Published in Genomics on April 01, 2001
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res (2005) 11.23
Non-canonical inflammasome activation targets caspase-11. Nature (2011) 8.85
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron (2011) 6.93
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 6.87
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68
The cells and logic for mammalian sour taste detection. Nature (2006) 4.65
High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc Natl Acad Sci U S A (2001) 4.30
Functional map of human cytomegalovirus AD169 defined by global mutational analysis. Proc Natl Acad Sci U S A (2003) 4.21
Recombineering: a homologous recombination-based method of genetic engineering. Nat Protoc (2009) 4.15
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication. Genome Res (2002) 3.61
Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods (2009) 3.35
Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli. BMC Mol Biol (2003) 3.32
High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. PLoS Biol (2007) 3.22
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Transcriptional control of adipose lipid handling by IRF4. Cell Metab (2011) 2.95
Probing allostery through DNA. Science (2013) 2.92
A committed precursor to innate lymphoid cells. Nature (2014) 2.77
Shadow enhancers foster robustness of Drosophila gastrulation. Curr Biol (2010) 2.63
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res (2005) 2.61
Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteins. Proc Natl Acad Sci U S A (2005) 2.53
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol (2007) 2.48
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol (2006) 2.45
Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers. J Neurosci (2010) 2.44
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron (2009) 2.26
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons. Proc Natl Acad Sci U S A (2004) 2.17
The transcriptome of retinal Müller glial cells. J Comp Neurol (2008) 2.17
SLiCE: a novel bacterial cell extract-based DNA cloning method. Nucleic Acids Res (2012) 2.17
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest (2012) 2.12
Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology. J Physiol (2006) 2.12
Recombineering with overlapping single-stranded DNA oligonucleotides: testing a recombination intermediate. Proc Natl Acad Sci U S A (2003) 2.11
Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol (2005) 2.06
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest (2011) 1.99
Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem (2007) 1.93
Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci (2009) 1.92
Molecular neuroanatomy's "Three Gs": a primer. Neuron (2007) 1.91
Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol (2006) 1.89
Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability. Mol Cell Biol (2006) 1.89
Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus. J Bacteriol (2006) 1.86
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet (2006) 1.86
Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells. EMBO J (2012) 1.85
The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81
Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo. Proc Natl Acad Sci U S A (2011) 1.80
Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages. Proc Natl Acad Sci U S A (2008) 1.78
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A (2007) 1.78
The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport. J Virol (2006) 1.77
TRPV1-lineage neurons are required for thermal sensation. EMBO J (2010) 1.77
A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res (2003) 1.77
A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9. J Virol (2007) 1.76
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res (2010) 1.75
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun (2013) 1.73
Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A (2012) 1.73
Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology (2008) 1.72
CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. PLoS Genet (2008) 1.72
Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch. Neuron (2011) 1.72
Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression. Mamm Genome (2007) 1.71
Transcriptional code and disease map for adult retinal cell types. Nat Neurosci (2012) 1.71
Prospective isolation of skeletal muscle stem cells with a Pax7 reporter. Stem Cells (2008) 1.71
Dynamic visualization of RANKL and Th17-mediated osteoclast function. J Clin Invest (2013) 1.68
A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. J Biol Chem (2010) 1.67
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol (2007) 1.66
Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoter. Mol Cell Biol (2007) 1.66
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet (2007) 1.63
A recombineering based approach for high-throughput conditional knockout targeting vector construction. Nucleic Acids Res (2007) 1.63
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells. J Virol (2009) 1.63
Zfp423 is required for normal cerebellar development. Mol Cell Biol (2006) 1.62
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A (2008) 1.62
The chemokine stromal cell-derived factor-1 regulates GABAergic inputs to neural progenitors in the postnatal dentate gyrus. J Neurosci (2008) 1.59
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J Neurosci (2009) 1.59
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol (2014) 1.57
Biochemical and genetic analysis of ANK in arthritis and bone disease. Am J Hum Genet (2006) 1.56
Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli. Nucleic Acids Res (2003) 1.56
Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins. J Biol Chem (2009) 1.55
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library. Stem Cells (2006) 1.55
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev (2008) 1.54
Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli. Nucleic Acids Res (2005) 1.51
TGF-beta signaling is essential for joint morphogenesis. J Cell Biol (2007) 1.51
Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest (2010) 1.50
Phage annealing proteins promote oligonucleotide-directed mutagenesis in Escherichia coli and mouse ES cells. BMC Mol Biol (2003) 1.50
A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Genome Res (2003) 1.49
Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience (2010) 1.49
Mobilization of giant piggyBac transposons in the mouse genome. Nucleic Acids Res (2011) 1.49
Two modes of herpesvirus trafficking in neurons: membrane acquisition directs motion. J Virol (2006) 1.48
Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network. Dev Biol (2007) 1.48
Critical role of the virus-encoded microRNA-155 ortholog in the induction of Marek's disease lymphomas. PLoS Pathog (2011) 1.48
Caenorhabditis elegans reporter fusion genes generated by seamless modification of large genomic DNA clones. Nucleic Acids Res (2006) 1.48
Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol (2008) 1.45
Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol (2008) 1.44
An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet (2001) 8.35
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma. J Immunother (2001) 5.83
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (1993) 5.50
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron (1995) 5.43
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science (1993) 5.04
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature (1981) 4.77
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33
High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc Natl Acad Sci U S A (2001) 4.30
A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19
Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet (1998) 4.06
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06
High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, type of processing, and practice. Cereb Cortex (1997) 4.00
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99
Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature (1991) 3.95
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A (1999) 3.82
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J (1995) 3.78
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75
The promise of comparative genomics in mammals. Science (1999) 3.67
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell (1983) 3.66
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med (2001) 3.64
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
Analysis of Hox gene expression in the chick limb bud. Development (1996) 3.47
Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes. Nat Genet (1997) 3.47
microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev (1994) 3.42
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40
The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet (1995) 3.40
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37
The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol (1997) 3.34
Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet (1996) 3.32
Cerebral response to patient's own name in the vegetative and minimally conscious states. Neurology (2007) 3.26
Direct interaction of microtubule- and actin-based transport motors. Nature (1999) 3.25
Rapid confirmation of single copy lambda prophage integration by PCR. Nucleic Acids Res (1994) 3.19
Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet (1999) 3.19