PubRank

G F Joyce

Author PubWeight™ 78.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Randomization of genes by PCR mutagenesis. PCR Methods Appl 1992 6.76
2 A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci U S A 1997 6.02
3 Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 1990 5.02
4 A DNA enzyme that cleaves RNA. Chem Biol 1994 3.88
5 Directed evolution of an RNA enzyme. Science 1992 3.68
6 Mutagenic PCR. PCR Methods Appl 1994 3.33
7 Continuous in vitro evolution of catalytic function. Science 1997 2.88
8 RNA cleavage by a DNA enzyme with extended chemical functionality. J Am Chem Soc 2000 2.63
9 Evolution in vitro of an RNA enzyme with altered metal dependence. Nature 1993 2.50
10 Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry 1998 2.27
11 A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. Chem Biol 1995 2.16
12 The case for an ancestral genetic system involving simple analogues of the nucleotides. Proc Natl Acad Sci U S A 1987 2.12
13 The effect of cytidine on the structure and function of an RNA ligase ribozyme. RNA 2001 1.69
14 Production of RNA by a polymerase protein encapsulated within phospholipid vesicles. J Mol Evol 1994 1.66
15 Inventing and improving ribozyme function: rational design versus iterative selection methods. Trends Biotechnol 1994 1.61
16 Chiral selection in poly(C)-directed synthesis of oligo(G). Nature 1984 1.49
17 Crystal structure of an 82-nucleotide RNA-DNA complex formed by the 10-23 DNA enzyme. Nat Struct Biol 1999 1.47
18 Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. J Mol Biol 1984 1.41
19 A ribozyme that lacks cytidine. Nature 1999 1.38
20 A complex ligase ribozyme evolved in vitro from a group I ribozyme domain. Proc Natl Acad Sci U S A 1999 1.33
21 A DNA enzyme with N-glycosylase activity. Proc Natl Acad Sci U S A 2000 1.26
22 Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme. Biochemistry 1994 1.19
23 Cleavage of an amide bond by a ribozyme. Science 1995 1.16
24 Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance. J Am Chem Soc 1997 1.16
25 Origin and ancestor: separate environments. Science 1999 1.11
26 Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron. Biochemistry 1990 1.11
27 Evolution in vitro: analysis of a lineage of ribozymes. Curr Biol 1993 1.11
28 Medical care expenditures under gatekeeper and point-of-service arrangements. Health Serv Res 2001 1.09
29 Template-directed synthesis on the pentanucleotide CpCpGpCpC. J Mol Biol 1984 1.07
30 Emergence of a replicating species from an in vitro RNA evolution reaction. Proc Natl Acad Sci U S A 1994 1.05
31 Template-directed ligation of peptides to oligonucleotides. Chem Biol 1996 1.03
32 Circumstances at HIV diagnosis and progression of disease in older HIV-infected Americans. Am J Public Health 2001 1.03
33 Alternative conformations of a nucleic acid four-way junction. J Mol Biol 2000 1.00
34 Expenditures for physician services under alternative models of managed care. Med Care Res Rev 2000 0.97
35 Self-incorporation of coenzymes by ribozymes. J Mol Evol 1995 0.93
36 The impact of state policy on the costs of HIV infection. Med Care Res Rev 2001 0.93
37 Continuous in vitro evolution of bacteriophage RNA polymerase promoters. Biochemistry 1994 0.92
38 A molecular description of the evolution of resistance. Chem Biol 1999 0.91
39 Specialization of the DNA-cleaving activity of a group I ribozyme through in vitro evolution. J Mol Biol 1996 0.90
40 Amide cleavage by a ribozyme: correction. Science 1996 0.85
41 In vitro evolution of randomized ribozymes. Methods Enzymol 1996 0.81
42 Crystallization of the 10-23 DNA enzyme using a combinatorial screen of paired oligonucleotides. Acta Crystallogr D Biol Crystallogr 1999 0.80
43 Non-enzymic template-directed synthesis on RNA random copolymers. Poly(C, G) templates. J Mol Biol 1986 0.79
44 Nucleoglycoconjugates: design and synthesis of a new class of DNA-carbohydrate conjugates. Angew Chem Int Ed Engl 2000 0.77
45 The instability of the autogen. J Mol Evol 1983 0.75
46 A simple procedure for constructing 5'-amino-terminated oligodeoxynucleotides in aqueous solution. Nucleic Acids Res 1997 0.75
47 Targeting sites within HIV-1 cDNA with a DNA-cleaving ribozyme. Biochemistry 1996 0.75
48 In vitro evolution of a ribozyme that contains 5-bromouridine. Helv Chim Acta 2000 0.75
49 Non-enzymatic template-directed synthesis of RNA copolymers. Orig Life 1984 0.75
50 Automata simulation of the selection process. Biosystems 1984 0.75
51 Concern over the standard of tuberculin testing in deer. N Z Vet J 1985 0.75
52 Retinal disease in the N.Z. working dog. N Z Vet J 1981 0.75
53 Amide cleavage by a ribozyme: correction. Science 1996 0.75