Published in Int J Parasitol on May 01, 2001
New Therapies and Biomarkers for Chagas Infection (TESEO) | NCT03981523
The challenges of Chagas Disease-- grim outlook or glimmer of hope. PLoS Med (2007) 2.79
Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis (2009) 1.60
Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe (2013) 1.57
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun (2002) 1.45
Pathogenesis of chagas' disease: parasite persistence and autoimmunity. Clin Microbiol Rev (2011) 1.38
Bioluminescent imaging of Trypanosoma cruzi infection. Int J Parasitol (2008) 1.23
Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J Exp Med (2007) 1.21
Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines (2012) 1.21
Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy. Parasitol Res (2003) 1.19
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS Negl Trop Dis (2008) 1.19
Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect Immun (2005) 1.15
Chagas cardiomyopathy in the context of the chronic disease transition. PLoS Negl Trop Dis (2010) 1.14
Trypanosoma cruzi in persons without serologic evidence of disease, Argentina. Emerg Infect Dis (2003) 1.11
Advances and challenges towards a vaccine against Chagas disease. Hum Vaccin (2011) 1.11
Impact of aetiological treatment on conventional and multiplex serology in chronic Chagas disease. PLoS Negl Trop Dis (2011) 1.10
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi. Antimicrob Agents Chemother (2010) 1.07
Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region. BMC Genomics (2006) 1.03
Pathology affects different organs in two mouse strains chronically infected by a Trypanosoma cruzi clone: a model for genetic studies of Chagas' disease. Infect Immun (2004) 1.03
Chagas disease and the london declaration on neglected tropical diseases. PLoS Negl Trop Dis (2014) 1.00
Modulation of autoimmunity by treatment of an infectious disease. Infect Immun (2007) 0.98
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins. Infect Immun (2004) 0.97
DNA Vaccines against Protozoan Parasites: Advances and Challenges. J Biomed Biotechnol (2007) 0.95
NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms. Infect Immun (2004) 0.94
Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection. Parasitol Res (2004) 0.94
Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infect Immun (2006) 0.94
A DNA vaccine encoding for TcSSP4 induces protection against acute and chronic infection in experimental Chagas disease. Int J Biol Sci (2011) 0.93
Combining residual insecticide spraying campaigns with targeted detection and specific chemotherapy for Trypanosoma cruzi infection in children. PLoS Negl Trop Dis (2007) 0.92
Identification of strain-specific B-cell epitopes in Trypanosoma cruzi using genome-scale epitope prediction and high-throughput immunoscreening with peptide arrays. PLoS Negl Trop Dis (2013) 0.91
Trypanosoma cruzi infection and nuclear factor kappa B activation prevent apoptosis in cardiac cells. Infect Immun (2006) 0.90
Variability of kinetoplast DNA gene signatures of Trypanosoma cruzi II strains from patients with different clinical forms of Chagas' disease in Brazil. J Clin Microbiol (2006) 0.89
Specific humoral immunity versus polyclonal B cell activation in Trypanosoma cruzi infection of susceptible and resistant mice. PLoS Negl Trop Dis (2010) 0.88
Acute heart inflammation: ultrastructural and functional aspects of macrophages elicited by Trypanosoma cruzi infection. J Cell Mol Med (2008) 0.87
The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi. Front Immunol (2013) 0.86
Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi. Parasitol Res (2004) 0.84
Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease. Clin Vaccine Immunol (2008) 0.84
Chagas disease: still many unsolved issues. Mediators Inflamm (2014) 0.82
Electrocardiographic findings in acutely and chronically T. cruzi-infected mice treated by a phenyl-substituted analogue of furamidine DB569. Drug Target Insights (2007) 0.81
Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children. PLoS One (2011) 0.80
Inhibitory effects of Trypanosoma cruzi sialoglycoproteins on CD4+ T cells are associated with increased susceptibility to infection. PLoS One (2013) 0.80
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease. PLoS One (2015) 0.79
Characterization of an immunodominant antigenic epitope from Trypanosoma cruzi as a biomarker of chronic Chagas' disease pathology. Clin Vaccine Immunol (2011) 0.79
Influence of Trypanosoma cruzi chronic infection in the depletion of esophageal neurons in Calomys callosus. Dig Dis Sci (2006) 0.78
Effect of treatment with cyclophosphamide in low doses upon the onset of delayed type hypersensitivity in mice chronically infected with Trypanosoma cruzi: involvement of heart interstitial dendritic cells. Mem Inst Oswaldo Cruz (2013) 0.78
Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage. Am J Trop Med Hyg (2011) 0.78
Substance P enhances neuronal area and epithelial cell proliferation after colon denervation in rats. Dig Dis Sci (2003) 0.78
Challenge of chronically infected mice with homologous trypanosoma cruzi parasites enhances the immune response but does not modify cardiopathy: implications for the design of a therapeutic vaccine. Clin Vaccine Immunol (2012) 0.77
Disruption of myofibrillar proteins in cardiac muscle of Calomys callosus chronically infected with Trypanosoma cruzi and treated with immunosuppressive agent. Parasitol Res (2005) 0.77
Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis. PLoS Negl Trop Dis (2014) 0.77
Putting Infection Dynamics at the Heart of Chagas Disease. Trends Parasitol (2016) 0.77
Trypanosoma cruzi P21: a potential novel target for chagasic cardiomyopathy therapy. Sci Rep (2015) 0.76
Cardiac autonomic control mechanisms in the pathogenesis of chagas' heart disease. Interdiscip Perspect Infect Dis (2012) 0.76
3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease. PLoS One (2011) 0.76
Epidemiological modeling of Trypanosoma cruzi: Low stercorarian transmission and failure of host adaptive immunity explain the frequency of mixed infections in humans. PLoS Comput Biol (2017) 0.75
Evasion and Immuno-Endocrine Regulation in Parasite Infection: Two Sides of the Same Coin in Chagas Disease? Front Microbiol (2016) 0.75
Parasites and immunotherapy: with or against? J Parasit Dis (2014) 0.75
Expression of cytokines and chemokines and microvasculature alterations of the tongue from patients with chronic Chagas' disease. Parasitol Res (2009) 0.75