Photooxygenation of the helimers of (-)-isocolchicine: regio- and facial selectivity of the [4 + 2] cycloaddition with singlet oxygen and surprising endoperoxide transformations.

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Published in J Org Chem on May 04, 2001

Authors

R Brecht1, F Büttner, M Böhm, G Seitz, G Frenzen, A Pilz, W Massa

Author Affiliations

1: Institut für Pharmazeutische Chemie, Universität Marburg, Marbacher Weg 6, D-35032 Marburg, Germany.

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Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation (2000) 1.41

Xamoterol and the failing heart. Lancet (1989) 1.41

[Limited surgical radicality in occult cancer of Vater's papilla]. Langenbecks Arch Chir (1991) 1.40

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke (2000) 1.40

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[Preoperative cardiovascular risk evaluation--diagnosis]. Dtsch Med Wochenschr (2004) 1.39

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Myositis caused by Borrelia burgdorferi: report of four cases. J Neurol Sci (1989) 1.01

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Application of cell culture for the production of bioactive compounds from sponges: synthesis of avarol by primmorphs from Dysidea avara. J Nat Prod (2000) 1.01

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Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect. J Pharmacol Exp Ther (1984) 1.00

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Differential effects of estrogen and progesterone on AT(1) receptor gene expression in vascular smooth muscle cells. Circulation (2000) 0.98

Microsatellite instability in sporadic carcinomas of the proximal colon: association with diploid DNA content, negative protein expression of p53, and distinct histomorphologic features. Surgery (1998) 0.98

Atorvastatin stent coating does not reduce neointimal proliferation after coronary stenting. Z Kardiol (2003) 0.98

Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. Circulation (1999) 0.97

Alcohol and the risk of myocardial infarction. Basic Res Cardiol (2001) 0.97

Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. Aliment Pharmacol Ther (2006) 0.97