Published in Exp Neurol on September 01, 2001
The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol (2013) 1.27
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci (2009) 1.19
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J Neuroinflammation (2005) 1.16
Innate immunity in Alzheimer's disease: a complex affair. CNS Neurol Disord Drug Targets (2013) 1.05
Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. Free Radic Biol Med (2008) 1.02
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol (2005) 1.02
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. NeuroRx (2006) 1.01
Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci (2013) 0.98
Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques. Histochem Cell Biol (2005) 0.94
Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: initial results. Magn Reson Imaging (2012) 0.93
The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacol Sin (2010) 0.87
Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death Dis (2014) 0.87
Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol (2008) 0.81
Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer's disease. Int J Clin Exp Pathol (2012) 0.81
17α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice. J Alzheimers Dis (2011) 0.80
Modeling Alzheimer's disease: from past to future. Front Pharmacol (2013) 0.79
Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice. Lett Drug Des Discov (2009) 0.78
Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease. Sci Rep (2016) 0.77
β-Asarone Mitigates Amyloidosis and Downregulates RAGE in a Transgenic Mouse Model of Alzheimer's Disease. Cell Mol Neurobiol (2015) 0.75
Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans. Biochem J (1999) 8.68
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature (2001) 7.35
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet (2000) 6.12
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med (1998) 5.78
Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry (2007) 5.49
Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci (1999) 3.77
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis (2000) 3.46
The isolation and amino acid composition of senile plaque core protein. Brain Res (1983) 3.26
A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease. J Clin Microbiol (2007) 2.83
Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol Neurosurg Psychiatry (2002) 2.42
An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup Environ Med (2001) 2.03
Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. Neurosci Lett (1986) 2.01
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. J Biol Chem (1999) 2.00
The dangers of rationing dialysis treatment: the dilemma facing a developing country. Kidney Int (2006) 1.99
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87
Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A (2001) 1.87
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 1.87
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet (1999) 1.74
Rapid isolation of CA microsatellites from the tilapia genome. Anim Genet (2002) 1.68
Short-term reproducibility of a commercial interferon gamma release assay. Clin Vaccine Immunol (2009) 1.67
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol (2000) 1.66
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol (2001) 1.66
Increased aquaporin 1 water channel expression in human brain tumours. Br J Cancer (2002) 1.61
Single-day apolipoprotein E genotyping. J Neurosci Methods (1994) 1.59
Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours. Aliment Pharmacol Ther (2009) 1.58
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. J Neuropathol Exp Neurol (2001) 1.53
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat. Br J Pharmacol (1989) 1.52
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci (1998) 1.50
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol Dis (2001) 1.48
CNS amyloid proteins in neurodegenerative diseases. Neurology (1988) 1.47
Pathophysiology of septic encephalopathy: a review. Crit Care Med (2000) 1.46
Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide. Neurodegeneration (1995) 1.45
Gene transcript analysis blood values correlate with ⁶⁸Ga-DOTA-somatostatin analog (SSA) PET/CT imaging in neuroendocrine tumors and can define disease status. Eur J Nucl Med Mol Imaging (2015) 1.41
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nat Genet (1992) 1.40
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem (1999) 1.39
Emerging molecular mechanisms of brain tumour oedema. Br J Neurosurg (2001) 1.39
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis (1999) 1.38
A comparative study of [3H]haloperidol and [3H]spiroperidol binding to receptors on rat cerebral membranes. FEBS Lett (1978) 1.35
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil. Biochem Pharmacol (1987) 1.34
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport (1995) 1.32
Senile plaque amyloid, paired helical filaments, and cerebrovascular amyloid in Alzheimer's disease are all deposits of the same protein. Lancet (1985) 1.31
Computationally derived structural models of the beta-amyloid found in Alzheimer's disease plaques and the interaction with possible aggregation inhibitors. Biopolymers (1999) 1.30
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide. Biochem J (2000) 1.23
