Published in Br J Cancer on April 06, 2001
Increased muscle proteasome activity correlates with disease severity in gastric cancer patients. Ann Surg (2003) 1.28
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Calpain activity and muscle wasting in sepsis. Am J Physiol Endocrinol Metab (2008) 1.14
Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training. Heart Fail Rev (2008) 1.09
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Serological muscle loss biomarkers: an overview of current concepts and future possibilities. J Cachexia Sarcopenia Muscle (2012) 0.99
Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia. Aging Cell (2012) 0.98
Loss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatment. J Cachexia Sarcopenia Muscle (2015) 0.90
A multifactorial anti-cachectic approach for cancer cachexia in a rat model undergoing chemotherapy. J Cachexia Sarcopenia Muscle (2015) 0.81
Motor protein function in skeletal abdominal muscle of cachectic cancer patients. J Cell Mol Med (2013) 0.81
Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse. Int J Oncol (2013) 0.80
Disruption of pro-oxidant and antioxidant systems with elevated expression of the ubiquitin proteosome system in the cachectic heart muscle of nude mice. J Cachexia Sarcopenia Muscle (2013) 0.79
Functional overload attenuates plantaris atrophy in tumor-bearing rats. BMC Cancer (2007) 0.78
A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart. Biomed Res Int (2016) 0.77
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Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation. J Cachexia Sarcopenia Muscle (2016) 0.75
Pay attention to cardiac remodeling in cancer cachexia. Support Care Cancer (2016) 0.75
Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2-independent mechanisms, unlike muscular dystrophy. J Cachexia Sarcopenia Muscle (2015) 0.75
Interference with Ca(2+)-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia. Front Physiol (2017) 0.75
Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A. Cell (1995) 4.41
Biology of cachexia. J Natl Cancer Inst (1997) 4.18
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J (1996) 2.05
Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma. Am J Physiol (1995) 1.98
Calpain: a protease in search of a function? Biochem Biophys Res Commun (1998) 1.82
Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. Cancer Res (1991) 1.74
Purification of the (Ca2+-Mg2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column. J Biol Chem (1979) 1.61
Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats. Cancer Res (1994) 1.57
Cancer cachexia: from experimental models to patient management. Curr Opin Clin Nutr Metab Care (2000) 1.54
Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. J Clin Invest (1993) 1.53
The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid. J Biol Chem (1986) 1.46
Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB. Mol Cell Biol (1997) 1.46
The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons. J Neurochem (1998) 1.38
Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells. Am J Physiol (1995) 1.35
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB J (1999) 1.31
The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer. Surgery (1999) 1.26
Specific cleavage of transcription factors by the thiol protease, m-calpain. Nucleic Acids Res (1993) 1.15
Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Lett (1991) 1.13
Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia. Biochem J (1987) 1.12
Increased protein turnover despite normal energy metabolism and responses to feeding in patients with lung cancer. Cancer Res (1990) 1.03
Humoral mediation for cachexia in tumour-bearing rats. Br J Cancer (1993) 1.02
Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals. Arch Biochem Biophys (1993) 1.01
The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium (1994) 0.94
Proteolytic processing of nuclear factor kappa B by calpain in vitro. FEBS Lett (1996) 0.93
Muscle wasting associated with cancer cachexia is linked to an important activation of the ATP-dependent ubiquitin-mediated proteolysis. Int J Cancer (1995) 0.92
