Published in Infect Immun on July 01, 1979
Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect Immun (1980) 4.87
Selective medium for isolation of Actinobacillus actinomycetemcomitans. J Clin Microbiol (1982) 2.75
Biochemical and morphological characterization of the killing of human monocytes by a leukotoxin derived from Actinobacillus actinomycetemcomitans. Infect Immun (1980) 2.46
Characterization of the lipopolysaccharide from Actinobacillus actinomycetemcomitans Y4 and N27. Infect Immun (1980) 2.34
Extraction and isolation of a leukotoxin from Actinobacillus actinomycetemcomitans with polymyxin B. Infect Immun (1984) 2.10
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans. Clin Exp Immunol (1982) 1.93
Studies of leukotoxin from Actinobacillus actinomycetemcomitans using the promyelocytic HL-60 cell line. Infect Immun (1983) 1.53
Morphology and ultrastructure of oral strains of Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus. Infect Immun (1980) 1.42
Regulation of leukotoxin in leukotoxic and nonleukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun (1991) 1.39
Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy. J Dent Res (2010) 1.38
Inhibition of fibroblast proliferation by Actinobacillus actinomycetemcomitans. Infect Immun (1982) 1.35
Lethal effects of Actinobacillus actinomycetemcomitans leukotoxin on human T lymphocytes. Infect Immun (1991) 1.32
Killing of human myelomonocytic leukemia and lymphocytic cell lines by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun (1988) 1.25
Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun (2003) 1.18
Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans. Infect Immun (2006) 1.17
Detection of a fibroblast proliferation inhibitory factor from Capnocytophaga sputigena. Infect Immun (1980) 1.14
Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Infect Immun (2007) 1.08
Evidence for apoptosis of murine macrophages by Actinobacillus actinomycetemcomitans infection. Infect Immun (1995) 1.06
cis Elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans. Infect Immun (1996) 1.04
TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter (Actinobacillus) actinomycetemcomitans. Gene (2006) 1.03
Monocyte chemoattractant protein 1 and interleukin-8 production in mononuclear cells stimulated by oral microorganisms. Infect Immun (1996) 1.02
Heterogeneity of Actinobacillus actinomycetemcomitans strains in various human infections and relationships between serotype, genotype, and antimicrobial susceptibility. J Clin Microbiol (2000) 1.00
Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory response. Toxins (Basel) (2011) 0.99
Abundant secretion of bioactive interleukin-1beta by human macrophages induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun (2005) 0.98
Characterization of an inducible bacteriophage from a leukotoxic strain of Actinobacillus actinomycetemcomitans. Infect Immun (1982) 0.95
Natural occurrence of black-pigmented Bacteroides species in the gingival crevice of the squirrel monkey. Infect Immun (1988) 0.94
Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis. J Oral Microbiol (2014) 0.94
Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface. Infect Immun (1993) 0.93
Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron. J Bacteriol (2006) 0.90
Lytic sensitivity of Actinobacillus actinomycetemcomitans Y4 to lysozyme. Infect Immun (1983) 0.90
A new member of the S-layer protein family: characterization of the crs gene from Campylobacter rectus. Infect Immun (1998) 0.87
Nuclease-sensitive binding of an Actinobacillus actinomycetemcomitans leukotoxin to the bacterial cell surface. Infect Immun (1991) 0.87
Lipopolysaccharide complexes with Pasteurella haemolytica leukotoxin. Infect Immun (1999) 0.86
Proteomics of protein secretion by Aggregatibacter actinomycetemcomitans. PLoS One (2012) 0.84
Lipopolysaccharides mediate leukotoxin secretion in Aggregatibacter actinomycetemcomitans. Mol Oral Microbiol (2011) 0.83
Directed genomic integration in Actinobacillus actinomycetemcomitans: generation of defined leukotoxin-negative mutants. Infect Immun (1995) 0.81
The cyclic-AMP receptor protein (CRP) regulon in Aggregatibacter actinomycetemcomitans includes leukotoxin. Microb Pathog (2011) 0.81
Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1. Comp Med (2013) 0.81
Sialic acid residues are essential for cell lysis mediated by leukotoxin from Aggregatibacter actinomycetemcomitans. Infect Immun (2014) 0.79
