M E Bruce

Author PubWeight™ 50.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biological evidence that scrapie agent has an independent genome. J Gen Virol 1987 2.76
2 Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells. Nat Med 1999 2.14
3 Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie. Nat Med 2001 1.99
4 Transmission of bovine spongiform encephalopathy and scrapie to mice. J Gen Virol 1992 1.90
5 Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues. Lancet 2001 1.84
6 PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice. J Pathol 1992 1.79
7 Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie. Nat Med 2000 1.78
8 Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641. J Gen Virol 1999 1.62
9 Scrapie strains maintain biological phenotypes on propagation in a cell line in culture. EMBO J 2001 1.50
10 Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy. J Pathol 2000 1.45
11 Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie. J Virol 2000 1.34
12 Infectious etiology of neuritic (senile) plaques in mice. Science 1975 1.23
13 Effect of route of infection on the frequency and distribution of cerebral amyloid plaques in scrapie mice. Neuropathol Appl Neurobiol 1981 1.15
14 T-lymphocyte activation and the cellular form of the prion protein. Immunology 1997 1.13
15 Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice. Neuropathol Appl Neurobiol 2003 1.09
16 The immunobiology of TSE diseases. J Gen Virol 2001 1.08
17 In vivo toxicity of prion protein in murine scrapie: ultrastructural and immunogold studies. Neuropathol Appl Neurobiol 1997 1.05
18 Immunostaining of scrapie cerebral amyloid plaques with antisera raised to scrapie-associated fibrils (SAF). Neuropathol Appl Neurobiol 1989 1.00
19 Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy. J Gen Virol 1997 1.00
20 Infection specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie infected mice. Neurosci Lett 1992 0.99
21 Agent replication dynamics in a long incubation period model of mouse scrapie. J Gen Virol 1985 0.96
22 Genetic control of amyloid plaque production and incubation period in scrapie-infected mice. J Neuropathol Exp Neurol 1985 0.95
23 Effects of age on cerebral amyloid plaques in murine scrapie. Neuropathol Appl Neurobiol 1982 0.94
24 Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathology throughout the incubation period of scrapie-infected mice. Exp Neurol 1998 0.94
25 Determination of the frequency and distribution of vascular and parenchymal amyloid with polyclonal and N-terminal-specific PrP antibodies in scrapie-affected sheep and mice. Vet Rec 1998 0.93
26 Focal and asymmetrical vacuolar lesions in the brains of mice infected with certain strains of scrapie. Acta Neuropathol 1982 0.93
27 Murine scrapie infection causes an abnormal germinal centre reaction in the spleen. J Comp Pathol 2004 0.92
28 Straining the prion hypothesis. Nature 1998 0.91
29 Morphogenesis of amyloid plaques in 87V murine scrapie. Neuropathol Appl Neurobiol 1994 0.90
30 Ultrastructural immuno-localization of synthetic prion protein peptide antibodies in 87V murine scrapie. Neurodegeneration 1996 0.90
31 Transmission of feline spongiform encephalopathy to mice. Vet Rec 1994 0.89
32 Retinopathy in mice with experimental scrapie. Neuropathol Appl Neurobiol 1986 0.87
33 Detection of PrP in extraneural tissues. Microsc Res Tech 2000 0.86
34 Involvement of the immune system in TSE pathogenesis. Immunol Today 1998 0.85
35 Murine scrapie-infected neurons in vivo release excess prion protein into the extracellular space. Neurosci Lett 1994 0.84
36 'New variant' Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. Nat Med 2000 0.84
37 Cerebrovascular amyloidosis in scrapie-affected sheep. Neuropathol Appl Neurobiol 1986 0.83
38 Serial studies on the development of cerebral amyloidosis and vacuolar degeneration in murine scrapie. J Comp Pathol 1981 0.83
39 Infection-specific prion protein (PrP) accumulates on neuronal plasmalemma in scrapie-infected mice. Ann N Y Acad Sci 1994 0.82
40 Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process. Virchows Arch B Cell Pathol Incl Mol Pathol 1991 0.82
41 Experimental control of cerebral amyloid in scrapie in mice. Prog Brain Res 1983 0.79
42 The molecular pathology of scrapie and the biological basis of lesion targeting. Prog Clin Biol Res 1989 0.78
43 Follicular dendritic cells in scrapie pathogenesis. Arch Virol Suppl 2000 0.76
44 Scrapie and Alzheimer's disease. Psychol Med 1984 0.76
45 Scrapie-induced neuron loss is reduced by treatment with basic fibroblast growth factor. Neuroreport 1997 0.75
46 No evidence for involvement of plasma proteins or blood-borne cells in amyloid plaque formation in scrapie-affected mice. An immunohistoperoxidase study. Virchows Arch B Cell Pathol Incl Mol Pathol 1987 0.75
47 Scrapie in immunodeficient mice. Biochem Soc Trans 1997 0.75
48 T lymphocyte activation and the cellular form of the prion protein, PrPc. Biochem Soc Trans 1997 0.75
49 Treating tuberculosis: the essential role of social work. Soc Work Health Care 1998 0.75
50 Altered clinical and histological features of male MM mouse pyelonephritis associated with a change in its microbiology. Lab Anim 1988 0.75