Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 11403205)

Published in Inflammation on June 01, 2001

Authors

A A Stecenko1, G King, K Torii, R M Breyer, R Dworski, T S Blackwell, J W Christman, K L Brigham

Author Affiliations

1: Center for Lung Research and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2650, USA.

Articles citing this

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28

CFTR is a negative regulator of NFkappaB mediated innate immune response. PLoS One (2009) 1.57

Genetic variation and clinical heterogeneity in cystic fibrosis. Annu Rev Pathol (2011) 1.16

Modulation of cystic fibrosis lung disease by variants in interleukin-8. Genes Immun (2008) 1.06

Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. BMC Immunol (2010) 1.04

Impact of Aspergillus fumigatus in allergic airway diseases. Clin Transl Allergy (2011) 1.03

Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. J Biol Chem (2010) 0.99

Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells. Part Fibre Toxicol (2012) 0.98

Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Mol Cell Biol (2004) 0.96

Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms. J Biol Chem (2011) 0.91

SERCA2 regulates non-CF and CF airway epithelial cell response to ozone. PLoS One (2011) 0.84

Spectrum of viral infections in patients with cystic fibrosis. Eur J Microbiol Immunol (Bp) (2012) 0.83

Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells? Am J Physiol Lung Cell Mol Physiol (2012) 0.82

Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One (2013) 0.82

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus. Am J Respir Crit Care Med (2016) 0.81

Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue DeltaF508 cystic fibrosis mouse. Am J Physiol Gastrointest Liver Physiol (2010) 0.81

Effect of polarized release of CXC-chemokines from wild-type and cystic fibrosis murine airway epithelial cells. Am J Respir Cell Mol Biol (2010) 0.81

Disruption of interleukin-1β autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function. PLoS One (2014) 0.79

Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator. Respir Res (2006) 0.76

Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis. Pathogens (2017) 0.75

High-Dose Ibuprofen in Cystic Fibrosis. Pharmaceuticals (Basel) (2010) 0.75

Articles cited by this

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive. Nature (1992) 8.47

Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med (1995) 6.56

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell (1993) 6.25

Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem (1998) 3.93

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res (1988) 3.78

The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem (1998) 3.64

Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med (1995) 3.47

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med (1994) 3.24

Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR. Nature (1992) 3.06

The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol (1997) 2.89

A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am J Respir Cell Mol Biol (1991) 2.83

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature (1993) 2.37

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J (1995) 2.31

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am J Respir Crit Care Med (1994) 2.26

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6. J Immunol (1994) 2.22

Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J Clin Invest (1997) 2.10

Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J (1996) 2.00

Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. J Infect Dis (1997) 1.76

Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am J Physiol (1997) 1.54

Cytokines in sputum and serum from patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection as markers of destructive inflammation in the lungs. Pediatr Pulmonol (1993) 1.51

Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol (2000) 1.43

Release of interleukin-8, interleukin-6, and colony-stimulating factors by upper airway epithelial cells: implications for cystic fibrosis. Am J Respir Cell Mol Biol (1993) 1.38

Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells. Proc Natl Acad Sci U S A (1992) 1.11

Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. Am J Respir Cell Mol Biol (1995) 1.06

Regulation of cytokine secretion by cystic fibrosis airway epithelial cells. Eur Respir J (1993) 1.06

Expression and regulation of tumor necrosis factor in macrophages from cystic fibrosis patients. Am J Respir Cell Mol Biol (1993) 1.01

Multiple epithelial cell-derived factors enhance neutrophil survival. Regulation by glucocorticoids and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol (1999) 0.97

Interleukin-8 production by cystic fibrosis nasal epithelial cells after tumor necrosis factor-alpha and respiratory syncytial virus stimulation. Am J Respir Cell Mol Biol (1998) 0.91

Porins of Pseudomonas aeruginosa induce release of tumor necrosis factor alpha and interleukin-6 by human leukocytes. Infect Immun (1997) 0.88

Cytokine soup: making sense of inflammation in cystic fibrosis. Pediatr Pulmonol (1996) 0.80

