Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial.

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Published in Blood on September 01, 2001

Authors

A H Goldstone1, A K Burnett, K Wheatley, A G Smith, R M Hutchinson, R E Clark, Medical Research Council Adult Leukemia Working Party

Author Affiliations

1: Department of Haematology, University College Hospital, London, United Kingdom.

Associated clinical trials:

Intrabone Infusion of Cord Blood in Adults With Hematological Malignancies (IBCB) | NCT00886522

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Early and late healing responses of normal canine artery to excimer laser irradiation. J Thorac Cardiovasc Surg (1988) 1.42

Molecular basis for dominantly inherited inclusion body beta-thalassemia. Proc Natl Acad Sci U S A (1990) 1.42

The detection by immunodiffusion of tumour associated antigenic components in extracts of human bronchongenic carcinoma. Br J Cancer (1975) 1.42

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Nucleic acid concentrations in normal human plasma. Clin Chem (1972) 1.42

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Clinical study of location and reproducibility of three mandibular positions in relation to body posture and muscle function. J Prosthet Dent (1995) 1.41

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