Published in Arthritis Rheum on March 01, 2001
Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease | NCT02398435
Diagnosis and management of adult onset Still's disease. Ann Rheum Dis (2005) 2.32
Interleukin-18 and IL-18 binding protein. Front Immunol (2013) 1.93
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood (2005) 1.53
Th17 response and inflammatory autoimmune diseases. Int J Inflam (2011) 1.29
Adult-onset Still's disease. Rheumatol Int (2009) 1.27
Increased serum HO-1 in hemophagocytic syndrome and adult-onset Still's disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther (2005) 1.11
Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine. Proc Natl Acad Sci U S A (2003) 1.06
Macrophage activation syndrome and cytokine-directed therapies. Best Pract Res Clin Rheumatol (2014) 1.06
Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease. Ann Rheum Dis (2004) 1.04
Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al. Arthritis Rheum (2002) 1.03
Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis. Ann Rheum Dis (2004) 1.00
A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis. Clin Rheumatol (2005) 0.97
Interleukin-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis. Arthritis Res Ther (2010) 0.93
Serum interleukin-18 levels in patients with Behçet's disease. Is its expression associated with disease activity or clinical presentations? Rheumatol Int (2005) 0.90
Cutaneous manifestations associated with adult-onset Still's disease: important diagnostic values. Rheumatol Int (2011) 0.89
Emerging role of anti-tumor necrosis factor therapy in rheumatic diseases. Arthritis Res (2002) 0.88
Adult-Onset Still's Disease: From Pathophysiology to Targeted Therapies. Int J Inflam (2012) 0.88
Perspectives for TNF-alpha-targeting therapies. Arthritis Res (2002) 0.88
A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population. Arthritis Res Ther (2006) 0.86
Successful treatment of adult-onset Still's disease with tocilizumab monotherapy: two case reports and literature review. Clin Rheumatol (2012) 0.85
Is Still's Disease an Autoinflammatory Syndrome? Int J Inflam (2012) 0.84
Serum proinflammatory cytokines directing T helper 1 polarization in patients with familial Mediterranean fever. Rheumatol Int (2007) 0.84
Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker. BMC Med (2012) 0.84
Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis. Arthritis Res Ther (2011) 0.83
Adult-onset Still disease: a rare disorder with a potentially fatal outcome. Auto Immun Highlights (2010) 0.82
Elevated interleukin-18 and skewed Th1:Th2 immune response in lupus nephritis. Rheumatol Int (2010) 0.81
IL-18 Serum Level in Adult Onset Still's Disease: A Marker of Disease Activity. Int J Inflam (2012) 0.81
Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis. Clin Rheumatol (2006) 0.81
Steroid-refractory severe hepatic failure in adult onset Still's disease responding to cyclosporine. Clin Rheumatol (2008) 0.79
Correlation of serum CX3CL1 level with disease activity in adult-onset Still's disease and significant involvement in hemophagocytic syndrome. Clin Rheumatol (2012) 0.79
Successful Use of Higher-Dose Etanercept for Multirefractory Systemic Flare of Adult-Onset Still's Disease with Liver Failure with No Response to Tocilizumab Therapy. Case Rep Rheumatol (2013) 0.78
Serum interleukin-18 levels are associated with physical activity in Japanese men. PLoS One (2013) 0.78
Adult-Onset Still's Disease Masquerading as Sepsis in an Asplenic Active Duty Soldier. Case Rep Med (2012) 0.76
Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease. Clin Rheumatol (2006) 0.76
Macrophage activation syndrome in the era of biologic therapy. Nat Rev Rheumatol (2016) 0.76
Adult-onset Still's disease revealed by perimyocarditis and a concomitant reactivation of an EBV infection. BMJ Case Rep (2012) 0.75
Hemophagocytic syndrome secondary to adult-onset Still's disease but very similar to lymphoma. Int J Clin Exp Pathol (2012) 0.75
Elevated circulating levels of the interferon-γ-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. Sci Rep (2017) 0.75
A series of 22 patients with adult-onset Still's disease presenting with fever of unknown origin. A difficult diagnosis? Clin Rheumatol (2011) 0.75
Association analysis between genetic variants in interleukin genes among different populations with hyperuricemia in Xinjiang Autonomous Region. Int J Clin Exp Pathol (2015) 0.75
The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult-onset still's disease. BMC Musculoskelet Disord (2015) 0.75
[Adult-onset Still's disease, Schnitzler syndrome, and autoinflammatory syndromes in adulthood]. Z Rheumatol (2009) 0.75
Extremely high serum ferritin levels as a main diagnostic tool of adult-onset Still's disease. Rheumatol Int (2011) 0.75
Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature (1995) 10.89
Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci (1995) 6.36
Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites). Proc Natl Acad Sci U S A (1972) 5.30
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (1997) 5.16
Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci U S A (1970) 5.12
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest (1999) 3.86
New antibiotics, bleomycin A and B. J Antibiot (Tokyo) (1966) 3.58
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood (1999) 3.46
Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest (1993) 3.15
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
Cytokine production at the site of disease in human tuberculosis. Infect Immun (1993) 3.04
Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. Relationship to chemical structure. J Immunol (1992) 3.03
The association of cancer and the nephrotic syndrome. Ann Intern Med (1966) 2.88
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature (1985) 2.82
Immune abnormalities associated with chronic mucocutaneous candidiasis. Cell Immunol (1973) 2.81
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol (1996) 2.80
Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol (1996) 2.67
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo) (2000) 2.64
Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58
Circulating HER-2/erbB-2/c-neu (HER-2) extracellular domain as a prognostic factor in patients with metastatic breast cancer: Cancer and Leukemia Group B Study 8662. Clin Cancer Res (2001) 2.53
