesity show greater activation of striatal and somatosensory regions to food. J Neurosci (2011) 1.84

GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol (2003) 1.83

Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity. Psychopharmacology (Berl) (2011) 1.77

Sugar and fat bingeing have notable differences in addictive-like behavior. J Nutr (2009) 1.77

From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74

Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr (2013) 1.73

Differential effects of daily snack food intake on the reinforcing value of food in obese and nonobese women. Am J Clin Nutr (2009) 1.71

Diet, urate, and Parkinson's disease risk in men. Am J Epidemiol (2008) 1.69

The neuropsychology of cocaine addiction: recent cocaine use masks impairment. Neuropsychopharmacology (2008) 1.63

Obesity and restless legs syndrome in men and women. Neurology (2009) 1.61

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57

Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int J Obes (Lond) (2011) 1.56

Repeated sucrose access influences dopamine D2 receptor density in the striatum. Neuroreport (2002) 1.54

Relation of obesity to consummatory and anticipatory food reward. Physiol Behav (2009) 1.52

Disorders of compulsivity: a common bias towards learning habits. Mol Psychiatry (2014) 1.48

Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab (2012) 1.47

Feeding and reward: perspectives from three rat models of binge eating. Physiol Behav (2011) 1.44

Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity. PLoS One (2015) 1.44

Decreased dopamine type 2 receptor availability after bariatric surgery: preliminary findings. Brain Res (2010) 1.41

Roux-en-Y gastric bypass surgery changes food reward in rats. Int J Obes (Lond) (2010) 1.41

Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents. Int J Endocrinol (2016) 1.40

Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care (2011) 1.38

Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry (2002) 1.35

Chronic high-fat diet drives postnatal epigenetic regulation of μ-opioid receptor in the brain. Neuropsychopharmacology (2011) 1.34

Dorsal striatum and its limbic connectivity mediate abnormal anticipatory reward processing in obesity. PLoS One (2012) 1.33

Preventing excessive weight gain in adolescents: interpersonal psychotherapy for binge eating. Obesity (Silver Spring) (2007) 1.33

Stress as a common risk factor for obesity and addiction. Biol Psychiatry (2013) 1.32

Inhibiting food reward: delay discounting, food reward sensitivity, and palatable food intake in overweight and obese women. Obesity (Silver Spring) (2011) 1.32

The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev (2012) 1.30

Brain-derived neurotrophic factor regulates hedonic feeding by acting on the mesolimbic dopamine system. J Neurosci (2010) 1.30

Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Res (2011) 1.29

Roux en Y gastric bypass increases ethanol intake in the rat. Obes Surg (2013) 1.25

Energy regulatory signals and food reward. Pharmacol Biochem Behav (2010) 1.25

From observation to experimentation: leptin action in the mediobasal hypothalamus. Am J Clin Nutr (2009) 1.23

Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. J Biol Chem (2010) 1.23

Reduced accumbens dopamine in Sprague-Dawley rats prone to overeating a fat-rich diet. Physiol Behav (2010) 1.22

Metabolic hormones, dopamine circuits, and feeding. Front Neuroendocrinol (2009) 1.22

Dopamine signaling in reward-related behaviors. Front Neural Circuits (2013) 1.21

Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study. Int J Eat Disord (2010) 1.21

Food-addiction scale measurement in 2 cohorts of middle-aged and older women. Am J Clin Nutr (2014) 1.21

Psychological treatments for binge eating disorder. Curr Psychiatry Rep (2012) 1.20

Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry (2013) 1.19

Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience (2012) 1.18

Variability in reward responsivity and obesity: evidence from brain imaging studies. Curr Drug Abuse Rev (2011) 1.17

Neurobehavioural correlates of body mass index and eating behaviours in adults: a systematic review. Neurosci Biobehav Rev (2012) 1.15

Altered processing of sweet taste in the brain of diet soda drinkers. Physiol Behav (2012) 1.15

Regulation of fat intake in the absence of flavour signalling. J Physiol (2012) 1.14

Imaging of brain dopamine pathways: implications for understanding obesity. J Addict Med (2009) 1.14

Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit Rev Biochem Mol Biol (2012) 1.14

Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. Diabetes Care (2012) 1.14

Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling. Neuroscience (2009) 1.14

Is food addiction a valid and useful concept? Obes Rev (2012) 1.14

Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity (Silver Spring) (2008) 1.13

"Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. Am J Physiol Regul Integr Comp Physiol (2011) 1.13

Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity. Neuroimage (2012) 1.13

Individual differences in the neurophysiology of reward and the obesity epidemic. Int J Obes (Lond) (2009) 1.13

The dark side of food addiction. Physiol Behav (2011) 1.12

Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Am J Physiol Regul Integr Comp Physiol (2005) 1.11

Reliance on habits at the expense of goal-directed control following dopamine precursor depletion. Psychopharmacology (Berl) (2011) 1.10

Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring) (2006) 1.09

Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults. Brain Res (2011) 1.08

A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Synapse (2013) 1.07

Dopamine and binge eating behaviors. Pharmacol Biochem Behav (2010) 1.06

Molecular gastronomy: a new emerging scientific discipline. Chem Rev (2010) 1.06

Fructose: it's "alcohol without the buzz". Adv Nutr (2013) 1.05

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity. Neuroendocrinology (2008) 1.05

Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One (2012) 1.04

Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. J Neurochem (2008) 1.04

Insulin signaling and addiction. Neuropharmacology (2011) 1.04

Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab (1996) 9.49

Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab (1990) 6.62

A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev (1998) 5.14

Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex (2000) 4.61

Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. Am J Psychiatry (2001) 4.37

Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am J Psychiatry (2001) 4.13

Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse (1993) 4.13

The relationship of the spleen to the formation of the blood corpuscles. J Physiol (1902) 3.98

Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell (2001) 3.97

Dopamine in drug abuse and addiction: results from imaging studies and treatment implications. Mol Psychiatry (2004) 3.80

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature (1997) 3.76

Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. J Neurosci (2001) 3.46

The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol (1986) 3.36

Imaging dopamine's role in drug abuse and addiction. Neuropharmacology (2008) 3.28

Optimal spliced alignment of homologous cDNA to a genomic DNA template. Bioinformatics (2000) 3.14

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc Natl Acad Sci U S A (1984) 3.11

Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. Am J Psychiatry (1998) 3.02

Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature (1997) 2.94

Changes in brain glucose metabolism in cocaine dependence and withdrawal. Am J Psychiatry (1991) 2.89

Inhibition of monoamine oxidase B in the brains of smokers. Nature (1996) 2.62

Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry (1998) 2.50

Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am J Psychiatry (1999) 2.49

PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J (1998) 2.44

Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci (2001) 2.41

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J Virol (1984) 2.39

Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci (1999) 2.35

Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator element. Cell (1985) 2.29

The biphasic poroviscoelastic behavior of articular cartilage: role of the surface zone in governing the compressive behavior. J Biomech (1993) 2.19

Evolutionary strategies for the elucidation of cis and trans factors that regulate the developmental switching programs of the beta-like globin genes. Mol Phylogenet Evol (1996) 2.17

Long-term frontal brain metabolic changes in cocaine abusers. Synapse (1992) 2.16

Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. Synapse (1997) 2.15

Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes (2007) 2.13

Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors. J Pharmacol Exp Ther (1999) 2.11

New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry (2011) 2.11

Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res (1996) 2.09

Altered glucose metabolism in microvessels from patients with Alzheimer's disease. Ann Neurol (1989) 2.08

Metabolic trapping as a principle of oradiopharmaceutical design: some factors resposible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose. J Nucl Med (1978) 2.07

Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation (2001) 2.04

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry (2011) 2.03

A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med (1980) 2.01

Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry (1995) 2.00

Aging and functional brain networks. Mol Psychiatry (2011) 1.99

Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies. Behav Pharmacol (2002) 1.95

Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction. Neuroscience (2006) 1.93

Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci (2012) 1.90

Differential display using one-base anchored oligo-dT primers. Nucleic Acids Res (1994) 1.85

Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism. Am J Psychiatry (2000) 1.85

The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev (1995) 1.84

Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. Am J Psychiatry (1999) 1.81

Is [1-11C]putrescine useful as a brain tumor marker? J Nucl Med (1992) 1.80

A strategy for removing the bias in the graphical analysis method. J Cereb Blood Flow Metab (2001) 1.79

Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol (1999) 1.78

123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur J Pharmacol (1996) 1.78

Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci U S A (1996) 1.78

A review of the statistical analysis used in papers published in Clinical Radiology and British Journal of Radiology. Clin Radiol (1996) 1.74

Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing. Radiology (1993) 1.69

Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse (1994) 1.68

Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am J Psychiatry (1990) 1.66

Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem (2001) 1.66

An Experimentally Validated Numerical Modeling Technique for Perforated Plate Heat Exchangers. J Heat Transfer (2010) 1.64

Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study. J Nucl Med (1995) 1.62

What do physicians tell patients with end-stage COPD about intubation and mechanical ventilation? Chest (1996) 1.60

Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100. J Clin Invest (1998) 1.59

Mechanism of action of methylphenidate: insights from PET imaging studies. J Atten Disord (2002) 1.57

EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. Oncogene (2011) 1.56

The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon. Nat Struct Biol (1996) 1.56

Homologues of neisserial heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa. J Bacteriol (2001) 1.55

Addiction changes orbitofrontal gyrus function: involvement in response inhibition. Neuroreport (2001) 1.55

Intersubject variability of brain glucose metabolic measurements in young normal males. J Nucl Med (1994) 1.54