Published in Nat Rev Mol Cell Biol on May 01, 2001
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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Genome-wide analysis of mRNAs targeted to yeast mitochondria. EMBO Rep (2002) 2.94
Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A (2008) 2.59
MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A (2007) 2.28
Finding the right organelle. Targeting signals in mitochondrial outer-membrane proteins. EMBO Rep (2003) 1.97
Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell (2004) 1.92
Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet (2009) 1.90
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Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins. EMBO J (2006) 1.83
The function of genomes in bioenergetic organelles. Philos Trans R Soc Lond B Biol Sci (2003) 1.83
Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. EMBO J (2001) 1.77
Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. Mol Biol Cell (2002) 1.76
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol (2003) 1.71
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Diversity and reductive evolution of mitochondria among microbial eukaryotes. Philos Trans R Soc Lond B Biol Sci (2010) 1.58
The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J (2002) 1.55
J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A (2003) 1.55
Escherichia coli YidC is a membrane insertase for Sec-independent proteins. EMBO J (2004) 1.47
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In Saccharomyces cerevisiae, ATP2 mRNA sorting to the vicinity of mitochondria is essential for respiratory function. EMBO J (2002) 1.41
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Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ. Biochem J (2004) 1.36
The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol (2002) 1.33
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Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states. EMBO J (2007) 1.31
The Arabidopsis ppi1 mutant is specifically defective in the expression, chloroplast import, and accumulation of photosynthetic proteins. Plant Cell (2003) 1.29
Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins. EMBO J (2003) 1.27
A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Plant Physiol (2004) 1.27
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta (2009) 1.26
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. Nucleic Acids Res (2002) 1.20
Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol Cell Biol (2002) 1.19
Functional definition of outer membrane proteins involved in preprotein import into mitochondria. Plant Cell (2007) 1.19
Microsporidian mitosomes retain elements of the general mitochondrial targeting system. Proc Natl Acad Sci U S A (2006) 1.19
Multiple secondary origins of the anaerobic lifestyle in eukaryotes. Philos Trans R Soc Lond B Biol Sci (2006) 1.17
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol (2009) 1.15
Refining the definition of plant mitochondrial presequences through analysis of sorting signals, N-terminal modifications, and cleavage motifs. Plant Physiol (2009) 1.15
Characterization of the preprotein and amino acid transporter gene family in Arabidopsis. Plant Physiol (2006) 1.15
Mitochondria and hydrogenosomes are two forms of the same fundamental organelle. Philos Trans R Soc Lond B Biol Sci (2003) 1.14
Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. Mol Cell Biol (2003) 1.14
Import of small Tim proteins into the mitochondrial intermembrane space. EMBO J (2003) 1.12
Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophys J (2007) 1.09
The basal flux of Akt in the mitochondria is mediated by heat shock protein 90. J Neurochem (2009) 1.06
Mitochondrial biogenesis and function in Arabidopsis. Arabidopsis Book (2008) 1.06
The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J (2002) 1.06
An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Genetics (2006) 1.06
Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem (2012) 1.06
Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex. Mol Cell Biol (2003) 1.05
Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane. EMBO J (2001) 1.05
The outer plastid envelope protein Oep16: role as precursor translocase in import of protochlorophyllide oxidoreductase A. Proc Natl Acad Sci U S A (2004) 1.04
MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx. Antioxid Redox Signal (2013) 1.04
Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei. Mol Biochem Parasitol (2008) 1.04
Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis. J Exp Med (2006) 1.04
Reconstituted TOM core complex and Tim9/Tim10 complex of mitochondria are sufficient for translocation of the ADP/ATP carrier across membranes. Mol Biol Cell (2003) 1.02
The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration. J Biol Chem (2008) 1.02
The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis. EMBO J (2006) 1.02
An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. Mol Biol Cell (2006) 1.02
Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms. Cell Death Differ (2008) 1.02
Roles of Tom70 in import of presequence-containing mitochondrial proteins. J Biol Chem (2009) 1.01
Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep (2014) 1.00
AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. J Cell Biol (2003) 0.99
Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria. J Cell Biol (2005) 0.99
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. J Neurosci (2012) 0.99
Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA. Nat Protoc (2010) 0.99
Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther (2010) 0.98
Dual targeted mitochondrial proteins are characterized by lower MTS parameters and total net charge. PLoS One (2008) 0.98
Comparison of the TIM and TOM channel activities of the mitochondrial protein import complexes. Biophys J (2003) 0.97
Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis. Hepatology (2004) 0.97
Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet (2010) 0.96
Occurrence of mitochondria-targeted Late Embryogenesis Abundant (LEA) gene in animals increases organelle resistance to water stress. J Biol Chem (2009) 0.96
The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family. Mol Biol Cell (2004) 0.95
Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation. Proc Natl Acad Sci U S A (2004) 0.94
Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages. Exp Parasitol (2007) 0.93
Understanding the functional interplay between mammalian mitochondrial Hsp70 chaperone machine components. J Biol Chem (2010) 0.93
Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. J Virol (2009) 0.93
Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. J Biol Chem (2010) 0.93
Why genes persist in organelle genomes. Genome Biol (2005) 0.91
Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis. Plant Physiol (2003) 0.91
Thylakoid targeting of Tat passenger proteins shows no delta pH dependence in vivo. EMBO J (2003) 0.91
Translocation of a functional protein by a voltage-dependent ion channel. Proc Natl Acad Sci U S A (2002) 0.90
Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins. Cell Mol Life Sci (2014) 0.89
A co-translational model to explain the in vivo import of proteins into HeLa cell mitochondria. Biochem J (2004) 0.88
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Mitochondrial dysfunction in lyssavirus-induced apoptosis. J Virol (2008) 0.86
SLocX: Predicting Subcellular Localization of Arabidopsis Proteins Leveraging Gene Expression Data. Front Plant Sci (2011) 0.85
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Protein translocation through Tom40: kinetics of peptide release. Biophys J (2012) 0.85
Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo. Curr Genet (2003) 0.84
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A general strategy to determine the congruence between a hierarchical and a non-hierarchical classification. BMC Bioinformatics (2007) 0.83
Identification of sequences required for the import of human protoporphyrinogen oxidase to mitochondria. Biochem J (2004) 0.83
In Silico screening for functional candidates amongst hypothetical proteins. BMC Bioinformatics (2009) 0.83
Dynamics of the preprotein translocation channel of the outer membrane of mitochondria. Biophys J (2008) 0.82
A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis. BMC Genomics (2010) 0.82
A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol (2001) 3.06
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