PubRank

R Beyaert

Author PubWeight™ 90.82‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998 4.08
2 Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 1992 3.76
3 Two tumour necrosis factor receptors: structure and function. Trends Cell Biol 1995 3.67
4 More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 1999 3.42
5 Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. Mol Cell 2000 2.98
6 Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J 1993 2.98
7 The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J Cell Biol 1999 2.81
8 Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene 2008 2.71
9 Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 2003 2.59
10 TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci 2008 2.23
11 The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett 1999 2.12
12 Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ 2001 2.03
13 Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett 1999 1.83
14 The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene 1999 1.59
15 Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. Cytokine 1997 1.54
16 Isolation and characterization of two novel A20-like proteins. Biochem J 2001 1.49
17 The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. J Cell Mol Med 2007 1.44
18 Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett 1997 1.44
19 Function and regulation of tumor necrosis factor receptor type 2. Curr Med Chem 2004 1.40
20 Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. FEBS Lett 2001 1.37
21 Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 2001 1.32
22 TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis. J Inflamm 1997 1.27
23 Characterization of seven murine caspase family members. FEBS Lett 1997 1.26
24 Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene 1993 1.24
25 Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. J Biol Chem 2001 1.20
26 Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism. Biochem Biophys Res Commun 1987 1.17
27 Cathepsin B-mediated activation of the proinflammatory caspase-11. Biochem Biophys Res Commun 1998 1.15
28 Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis. Cell Death Differ 2011 1.13
29 Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. Cancer Res 1991 1.12
30 A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid. Cell Death Differ 2002 1.08
31 TRAF1 is a TNF inducible regulator of NF-kappaB activation. FEBS Lett 1999 1.06
32 A20, an inhibitor of cell death, self-associates by its zinc finger domain. FEBS Lett 1996 1.05
33 Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells. J Invest Dermatol 2001 1.04
34 Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se. Eur J Biochem 1991 1.03
35 Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein. J Biol Chem 2001 0.96
36 ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells. Oncogene 2008 0.96
37 Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity. Eur J Biochem 1988 0.96
38 Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex. Mol Cell Biol Res Commun 2001 0.95
39 Caspases are not localized in mitochondria during life or death. Cell Death Differ 2002 0.95
40 A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem Biophys Res Commun 1997 0.91
41 TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways. FEBS Lett 1998 0.91
42 Functional characterization of the prodomain of interleukin-1beta-converting enzyme. J Biol Chem 1996 0.91
43 Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies. J Cell Biochem 1998 0.88
44 Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. Eur J Biochem 1999 0.86
45 Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 1997 0.85
46 Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity. Cell Death Differ 2000 0.85
47 The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide. J Biol Chem 2001 0.84
48 Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. Anticancer Res 2000 0.83
49 Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes. Cell Prolif 2007 0.83
50 Cleavage of caspase family members by granzyme B: a comparative study in vitro. Eur J Immunol 1997 0.83
51 Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells. Hepatology 1996 0.82
52 TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells. Anticancer Res 1989 0.82
53 A novel link between Lck, Bak expression and chemosensitivity. Oncogene 2006 0.82
54 Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine 1998 0.82
55 The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens. Avian Pathol 2008 0.81
56 Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. J Vet Pharmacol Ther 2010 0.81
57 Use of the yeast three-hybrid system as a tool to study caspases. Anal Biochem 1998 0.81
58 Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism. Oncogene 2008 0.81
59 Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives. Int J Cancer 1990 0.81
60 TNF: its potential as an antitumour agent. Dev Biol Stand 1988 0.80
61 Gene cloning and structure--function relationship of cytokines such as TNF and interleukins. Immunol Lett 1987 0.79
62 Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter. FEBS Lett 1990 0.79
63 Tumor necrosis factor cytotoxicity is associated with phospholipase D activation. Eur J Biochem 1993 0.78
64 Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine 1997 0.78
65 The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome. Cell Death Dis 2013 0.77
66 Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome. Neurobiol Dis 1999 0.77
67 Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. Circ Shock 1994 0.76
68 GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays. Mol Cell Biol Res Commun 1999 0.76
69 Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level. Scand J Clin Lab Invest Suppl 1990 0.75
70 Apoptosis induced by gamma irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases. Cell Biol Int 1999 0.75
71 Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways. FEBS Lett 1997 0.75
72 Tumor necrosis factor: a potential antitumor agent? J Interferon Res 1987 0.75
73 Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens. Avian Pathol 2009 0.75