Published in Br J Pharmacol on May 01, 2001
The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity (2008) 10.55
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44
Th17 cells and mucosal host defense. Semin Immunol (2007) 3.17
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa. Mucosal Immunol (2009) 3.01
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol (2010) 3.00
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther (2004) 2.54
Interleukin-17 and systemic lupus erythematosus: current concepts. Clin Exp Immunol (2009) 1.95
Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med (2010) 1.50
Up for Mischief? IL-17/Th17 in the tumour microenvironment. Oncogene (2010) 1.32
TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discov (2011) 1.26
Anti-inflammatory role of IL-17 in experimental autoimmune uveitis. J Immunol (2009) 1.23
Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotechnol (2011) 1.16
Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice. Cytokine (2009) 1.08
IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model. PLoS One (2014) 1.01
IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis. Am J Physiol Lung Cell Mol Physiol (2012) 0.99
Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect Immun (2004) 0.98
IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection. Clin Dev Immunol (2013) 0.97
Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells. J Clin Immunol (2012) 0.96
Interleukin-17 regulation: an attractive therapeutic approach for asthma. Respir Res (2010) 0.93
Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem (2011) 0.87
Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches. J Biomed Biotechnol (2010) 0.85
The other T helper cells in asthma pathogenesis. J Allergy (Cairo) (2010) 0.84
Grape seed proanthocyanidin extract inhibits interleukin-17-induced interleukin-6 production via MAPK pathway in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.83
Genetics of asthma: a molecular biologist perspective. Clin Mol Allergy (2009) 0.83
Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. Br J Pharmacol (2002) 0.82
Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut? Semin Immunopathol (2010) 0.80
Role of Interleukin-17 in defense against pseudomonas aeruginosa infection in lungs. Int J Clin Exp Med (2014) 0.80
CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2. Int J Clin Exp Pathol (2015) 0.80
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses. Drug Des Devel Ther (2015) 0.79
Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses. Biomol Concepts (2012) 0.79
Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media. Infect Immun (2014) 0.79
Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model. PLoS One (2016) 0.78
ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A (2016) 0.77
The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis (2016) 0.76
IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB. Int J Mol Med (2015) 0.76
The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU). Cytokine (2015) 0.76
Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells. PLoS One (2015) 0.75
Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid. Allergy Asthma Immunol Res (2017) 0.75
Maternal IL-17A in autism. Exp Neurol (2017) 0.75
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem (1995) 14.14
Mitogen-activated protein kinase pathways. Curr Opin Cell Biol (1997) 9.10
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med (1996) 8.59
Human IL-17: a novel cytokine derived from T cells. J Immunol (1995) 6.65
Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol (1999) 6.15
CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol (1994) 4.62
Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol (1994) 3.32
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther (1996) 2.63
Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem (1998) 2.43
CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis (1992) 2.38
Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol (1993) 2.14
NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol (1999) 2.06
Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine (1997) 1.87
Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J Clin Invest (1994) 1.85
Neutrophil mediators, Pseudomonas, and pulmonary dysfunction in cystic fibrosis. J Lab Clin Med (1993) 1.83
Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am J Physiol (1998) 1.47
Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J Immunol (1995) 1.35
Bronchial neutrophilia in patients with noninfectious status asthmaticus. Am J Respir Crit Care Med (1998) 1.34
Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol (2000) 1.32
Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol (1994) 1.21
Functional characteristics of bronchial epithelium obtained by brushing from asthmatic and normal subjects. Am Rev Respir Dis (1993) 1.17
Multiple signaling pathways for the activation of JNK in mast cells: involvement of Bruton's tyrosine kinase, protein kinase C, and JNK kinases, SEK1 and MKK7. J Immunol (1998) 1.12
Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells. J Immunol (1996) 1.10
Long-term culture of normal and cystic fibrosis epithelial cells grown under serum-free conditions. In Vitro Cell Dev Biol (1990) 1.08
Growth inhibition of human lung cancer cell lines by interleukin 6 in vitro: a possible role in tumor growth via an autocrine mechanism. Cancer Res (1993) 1.07
Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction. Biochem J (1995) 1.06
The role of MAP kinases in intracellular signal transduction in bronchial epithelium. Clin Exp Allergy (2000) 1.03
Increased bronchoalveolar granulocytes and granulocyte/macrophage colony-stimulating factor during exacerbations of chronic bronchitis. Eur Respir J (1997) 1.01
Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. J Allergy Clin Immunol (1998) 1.01
Dose-dependent activation of lymphocytes in endotoxin-induced airway inflammation. Infect Immun (2000) 0.99
Tumor necrosis factor-alpha induces interleukin-6 production and integrin ligand expression by distinct transduction pathways. J Biol Chem (1998) 0.97
Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways. J Immunol (1997) 0.91
Role of neutrophils in mediating human epithelial cell detachment from native basement membrane. J Allergy Clin Immunol (1995) 0.89
Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355. Am J Physiol (1992) 0.85
Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release. Inflammation (1995) 0.81
Elastase-induced emphysema: asynchronous bronchial, alveolar and endothelial cell proliferation during the acute response to injury. J Pathol (1982) 0.79
Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol (1999) 6.15
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25
Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med (1999) 3.44
The diagnosis and management of chronic cough. Eur Respir J (2004) 2.96
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax (1998) 2.71
A community study of sleep-disordered breathing in middle-aged Chinese men in Hong Kong. Chest (2001) 2.66
Inflammatory mediators of asthma: an update. Pharmacol Rev (1998) 2.54
