PubRank

P H Maxwell

Author PubWeight™ 101.19‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001 23.83
2 C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001 19.75
3 Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000 5.74
4 Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000 5.58
5 The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000 5.21
6 Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 2001 5.20
7 Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 1998 3.67
8 Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum Mol Genet 2001 2.56
9 Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001 2.12
10 Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol 1998 1.78
11 Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. J Biol Chem 1998 1.78
12 Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 2000 1.57
13 Paediatric gastroenteritis in the eastern Malaysian state of Sarawak: an epidemiological and clinical study. Trans R Soc Trop Med Hyg 1988 1.39
14 The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene 2001 1.34
15 Targeting tumors through the HIF system. Nat Med 2000 1.19
16 Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant. Am J Transplant 2010 1.16
17 Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin. Br J Haematol 1997 1.14
18 The hypoxia response pathway and β-cell function. Diabetes Obes Metab 2010 1.12
19 Evolution of VHL tumourigenesis in nerve root tissue. J Pathol 2006 1.11
20 Do professions have a future? BMJ 1997 1.07
21 Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life 2001 1.00
22 Oxygen regulated gene expression: erythropoietin as a model system. Kidney Int 1997 1.00
23 Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. J Appl Physiol (1985) 2000 0.95
24 Hypoxia response elements. Oncol Res 1997 0.91
25 The HIF pathway: implications for patterns of gene expression in cancer. Novartis Found Symp 2001 0.90
26 Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. Adv Exp Med Biol 2008 0.89
27 Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element. Oncogene 2011 0.88
28 Xenon treatment protects against cold ischemia associated delayed graft function and prolongs graft survival in rats. Am J Transplant 2013 0.87
29 Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. Br J Cancer 2011 0.86
30 Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways. Breast Cancer Res 2001 0.85
31 Epididymal cystadenomas and epithelial tumourlets: effects of VHL deficiency on the human epididymis. J Pathol 2006 0.82
32 Rupture of a pseudoaneurysm of a saphenous vein coronary arterial bypass graft presenting with superior caval venous obstruction. Int J Cardiol 1989 0.82
33 Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. J Biol Chem 2001 0.81
34 Haemophilus influenzae as a rare cause of CAPD peritonitis. J Infect 1993 0.78
35 From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia. Integr Comp Biol 2007 0.78
36 Regulation of gene expression by oxygen levels in mammalian cells. Adv Nephrol Necker Hosp 1999 0.77
37 Regulation of the erythropoietin gene. Nephrol Dial Transplant 1995 0.77
38 Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines. Ann N Y Acad Sci 1994 0.76
39 New insights into the regulation of erythropoietin production. Br J Anaesth 2000 0.75
40 Guiding hands of our teachers. Lancet 2001 0.75
41 Beyond erythropoietin: the oxygen sensor. Nephrol Dial Transplant 1997 0.75