The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions.

PubWeight™: 1.24‹?› | Rank: Top 10%

🔗 View Article (PMID 11513139)

Published in Immunol Rev on June 01, 2001

Authors

C L Sutherland1, N J Chalupny, D Cosman

Author Affiliations

1: Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA. sutherlandc@immunex.com

Articles citing this

Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol (2003) 3.97

Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J (2003) 3.06

Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev (2009) 2.75

Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J Exp Med (2003) 2.20

Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood (2007) 1.54

Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts. J Exp Med (2003) 1.41

NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer. J Exp Med (2004) 1.35

Natural killer cells: integrating diversity with function. Immunology (2009) 1.25

Feeling manipulated: cytomegalovirus immune manipulation. Virol J (2009) 1.19

NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection. J Immunol (2008) 1.12

Involvement of activating NK cell receptors and their modulation in pathogen immunity. J Biomed Biotechnol (2011) 1.10

Killing of avian and Swine influenza virus by natural killer cells. J Virol (2010) 1.03

The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions. Blood (2005) 0.98

Defective infiltration of natural killer cells in MICA/B-positive renal cell carcinoma involves beta(2)-integrin-mediated interaction. Neoplasia (2009) 0.98

NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood (2004) 0.97

Murine NKG2D ligands: "double, double toil and trouble". Mol Immunol (2008) 0.96

How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance. J Biomed Biotechnol (2011) 0.90

Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells. Clin Dev Immunol (2010) 0.89

Polymorphisms within human cytomegalovirus chemokine (UL146/UL147) and cytokine receptor genes (UL144) are not predictive of sequelae in congenitally infected children. Virology (2008) 0.88

Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. Immunogenetics (2009) 0.87

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells. J Immunol (2009) 0.86

The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions. Semin Immunol (2006) 0.81

The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies. Front Immunol (2015) 0.77

The role of NK cells in HIV-1 protection: autologous, allogeneic or both? AIDS Res Ther (2016) 0.77

The role of natural killer cells in chronic myeloid leukemia. Rev Bras Hematol Hemoter (2011) 0.75

Articles by these authors

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature (1997) 8.59

RANK is essential for osteoclast and lymph node development. Genes Dev (1999) 5.85

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J (1994) 5.69

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity (2001) 5.42

A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science (1990) 4.90

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell (1990) 3.98

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J (1995) 3.59

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science (1988) 3.56

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J (1992) 3.10

Cloning, sequence and expression of human interleukin-2 receptor. Nature (1985) 3.02

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell (1990) 2.95

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J (1991) 2.85

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor. J Biol Chem (1987) 2.78

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J (1991) 2.56

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J Biol Chem (1988) 2.46

Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. Proc Natl Acad Sci U S A (1989) 2.46

Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells. J Exp Med (1989) 2.30

Secretion of a transplantation-related antigen. Cell (1983) 2.12

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J Immunol (1997) 2.09

Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. Mol Immunol (1988) 1.97

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J Biol Chem (1996) 1.89

Soluble forms of CD40 inhibit biologic responses of human B cells. J Immunol (1992) 1.88

The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem (1998) 1.86

Murine thymocytes proliferate in direct response to interleukin-7. Blood (1989) 1.86

cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature (1994) 1.85

IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J Leukoc Biol (1995) 1.84

IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression. J Immunol (1999) 1.77

Tissue-specific expression of an unusual H-2 (class I)-related gene. Proc Natl Acad Sci U S A (1982) 1.76

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. J Immunol (1995) 1.70

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A (1991) 1.66

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains. J Exp Med (1990) 1.63

Expression, purification and characterization of recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast. Gene (1987) 1.50

Three classes of mouse H-2 messenger RNA distinguished by analysis of cDNA clones. Nature (1982) 1.48

Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood (1989) 1.47

ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur J Immunol (2001) 1.37

The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol (1998) 1.36

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. Blood (1991) 1.35

Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex. Proc Natl Acad Sci U S A (1992) 1.28

Induction of an interleukin-1 receptor (IL-1R) on monocytic cells. Evidence that the receptor is not encoded by a T cell-type IL-1R mRNA. J Biol Chem (1990) 1.26

The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1 + NK cell clones. Int Immunol (1999) 1.24

Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1 alpha and 1 beta. Proc Natl Acad Sci U S A (1987) 1.20

LIRs/ILTs/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells. Cytokine Growth Factor Rev (2000) 1.20

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood (1995) 1.20

The CD85/LIR-1/ILT2 inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions. J Immunol (2000) 1.20

Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. Proc Natl Acad Sci U S A (1994) 1.19

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell (1991) 1.18

Cloning, sequence, and expression of bovine interferon-gamma. J Immunol (1986) 1.17

Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. Cell Growth Differ (1991) 1.12

Cloning, sequence, and expression of bovine interleukin 2. Proc Natl Acad Sci U S A (1986) 1.10

Stably transmitted triple-promoter retroviral vectors and their use in transformation of primary mammalian cells. Mol Cell Biol (1988) 1.09

Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain. J Biol Chem (1986) 1.07

Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction. Biochemistry (1995) 1.06

T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro. Blood (1990) 1.05

Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene. Mol Immunol (1988) 1.05

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene (1993) 1.04

Reconstitution of a functional interleukin (IL)-7 receptor demonstrates that the IL-2 receptor gamma chain is required for IL-7 signal transduction. Eur J Immunol (1995) 1.03

Retention of ligand binding activity by the extracellular domain of the IL-1 receptor. J Immunol (1989) 1.02

Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis. Biochemistry (1995) 1.01

Further evidence for a common mechanism for shedding of cell surface proteins. FEBS Lett (1997) 1.00

New nomenclature for MHC receptors. Nat Immunol (2001) 0.99

Regulation of antibody production in vitro by granulocyte-macrophage colony stimulating factor. J Mol Cell Immunol (1986) 0.99

The interleukin-4 receptor: structure, function, and signal transduction. Chem Immunol (1992) 0.96

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells. Exp Hematol (1991) 0.93

Nature and specificity of lymphokine independence induced by a selectable retroviral vector expressing v-src. Mol Cell Biol (1987) 0.92

The R27080 glycoprotein is abundantly secreted from human cytomegalovirus-infected fibroblasts. J Gen Virol (1999) 0.92

Expression and purification of native human granulocyte-macrophage colony-stimulating factor from an Escherichia coli secretion vector. DNA (1987) 0.91

Characterization of the human and murine IL-7 genes. J Immunol (1990) 0.91

Interleukin-15 up-regulates interleukin-2 receptor alpha chain but down-regulates its own high-affinity binding sites on human T and B cells. Eur J Immunol (1996) 0.90

The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7. Genomics (1991) 0.88

Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB. J Biol Chem (1997) 0.88

Allelic and interlocus comparison of the PERB11 multigene family in the MHC. Immunogenetics (1997) 0.88

Experimental and theoretical studies of the three-dimensional structure of human interleukin-4. Proteins (1991) 0.87

Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: interleukin-15 binds to the B cells but is not internalized efficiently. Blood (1995) 0.86

Molecular characterization of the interleukin-1 receptor (IL-1R) on monocytes and polymorphonuclear cells. Cytokine (1992) 0.85

The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulators. J Leukoc Biol (1999) 0.83

Production of recombinant human colony stimulating factors in yeast. Behring Inst Mitt (1988) 0.83

Colony-stimulating factors in vivo and in vitro. Immunol Today (1988) 0.82

Human rhinovirus 3C protease: cloning and expression of an active form in Escherichia coli. Biochemistry (1988) 0.81

Recombinant globulins: novel research tools and possible pharmaceuticals. Curr Opin Immunol (1992) 0.80

Bovine GM-CSF: molecular cloning and biological activity of the recombinant protein. Mol Immunol (1988) 0.80

Functional role of interleukin-4 (IL-4) and IL-7 in the development of X-linked severe combined immunodeficiency. Blood (1999) 0.80

Identification of regions in interleukin-1 alpha important for activity. J Biol Chem (1993) 0.80

A novel mutant gammac chain from a patient with typical phenotype of X-linked severe combined immunodeficiency (SCID) has partial signalling function for mediating IL-2 and IL-4 receptor action. Clin Exp Immunol (1999) 0.80

Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family. Clin Exp Immunol (1996) 0.79

Expression of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells. Curr Eye Res (1996) 0.78

High level stable expression of human interleukin-2 receptors in mouse cells generates only low affinity interleukin-2 binding sites. Mol Immunol (1986) 0.78

Interactions of LIRs, a family of immunoreceptors expressed in myeloid and lymphoid cells, with viral and cellular MHC class I antigens. Curr Top Microbiol Immunol (1999) 0.77

Membrane bound forms of human macrophage colony stimulating factor (M-CSF, CSF-1). Prog Clin Biol Res (1990) 0.77

Molecular modification of lymphokines by in vitro mutagenesis. Ann N Y Acad Sci (1987) 0.75

Lymphokines: from conjecture to the clinic. Semin Oncol (1986) 0.75

Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3. Ann N Y Acad Sci (1989) 0.75

Improved survival and leukocyte reconstitution without detrimental effects on engraftment in murine recipients of human recombinant granulocyte colony-stimulating factor after transplantation of T-cell-depleted histoincompatible bone marrow. Blood (1989) 0.75