Published in Infect Immun on September 01, 2001
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog (2006) 1.93
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infect Immun (2002) 1.45
Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection. Infect Immun (2006) 1.20
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS Negl Trop Dis (2008) 1.19
Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice. Infect Immun (2002) 1.18
Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection. Infect Immun (2003) 1.15
Type 1 immunity provides both optimal mucosal and systemic protection against a mucosally invasive, intracellular pathogen. Infect Immun (2005) 1.13
CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infect Immun (2005) 1.11
Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy. Infect Immun (2002) 0.99
Humoral and cellular immune responses to Trypanosoma cruzi-derived paraflagellar rod proteins in patients with Chagas' disease. Infect Immun (2003) 0.98
DNA Vaccines against Protozoan Parasites: Advances and Challenges. J Biomed Biotechnol (2007) 0.95
A DNA vaccine encoding for TcSSP4 induces protection against acute and chronic infection in experimental Chagas disease. Int J Biol Sci (2011) 0.93
Intranasal vaccinations with the trans-sialidase antigen plus CpG Adjuvant induce mucosal immunity protective against conjunctival Trypanosoma cruzi challenges. Infect Immun (2010) 0.87
Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. J Parasitol Res (2011) 0.84
Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease. Clin Vaccine Immunol (2008) 0.84
Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS Negl Trop Dis (2014) 0.84
An immunoinformatic approach for identification of Trypanosoma cruzi HLA-A2-restricted CD8(+) T cell epitopes. Hum Vaccin Immunother (2015) 0.82
Genetic immunization converts the trypanosoma cruzi B-Cell mitogen proline racemase to an effective immunogen. Infect Immun (2009) 0.82
Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection. Mem Inst Oswaldo Cruz (2010) 0.81
CD8(+) T cell-mediated immunity during Trypanosoma cruzi infection: a path for vaccine development? Mediators Inflamm (2014) 0.80
Genetic vaccination against experimental infection with myotropic parasite strains of Trypanosoma cruzi. Mediators Inflamm (2014) 0.79
Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen. PLoS One (2015) 0.78
Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi. PLoS Pathog (2016) 0.76
Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells. Infect Immun (2016) 0.75
Parasite-induced chronic inflammation is not exacerbated by immunotherapy before or during Trypanosoma cruzi Infection. Clin Vaccine Immunol (2007) 0.75
Costimulatory Effects of an Immunodominant Parasite Antigen Paradoxically Prevent Induction of Optimal CD8 T Cell Protective Immunity. PLoS Pathog (2016) 0.75
Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria. Proc Natl Acad Sci U S A (1993) 2.44
Protective effects of specific antibodies in Trypanosoma cruzi infections. J Immunol (1976) 2.20
Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur J Immunol (1992) 1.96
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun (1998) 1.89
Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol (1994) 1.89
Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun (1993) 1.59
Chagas disease etiology: autoimmunity or parasite persistence? Parasitol Today (1999) 1.48
beta-Chemokines enhance parasite uptake and promote nitric oxide-dependent microbiostatic activity in murine inflammatory macrophages infected with Trypanosoma cruzi. Infect Immun (1999) 1.44
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol (1996) 1.43
Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes. J Immunol (1999) 1.41
DNA immunization with minigenes: low frequency of memory cytotoxic T lymphocytes and inefficient antiviral protection are rectified by ubiquitination. J Virol (1998) 1.34
Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice. Vaccine (1998) 1.33
Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies. J Cell Sci (2000) 1.33
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Infect Immun (1998) 1.31
The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi. Parasite Immunol (1998) 1.31
Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses. J Immunol (1997) 1.25
DNA-Based immunization with Trypanosoma cruzi complement regulatory protein elicits complement lytic antibodies and confers protection against Trypanosoma cruzi infection. Infect Immun (2000) 1.23
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol (2000) 1.22
Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL. J Immunol (1998) 1.21
Cell-mediated immunity in experimental Trypanosoma cruzi infection. Parasitol Today (1997) 1.19
Optimization of codon usage of plasmid DNA vaccine is required for the effective MHC class I-restricted T cell responses against an intracellular bacterium. J Immunol (1998) 1.19
Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease. J Exp Med (1995) 1.18
Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene. Infect Immun (1999) 1.13
Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and trans-sialidase on the trypanosome. Mol Biochem Parasitol (1993) 1.10
Cytotoxic T cell responses to DNA vaccination: dependence on antigen presentation via class II MHC. J Immunol (1998) 1.07
Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO J (1992) 1.05
Granulysin: a lethal weapon of cytolytic T cells. Immunol Today (1999) 1.03
Epitope affinity for MHC class I determines helper requirement for CTL priming. Nat Immunol (2000) 1.02
Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses. J Clin Invest (1998) 1.01
Genetic immunization of mice against Listeria monocytogenes using plasmid DNA encoding listeriolysin O. J Immunol (1999) 0.97
Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Glycobiology (1997) 0.97
Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine. Vaccine (2000) 0.94
CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanism. Immunol Lett (2000) 0.94
Protection of mice against Trypanosoma cruzi by immunization with paraflagellar rod proteins requires T cell, but not B cell, function. J Immunol (1997) 0.90
Epitope-specific cytotoxic T lymphocyte induction by minigene DNA immunization. Vaccine (1999) 0.87
Analysis and partial epitope mapping of human T cell responses to Trypanosoma cruzi cysteinyl proteinase. J Immunol (1993) 0.87
Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes. Vaccine (1999) 0.85
Quantification of antigen specific CD8+ T cells using an ELISPOT assay. J Immunol Methods (1995) 2.82
Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology (1984) 2.12
Corneal dystrophies. II. Endothelial dystrophies. Surv Ophthalmol (1979) 1.90
Argon laser iridotomy in the treatment of patients with primary angle-closure or pupillary block glaucoma: a clinicopathologic study. Ophthalmology (1978) 1.82
Anterior chamber cleavage syndrome. A stepladder classification. Surv Ophthalmol (1975) 1.78
Corneal dystrophies. I. Dystrophies of the epithelium, Bowman's layer and stroma. Surv Ophthalmol (1978) 1.65
Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria. Infect Immun (1997) 1.53
Disorders of the corneal epithelium. A clinicopathologic study of dot, geographic, and fingerprint patterns. Arch Ophthalmol (1974) 1.49
Clinicopathologic correlation of microphthalmos with cyst. Am J Ophthalmol (1976) 1.40
Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats. J Clin Invest (1981) 1.40
Effect of local diets with added sucrose on glycemic profiles of healthy and diabetic Brazilian subjects. J Am Coll Nutr (1994) 1.39
Longevity of naturally acquired antibody responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1. Am J Trop Med Hyg (1999) 1.35
Macular corneal dystrophy: failure to synthesize a mature keratan sulfate proteoglycan. Proc Natl Acad Sci U S A (1980) 1.34
Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice. Vaccine (1998) 1.33
Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodies. J Cell Sci (2000) 1.33
Electron microscopy of argon laser therapy in phakic open-angle glaucoma. Ophthalmology (1982) 1.30
Modulation of experimental autoimmune uveitis with cyclosporin A. Arch Ophthalmol (1982) 1.28
Congenital fibrosis of the extraocular muscles. J Pediatr Ophthalmol Strabismus (1979) 1.28
Spheno-orbital meningioma with optociliary veins. Am J Ophthalmol (1976) 1.23
Specificity of bactericidal antibody response to serogroup B meningococcal strains in Brazilian children after immunization with an outer membrane vaccine. Infect Immun (1998) 1.20