Oxidative inactivation of Actinobacillus actinomycetemcomitans leukotoxin by the neutrophil myeloperoxidase system. Infect Immun (1986) 0.79
Role of neutrophil degranulation in streptococcal leukotoxicity. Infect Immun (1981) 0.79
LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes. Leuk Res (2015) 0.78
Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease. J Appl Oral Sci (2012) 0.77
Novel loop-mediated isothermal amplification method for detection of the JP2 clone of Aggregatibacter actinomycetemcomitans in subgingival plaque. J Clin Microbiol (2007) 0.77
Inhibition of P2X receptors protects human monocytes against damage by leukotoxin from Aggregatibacter actinomycetemcomitans and α-hemolysin from Escherichia coli. Infect Immun (2016) 0.76
Bacterial adherence in oral microbial ecology. Annu Rev Microbiol (1975) 11.44
EXPERIMENTAL GINGIVITIS IN MAN. J Periodontol (1965) 7.13
Studies of the microbiology of periodontosis. J Periodontol (1976) 4.03
Membrane fusion. Biochim Biophys Acta (1973) 3.75
Microbiology of periodontal disease -- present status and future considerations. J Periodontol (1977) 3.62
Bacteriological studies of developing supragingival dental plaque. J Periodontal Res (1977) 3.38
Relationship of bacteria to the etiology of periodontal disease. J Dent Res (1970) 3.36
Predominant cultivable microbiota in periodontosis. J Periodontal Res (1977) 3.35
Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol (1976) 3.21
Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest (1976) 3.21
The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res (1976) 2.74
Interaction of inflammatory cells and oral microorganisms. VIII. Detection of leukotoxic activity of a plaque-derived gram-negative microorganism. Infect Immun (1979) 2.64
Subgingival microflora and periodontitis. J Periodontal Res (1976) 2.30
ELECTRON MICROSCOPIC OBSERVATIONS ON THE BACTERIAL FLORA OF ACUTE NECROTIZING ULCERATIVE GINGIVITIS. J Periodontol (1965) 2.01
The case for periodontosis as a clinical entity. J Periodontol (1971) 1.73
Histological changes in experimental periodontal disease in rats mono-infected with a gram-negative organism. Arch Oral Biol (1975) 1.64
Defective polymorphonuclear leukocyte function in a human periodontal disease. Nature (1977) 1.59
A functional differentiation of human neutrophil granules: generation of C5a by a specific (secondary) granule product and inactivation of C5a by azurophil (primary) granule products. J Immunol (1977) 1.47
Formation and isolation of leucocidin from Pseudomonas aeruginosa. J Gen Microbiol (1976) 1.37
Defective neutrophil chemotaxis in juvenile periodontitis. Infect Immun (1977) 1.36
The cytotoxic action of leucocidan from Pseudomonas aeruginosa on human polymorphonuclear leucocytes. J Gen Microbiol (1976) 1.34
Purification and characterization of leucocidin from Pseudomonas aeruginosa. J Gen Microbiol (1976) 1.28
Immunological aspects of juvenile periodontitis (periodontosis). J Periodontal Res (1974) 1.25
Interaction of inflammatory cells and oral bacteria: release of lysosomal hydrolases from rabbit polymorphonuclear leukocytes exposed to gram-positive plaque bacteria. Arch Oral Biol (1976) 1.10
Electron microscopic features of chronically inflamed human gingiva. J Periodontal Res (1968) 1.07
Interaction of inflammatory cells and oral microorganisms. IV. In vitro release of lysosomal constituents from polymorphonuclear leukocytes exposed to supragingival and subgingival bacterial plaque. Infect Immun (1977) 1.04
Clinical features of juvenile periodontitis (periodontosis). J Periodontol (1974) 1.02
Microbes and periodontal disease. J Clin Periodontol (1974) 0.90
Microbial succession in subgingival plaque of man. J Periodontal Res (1976) 0.86
Interaction of inflammatory cells and oral microorganisms. V. Electron microscopic and biochemical study on the mechanisms of release of lysosomal constituents from human polymorphonuclear leukocytes exposed to dental plaque. J Periodontal Res (1978) 0.84
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res (2001) 5.78
Acute gas-producing bacterial renal infection: correlation between imaging findings and clinical outcome. Radiology (1996) 3.22
Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol (1997) 2.91
Platelet aggregation and release of ADP, serotonin and histamine associated with phagocytosis of antigen-antibody complexes. Proc Soc Exp Biol Med (1965) 2.91
Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med (1995) 2.79
Isolation of a lentivirus from a macaque with lymphoma: comparison with HTLV-III/LAV and other lentiviruses. J Virol (1986) 2.77
Capnocytophaga: new genus of gram-negative gliding bacteria. III. Physiological characterization. Arch Microbiol (1979) 2.69
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev (2001) 2.68
Interaction of inflammatory cells and oral microorganisms. VIII. Detection of leukotoxic activity of a plaque-derived gram-negative microorganism. Infect Immun (1979) 2.64
Biochemical and morphological characterization of the killing of human monocytes by a leukotoxin derived from Actinobacillus actinomycetemcomitans. Infect Immun (1980) 2.46
Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. J Biol Chem (2001) 2.41
Organization of DNA in chromatin. Proc Natl Acad Sci U S A (1976) 2.34
Visualization of drug-nucleic acid interactions at atomic resolution. II. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodocytidylyl (3'-5') guanosine. J Mol Biol (1977) 2.30
Visualization of drug-nucleic acid interactions at atomic resolution. I. Structure of an ethidium/dinucleoside monophosphate crystalline complex, ethidium:5-iodouridylyl (3'-5') adenosine. J Mol Biol (1977) 2.15
Filamentous bacteria isolated from human root surface caries. Arch Oral Biol (1972) 2.11
Extraction and isolation of a leukotoxin from Actinobacillus actinomycetemcomitans with polymyxin B. Infect Immun (1984) 2.10
Analysis of the Actinobacillus actinomycetemcomitans leukotoxin gene. Delineation of unique features and comparison to homologous toxins. J Biol Chem (1989) 2.03
Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. J Virol (1988) 1.91
Isolation and characterization of monoclonal antibodies specific for antigen P1, a major surface protein of mutans streptococci. Infect Immun (1987) 1.90
Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis. Science (1984) 1.89
Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases. J Oral Pathol Med (1995) 1.82
X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine. Proc Natl Acad Sci U S A (1975) 1.76
Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus. J Virol (2000) 1.74
Comparative studies on the biology of Actinobacillus actinomycetemcomitans leukotoxin in primates. Oral Microbiol Immunol (1987) 1.74
Retroperitoneal fibromatosis and acquired immunodeficiency syndrome in macaques. Pathologic observations and transmission studies. Am J Pathol (1985) 1.65
Leukotoxic activity in different strains of the bacterium Actinobacillus actinomycetemcomitans isolated from juvenile periodontitis in man. Arch Oral Biol (1981) 1.64
Antigens and surface components associated with virulence of Actinomyces viscosus. J Dent Res (1976) 1.63
Purification and characterization of a potent 70-kDa thiol lysyl-proteinase (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen. J Biol Chem (1993) 1.61
Pulsatile patterns of gonadotropin release in subjects with and without ovarian function. J Clin Endocrinol Metab (1972) 1.59
Effects of orthodontic bands on microbiologic and clinical parameters. Am J Orthod Dentofacial Orthop (1990) 1.56
Suppression of human lymphocyte responses by oral spirochetes: a monocyte-dependent phenomenon. J Immunol (1984) 1.51
The role of ERCP and therapeutic biliary endoscopy in laparoscopic cholecystectomy. J Laparoendosc Surg (1993) 1.46
Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis. J Clin Periodontol (1981) 1.45
Role of colonization in the virulence of Actinomyces viscosus strains T14-Vi and T14-Av. Infect Immun (1978) 1.41
Immune suppression induced by Actinobacillus actinomycetemcomitans. I. Effects on human peripheral blood lymphocyte responses to mitogens and antigens. J Immunol (1982) 1.40
An easy way to prepare microskin grafts. Burns (1994) 1.38
Suppression of fibroblast proliferation by oral spirochetes. Infect Immun (1984) 1.37
Identification and expression of the Actinobacillus actinomycetemcomitans leukotoxin gene. Biochem Biophys Res Commun (1989) 1.37
In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation. J Biomater Sci Polym Ed (1999) 1.36
Leukotoxicity of an extract from Actinobacillus actinomycetemcomitans for human gingival polymorphonuclear leukocytes. Inflammation (1981) 1.35
Inhibition of fibroblast proliferation by Actinobacillus actinomycetemcomitans. Infect Immun (1982) 1.35