ERS guidelines on the assessment of cough. Eur Respir J (2007) 2.36
Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax (2004) 2.36
Difficult asthma. BMJ (1989) 2.28
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med (1998) 2.19
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J (2001) 2.18
Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J (2004) 2.18
Inflammatory mediators and asthma. Pharmacol Rev (1988) 2.17
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J (2004) 2.06
Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J (2002) 2.04
Inhaled dry-powder formoterol and salmeterol in asthmatic patients: onset of action, duration of effect and potency. Eur Respir J (1997) 1.98
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol (2009) 1.89
Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder. Eur Respir J (1994) 1.89
Predicting and evaluating response to omalizumab in patients with severe allergic asthma. Respir Med (2007) 1.86
Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy (2004) 1.84
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med (1997) 1.84
Regulation of human lung epithelial cell numbers by diesel exhaust particles. Eur Respir J (2006) 1.79
International consensus on (ICON) pediatric asthma. Allergy (2012) 1.79
Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax (2001) 1.76
Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med (2000) 1.75
Role of inflammation in the hyperreactivity of the airways in asthma. Thorax (1986) 1.68
Inflammatory biomarkers in airways of patients with severe asthma compared with non-severe asthma. Clin Exp Allergy (2009) 1.67
Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med (1998) 1.65
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med (1996) 1.65
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med (2001) 1.63
Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. J Pharmacol Exp Ther (1986) 1.62
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax (2008) 1.62
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol (1985) (1995) 1.58
Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs. Clin Exp Allergy (1992) 1.57
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis (1990) 1.57
Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible NO synthase upregulation in alveolar macrophages. Eur Respir J (1998) 1.56
Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol (2001) 1.55
Dyspnoea, asthma, and bronchospasm in relation to treatment with angiotensin converting enzyme inhibitors. BMJ (1994) 1.52
Efficacy of a cell phone-based exercise programme for COPD. Eur Respir J (2008) 1.52
Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. J Appl Physiol (1985) (1987) 1.50
Neutrophil recruitment by interleukin-17 into rat airways in vivo. Role of tachykinins. Am J Respir Crit Care Med (1999) 1.49
Murine models of asthma. Eur Respir J (2003) 1.49
Why are long-acting beta-adrenoceptor agonists long-acting? Eur Respir J (1994) 1.49
Comparison of the relative efficacy of formoterol and salmeterol in asthmatic patients. Am J Respir Crit Care Med (1999) 1.45
Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat Med (1996) 1.45
Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med (2000) 1.44
Severe acute respiratory syndrome: global initiatives for disease diagnosis. QJM (2003) 1.44
Management of difficult asthma. Br J Hosp Med (1994) 1.44
Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. Respir Med (2004) 1.43
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. Am J Respir Crit Care Med (1999) 1.42
Indirect airway challenges. Eur Respir J (2003) 1.42
Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma. Thorax (1989) 1.41
Interleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma. Am J Respir Crit Care Med (2001) 1.41
Equivalent therapeutic ratio of salbutamol given by Turbuhaler and Diskus. Respir Med (2000) 1.38
Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol (1997) 1.38
Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J (1996) 1.35
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med (1998) 1.34
PAF antagonists in asthma. Lancet (1989) 1.33
Systematic assessment of difficult-to-treat asthma. Eur Respir J (2003) 1.33
Stimulation of degranulation from human eosinophils by platelet-activating factor. J Immunol (1989) 1.32
Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol (2000) 1.32
Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology (2002) 1.31
Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis (1990) 1.31
Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax (2004) 1.29
Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. Am J Respir Cell Mol Biol (1999) 1.28
Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs. Thorax (1990) 1.28
Genome-wide association study to identify genetic determinants of severe asthma. Thorax (2012) 1.27
Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. Am J Respir Crit Care Med (1995) 1.27
Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur Respir J (2002) 1.27
Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo. Br J Pharmacol (1988) 1.27
Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med (2002) 1.27
Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology (2004) 1.26
Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax (2003) 1.26
Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper. Allergy (2010) 1.24
Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis (1991) 1.23
Acupuncture for insomnia. Cochrane Database Syst Rev (2007) 1.22
Platelet-activating factor as a mediator of allergic disease. J Allergy Clin Immunol (1988) 1.21
Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet (1987) 1.21
A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha. Eur Respir J (2003) 1.20
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects. Thorax (1998) 1.20
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma. Thorax (2000) 1.20
Exosomes - nanovesicles with possible roles in allergic inflammation. Allergy (2008) 1.19
Histamine dose-response relationships in normal and asthmatic subjects. The importance of starting airway caliber. Am Rev Respir Dis (1982) 1.18
Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. J Immunol (1995) 1.17
Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma. J Immunol (2001) 1.16
Effects of inhaled corticosteroid therapy on expression and DNA-binding activity of nuclear factor kappaB in asthma. Am J Respir Crit Care Med (2000) 1.16
Fundamentals of pulmonary drug delivery. Respir Med (2003) 1.16
Antigen-induced airway hyperresponsiveness and pulmonary inflammation in allergic dogs. J Appl Physiol (1985) (1985) 1.15
Increased number of CD34+ cells in nasal mucosa of allergic rhinitis patients: inhibition by a local corticosteroid. Clin Exp Allergy (2005) 1.15
Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma. Lancet (1990) 1.14
Personality, adherence, asthma control and health-related quality of life in young adult asthmatics. Respir Med (2009) 1.14
Generation of oxygen free radicals from blood eosinophils from asthma patients after stimulation with PAF or phorbol ester. Eur Respir J (1990) 1.14
Effect of prior bronchoconstriction on the airway response to histamine in normal subjects. Thorax (1984) 1.13