Published in Immunity on July 01, 2001
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. Proc Natl Acad Sci U S A (2004) 2.12
Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Arch Biochem Biophys (2007) 1.75
TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity. Mol Cell Biol (2002) 1.72
Transcription of Satellite III non-coding RNAs is a general stress response in human cells. Nucleic Acids Res (2007) 1.58
Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration. Proc Natl Acad Sci U S A (2002) 1.56
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A (2004) 1.38
Osmoprotective transcription factor NFAT5/TonEBP modulates nuclear factor-kappaB activity. Mol Biol Cell (2010) 1.38
Transcriptional control of the TNF gene. Curr Dir Autoimmun (2010) 1.32
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Sci Signal (2009) 1.30
cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein. Proc Natl Acad Sci U S A (2002) 1.29
Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. J Exp Med (2012) 1.28
Regulation of NFATc1 in Osteoclast Differentiation. J Bone Metab (2014) 1.15
The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One (2009) 1.15
Role of NFAT5 in inflammatory disorders associated with osmotic stress. Curr Genomics (2010) 1.10
Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells. Am J Pathol (2002) 1.08
NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone. Nucleic Acids Res (2005) 1.06
The role of hyperosmotic stress in inflammation and disease. Biomol Concepts (2012) 1.05
Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC Mol Biol (2008) 1.03
Alternative splicing networks regulated by signaling in human T cells. RNA (2012) 1.03
Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity. Nucleic Acids Res (2010) 1.02
NF-kappaB modulates aquaporin-2 transcription in renal collecting duct principal cells. J Biol Chem (2008) 1.01
Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell (2014) 1.00
NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog (2006) 0.99
Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin. Nucleic Acids Res (2012) 0.98
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance. J Mol Signal (2013) 0.94
The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. J Biol Chem (2010) 0.92
Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neurosci (2010) 0.91
Regulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathway. PLoS Pathog (2012) 0.89
Novel nuclear localization signal regulated by ambient tonicity in vertebrates. J Biol Chem (2008) 0.89
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Exp Mol Med (2008) 0.88
NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells. Mediators Inflamm (2012) 0.87
Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells. Am J Physiol Renal Physiol (2009) 0.87
Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP. Matrix Biol (2014) 0.87
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathog (2009) 0.86
Inducible nucleosome depletion at OREBP-binding-sites by hypertonic stress. PLoS One (2009) 0.86
PPE38 of Mycobacterium marinum triggers the cross-talk of multiple pathways involved in the host response, as revealed by subcellular quantitative proteomics. J Proteome Res (2013) 0.85
Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. J Lipid Res (2012) 0.85
Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood) (2012) 0.83
Monitoring the immune response to vaccination with an inactivated vaccine associated to bovine neonatal pancytopenia by deep sequencing transcriptome analysis in cattle. Vet Res (2013) 0.83
Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro. Arthritis Res Ther (2010) 0.82
Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes. Exp Mol Med (2013) 0.82
Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther (2013) 0.82
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol (2015) 0.82
Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase. PLoS One (2009) 0.81
Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway. Mol Biol Cell (2014) 0.81
Placental TonEBP/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restriction. Biol Reprod (2012) 0.81
Mutations in DNA-binding loop of NFAT5 transcription factor produce unique outcomes on protein-DNA binding and dynamics. J Phys Chem B (2013) 0.81
Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renal carcinoma cells. Oncol Lett (2016) 0.80
The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature. J Transl Med (2011) 0.80
Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus. Brain Res (2013) 0.80
Generation of a conditional knockout allele for the NFAT5 gene in mice. Front Physiol (2015) 0.80
MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. J Clin Invest (2015) 0.79
Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One (2016) 0.78
NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development. Proc Natl Acad Sci U S A (2013) 0.78
