PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.

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Published in Hum Mol Genet on March 15, 2001

Authors

L P Weng1, W M Smith, J L Brown, C Eng

Author Affiliations

1: Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.

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