Immune markers measured before treatment predict outcome of intensive phase tuberculosis therapy. Clin Exp Immunol (2006) 1.21
Rarity of colon cancer in Africans is associated with low animal product consumption, not fiber. Am J Gastroenterol (1999) 1.19
The control of sexual differentiation of the reproductive system and brain. Reproduction (2007) 1.19
Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex. Clin Sci (Lond) (1999) 1.16
Methodology for developing educational hypermedia systems. Stud Health Technol Inform (1998) 1.16
Validity of the K-10 in detecting DSM-IV-defined depression and anxiety disorders among HIV-infected individuals. AIDS Care (2009) 1.14
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. Mol Cell Neurosci (2000) 1.14
T cell responses to vaccines in infants: defective IFNgamma production after oral polio vaccination. Clin Exp Immunol (2002) 1.12
Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res (2000) 1.11
Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J Neurosci (1999) 1.11
beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide. FEBS Lett (1994) 1.11
Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders. Clin Exp Immunol (2006) 1.09
Modulation of A(beta) peptides by estrogen in mouse models. J Neurochem (2002) 1.09
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease. Neuroscience (2001) 1.08
The tissue distribution of the human beta3-adrenoceptor studied using a monoclonal antibody: direct evidence of the beta3-adrenoceptor in human adipose tissue, atrium and skeletal muscle. Int J Obes Relat Metab Disord (1999) 1.08
Subacute inclusion body encephalitis. A histological and electron microscopical study. Acta Neuropathol (1966) 1.07
Some factors affecting attendance at ante-natal clinics. Soc Sci Med D (1981) 1.07
Pharmacotherapy of neuroendocrine cancers. Expert Opin Pharmacother (2008) 1.06
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol Dis (2001) 1.04
Immunohistochemical evidence for the derivation of a peptide ligand from the amyloid beta-protein precursor of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 1.03
A simplified apparatus for the microbiological isolation of calves. Br Vet J (1977) 1.03
Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction. Metab Brain Dis (2007) 1.02
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. Neuroreport (1996) 1.02
Electron microscopy of human cerebral aneurysms. J Neurosurg (1965) 0.98
The 30-year cardiovascular risk profile of South Africans with diagnosed diabetes, undiagnosed diabetes, pre-diabetes or normoglycaemia: the Bellville, South Africa pilot study. Cardiovasc J Afr (2012) 0.98
Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation. Diabetes Obes Metab (2011) 0.97
Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol Dis (2003) 0.97
Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans. J Med Chem (1990) 0.96
Molecular mechanisms in therapy of acid-related diseases. Cell Mol Life Sci (2008) 0.95
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur J Pharmacol (1988) 0.95
Occludin expression in microvessels of neoplastic and non-neoplastic human brain. Neuropathol Appl Neurobiol (2001) 0.94
Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-beta protein monoclonal antibody. Lab Invest (1987) 0.93
The Cameroon 2008 Burkitt lymphoma protocol: improved event-free survival with treatment adapted to disease stage and the response to induction therapy. Pediatr Hematol Oncol (2012) 0.92
Improvement in mycobacterial yield and reduced time to detection in pediatric samples by use of a nutrient broth growth supplement. J Clin Microbiol (2009) 0.92
Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats. Gastroenterology (1999) 0.91
The effects of metal ions on the binding of a new alpha 2-adrenoceptor antagonist radioligand (3H)-RX 781094 in rat cerebral cortex. Biochem Pharmacol (1983) 0.90
The derivation of gnotobiotic calves by a hysterotomy and slaughter technique. Br Vet J (1976) 0.90
Some electron microscopical observations on status spongiosus. Acta Neuropathol (1967) 0.89
Anomalous properties of [3H]spiperone binding sites in various areas of the rat limbic system. Mol Pharmacol (1979) 0.89
Effect of LED curing on the microleakage, shear bond strength and surface hardness of a resin-based composite restoration. Biomaterials (2005) 0.89
Carcinoid heart disease. Int J Cardiol (2008) 0.88
Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience (2003) 0.88
The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. Am J Physiol Gastrointest Liver Physiol (2011) 0.88
Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. J Neurol Neurosurg Psychiatry (1986) 0.88
The transverse acetabular ligament may be used to align the acetabular cup in total hip arthroplasty. Hip Int (2008) 0.88
Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells. Immunology (2001) 0.88
Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiol Dis (2000) 0.88
Clinical experience with antithrombin III concentrate in treatment of congenital and acquired deficiency of antithrombin. The Antithrombin III Study Group. Am J Med (1989) 0.88
Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. Neuroreport (2001) 0.87
Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. NMR Biomed (2007) 0.87
An electron microscopical comparison of primary and secondary demyelination in the rat central nervous system. Virchows Arch B Cell Pathol (1969) 0.87