Lipopolysaccharide-mediated induction of the bovine interleukin-6 gene in monocytes requires both NF-kappa B and C/EBP binding sites. DNA Cell Biol (1995) 0.78

Articles by these authors

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med (1994) 27.68

Armed conflict as a public health problem. BMJ (2002) 4.42

Studies on gonococcus infection. XI. Comparison of in vivo and vitro association of Neisseria gonorrhoeae with human neutrophils. J Infect Dis (1978) 3.85

Studies on Gonococcus infection. X. Pili and leukocyte association factor as mediators of interactions between gonococci and eukaryotic cells in vitro. Infect Immun (1975) 3.63

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell (1996) 3.60

Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med (1977) 3.43

Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med (1994) 3.21

Endotoxin and lung injury. Am Rev Respir Dis (1986) 3.20

Intestinal fluid and electrolyte transport in human cholera. J Clin Invest (1970) 3.09

The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol (1997) 2.89

The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev (2001) 2.53

Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med (2001) 2.34

Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ Res (1979) 2.32

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest (1981) 2.28

Replacement of water and electrolyte losses in cholera by an oral glucose-electrolyte solution. Ann Intern Med (1969) 2.28

Preparation of chronic lung lymph fistulas in sheep. J Surg Res (1975) 2.27

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med (1999) 2.26

The role of nuclear factor-kappa B in pulmonary diseases. Chest (2000) 2.08

Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care (1994) 2.07

The Respiratory Exchange in Fresh Water Fish. III. Gold-fish. Biochem J (1922) 2.06

Increased sheep lung vascular permeability caused by pseudomonas bacteremia. J Clin Invest (1974) 2.00

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol (1996) 1.96

Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax (2004) 1.96

Sepsis and cytokines: current status. Br J Anaesth (1996) 1.96

Studies on gonococcus infection. VIII. 125Iodine labeling of gonococci and studies on their in vitro interactions with eukaryotic cells. Infect Immun (1975) 1.91

Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med (1998) 1.86

Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol (2007) 1.82

Prostaglandin E receptors and the kidney. Am J Physiol Renal Physiol (2000) 1.79

The relationship between hetero-oligomer formation and function of the topological specificity domain of the Escherichia coli MinE protein. Mol Microbiol (1998) 1.78

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia (1999) 1.78

Functional and molecular aspects of renal prostaglandin receptors. J Am Soc Nephrol (1996) 1.75

Thyroid transcription factor 1 in pulmonary adenocarcinoma. J Clin Pathol (2004) 1.74

Free energy of charges in solvated proteins: microscopic calculations using a reversible charging process. Biochemistry (1986) 1.57

Ciguatera and mannitol: experience with a new treatment regimen. Med J Aust (1989) 1.55

Respiratory Exchange in Fresh Water Fish: Part IV. Further Comparison of Gold-fish and Trout. Biochem J (1922) 1.54

Acute effects of Escherichia coli endotoxin on the pulmonary microcirculation of anesthetized sheep structure:function relationships. Lab Invest (1983) 1.54

Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants. Am J Pathol (1986) 1.54

Polar explorers: membrane proteins that determine division site placement. Cell (2001) 1.52

Practical management of diabetes in critically ill patients. Am J Respir Crit Care Med (2001) 1.52

Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Surgery (1999) 1.50

Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep. Circ Res (1975) 1.48

Intestinal microflora in Asiatic cholera. II. The small bowel. J Infect Dis (1970) 1.46

Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol (2000) 1.43

G protein-coupled prostanoid receptors and the kidney. Annu Rev Physiol (2001) 1.43

Restriction fragment length polymorphisms associated with water use efficiency in tomato. Science (1989) 1.39

Early optical emission from the gamma-ray burst of 4 October 2002. Nature (2003) 1.38

Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am J Respir Crit Care Med (2001) 1.37

EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. Oncogene (2006) 1.37

Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem (1999) 1.34

Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation. Am J Respir Crit Care Med (2000) 1.33

High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. Am J Respir Crit Care Med (2001) 1.33

Double trouble: impact of inappropriate use of asthma medication on the use of health care resources. CMAJ (2001) 1.32

