Published in Gastroenterology on August 01, 2001
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
Inflammation, atrophy, and gastric cancer. J Clin Invest (2007) 4.29
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development (2004) 3.30
A cancer theory kerfuffle can lead to new lines of research. J Natl Cancer Inst (2014) 1.91
Development and differentiation of the intestinal epithelium. Cell Mol Life Sci (2003) 1.80
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58
The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus). Cell Cycle (2011) 1.57
Stem cell in gastrointestinal structure and neoplastic development. Gut (2004) 1.57
The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol (2008) 1.53
Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci (2008) 1.46
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut (2002) 1.46
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology (2010) 1.33
Identification of novel cellular targets in biliary tract cancers using global gene expression technology. Am J Pathol (2003) 1.33
Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am J Pathol (2007) 1.28
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer (2008) 1.24
Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology (2011) 1.23
FGF10 signaling controls stomach morphogenesis. Dev Biol (2006) 1.23
The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis. Gut Microbes (2013) 1.20
Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy. Br J Cancer (2008) 1.19
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis. Br J Cancer (2007) 1.08
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One (2013) 1.06
Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer. Bioorg Med Chem (2008) 1.06
Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Physiol Gastrointest Liver Physiol (2008) 1.05
Gastric cancer stem cells: a novel therapeutic target. Cancer Lett (2013) 1.04
Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. Lab Invest (2009) 1.03
The role of hedgehog signaling during gastric regeneration. J Gastroenterol (2009) 1.02
ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. BMC Cancer (2012) 1.00
Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer (2010) 1.00
Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy. Surg Today (2013) 0.98
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. Virchows Arch (2009) 0.97
Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. Br J Cancer (2010) 0.94
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J Anat (2007) 0.94
Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma. Am J Pathol (2011) 0.93
Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch (2004) 0.90
Infection with Helicobacter pylori affects all major secretory cell populations in the human antrum. Dig Dis Sci (2005) 0.88
MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation. Int J Mol Sci (2013) 0.87
Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse. Dig Dis Sci (2010) 0.86
Gastric stem cells and gastric cancer stem cells. Anat Cell Biol (2013) 0.86
Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? Curr Opin Endocrinol Diabetes Obes (2009) 0.85
Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology (2014) 0.84
The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology (2013) 0.83
Bone morphogenetic protein 2 induced differentiation toward superficial epithelial cells in the gastric mucosa. J Gastroenterol (2006) 0.83
Expression of bone morphogenic protein-4 is inversely related to prevalence of lymph node metastasis in gastric adenocarcinoma. Surg Today (2011) 0.83
Regulation of gastric epithelial cell homeostasis by gastrin and bone morphogenetic protein signaling. Physiol Rep (2015) 0.83
Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol (2013) 0.82
Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice. Gastroenterology (2014) 0.82
Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer. Dig Dis Sci (2011) 0.81
The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model. PLoS One (2015) 0.79
Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice. Am J Pathol (2011) 0.79
Identification of signature genes for detecting hedgehog signaling activation in gastric cancer. Mol Med Rep (2011) 0.78
Gastric epithelial cell modality and proton pump inhibitor. J Clin Biochem Nutr (2008) 0.78
Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice. Hum Mol Genet (2014) 0.78
The role of Sonic Hedgehog as a regulator of gastric function and differentiation. Vitam Horm (2012) 0.77
Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model. PLoS One (2014) 0.77
Helicobacter suis affects the health and function of porcine gastric parietal cells. Vet Res (2016) 0.77
Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process. J Gastric Cancer (2015) 0.76
Tracking down the hedgehog's lair in the pancreas. Gastroenterology (2010) 0.76
E. coli-produced BMP-2 as a chemopreventive strategy for colon cancer: a proof-of-concept study. Gastroenterol Res Pract (2012) 0.76
Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports (2015) 0.76
Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions. Cell Mol Gastroenterol Hepatol (2017) 0.75
Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling. Cell Mol Gastroenterol Hepatol (2017) 0.75
Hedgehog Signaling in Pancreatic Fibrosis and Cancer. Medicine (Baltimore) (2016) 0.75
