| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice.
|
Gastroenterology
|
1999
|
1.92
|
|
2
|
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.
|
Gastroenterology
|
1998
|
1.58
|
|
3
|
Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice.
|
J Hepatol
|
1996
|
1.46
|
|
4
|
Mitochondria in steatohepatitis.
|
Semin Liver Dis
|
2001
|
1.35
|
|
5
|
Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.
|
Biochem Pharmacol
|
1990
|
1.25
|
|
6
|
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.
|
Clin Res Hepatol Gastroenterol
|
2011
|
1.25
|
|
7
|
Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants.
|
J Pharmacol Exp Ther
|
2001
|
1.19
|
|
8
|
Hepatotoxicity due to mitochondrial dysfunction.
|
Cell Biol Toxicol
|
1999
|
1.16
|
|
9
|
Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients.
|
J Hepatol
|
1997
|
1.16
|
|
10
|
Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease.
|
Gastroenterology
|
2001
|
1.14
|
|
11
|
Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes.
|
J Pharmacol Exp Ther
|
1992
|
1.04
|
|
12
|
Multiple mtDNA deletions features in autosomal dominant and recessive diseases suggest distinct pathogeneses.
|
Neurology
|
1998
|
1.02
|
|
13
|
Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.
|
J Pharmacol Exp Ther
|
1994
|
0.99
|
|
14
|
Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions.
|
Hepatology
|
1994
|
0.95
|
|
15
|
Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease.
|
Gastroenterology
|
1997
|
0.91
|
|
16
|
Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome.
|
J Pharmacol Exp Ther
|
1991
|
0.87
|
|
17
|
Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.
|
Br J Pharmacol
|
2012
|
0.83
|
|
18
|
Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice.
|
Biochem Pharmacol
|
1991
|
0.82
|
|
19
|
Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction.
|
Gastroenterology
|
1996
|
0.82
|
|
20
|
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.
|
J Hepatol
|
1994
|
0.81
|
|
21
|
Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers.
|
Gut
|
1993
|
0.81
|
|
22
|
Assessment of the prevalence of genetic metabolic defects in acute fatty liver of pregnancy.
|
J Hepatol
|
1996
|
0.81
|
|
23
|
Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.
|
J Pharmacol Exp Ther
|
1994
|
0.80
|
|
24
|
Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids.
|
J Pharmacol Exp Ther
|
1990
|
0.80
|
|
25
|
Generation of free radicals during the reductive metabolism of the nitroaromatic compound, nilutamide.
|
J Pharmacol Exp Ther
|
1991
|
0.80
|
|
26
|
Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy.
|
Am J Physiol
|
1995
|
0.80
|
|
27
|
Decreased mitochondrial oxidation of fatty acids in pregnant mice: possible relevance to development of acute fatty liver of pregnancy.
|
Hepatology
|
1993
|
0.79
|
|
28
|
Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo.
|
Gastroenterology
|
1996
|
0.78
|
|
29
|
Effect of stavudine on mitochondrial genome and fatty acid oxidation in lean and obese mice.
|
J Pharmacol Exp Ther
|
2001
|
0.78
|
|
30
|
[Role of mitochondria in drug-induced hepatotoxicity].
|
Gastroenterol Clin Biol
|
1998
|
0.75
|
|
31
|
Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen.
|
Biochem Pharmacol
|
1992
|
0.75
|