Immunohistochemistry and electron microscopy of choroidal infiltrates and Dalen-Fuchs nodules in sympathetic ophthalmia. Ophthalmology (1985) 1.15
Retinal pigment epithelium in incontinentia pigmenti. Am J Ophthalmol (1975) 1.15
Long-term complications of virus-induced diabetes mellitus in mice. Nature (1982) 1.14
Spectrum of trabecular pigmentation in open-angle glaucoma: a clinicopathologic study. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol (1976) 1.11
Epithelialization of the corneal endothelium in posterior polymorphous dystrophy. Invest Ophthalmol Vis Sci (1980) 1.11
Tamoxifen retinopathy. A clinicopathologic report. Ophthalmology (1981) 1.10
Trypanosoma cruzi: description of a highly purified surface antigen defined by human antibodies. J Immunol (1983) 1.08
Comparison of the immunogenic properties of recombinant proteins representing the Plasmodium vivax vaccine candidate MSP1(19) expressed in distinct bacterial vectors. Vaccine (2001) 1.08
Posterior keratoconus. Arch Ophthalmol (1978) 1.08
Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. Proc Natl Acad Sci U S A (1986) 1.07
Human massive periretinal proliferation. In vitro characteristics of cellular components. Arch Ophthalmol (1981) 1.07
Characterization of avascular corneal wound healing fibroblasts. New insights into the myofibroblast. Am J Pathol (1987) 1.05
Lipofuscin pigment over benign and malignant choroidal tumors. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol (1977) 1.04
Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase. Parasite Immunol (2000) 1.04
Endothelial alterations in congenital corneal dystrophies. Am J Ophthalmol (1975) 1.03
Corneal epithelial lesions in keratosis follicularis (Darier's disease). Ophthalmology (1980) 1.03
Histopathology of 150 trabeculectomy specimens in glaucoma. Trans Ophthalmol Soc U K (1976) 1.03
Corneal elastosis. Appearance of band-like keratopathy and spheroidal degeneration. Arch Ophthalmol (1975) 1.02
Trypanosoma cruzi metacyclic trypomastigotes: neutralization by the stage-specific monoclonal antibody 1G7 and immunogenicity of 90 kD surface antigen. Parasite Immunol (1988) 1.02
Retinoblastoma. Immunohistochemistry and cell differentiation. Ophthalmology (1987) 1.02
Choroideremia: a clinical, electron microscopic, and biochemical report. Ophthalmology (1984) 1.01
Fuchs' corneal dystrophy. A clinicopathologic study of the variation in corneal edema. Ophthalmology (1986) 1.00
Alterations of Descemet's membrane in interstitial keratitis. Am J Ophthalmol (1976) 0.99
Trypanosoma cruzi defined antigens in the serological evaluation of an outbreak of acute Chagas disease in Brazil (Catolé do Rocha, Paraíba). Mem Inst Oswaldo Cruz (1996) 0.98
Detection of specific collagen types in normal and keratoconus corneas. Invest Ophthalmol Vis Sci (1981) 0.98
Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Glycobiology (1997) 0.97
Ocular involvement in xeroderma pigmentosum. Ophthalmology (1982) 0.97
Disseminated bilateral chorioretinitis due to Histoplasma capsulatum in a patient with the acquired immunodeficiency syndrome. Ophthalmology (1985) 0.97
Exogenous fungal endophthalmitis caused by Paecilomyces. Am J Ophthalmol (1975) 0.96
Altered antigenicity of keratan sulfate proteoglycan in selected corneal diseases. Invest Ophthalmol Vis Sci (1990) 0.96
Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein. Parasite Immunol (1999) 0.96
A histochemical, fluorescent, and electron microscopic examination. Am J Ophthalmol (1973) 0.96
Langerhans cells in the normal conjunctiva and peripheral cornea of selected species. Invest Ophthalmol Vis Sci (1981) 0.95
The crystal structures of two polymorphs of 5,5'-diethylbarbituric acid (barbital). Acta Crystallogr B (1969) 0.95
Congenital fibrosis of the extraocular muscles. Trans Am Ophthalmol Soc (1978) 0.94
A Plasmodium vivax vaccine candidate displays limited allele polymorphism, which does not restrict recognition by antibodies. Mol Med (1999) 0.93
Leishmaniasis affecting the eyelids. Arch Ophthalmol (1983) 0.92
Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clin Vaccine Immunol (2007) 0.92
