Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer.

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Published in J Clin Oncol on July 01, 2001

Authors

F Robert1, M P Ezekiel, S A Spencer, R F Meredith, J A Bonner, M B Khazaeli, M N Saleh, D Carey, A F LoBuglio, R H Wheeler, M R Cooper, H W Waksal

Author Affiliations

1: Division of Hematology/Oncology, Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, and Birmingham Veterans Administration, 35294-3330, USA. pacorobertuab@cs.com

Associated clinical trials:

Cetuximab (Erbitux®), Capecitabine and Radiotherapy in Neoadjuvant Treatment of Patients With Rectal Cancer (XERT) | NCT00689702

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An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity. Blood (1980) 1.34

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Recruitment failure in early neonatal research. Arch Dis Child Fetal Neonatal Ed (2004) 1.31

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Human immune response to monoclonal antibodies. J Immunother Emphasis Tumor Immunol (1994) 1.22

Mode of delivery and survival in babies weighing less than 2000 g at birth. Br Med J (1980) 1.21

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Human monocyte, lymphocyte, and granulocyte antibody-dependent cell-mediated cytotoxicity toward tumor cells. I. General characteristics of cytolysis. J Immunol (1979) 1.20

A Sindbis virus mRNA polynucleotide vector achieves prolonged and high level heterologous gene expression in vivo. Nucleic Acids Res (1995) 1.20

The effects of ascorbic acid on bactericidal mechanisms of neutrophils. J Infect Dis (1971) 1.19

Augmentation of human natural cell-mediated cytotoxicity by recombinant human interleukin 2. J Immunol (1984) 1.17

Induction of T-cells differentiation in vitro by thymus epithelial cells. Ann N Y Acad Sci (1975) 1.17

Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein. Mol Endocrinol (1988) 1.17

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Superoxide generation by human monocytes and macrophages. Am J Hematol (1978) 1.16

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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 May 2009-31 July 2009. Mol Ecol Resour (2009) 1.15

Mesenteric angiopathy, intestinal gangrene, and midgut carcinoids. Surgery (1981) 1.15