Modulation of NFAT-5, an outlying member of the NFAT family, in human keratinocytes and skin. Am J Transl Res (2009) 0.77
NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake. Am J Physiol Renal Physiol (2012) 0.77
The Potential Role of NFAT5 and Osmolarity in Peritoneal Injury. Biomed Res Int (2015) 0.77
The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology. Expert Rev Endocrinol Metab (2010) 0.77
Th17/Treg Imbalance Induced by Dietary Salt Variation Indicates Inflammation of Target Organs in Humans. Sci Rep (2016) 0.77
NFAT5 genes are part of the osmotic regulatory system in Atlantic salmon (Salmo salar). Mar Genomics (2016) 0.76
NFATc2 is an intrinsic regulator of melanoma dedifferentiation. Oncogene (2015) 0.76
Mariner Transposons Contain a Silencer: Possible Role of the Polycomb Repressive Complex 2. PLoS Genet (2016) 0.76
Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis. J Clin Invest (2017) 0.75
Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Part Fibre Toxicol (2016) 0.75
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5. Immunol Cell Biol (2016) 0.75
RNA sequencing reveals a role of TonEBP in regulation of pro-inflammatory genes in response to hyperosmolarity in healthy nucleus pulposus cells: A homeostatic response? J Biol Chem (2016) 0.75
Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine (2017) 0.75
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science (1997) 11.89
Y chromosome sequence variation and the history of human populations. Nat Genet (2000) 8.34
VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach. Genetics (1993) 8.22
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20
Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography. Genome Res (1997) 6.73
Ethnic-affiliation estimation by use of population-specific DNA markers. Am J Hum Genet (1997) 6.72
Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics (1992) 6.40
Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet (2001) 5.41
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity (1998) 5.38
Localization of neuronal and glial glutamate transporters. Neuron (1994) 5.14
Kin selection, social structure, gene flow, and the evolution of chimpanzees. Science (1994) 5.08
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history. Proc Natl Acad Sci U S A (1996) 4.52
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature (1993) 4.26
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (1999) 4.20
Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol (2001) 4.09
A unified approach to study hypervariable polymorphisms: statistical considerations of determining relatedness and population distances. EXS (1993) 3.86
Partners in transcription: NFAT and AP-1. Oncogene (2001) 3.83
Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina. Am J Phys Anthropol (2001) 3.76
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature (1998) 3.71
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell (2000) 3.44
Nuclear factor of activated T cells contains Fos and Jun. Nature (1992) 3.43
The Eurasian heartland: a continental perspective on Y-chromosome diversity. Proc Natl Acad Sci U S A (2001) 3.38
Transcriptional regulation of the IL-2 gene. Curr Opin Immunol (1995) 3.14
Population genetics of dinucleotide (dC-dA)n.(dG-dT)n polymorphisms in world populations. Am J Hum Genet (1995) 3.12
Variances of the average numbers of nucleotide substitutions within and between populations. Mol Biol Evol (1989) 3.11
GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J Cell Biol (1997) 2.92
Quality of diabetes care in community health centers. Am J Public Health (2000) 2.76
Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child (2008) 2.71
Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67
A novel measure of genetic distance for highly polymorphic tandem repeat loci. Mol Biol Evol (1995) 2.65
Genetic relationship of populations in China. Proc Natl Acad Sci U S A (1998) 2.65
An enhanced immune response in mice lacking the transcription factor NFAT1. Science (1996) 2.55
Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nat Med (2000) 2.52
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci U S A (1999) 2.48
p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol (1999) 2.47
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron (1998) 2.45
Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol Cell (1998) 2.44
Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature (1997) 2.41
Clinical intestinal transplantation: new perspectives and immunologic considerations. J Am Coll Surg (1998) 2.31
Limited humoral immunity in hepatitis C virus infection. Gastroenterology (1999) 2.31
The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures. Am J Hum Genet (2001) 2.29
Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A (1995) 2.24
