Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanate.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMID 11454729)

Published in Drug Metab Dispos on August 01, 2001

Authors

M Nakajima1, R Yoshida, N Shimada, H Yamazaki, T Yokoi

Author Affiliations

1: Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi 13-1, Kanazawa 920-0934, Japan. nmiki@kenroku.kanazawa-u.ac.jp

Articles citing this

Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J (2009) 1.95

The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr (2008) 1.55

Dietary effects on drug metabolism and transport. Clin Pharmacokinet (2003) 1.11

Molecular targets of isothiocyanates in cancer: recent advances. Mol Nutr Food Res (2014) 1.08

Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J Biol Chem (2009) 1.08

Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer (2006) 1.06

Whole genome and tandem duplicate retention facilitated glucosinolate pathway diversification in the mustard family. Genome Biol Evol (2013) 0.98

Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms. Biochim Biophys Acta (2014) 0.88

Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity. Am J Physiol Cell Physiol (2013) 0.86

High-throughput screening assays for CYP2B6 metabolism and inhibition using fluorogenic vivid substrates. AAPS PharmSci (2003) 0.84

Effects of Food Natural Products on the Biotransformation of PCBs. Environ Toxicol Pharmacol (2008) 0.84

Transthiocarbamoylation of proteins by thiolated isothiocyanates. J Biol Chem (2011) 0.84

Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal model. Biopharm Drug Dispos (2012) 0.83

Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity. Br J Clin Pharmacol (2004) 0.83

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. Drug Metab Dispos (2012) 0.82

GST polymorphism and excretion of heterocyclic aromatic amine and isothiocyanate metabolites after Brassica consumption. Environ Mol Mutagen (2009) 0.81

Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J (2014) 0.79

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers. Cancer Prev Res (Phila) (2016) 0.79

The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation. Drug Metab Dispos (2013) 0.79

Induction of epoxide hydrolase, glucuronosyl transferase, and sulfotransferase by phenethyl isothiocyanate in male Wistar albino rats. Biomed Res Int (2014) 0.77

Lineage-specific evolution of Methylthioalkylmalate synthases (MAMs) involved in glucosinolates biosynthesis. Front Plant Sci (2015) 0.76

Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline. Bioorg Med Chem Lett (2009) 0.76

Fire and Brimstone: Molecular Interactions between Sulfur and Glucosinolate Biosynthesis in Model and Crop Brassicaceae. Front Plant Sci (2016) 0.75

Drug-phytochemical interactions. Inflammopharmacology (2003) 0.75

Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole. Drug Metab Dispos (2016) 0.75

Articles by these authors

Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92

Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell (1998) 5.32

Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med (1993) 5.32

Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions. Proc Natl Acad Sci U S A (2000) 5.23

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther (1994) 5.22

T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62

KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell (1994) 4.17

The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell (1995) 3.90

Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta-lactamase gene blaIMP. Antimicrob Agents Chemother (1998) 3.57

Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J (2004) 2.75

Spread of drug-resistant Streptococcus pneumoniae in Asian countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study. Clin Infect Dis (1999) 2.74

Various abiotic stresses rapidly activate Arabidopsis MAP kinases ATMPK4 and ATMPK6. Plant J (2000) 2.48

Inhibition of DNA-dependent RNA synthesis by rifamycins. J Antibiot (Tokyo) (1968) 2.41

Alpha-amylase genes (amyR2 and amyE+) from an alpha-amylase-hyperproducing Bacillus subtilis strain: molecular cloning and nucleotide sequences. J Bacteriol (1983) 2.36

Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens (2005) 2.36

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res (1996) 2.34

Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20

Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant (2000) 2.15

The GCR1 gene encodes a positive transcriptional regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families in Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.14

Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. Proc Natl Acad Sci U S A (1981) 2.10

CO2 microbubble contrast enhancement in x-ray angiography. Clin Radiol (2012) 1.97

Transcription of the constitutively expressed yeast enolase gene ENO1 is mediated by positive and negative cis-acting regulatory sequences. Mol Cell Biol (1987) 1.93

Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus. Am J Kidney Dis (1998) 1.88

Synthesis, structural characterization and antimicrobial activities of 4- and 6-coordinate nickel(II) complexes with three thiosemicarbazones and semicarbazone ligands. J Inorg Biochem (2001) 1.87

Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. Development (2000) 1.83

Changes in left ventricular output from fetal to early neonatal life. J Pediatr (1991) 1.81

Inhibition of DNA-dependent RNA polymerase reaction of Escherichia coli by an antimicrobial antibiotic, streptovaricin. Biochim Biophys Acta (1968) 1.81

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes. J Pharmacol Exp Ther (1996) 1.74

Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood (1992) 1.72

Identification of a regulatory region that mediates glucose-dependent induction of the Saccharomyces cerevisiae enolase gene ENO2. Mol Cell Biol (1986) 1.69

Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int Immunol (2001) 1.68

Acute exacerbation in idiopathic pulmonary fibrosis. Analysis of clinical and pathologic findings in three cases. Chest (1993) 1.67

Patchy atrophy and lacquer cracks predispose to the development of choroidal neovascularisation in pathological myopia. Br J Ophthalmol (2003) 1.66

Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. Proc Natl Acad Sci U S A (1979) 1.66

In vitro and in vivo activities of sparfloxacin against Mycoplasma pneumoniae. Antimicrob Agents Chemother (1994) 1.65

Effect of cycloheximide on the nucleolar RNA synthesis in rat liver. J Mol Biol (1970) 1.61

Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide. Proc Natl Acad Sci U S A (1978) 1.60

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Kinesin superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite building. J Cell Biol (2000) 1.60

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem (1986) 1.58

Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer (1998) 1.58

Detection by in situ hybridization and phenotypic characterization of cells expressing IL-6 mRNA in human stimulated blood. J Immunol (1990) 1.57

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res (1996) 1.55

Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol (1990) 1.52

Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans. J Biochem (1999) 1.50

The pins and rubbers traction system for treatment of comminuted intraarticular fractures and fracture-dislocations in the hand. J Hand Surg Br (1994) 1.50

Regulation of B cell differentiation by T cell subsets defined with monoclonal OKT4 and OKT8 antibodies in human cord blood. J Immunol (1981) 1.46

Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer. Eur J Cancer (1999) 1.46

Involvement of CYP2E1 as A low-affinity enzyme in phenacetin O-deethylation in human liver microsomes. Drug Metab Dispos (1999) 1.45

Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors. Development (1998) 1.44

Physiological profile of middle-aged and older climbers who ascended Gasherbrum II, an 8035-m Himalayan peak. J Gerontol A Biol Sci Med Sci (2000) 1.44

Interstitial pneumonia in Hermansky-Pudlak syndrome: significance of florid foamy swelling/degeneration (giant lamellar body degeneration) of type-2 pneumocytes. Virchows Arch (2000) 1.44

Tissue response of a small saccular aneurysm after incomplete occlusion with a Guglielmi detachable coil. AJNR Am J Neuroradiol (1999) 1.43

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy. Intern Med (2001) 1.40

Abnormally high rate of cyclic AMP excretion from an Escherichia coli mutant deficient in cyclic AMP receptor protein. Biochem Biophys Res Commun (1974) 1.40

Two cases of adult T-cell leukemia associated with acute pancreatitis due to hypercalcemia. Am J Med (1991) 1.39

Effect of prolonged low-dose methylprednisolone therapy in acute exacerbation of idiopathic pulmonary fibrosis. Respir Care (2001) 1.39

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect. Bone Marrow Transplant (2006) 1.39

Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. Eur J Cancer (1999) 1.37

High-risk and multiple human papillomavirus infections associated with cervical abnormalities in Japanese women. Cancer Epidemiol Biomarkers Prev (2001) 1.37

The acute phase nature of interleukin 6: studies in Kawasaki disease and other febrile illnesses. Clin Exp Immunol (1989) 1.36

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. Arch Biochem Biophys (1980) 1.36

Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4. Drug Metab Dispos (1998) 1.35

A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells. Eur J Immunol (1998) 1.35

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem Res Toxicol (1998) 1.32

Formation of ppGpp in a relaxed and stringent strain of Escherichia coli during diauxie lag. Biochemistry (1971) 1.32

GDP does not mediate but rather inhibits hormonal signal to adenylate cyclase. J Biol Chem (1983) 1.32

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene. Cancer Epidemiol Biomarkers Prev (1994) 1.30

Molecular markers for the agouti coat color locus of the mouse. Genetics (1987) 1.30

Changes in the properties and molecular weights of Bacillus subtilis M-type and N-type alpha-amylases resulting from a spontaneous deletion. J Biochem (1984) 1.30

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol Aging (2004) 1.29

Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in fungi. Biosci Biotechnol Biochem (2000) 1.29

Inhibition of initiation of DNA-dependent RNA synthesis by an antibiotic B44p. Biochem Biophys Res Commun (1968) 1.28

Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst (1991) 1.28

Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27

A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors. Bioorg Med Chem Lett (1998) 1.25

Urinary podocytes for the assessment of disease activity in lupus nephritis. Am J Med Sci (2000) 1.24

Deficient cotinine formation from nicotine is attributed to the whole deletion of the CYP2A6 gene in humans. Clin Pharmacol Ther (2000) 1.23

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities. Bioorg Med Chem Lett (1998) 1.23

Activated platelets induce superoxide anion release by monocytes and neutrophils through P-selectin (CD62). J Immunol (1993) 1.22

Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment. Am J Med Sci (1998) 1.21

Fatty liver and its fibrous changes found in simple obesity of children. J Pediatr Gastroenterol Nutr (1984) 1.20

Estimation of validity of mass screening program for gastric cancer in Osaka, Japan. Cancer (1990) 1.20

Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. Br J Clin Pharmacol (2000) 1.18

Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. Proc Natl Acad Sci U S A (1986) 1.18

Adjustment of RNA content during temperature upshift in Escherichia coli. Biochem Biophys Res Commun (1977) 1.17

Nonidentical subunits of protocatechuate 3,4-dioxygenase. Biochemistry (1976) 1.17

Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J Biol Chem (2001) 1.17

Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma. Eur J Cancer (1999) 1.16