High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy. J Am Coll Cardiol (1984) 1.32
Lethal effects of Actinobacillus actinomycetemcomitans leukotoxin on human T lymphocytes. Infect Immun (1991) 1.32
Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation (1987) 1.28
Intractable oesophageal variceal bleeding caused by splenic arteriovenous fistula: treatment by transcatheter arterial embolization. Postgrad Med J (1999) 1.28
Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex. Proc Natl Acad Sci U S A (1977) 1.26
A case-control study of oral cancer in Changhua County, Taiwan. J Oral Pathol Med (1996) 1.25
Killing of human myelomonocytic leukemia and lymphocytic cell lines by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun (1988) 1.25
Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide. J Med Primatol (2007) 1.23
Clinical and microbiological characteristics of smokers with early onset periodontitis. J Periodontal Res (1999) 1.21
Feasibility study of a natural crosslinking reagent for biological tissue fixation. J Biomed Mater Res (1998) 1.21
Epidemiology and etiology of diarrhea in colony-born Macaca nemestrina. Lab Anim Sci (1987) 1.20
Demonstration of antigen on the surface of sensitized rat mast cells. Nature (1966) 1.19
Cloning and secondary structure analysis of caleosin, a unique calcium-binding protein in oil bodies of plant seeds. Plant Cell Physiol (1999) 1.19
Capnocytophaga: new genus of gram-negative gliding bacteria. IV. DNA base composition and sequence homology. Arch Microbiol (1979) 1.18
Vascular endothelial growth factor in human periodontal disease. J Periodontal Res (1998) 1.14
Detection of a fibroblast proliferation inhibitory factor from Capnocytophaga sputigena. Infect Immun (1980) 1.14
Sporadic anicteric leptospirosis in South Vietnam. A study in 150 patients. Ann Intern Med (1973) 1.14
Leukotoxic effects of Actinobacillus actinomycetemcomitans. Modulation by serum components. J Periodontal Res (1981) 1.12
Biocompatibility study of a biological tissue fixed with a naturally occurring crosslinking reagent. J Biomed Mater Res (1998) 1.11
Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex. Microb Pathog (1991) 1.11
Interaction of inflammatory cells and oral bacteria: release of lysosomal hydrolases from rabbit polymorphonuclear leukocytes exposed to gram-positive plaque bacteria. Arch Oral Biol (1976) 1.10
Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis. Phytother Res (2001) 1.10
Enterococci in human periodontitis. Oral Microbiol Immunol (1992) 1.10
Studies on the interaction of human neutrophils with plaque spirochetes. J Periodontal Res (1986) 1.10
Comparative ultrastructure of leukotoxic and non-leukotoxic strains of Actinobacillus actinomycetemcomitans. J Periodontal Res (1981) 1.10
Effects of cations and osmotic protectants on cytolytic activity of Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun (1990) 1.10
Cardioprotective effects of 17 beta-estradiol produced by activation ofmitochondrial ATP-sensitive K(+)Channels in canine hearts. J Mol Cell Cardiol (2000) 1.10
Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat (2008) 1.09
Gonadotropin dynamics in patients with gonadal dysgenesis: a model for the study of gonadotropin regulation. J Clin Endocrinol Metab (1972) 1.09
Dynamics of infection by leukotoxic strains of Actinobacillus actinomycetemcomitans in juvenile periodontitis. J Clin Periodontol (1986) 1.09
Isolation and serological characterization of a cell wall antigen of Rothia dentocariosa. J Bacteriol (1970) 1.09
Human immune responses to oral microorganisms. II. Serum antibody responses to antigens from Actinobacillus actinomycetemcomitans and the correlation with localized juvenile periodontitis. J Clin Immunol (1983) 1.08
Immunocompetent cells of the chicken. I. Specific surface antigenic markers on bursa and thymus cells. J Exp Med (1971) 1.08
Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis. Br J Pharmacol (2009) 1.07
Electron microscopic features of chronically inflamed human gingiva. J Periodontal Res (1968) 1.07
Maternal-fetal transmission of SIV in macaques: disseminated adenovirus infection in an offspring with congenital SIV infection. J Med Primatol (1991) 1.07
Cytopathic effects of Actinobacillus actinomycetemcomitans on monkey blood leukocytes. J Periodontal Res (1984) 1.07
Antimicrobial activity of tannin components from Vaccinium vitis-idaea L. J Pharm Pharmacol (2001) 1.06