In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMID 11453749)

Published in J Agric Food Chem on July 01, 2001

Authors

S Heinonen1, T Nurmi, K Liukkonen, K Poutanen, K Wähälä, T Deyama, S Nishibe, H Adlercreutz

Author Affiliations

1: Folkhälsan Research Center and Department of Clinical Chemistry, P.O. Box 60, FIN-00014 University of Helsinki, Finland.

Articles citing this

Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal (2012) 1.96

Bioconversion of Pinoresinol Diglucoside and Pinoresinol from Substrates in the Phenylpropanoid Pathway by Resting Cells of Phomopsis sp.XP-8. PLoS One (2015) 1.39

Role of the normal gut microbiota. World J Gastroenterol (2015) 1.12

Dietary lignans: physiology and potential for cardiovascular disease risk reduction. Nutr Rev (2010) 1.00

Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int (2015) 1.00

Interindividual differences in phytochemical metabolism and disposition. Semin Cancer Biol (2007) 0.92

In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: perspectives on cancer treatment. Int J Mol Sci (2015) 0.92

Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women. Diabetes Care (2014) 0.92

Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res (2009) 0.86

Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer Epidemiol Biomarkers Prev (2014) 0.82

Roles of Dietary Phytoestrogens on the Regulation of Epithelial-Mesenchymal Transition in Diverse Cancer Metastasis. Toxins (Basel) (2016) 0.82

No effect on adenoma formation in Min mice after moderate amount of flaxseed. Eur J Nutr (2004) 0.81

Ruminal Prevotella spp. may play an important role in the conversion of plant lignans into human health beneficial antioxidants. PLoS One (2014) 0.81

Assessment of information to substantiate a health claim on the prevention of prostate cancer by lignans. Nutrients (2010) 0.81

Antiproliferative activity and induction of apoptosis in estrogen receptor-positive and negative human breast carcinoma cell lines by Gmelina asiatica roots. Pharmacognosy Res (2010) 0.80

Suitability of a batch in vitro fermentation model using human faecal microbiota for prediction of conversion of flaxseed lignans to enterolactone with reference to an in vivo rat model. Eur J Nutr (2005) 0.80

Production of enterodiol from defatted flaxseeds through biotransformation by human intestinal bacteria. BMC Microbiol (2010) 0.79

Dietary intake and main sources of plant lignans in five European countries. Food Nutr Res (2013) 0.79

Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling. AAPS J (2014) 0.79

Essences in metabolic engineering of lignan biosynthesis. Metabolites (2015) 0.78

Phytoestrogens and their metabolites in bulk-tank milk: effects of farm management and season. PLoS One (2015) 0.77

Flaxseed ingestion alters ratio of enterolactone enantiomers in human serum. J Nutr Metab (2010) 0.76

Can rye intake decrease risk of human breast cancer? Food Nutr Res (2010) 0.75

Lignan Content in Cereals, Buckwheat and Derived Foods. Foods (2013) 0.75

In vitro microbiotic fermentation causes an extensive metabolite turnover of rye bran phytochemicals. PLoS One (2012) 0.75

Effects of Phytoestrogen Extracts Isolated from Elder Flower on Hormone Production and Receptor Expression of Trophoblast Tumor Cells JEG-3 and BeWo, as well as MCF7 Breast Cancer Cells. Nutrients (2016) 0.75

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice. Sci Rep (2016) 0.75

Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453). Genes Nutr (2006) 0.75

Occurrence of "mammalian" lignans in plant and water sources. Planta (2007) 0.75

Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial. Reprod Health (2010) 0.75

Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets. Food Funct (2017) 0.75

Articles by these authors

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. Proc Natl Acad Sci U S A (1989) 3.17

Plasmids in Yersinia enterocolitica serotypes O:3 and O:9: correlation with epithelial cell adherence in vitro. Infect Immun (1981) 2.85

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol (1989) 2.78

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature (1994) 2.49

Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci U S A (1993) 2.09

Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol (2003) 1.93

Evaluation of Fecatest, a new guaiac test for occult blood in feces. Clin Chem (1978) 1.91

Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int J Sports Med (1986) 1.91

Some aspects of the interaction between natural and synthetic female sex hormones and the liver. Am J Med (1970) 1.88

Estrogen metabolism and excretion in Oriental and Caucasian women. J Natl Cancer Inst (1994) 1.85

Rapid detection of rotavirus in stool by latex agglutination: comparison with radioimmunoassay and electron microscopy and clinical evaluation of the test. J Med Virol (1983) 1.84

Immunological detection of faecal occult blood in colorectal cancer. Br J Cancer (1984) 1.84

Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. N Engl J Med (1982) 1.77

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. J Biol Chem (1990) 1.75

Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res (1997) 1.58

Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer (2000) 1.56

Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study(1-4). J Nutr (2001) 1.55

A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens. Environ Health Perspect (1998) 1.55

Comparison of isoflavones among dietary intake, plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake. J Epidemiol (2000) 1.54

Synthesis and antifungal activity of coumarins and angular furanocoumarins. Bioorg Med Chem (1999) 1.54

Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet (2000) 1.53

Enzyme-linked immunosorbent assay (ELISA) with bacterial sonicate antigen for IgM, IgA, and IgG antibodies to Francisella tularensis: comparison with bacterial agglutination test and ELISA with lipopolysaccharide antigen. J Infect Dis (1983) 1.50

Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. J Steroid Biochem Mol Biol (1993) 1.47

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. J Biol Chem (1990) 1.47

Tofu and soy drinks contain phytoestrogens. J Am Diet Assoc (1994) 1.42

The "Fecatwin Sensitive" test for fecal occult blood is not intended for use without testing positives with the FECA-EIA assay. Clin Chem (1989) 1.39

Psychosocial stress and the insulin resistance syndrome. Metabolism (1996) 1.37

The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women. Am J Clin Nutr (1986) 1.35

Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J Nutr (1998) 1.34

Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures. J Exp Med (1981) 1.31

Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem (1986) 1.30

Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation. Chem Pharm Bull (Tokyo) (1995) 1.29

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes. J Biol Chem (1992) 1.28

Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr (1995) 1.27

Temperature adaptation in yeasts: the role of fatty acids. J Gen Microbiol (1990) 1.26

Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci U S A (1998) 1.24

Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr (2000) 1.21

Familial correlations, segregation analysis, and nongenetic correlates of soy isoflavone-metabolizing phenotypes. Exp Biol Med (Maywood) (2004) 1.19

Oat beta-glucan and xylan hydrolysates as selective substrates for Bifidobacterium and Lactobacillus strains. Appl Microbiol Biotechnol (1998) 1.19

Urinary coproporphyrin isomer distribution in the Dubin-Johnson syndrome. Clin Chem (1967) 1.17

Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin (2001) 1.17

In vitro bioassays of non-steroidal phytoestrogens. J Steroid Biochem Mol Biol (1993) 1.17

Dietary phyto-oestrogens and the menopause in Japan. Lancet (1992) 1.15

A method for the quantitative determination of urinary estriol conjugates in human pregnancy. J Steroid Biochem (1972) 1.12

Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol (1994) 1.11

Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev (2001) 1.11

Biliary excretion and intestinal metabolism of progesterone and estrogens in man. J Steroid Biochem (1980) 1.10

Antioxidants in vegan diet and rheumatic disorders. Toxicology (2000) 1.10

Dietary phytoestrogens and cancer: in vitro and in vivo studies. J Steroid Biochem Mol Biol (1992) 1.10

A diet high in fatty fish, bilberries and wholegrain products improves markers of endothelial function and inflammation in individuals with impaired glucose metabolism in a randomised controlled trial: the Sysdimet study. Diabetologia (2011) 1.10

Rye bread decreases postprandial insulin response but does not alter glucose response in healthy Finnish subjects. Eur J Clin Nutr (1999) 1.09

Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets. Clin Exp Immunol (1984) 1.08

Effect of diet on excretion of estrogens in pre- and postmenopausal women. Cancer Res (1981) 1.07

Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiol Biomarkers Prev (2001) 1.07

Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens. BMC Neurosci (2001) 1.07

Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a japanese population in comparison with dietary records and blood and urine isoflavones. J Nutr (2001) 1.06

Determinants of serum enterolactone concentration. Am J Clin Nutr (2001) 1.05

A new ELISA kit for measuring urinary 2-hydroxyestrone, 16alpha-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid. Cancer Epidemiol Biomarkers Prev (2000) 1.05

Letter: Effects of exertion on hormone secretion. Br Med J (1975) 1.05

Does antibacterial treatment for urinary tract infection contribute to the risk of breast cancer? Br J Cancer (2000) 1.04

Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand J Clin Lab Invest Suppl (1993) 1.03

MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase. J Biol Chem (2000) 1.03

Plasma cortisol, androstenedione, testosterone and luteinizing hormone in running exercise of different intensities. Scand J Clin Lab Invest (1980) 1.03

Intestinal metabolism of estrogens. J Clin Endocrinol Metab (1976) 1.01

Postoperative elevation of serum pancreatic secretory trypsin inhibitor. Am J Gastroenterol (1985) 1.01

Lignans in man and in animal species. Nature (1980) 1.01

Urinary isoflavonoid and lignan excretion on a Western diet: relation to soy, vegetable, and fruit intake. Cancer Epidemiol Biomarkers Prev (1999) 1.01

Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian postmenopausal women and in women with breast cancer. Lancet (1982) 1.00

Dietary fructooligosaccharides modify intestinal bioavailability of a single dose of genistein and daidzein and affect their urinary excretion and kinetics in blood of rats. J Nutr (2001) 1.00

Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate (2000) 1.00

Phytoestrogens and inhibition of angiogenesis. Baillieres Clin Endocrinol Metab (1998) 0.99

Bran fermentation as a means to enhance technological properties and bioactivity of rye. Food Microbiol (2006) 0.98

In vitro metabolism of estrogens by isolated intestinal micro-organisms and by human faecal microflora. J Steroid Biochem (1980) 0.98

Hepatic metabolism of estrogens in health and disease. N Engl J Med (1974) 0.98

Maternal and neonatal phytoestrogens in Japanese women during birth. Am J Obstet Gynecol (1999) 0.97

Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine. Environ Health Perspect (1997) 0.97

Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro. J Agric Food Chem (2002) 0.97

Five guaiac-based tests for occult blood in faeces compared in vitro and in vivo. Scand J Clin Lab Invest (1984) 0.97

Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids (2000) 0.97

Phytoestrogen content and estrogenic effect of legume fodder. Proc Soc Exp Biol Med (1995) 0.97

Influence of plasma estrogen levels on the length of the disease-free interval in postmenopausal women with breast cancer. Breast Cancer Res Treat (1996) 0.96

Genistein is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma human liver cancer cells and suppresses proliferation of these cells in culture. Steroids (1993) 0.96

Phytoestrogens and prostate disease. J Nutr (2000) 0.95

Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. J Biol Chem (1998) 0.95

Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst (1997) 0.95

The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS--I. Quantitation of estrogens after initial hydrolysis of conjugates. J Steroid Biochem (1987) 0.95

Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol Pharm Bull (1996) 0.94

Dietary soy-derived isoflavone phytoestrogens. Could they have a role in coronary heart disease prevention? Biochem Pharmacol (2000) 0.94

Regulation of production and secretion of sex hormone-binding globulin in HepG2 cell cultures by hormones and growth factors. J Clin Endocrinol Metab (1995) 0.94

Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period. Cancer Epidemiol Biomarkers Prev (1998) 0.94

Health and nutrition in newly resettled refugee children from Chile and the Middle East. Acta Paediatr Scand (1992) 0.94

Antidepressant effects of apocynum venetum leaves in a forced swimming test. Biol Pharm Bull (2001) 0.94

2-Methoxyestradiol arrests cells in mitosis without depolymerizing tubulin. Biochem Biophys Res Commun (1996) 0.93