Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2.

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Published in Neuron on September 13, 2001

Authors

B G Novitch1, A I Chen, T M Jessell

Author Affiliations

1: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA.

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ATP excites a subpopulation of rat dorsal horn neurones. Nature (1983) 2.12

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Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development (1992) 1.65

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Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate. J Neurosci (1985) 1.45

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Membrane properties of rat substantia gelatinosa neurons in vitro. J Neurophysiol (1989) 1.41

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Neural science: a century of progress and the mysteries that remain. Cell (2000) 1.35

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Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development (1998) 1.34

Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science (1979) 1.33

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Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis. Am J Gastroenterol (1992) 1.23

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Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Dev Biol (2000) 1.21

Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos. Development (1991) 1.21

Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Curr Biol (1995) 1.15

Neutrophil-activating peptide (interleukin-8) in colonic mucosa from patients with Crohn's disease. Scand J Gastroenterol (1993) 1.13

Sonic hedgehog: a common signal for ventral patterning along the rostrocaudal axis of the neural tube. Int J Dev Biol (1995) 1.09

Dopamine selectively increases 3H-GABA release from slices of rat substantia nigra in vitro. Nature (1977) 1.08

Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. Development (1999) 1.05

The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm. Development (1998) 1.05

Convergent inductive signals specify midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos. Neuron (1999) 1.00

Substance P: localization in synaptic vesicles in rat central nervous system. J Neurochem (1977) 0.99

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Neural science: a century of progress and the mysteries that remain. Neuron (2000) 0.99

Sensory transmitters regulate intracellular calcium in dorsal horn neurons. Nature (1988) 0.99

Vasoactive intestinal polypeptide (VIP): vesicular localization and potassium evoked release from rat hypothalamus. Brain Res (1978) 0.99

Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo. Development (2000) 0.97

Structure and expression of differentiation antigens on functional subclasses of primary sensory neurons. Philos Trans R Soc Lond B Biol Sci (1985) 0.97

Differentiated properties of identified serotonin neurons in dissociated cultures of embryonic rat brain stem. J Cell Biol (1981) 0.97