Identification of two calpastatin forms in rat skeletal muscle and their susceptibility to digestion by homologous calpains. Arch Biochem Biophys (1991) 0.92
Increased whole-body protein turnover in sick children with newly diagnosed leukemia or lymphoma. Cancer Res (1983) 0.89
Close association of accelerated rates of whole body protein turnover (synthesis and breakdown) and energy expenditure in children with newly diagnosed acute lymphocytic leukemia. JPEN J Parenter Enteral Nutr (1987) 0.89
Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats. Biochem Biophys Res Commun (1996) 0.87
Modulation of calpastatin specificity in rat tissues by reversible phosphorylation and dephosphorylation. Biochem Biophys Res Commun (1994) 0.86
Calcium ATPase in erythrocytes of spontaneously hypertensive rats of the Milan strain. J Hypertens (1985) 0.86
Calpain-3 gene expression is decreased during experimental cancer cachexia. Biochim Biophys Acta (2000) 0.85
Temporal effects of cytokines on neonatal cardiac myocyte Ca2+ transients and adenylate cyclase activity. Am J Physiol (1997) 0.84
Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice. Cancer Res (1980) 0.82
Different susceptibility of red cell membrane proteins to calpain degradation. Arch Biochem Biophys (1992) 0.81
Modulation of inhibitory efficiency of rat skeletal muscle calpastatin by phosphorylation. Biochem Biophys Res Commun (1992) 0.80
Degradation of sarcoplasmic reticulum calcium-pumping ATPase in ischemic-reperfused myocardium: role of calcium-activated neutral protease. Basic Res Cardiol (1991) 0.80
Erythrocyte deficiency in calpain inhibitor activity in essential hypertension. Hypertension (1988) 0.79
Anabolic and catabolic mediators. Curr Opin Clin Nutr Metab Care (1999) 0.77
Decreased level of calpain inhibitor activity in red blood cells from Milan hypertensive rats. Biochem Biophys Res Commun (1986) 0.77
Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA (1999) 7.37
Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol (1984) 2.33
Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway. Biochem J (1977) 1.93
Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisin. Arch Biochem Biophys (1972) 1.82
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis (1993) 1.80
Extralysosomal protein degradation. Annu Rev Biochem (1986) 1.74
Cancer cachexia: from experimental models to patient management. Curr Opin Clin Nutr Metab Care (2000) 1.54
Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. J Clin Invest (1993) 1.53
The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid. J Biol Chem (1986) 1.46
Protein kinase C activity and hexamethylenebisacetamide-induced erythroleukemia cell differentiation. Proc Natl Acad Sci U S A (1987) 1.34
Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase. Proc Natl Acad Sci U S A (1985) 1.33
Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br J Cancer (2000) 1.31
The calpains. Trends Neurosci (1989) 1.29
Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. Biochem J (1995) 1.26
Studies on the structure-bound sedimentabolity of some rat liver lysosome hydrolases. Biochem J (1971) 1.23
Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochem Biophys Res Commun (1999) 1.23
Fructose 1,6-bisphosphatase: properties of the neutral enzyme and its modification by proteolytic enzymes. Adv Enzymol Relat Areas Mol Biol (1975) 1.21
Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer. Cancer (1994) 1.20
Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation. Neuroscience (1998) 1.18
Role of full-length osteoprotegerin in tumor cell biology. Cell Mol Life Sci (2009) 1.14
Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia. Biochem J (1987) 1.12
Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp Cell Res (1995) 1.12
Muscle myostatin signalling is enhanced in experimental cancer cachexia. Eur J Clin Invest (2008) 1.11
Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinases. J Biol Chem (1990) 1.10
Secretion and binding of HMG1 protein to the external surface of the membrane are required for murine erythroleukemia cell differentiation. FEBS Lett (1997) 1.10
Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate. Proc Natl Acad Sci U S A (1987) 1.10
Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase. J Biol Chem (1986) 1.09
Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway. J Clin Invest (1995) 1.09
Conversion of neutral to alkaline liver fructose 1,6-bisphosphatase: changes in molecular properties of the enzyme. Proc Natl Acad Sci U S A (1973) 1.07
Inhibition of basal protein degradation in rat embryo fibroblasts by cycloheximide: correlation with activities of lysosomal proteases. J Cell Physiol (1978) 1.07
Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130). Br J Cancer (1992) 1.06
Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C. J Biol Chem (1988) 1.05
Extracellular high-mobility group 1 protein is essential for murine erythroleukaemia cell differentiation. Biochem J (1996) 1.04
Fine tuning of protein kinase C (PKC) isoforms in cancer: shortening the distance from the laboratory to the bedside. Mini Rev Med Chem (2011) 1.04
Fructose 1,6-bisphosphatase: the role of lysosomal enzymes in the modification of catalytic and structural properties. Proc Natl Acad Sci U S A (1973) 1.04
Cytosolic Ca2+-dependent neutral proteinases from rabbit liver: activation of the proenzymes by Ca2+ and substrate. Proc Natl Acad Sci U S A (1984) 1.04
Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase. Proc Natl Acad Sci U S A (1986) 1.03
Reversible activation of human neutrophil calpain promoted by interaction with plasma membranes. Biochem Int (1985) 1.02
Cytosolic calcium dependent proteinase of human erythrocytes: formation of an enzyme-natural inhibitor complex induced by Ca2+ ions. Biochem Biophys Res Commun (1982) 1.02
Humoral mediation for cachexia in tumour-bearing rats. Br J Cancer (1993) 1.02
Structural equivalents of latency for lysosome hydrolases. Biochem J (1975) 1.02
Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim Biophys Acta (2001) 1.02
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Control of cell protein degradation. Changes in activities of lysosomal proteases. Biochim Biophys Acta (1977) 1.01
Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals. Arch Biochem Biophys (1993) 1.01
Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization. FEBS Lett (1996) 1.01
Binding to erythrocyte membrane is the physiological mechanism for activation of Ca2+-dependent neutral proteinase. Biochem Biophys Res Commun (1985) 1.01
Epidemiological study of urinary tract stones in a northern Italian city. Br J Urol (1990) 1.00
Changes in rabbit-liver lysosomes and fructose 1,6-bisphosphatase induced by cold and fasting. Proc Natl Acad Sci U S A (1973) 0.99
Increased muscle ubiquitin mRNA levels in gastric cancer patients. Am J Physiol Regul Integr Comp Physiol (2001) 0.99
Supravital exposure to propidium iodide identifies apoptosis on adherent cells. Cytometry (2001) 0.99
Evidence for an interaction between fructose 1,6-bisphosphatase and fructose 1,6-bisphosphate aldolase. Arch Biochem Biophys (1979) 0.98
Altered pattern of lipid metabolism in patients with lung cancer. Oncology (1992) 0.98
Isovalerylcarnitine is a specific activator of the high calcium requiring calpain forms. Biochem Biophys Res Commun (1990) 0.97
Site-directed activation of calpain is promoted by a membrane-associated natural activator protein. Biochem J (1993) 0.96
Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody. Cell Death Differ (2003) 0.96
Activation of neutrophil calpain following its translocation to the plasma membrane induced by phorbol ester or fMet-Leu-Phe. Biochem Biophys Res Commun (1989) 0.96
Changes in activity and molecular properties of fructose 1, 6-bisphosphatase during fasting and refeeding. Proc Natl Acad Sci U S A (1974) 0.95
Echocardiographic parameters and indices in the normal beagle dog. Lab Anim (1992) 0.95
Changes in intracellular localization of calpastatin during calpain activation. Biochem J (1999) 0.95
Ca2+-dependent neutral proteinase from human erythrocytes: activation by Ca2+ ions and substrate and regulation by the endogenous inhibitor. Biochem Int (1984) 0.94
On the mechanism of inhibition of fructose 1,6-bisphosphatase by fructose 2,6-bisphosphate. Arch Biochem Biophys (1982) 0.94
The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium (1994) 0.94
Characterization of three rabbit liver lysosomal proteinases with fructose 1,6-bisphosphatase converting enzyme activity. Arch Biochem Biophys (1981) 0.93