Ludloff's medial approach for open reduction of congenital dislocation of the hip. A 20-year follow-up. J Bone Joint Surg Br (1996) 2.45
IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol (1997) 2.29
Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol (1999) 2.26
Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium. Infect Immun (1999) 2.14
Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res (1990) 2.13
Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans. Rheumatology (Oxford) (2008) 2.11
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11
Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound. J Neuropathol Exp Neurol (1965) 2.05
The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol (1993) 2.04
Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study. Ann Rheum Dis (2010) 2.04
Pole test is a useful method for evaluating the mouse movement disorder caused by striatal dopamine depletion. J Neurosci Methods (1997) 2.04
Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low-dose aspirin. Aliment Pharmacol Ther (2014) 2.03
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J Immunol (1993) 2.00
A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun (1995) 1.99
Spondyloarthropathies in Japan: nationwide questionnaire survey performed by the Japan Ankylosing Spondylitis Society. J Rheumatol (2001) 1.99
Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. J Biol Chem (1983) 1.98
Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells. Infect Immun (1998) 1.95
High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells. Exp Cell Res (1974) 1.94
Altered cerebral energy metabolism in Alzheimer's disease: a PET study. J Nucl Med (1994) 1.90
Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction. Clin Exp Immunol (1993) 1.88
Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell (2001) 1.88
Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus. Mol Cell Biol (1986) 1.87
Standardisation of the mixed lymphocyte reaction. J Immunol Methods (1976) 1.77
Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development. Eur J Immunol (1998) 1.77
Effect of pepstatin on acid proteases. J Antibiot (Tokyo) (1971) 1.75
Prognostic significance of serosal invasion and free intraperitoneal cancer cells in gastric cancer. Br J Surg (1990) 1.75
IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J Immunol (1998) 1.73
Takayasu's arteritis associated with ulcerative colitis; genetic factors in this association. Intern Med (1996) 1.72
Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J Immunol (1998) 1.71
Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect Immun (1997) 1.71
[Studies on the immune bacteriolysis. XIV. Requirement of all nine components of complement for immune bacteriolysis]. Biken J (1968) 1.70
Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheum (1998) 1.69
Proinflammatory effects of IL-10 during human endotoxemia. J Immunol (2000) 1.69
Hepatitis C virus antibody in patients with primary liver cancer (hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma) in Japan. Cancer (1993) 1.68
Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas (1997) 1.68
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells. J Biol Chem (1982) 1.68
Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health (1986) 1.67
Nestin expression in the kidney with an obstructed ureter. Kidney Int (2007) 1.66
Electrogenesis in mouse neuroblastoma cells in vitro. J Cell Physiol (1971) 1.66
Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes. J Biol Chem (1988) 1.66
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J Antibiot (Tokyo) (1976) 1.66
IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol (1994) 1.65
Increased levels of circulating interleukin-18 in patients with advanced tuberculosis. Am J Respir Crit Care Med (2000) 1.65
Independent mitochondrial origin and historical genetic differentiation in North Eastern Asian cattle. Mol Phylogenet Evol (2004) 1.65
Three AML patients with existing or pre-existing intracerebral granulocytic sarcomas who were successfully treated with allogeneic bone marrow transplantations. Bone Marrow Transplant (1999) 1.65
Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia (2011) 1.63
Optical coherence tomographic pattern and focal electroretinogram in patients with retinitis pigmentosa. Eye (Lond) (2008) 1.62
Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA. Jpn J Genet (1989) 1.61
The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum (1997) 1.60
Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.60
Lymph node metastasis as a significant prognostic factor in gastric cancer: a multiple logistic regression analysis. Scand J Gastroenterol (2004) 1.59
On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice. J Exp Med (1997) 1.59
A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma. J Immunol (1997) 1.58
Hemolysins and related enzymes of Vibrio parahaemolyticus. I. Identification and partial purification of enzymes. Biken J (1970) 1.57
Brain functional activity during gait in normal subjects: a SPECT study. Neurosci Lett (1997) 1.57
Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients. Am J Surg Pathol (1999) 1.55
Neurological deficits in the presence of the sinking skin flap following decompressive craniectomy. Neurol Med Chir (Tokyo) (1977) 1.55
Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Development (1990) 1.55
IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production. J Immunol (1997) 1.55
Biopsy of labial salivary glands and lacrimal glands in the diagnosis of Sjögren's syndrome. J Rheumatol (1996) 1.55
IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol (2000) 1.54
Isolation of a cDNA clone encoding pancreatic polypeptide. Proc Natl Acad Sci U S A (1985) 1.54
A new semiquantitative radiometric opsonin assay. Selective measurement of opsonizing capacity of the alternative pathway. Immunology (1978) 1.53
Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study. Diabetologia (2011) 1.53
IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12. Eur J Immunol (2001) 1.51
Standardization of lymphocyte transformation to phytohaemagglutinin. Clin Exp Immunol (1973) 1.51
Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. J Infect Dis (1999) 1.51
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol (2001) 1.51
Absence of colorectal cancer metastasis to the cirrhotic liver. Am J Surg (1992) 1.51