Yeast sulfate-reducing system. 3. An intermediate in the reduction of 3'-phosphoryl-5'-adenosinephosphosulfate to sulfite. Biochim Biophys Acta (1967) 1.32

Characterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors. Hypertension (2000) 1.28

T cell tumours of disparate phenotype in mice transgenic for Rbtn-2. Oncogene (1994) 1.25

Pulmonary hypertension correlated to pulmonary thromboxane synthesis. Adv Prostaglandin Thromboxane Res (1980) 1.25

Immune cell infiltrates and prognosis in primary carcinoma of the lung. Lung Cancer (2000) 1.25

Induced sputum eicosanoid concentrations in asthma. Am J Respir Crit Care Med (1999) 1.24

Restriction by EcoKI is enhanced by co-operative interactions between target sequences and is dependent on DEAD box motifs. EMBO J (1996) 1.23

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J Clin Invest (1984) 1.21

Studies on gonococcus infection. VII. In vitro killing of gonococci by human leukocytes. Infect Immun (1975) 1.21

Sexual behavior change among human immunodeficiency virus-infected adolescents with hemophilia. Adolescent Hemophilia Behavioral Intervention Evaluation Project Study Group. Pediatrics (2000) 1.21

Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro. Endocrinology (2000) 1.20

Detailed occupational history: the cornerstone in diagnosis of asbestos-related lung disease. Am J Respir Crit Care Med (2001) 1.19

Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut (2009) 1.16

Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor. J Clin Invest (1998) 1.16

Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med (2000) 1.15

Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses (2005) 1.15

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides. Proc Natl Acad Sci U S A (1996) 1.15

Immunocytochemical study of Peyer's patches follicular-associated epithelium in the marsupial, Didelphis albiventris. Dev Comp Immunol (1994) 1.14

Random mutagenesis of protein sequences using oligonucleotide cassettes. Methods Enzymol (1991) 1.14

Mechanism of the serotonin effect on lung transvascular fluid and protein movement in awake sheep. Circ Res (1975) 1.13

Conceptual and methodological issues in the use of race as a variable: policy implications. Milbank Q (1987) 1.13

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. J Clin Invest (1983) 1.13

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm. Biochem Biophys Res Commun (1991) 1.12

Increased sheep lung vascular permeability caused by histamine. Circ Res (1975) 1.12

The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J Biol Chem (1995) 1.12

Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am J Respir Crit Care Med (2000) 1.12

A possible intermediate in the reduction of 3'-phosphoryl-5'-adenosinephosphosulfate to sulfite. Biochem Biophys Res Commun (1964) 1.12

Respiratory Exchange in Fresh-water Fish: Part VI. On Pike (Esox lucius). Biochem J (1923) 1.11

Intestinal microflora in Asiatic cholera. I. "Rice-water" stool. J Infect Dis (1970) 1.11

EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2. Am J Physiol Lung Cell Mol Physiol (2001) 1.10

Interactions of granulocytes with the lungs. Circ Res (1984) 1.10

Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics. Am J Respir Crit Care Med (1996) 1.09

Non-enzymatic retrieval of antigen permits staining of follicle centre cells by the rabbit polyclonal antibody to protein gene product 9.5. J Pathol (1994) 1.09

Major histocompatibility complex class II antigen (HLA-DR, DQ and DP) expression in human fetal skin. Tissue Antigens (1986) 1.09

Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene (2010) 1.09

Chest pain evaluation unit: a cost-effective approach for ruling out acute myocardial infarction. South Med J (1989) 1.09

Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.09

Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin. Am Rev Respir Dis (1990) 1.08

The effect of age on tooth movement and mineral density in the alveolar tissues of the rat. Am J Orthod Dentofacial Orthop (1988) 1.08

Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits. Am J Respir Cell Mol Biol (1994) 1.08

In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor. Kidney Int (1993) 1.08

Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits. J Biol Chem (1992) 1.08

Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol (2000) 1.07

Differential NF-kappaB activation after intratracheal endotoxin. Am J Physiol (1999) 1.07