Activation of NADPH oxidase and phosphorylation of membrane proteins in human neutrophils: coordinate inhibition by a surface antigen-directed monoclonal antibody. Biochem Biophys Res Commun (1986) 0.93
Role of phospholipids in the activation of the Ca2+-dependent neutral proteinase of human erythrocytes. Biochem Biophys Res Commun (1985) 0.93
Extinction and absorption coefficients and scattering phase functions of human tissues in vitro. Appl Opt (1989) 0.92
Identification of two calpastatin forms in rat skeletal muscle and their susceptibility to digestion by homologous calpains. Arch Biochem Biophys (1991) 0.92
Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats. Cytokine (2002) 0.92
Cell protein degradation in cultured rat embryo fibroblasts. Suppression by vinblastine of the enhanced proteolysis by serum-deficient media. Biochim Biophys Acta (1976) 0.92
Acute intravenous toxicity of dimethyl sulfoxide, polyethylene glycol 400, dimethylformamide, absolute ethanol, and benzyl alcohol in inbred mouse strains. Arzneimittelforschung (1994) 0.92
Mechanism of action of the calpain activator protein in rat skeletal muscle. Eur J Biochem (1991) 0.92
Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain. Biochim Biophys Acta (1985) 0.91
Reversible inactivation of calpain isoforms by nitric oxide. Biochem Biophys Res Commun (1995) 0.91
Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils. Proc Natl Acad Sci U S A (1990) 0.91
Activation by hemoglobin of the Ca2+-requiring neutral proteinase of human erythrocytes: structural requirements. Biochem Biophys Res Commun (1984) 0.90
An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+. Proc Natl Acad Sci U S A (1988) 0.89
Role of delta-PKC on the differentiation process of murine erythroleukemia cells. Biochem Biophys Res Commun (1993) 0.89
Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells. Biochem J (1991) 0.89
Phosphorylation by protein kinase C of a 20-kDa cytoskeletal polypeptide enhances its susceptibility to digestion by calpain. Proc Natl Acad Sci U S A (1987) 0.89
Interactions of Zn2+ and Mg2+ with rabbit liver fructose 1,6 bisphosphatase. Arch Biochem Biophys (1978) 0.89
Age-dependent degradation of calpastatin in kidney of hypertensive rats. J Biol Chem (2001) 0.89
Evidence for formation of a rabbit liver aldolase--rabbit liver fructose-1,6-bisphosphatase complex. Proc Natl Acad Sci U S A (1980) 0.89
Characterization of the single peptide generated from the amino-terminus end of alpha- and beta-hemoglobin chains by the Ca2+-dependent neutral proteinase. Biochim Biophys Acta (1984) 0.88
Cytosolic calcium dependent neutral proteinase of human erythrocytes: the role of calcium ions on the molecular and catalytic properties of the enzyme. Biochem Biophys Res Commun (1982) 0.88
Differential expression of protein kinase C isoform genes in three murine erythroleukemia cell variants: implication for chemical induced differentiation. Biochem Biophys Res Commun (1994) 0.88
Pharmacological interference with tissue hypercatabolism in tumour-bearing rats. Biochem J (1994) 0.88
Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation. Int J Oncol (2005) 0.87
Activation of PKC-beta isoforms mediates HNE-induced MCP-1 release by macrophages. Biochem Biophys Res Commun (2002) 0.87
Phosphorylation of proteins in human neutrophils activated with phorbol myristate acetate or with chemotactic factor. Arch Biochem Biophys (1986) 0.87
Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions. Proc Natl Acad Sci U S A (1974) 0.87
Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats. Biochem Biophys Res Commun (1996) 0.87
Changes induced by fasting and cycloheximide in the vacuolar apparatus of rat hepatocytes. A morphometric investigation. Boll Soc Ital Biol Sper (1979) 0.87
Control of cell protein catabolism in rat liver. Effects of starvation and administration of cycloheximide. Biochem J (1982) 0.87
Acute hemorrhagic pancreatic necrosis in mice: the activity of lysosomal enzymes in the pancreas and the liver. Am J Pathol (1980) 0.86
Cathepsin M: a lysosomal proteinase with aldolase-inactivating activity. Arch Biochem Biophys (1982) 0.86