Determination of relatedness between individuals using DNA fingerprinting. Hum Biol (1993) 2.23
Evaluation of 13 short tandem repeat loci for use in personal identification applications. Am J Hum Genet (1994) 2.15
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J (2000) 2.14
Analysis of the AP-1 sites in the IL-2 promoter. J Immunol (1992) 2.14
Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity (2000) 2.13
Calcineurin: from structure to function. Curr Top Cell Regul (2000) 2.10
Feature (gene) selection in gene expression-based tumor classification. Mol Genet Metab (2001) 2.08
Heterozygote deficiency, population substructure and their implications in DNA fingerprinting. Hum Genet (1992) 2.06
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lipid Res (2000) 2.05
Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol Cell Biol (1996) 2.03
Medical and psychosocial services in drug abuse treatment: do stronger linkages promote client utilization? Health Serv Res (2000) 1.99
CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil Cytoskeleton (1993) 1.99
Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2. Genomics (1999) 1.97
Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Hum Genet (2000) 1.95
Postsynaptically silent synapses in single neuron cultures. Neuron (1998) 1.94
High polymorphism at the human melanocortin 1 receptor locus. Genetics (1999) 1.94
Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter. J Exp Med (1993) 1.93
Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26. J Mol Biol (1999) 1.93
Clinical characteristics and MR imaging features of nonalcoholic Wernicke encephalopathy. AJNR Am J Neuroradiol (2008) 1.92
Inbreeding and risk of late onset complex disease. J Med Genet (2003) 1.92
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem (1996) 1.91
NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J Biol Chem (1993) 1.84
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci U S A (1993) 1.84
Paternity evaluation in cases lacking a mother and nondetectable alleles. Int J Legal Med (1994) 1.83
Structure of the collagen-binding domain from a Staphylococcus aureus adhesin. Nat Struct Biol (1997) 1.80
Polynesian origins: insights from the Y chromosome. Proc Natl Acad Sci U S A (2000) 1.79
Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity (2000) 1.79
Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding. Nat Struct Biol (1997) 1.78
Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients. Rheumatology (Oxford) (2006) 1.77
UK measles outbreak in non-immune anthroposophic communities: the implications for the elimination of measles from Europe. Epidemiol Infect (2000) 1.77
Characterization of reentrant circuit in macroreentrant right atrial tachycardia after surgical repair of congenital heart disease: isolated channels between scars allow "focal" ablation. Circulation (2001) 1.73
Detailed quality of life assessment in patients treated with primary radiotherapy for squamous cell cancer of the base of the tongue. Head Neck (1997) 1.71
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest (2001) 1.70
A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem (1995) 1.70
Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A (1998) 1.68
Molecular epidemiology of measles virus: identification of pathways of transmission and implications for measles elimination. J Infect Dis (1996) 1.66
LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circ Res (2006) 1.65
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents. Bioorg Med Chem Lett (2001) 1.64
MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene (2012) 1.63
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol (1996) 1.61
Dispersion of human Y chromosome haplotypes based on five microsatellites in global populations. Genome Res (1996) 1.61
Mammalian Bax-induced plant cell death can be down-regulated by overexpression of Arabidopsis Bax Inhibitor-1 (AtBI-1). Proc Natl Acad Sci U S A (2001) 1.59
Appropriateness of medication selection for older persons in an urban academic emergency department. Acad Emerg Med (1999) 1.58
Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J Exp Med (1998) 1.58
Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biol (2008) 1.57
Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system. J Biol Chem (1994) 1.56
A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J (1994) 1.56
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ (2004) 1.54
Oxidative stress and antioxidants in epilepsy. Clin Chim Acta (2001) 1.53
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature (2001) 1.53
On-site primary care and mental health services in outpatient drug abuse treatment units. J Behav Health Serv Res (1999) 1.53
Impact of human immunodeficiency virus type 1 gp41 amino acid substitutions selected during enfuvirtide treatment on gp41 binding and antiviral potency of enfuvirtide in vitro. J Virol (2005) 1.53