Morphogenesis and maintenance of the gastric epithelium: a role for sonic hedgehog? Gastroenterology (2001) 0.75
αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation. Cell Rep (2017) 0.75
Usefulness of endoscopic brushing and magnified endoscopy with narrow band imaging (ME-NBI) to detect intestinal phenotype in columnar-lined esophagus. J Gastroenterol (2012) 0.75
Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet (1990) 9.49
Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology (1988) 8.27
Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut (1999) 7.14
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med (1995) 6.73
Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study group. Lancet (1999) 5.27
Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J Clin Microbiol (1986) 5.15
The endoscopic assessment of esophagitis: a progress report on observer agreement. Gastroenterology (1996) 4.69
Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction. Lancet (1993) 4.55
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology (1995) 4.39
Barrett's esophagus: development of dysplasia and adenocarcinoma. Gastroenterology (1989) 4.23
Functional gastroduodenal disorders. Gut (1999) 3.74
Mucosal tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8 production in patients with Helicobacter pylori infection. Scand J Gastroenterol (1994) 3.22
Randomised trial of endoscopic balloon dilation versus endoscopic sphincterotomy for removal of bileduct stones. Lancet (1997) 3.12
Needle-knife sphincterotomy as a precut procedure: a retrospective evaluation of efficacy and complications. Endoscopy (1996) 3.12
Recurrent massive haematemesis from Dieulafoy vascular malformations--a review of 101 cases. Gut (1986) 2.74
Regular review: treatment of Helicobacter pylori infection. BMJ (2000) 2.73
Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol (1996) 2.73
The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related diseases. J Infect Dis (1996) 2.66
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology (1999) 2.62
Long-term follow-up after endoscopic sphincterotomy for bile duct stones in patients younger than 60 years of age. Gastrointest Endosc (1996) 2.54
[Probiotic prophylaxis in patients with predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial]. Ned Tijdschr Geneeskd (2008) 2.52
Impact of endoscopic biopsy surveillance of Barrett's oesophagus on pathological stage and clinical outcome of Barrett's carcinoma. Gut (1998) 2.38
The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. Gastroenterology (1999) 2.37
Treatment of Helicobacter pylori infection: a review of the world literature. Helicobacter (1996) 2.26
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut (2002) 2.26
Collagenous sprue--an unrecognized type of malabsorption. N Engl J Med (1970) 2.21
Equally high prevalences of infection with cagA-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis-associated dyspepsia. J Clin Microbiol (1997) 2.18
Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease. Gastroenterology (1996) 2.17
A systematic review of Helicobacter pylori eradication therapy--the impact of antimicrobial resistance on eradication rates. Aliment Pharmacol Ther (1999) 2.14
Treatment of bile duct lesions after laparoscopic cholecystectomy. Gut (1996) 2.12
Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J Infect Dis (1998) 2.09
Oral cimetidine in reflux esophagitis: a double blind controlled trial. Gastroenterology (1978) 2.07
[Changed diagnosis and treatment of hepatocellular carcinoma]. Ned Tijdschr Geneeskd (1996) 2.04
Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut (1992) 1.96
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut (2002) 1.96
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis. Gut (1999) 1.94
14C-urea breath test in C pylori gastritis. Gut (1989) 1.89
Time trends in gastric carcinoma: changing patterns of type and location. Am J Gastroenterol (1992) 1.88
cagA-positive Helicobacter pylori populations in China and The Netherlands are distinct. Infect Immun (1998) 1.84
Gastric non-Hodgkin lymphomas of mucosa-associated lymphoid tissue are not associated with more aggressive Helicobacter pylori strains as identified by CagA. Am J Clin Pathol (1996) 1.84
Endoscopic palliative treatment in pancreatic cancer. Gastrointest Endosc (1986) 1.84
Analysis of the lympho-plasmacytic infiltrate in Crohn's disease with special reference to identification of lymphocyte-subpopulations. Gut (1976) 1.83
Biliary endoprostheses in elderly patients with endoscopically irretrievable common bile duct stones: report on 117 patients. Gastrointest Endosc (1995) 1.82
Choosing the best anti-Helicobacter pylori therapy: effect of antimicrobial resistance. Am J Gastroenterol (1996) 1.80
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology (1997) 1.79
Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index. Aliment Pharmacol Ther (1999) 1.76
Double-blind comparison of slow-release 5-aminosalicylate and sulfasalazine in remission maintenance in ulcerative colitis. Gastroenterology (1988) 1.75
Comparison of the efficacy and safety of 1.5 compared with 3.0 g oral slow-release mesalazine (Pentasa) in the maintenance treatment of ulcerative colitis. Dutch Pentasa Study Group. Eur J Gastroenterol Hepatol (1995) 1.74
Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease. Gastroenterology (1999) 1.74
Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16. Gastroenterology (1998) 1.73
Leptin is a growth factor for colonic epithelial cells. Gastroenterology (2001) 1.71
Endosonography and computed tomography of esophageal carcinoma. Preoperative classification compared to the new (1987) TNM system. Gastroenterology (1989) 1.70
Twenty-four-hour pH measurements in morbid obesity: effects of massive overweight, weight loss and gastric distension. Eur J Gastroenterol Hepatol (1996) 1.70
Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis, and clinical outcome. Am J Gastroenterol (1997) 1.69
Intragastric balloon in the treatment of super-morbid obesity. Double-blind, sham-controlled, crossover evaluation of 500-milliliter balloon. Gastroenterology (1990) 1.67
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut (2003) 1.67
Effect of Helicobacter pylori eradication on gastritis in relation to cagA: a prospective 1-year follow-up study. Gastroenterology (1997) 1.67
Intermethod variation in detection of human papillomavirus DNA in cervical smears. J Clin Microbiol (1995) 1.65
Impaired anamnestic cellular immune response in patients with Crohn's disease. Gut (1975) 1.65
A patient with osteomalacia as single presenting symptom of gluten-sensitive enteropathy. J Intern Med (1992) 1.64
Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Gastroenterology (1995) 1.61
Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy (2007) 1.60
Intestinal endotoxemia. Clinical significance. Gastroenterology (1988) 1.59
Benign biliary strictures. Surgery or endoscopy? Ann Surg (1993) 1.59
Loss of E-cadherin expression in early gastric cancer. Histopathology (1999) 1.59
Intragastric balloons for morbid obesity: results, patient tolerance and balloon life span. Br J Surg (1990) 1.58
Four years experience with short term stenting in primary sclerosing cholangitis. Am J Gastroenterol (1999) 1.57
Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. EMBO J (1993) 1.57
The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region. J Pathol (1998) 1.56
Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment. Clin Exp Immunol (1999) 1.53
Follow-up study of individuals with untreated Campylobacter pylori-associated gastritis and of noninfected persons with non-ulcer dyspepsia. J Infect Dis (1988) 1.52
Bile duct injury after laparoscopic cholecystectomy: the value of endoscopic retrograde cholangiopancreatography. Gut (1993) 1.52
Clogging of biliary endoprostheses: a new perspective. Gut (1990) 1.52
Early diagnosis and prevention of sporadic colorectal cancer. Endoscopy (2001) 1.51
Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function. Gastroenterology (2001) 1.51
Value of brush cytology for dominant strictures in primary sclerosing cholangitis. Endoscopy (1999) 1.51
Palliative treatment of obstructive jaundice by transpapillary introduction of large bore bile duct endoprosthesis. Gut (1982) 1.51
The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? Thromb Haemost (2001) 1.50
Influence of metronidazole resistance on efficacy of quadruple therapy for Helicobacter pylori eradication. Gut (1998) 1.50
A single drug for Helicobacter pylori infection: first results with a new bismuth triple monocapsule. Am J Gastroenterol (2000) 1.50
A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy. Gastrointest Endosc (2001) 1.49
Validation of the Rockall risk scoring system in upper gastrointestinal bleeding. Gut (1999) 1.49
Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of bilirubin in rodents. Gastroenterology (1998) 1.48
Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology. Gastrointest Endosc (2001) 1.48
Piperacillin to prevent cholangitis after endoscopic retrograde cholangiopancreatography. A randomized, controlled trial. Ann Intern Med (1996) 1.48
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut (2002) 1.46
Electron microscopic study of association between Helicobacter pylori and gastric and duodenal mucosa. J Clin Pathol (1994) 1.44
Diagnostic accuracy of fiberendoscopy in the detection of upper intestinal malignancy. A follow-up analysis. Gastroenterology (1977) 1.44
Analysis of a positional candidate gene for inflammatory bowel disease: NRAMP2. Inflamm Bowel Dis (2000) 1.44
A prospective randomized trial of Teflon versus polyethylene stents for distal malignant biliary obstruction. Endoscopy (1998) 1.44
The best therapy for Helicobacter pylori infection: should efficacy or side-effect profile determine our choice? Scand J Gastroenterol (1995) 1.43
Impact of metronidazole resistance on the eradication of Helicobacter pylori. Scand J Infect Dis (1994) 1.42
Results of conservative treatment of benign esophageal strictures: a follow-up study in 100 patients. Gastroenterology (1982) 1.42
Adalimumab in Crohn's disease patients: pharmacokinetics in the first 6 months of treatment. Aliment Pharmacol Ther (2014) 1.41
Treatment of instrumental oesophageal perforation. Gut (1984) 1.40
Suppression of Helicobacter pylori infection during intensive care stay: related to stress ulcer bleeding incidence? J Crit Care (2001) 1.40
Gastric metaplasia and Helicobacter pylori infection. Gut (1993) 1.40
[Barrett's esophagus: endoscopic treatment of high-grade dysplasia and early cancer]. Ned Tijdschr Geneeskd (2003) 1.39