Characterization of cellular immune response to chemically defined glycoconjugates from Leishmania mexicana subsp. amazonensis. Infect Immun (1986) 0.92
Clinical, electron microscopic, and monoclonal antibody studies of intraocular epithelial downgrowth. Trans Am Ophthalmol Soc (1986) 0.91
Intrasplenic immunization with infected hepatocytes: a mouse model for studying protective immunity against malaria pre-erythrocytic stage. Immunology (1994) 0.89
Light and electron microscopic observations on the pigmented layers of the developing human eye. Am J Ophthalmol (1972) 0.89
Interphotoreceptor retinoid-binding protein in retinal rod cells and pineal gland. Invest Ophthalmol Vis Sci (1986) 0.89
Posterior corneal crystalline deposits in benign monoclonal gammopathy: a clinicopathologic case report. Arch Ophthalmol (1979) 0.88
Passive transfer of a monoclonal antibody specific for a sialic acid-dependent epitope on the surface of Trypanosoma cruzi trypomastigotes reduces infection in mice. Infect Immun (1997) 0.88
Unusual superficial stromal corneal deposits in IgG kappa monoclonal gammopathy. Arch Ophthalmol (1980) 0.88
Immunogenic properties of the Plasmodium vivax vaccine candidate MSP1(19) expressed as a secreted non-glycosylated polypeptide from Pichia pastoris. Parasitology (2002) 0.88
Accumulation of HDL apolipoproteins accompanies abnormal cholesterol accumulation in Schnyder's corneal dystrophy. Arterioscler Thromb Vasc Biol (1996) 0.88
Antigenic properties of the merozoite surface protein 1 gene of Plasmodium vivax. Vaccine (1999) 0.88
Risk factors for ocular toxoplasmosis in Brazil. Epidemiol Infect (2013) 0.88
Chandler's syndrome as a variant of essential iris atrophy. A clinicopathologic study. Arch Ophthalmol (1978) 0.88
Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome. Ophthalmology (1986) 0.87
Spontaneous ulcerative keratitis in immunocompromised patients. Am J Ophthalmol (1993) 0.87
Ophthalmomyiasis of the eyelid caused by Cuterebra larva. Am J Ophthalmol (1974) 0.87
Polytetrafluoroethylene as an interpositional graft material for the correction of lower eyelid retraction. Ophthalmology (1989) 0.87
Steroid-induced glaucoma: A. Persistent elevation of intraocular pressure B. Histopathological aspects. Trans Am Ophthalmol Soc (1977) 0.87
Unusual superficial confluent form of granular corneal dystrophy. Ophthalmology (1983) 0.87
Dominantly inherited retinitis pigmentosa. Ultrastructure and biochemical analysis. Ophthalmology (1985) 0.86
Keratophakia and keratomileusis: histopathologic, ultrastructural, and experimental studies. Ophthalmology (1984) 0.86
Collagen, factor VIII antigen, and immunoglobulins in the human aqueous drainage channels. Ophthalmology (1980) 0.86
Patterns of pathologic response in the cornea. Surv Ophthalmol (1987) 0.86
Histopathologic verification of position of laser burns in argon laser trabeculoplasty. Ophthalmic Surg (1984) 0.85
C-reactive protein in human lattice corneal dystrophy. Curr Eye Res (1983) 0.85
Microfibrillar protein and phospholipid in granular corneal dystrophy. Arch Ophthalmol (1983) 0.85
Corpora amylacea of the optic nerve and retina: a form of neuronal degeneration. Invest Ophthalmol Vis Sci (1980) 0.85
Ultrastructure and successful keratoplasty of sclerocornea in Mietens' syndrome. Am J Ophthalmol (1980) 0.85
Panstromal Schnyder's corneal dystrophy. Ultrastructural and histochemical studies. Ophthalmology (1992) 0.85
Lack of evidence for protein AA reactivity in amyloid deposits of lattice corneal dystrophy and amyloid corneal degeneration. Am J Ophthalmol (1984) 0.84
Culture-proven cytomegalovirus retinitis in a homosexual man with the acquired immunodeficiency syndrome. Ophthalmology (1982) 0.84
Immunohistochemistry and electron microscopy of cyclitic membrane. Report of a case. Arch Ophthalmol (1986) 0.84
Orbital amyloidosis. Can J Ophthalmol (1976) 0.84
Clinical, electron microscopic, and immunohistochemical study of the corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. Am J Ophthalmol (1986) 0.84
Unesterified cholesterol in Schnyder's corneal crystalline dystrophy. Am J Ophthalmol (1987) 0.84
Induction of ocular inflammation by synthetic mediators. Arch Ophthalmol (1981) 0.83
Threshold for lens damage during Q-switched Nd:YAG laser iridectomy. A study of rhesus monkey eyes. Ophthalmology (1985) 0.83