PubRank

A L Fink

Author PubWeight™ 134.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Why are "natively unfolded" proteins unstructured under physiologic conditions? Proteins 2000 7.61
2 Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem 2001 3.60
3 Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism. Biochemistry 2001 3.47
4 Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J Biol Chem 2001 3.13
5 ATP-induced protein-Hsp70 complex dissociation requires K+ but not ATP hydrolysis. Nature 1993 2.77
6 Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding. Proc Natl Acad Sci U S A 1991 2.41
7 Acid-induced folding of proteins. Proc Natl Acad Sci U S A 1990 2.17
8 Conformational states of beta-lactamase: molten-globule states at acidic and alkaline pH with high salt. Biochemistry 1989 2.12
9 Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry 2001 2.12
10 Mechanism of acid-induced folding of proteins. Biochemistry 1990 2.06
11 Partially folded intermediates as critical precursors of light chain amyloid fibrils and amorphous aggregates. Biochemistry 2001 1.88
12 Protein denaturation: a small-angle X-ray scattering study of the ensemble of unfolded states of cytochrome c. Biochemistry 1998 1.69
13 Nativelike secondary structure in interleukin-1 beta inclusion bodies by attenuated total reflectance FTIR. Biochemistry 1994 1.67
14 Monitoring the assembly of Ig light-chain amyloid fibrils by atomic force microscopy. Proc Natl Acad Sci U S A 1999 1.63
15 Probing the mechanism of insulin fibril formation with insulin mutants. Biochemistry 2001 1.61
16 An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid 2000 1.56
17 Is Congo red an amyloid-specific dye? J Biol Chem 2001 1.48
18 Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett 2001 1.41
19 Aggregation and denaturation of apomyoglobin in aqueous urea solutions. Biochemistry 1993 1.38
20 Site-directed mutagenesis of beta-lactamase leading to accumulation of a catalytic intermediate. Biochemistry 1991 1.37
21 A catalytically-impaired class A beta-lactamase: 2 A crystal structure and kinetics of the Bacillus licheniformis E166A mutant. Protein Eng 1993 1.35
22 Transient dimer in the refolding kinetics of cytochrome c characterized by small-angle X-ray scattering. Biochemistry 1999 1.34
23 Fourier transform infrared spectroscopy in analysis of protein deposits. Methods Enzymol 1999 1.31
24 The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis. Biochemistry 1990 1.31
25 Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations. J Biol Chem 2001 1.29
26 Phase diagram for acidic conformational states of apomyoglobin. J Mol Biol 1990 1.29
27 Conformational characterization of DnaK and its complexes by small-angle X-ray scattering. Biochemistry 1996 1.20
28 DnaK, hsp73, and their molten globules. Two different ways heat shock proteins respond to heat. J Biol Chem 1992 1.19
29 Mechanism of Action of papain with a specific anilide substrate. Biochemistry 1979 1.17
30 Cryoenzymology of papain: reaction mechanism with an ester substrate. Biochemistry 1978 1.16
31 hsp70-protein complexes. Complex stability and conformation of bound substrate protein. J Biol Chem 1994 1.16
32 The analysis of enzyme progress curves by numerical differentiation, including competitive product inhibition and enzyme reactivation. Anal Biochem 1987 1.15
33 Protein conformational changes induced by 1,1'-bis(4-anilino-5-naphthalenesulfonic acid): preferential binding to the molten globule of DnaK. Biochemistry 1994 1.15
34 Natively unfolded human prothymosin alpha adopts partially folded collapsed conformation at acidic pH. Biochemistry 1999 1.14
35 Trimethylamine-N-oxide-induced folding of alpha-synuclein. FEBS Lett 2001 1.14
36 Reactivity and cryoenzymology of enzymes in the crystalline state. Annu Rev Biophys Bioeng 1977 1.12
37 The penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle. Mol Microbiol 1997 1.11
38 Isolation of a covalent intermediate in beta -lactamase I catalysis. FEBS Lett 1982 1.11
39 Site-directed mutagenesis of glutamate-166 in beta-lactamase leads to a branched path mechanism. Biochemistry 1994 1.10
40 Lysine-73 is involved in the acylation and deacylation of beta-lactamase. Biochemistry 2000 1.09
41 Do parallel beta-helix proteins have a unique fourier transform infrared spectrum? Biophys J 2000 1.05
42 Anion-induced folding of Staphylococcal nuclease: characterization of multiple equilibrium partially folded intermediates. J Mol Biol 1998 1.03
43 Cryoenzymology: the use of sub-zero temperatures and fluid solutions in the study of enzyme mechanisms. J Theor Biol 1976 1.02
44 Mechanism of thiol protease catalysis: detection and stabilization of a tetrahedral intermediate in papain catalysis. Biochemistry 1979 1.01
45 Thermally denatured ribonuclease A retains secondary structure as shown by FTIR. Biochemistry 1994 1.00
46 Time-resolved circular dichroism studies of protein folding intermediates of cytochrome c. Biochemistry 1998 1.00
47 A new attenuated total reflectance Fourier transform infrared spectroscopy method for the study of proteins in solution. Anal Biochem 1998 0.99
48 Intermediate conformational states of apocytochrome c. Biochemistry 1993 0.98
49 Guanidine hydrochloride-induced folding of proteins. J Mol Biol 1993 0.97
50 A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions. J Biol Chem 1995 0.97
51 Cold denaturation and 2H2O stabilization of a staphylococcal nuclease mutant. Proc Natl Acad Sci U S A 1991 0.97
52 Cryoenzymology of penicillopepsin; with an appendix: mechanism of action of aspartyl proteinases. Biochemistry 1984 0.96
53 Effect of proline mutations on the stability and kinetics of folding of staphylococcal nuclease. Biochemistry 1993 0.95
54 Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues. J Biol Chem 1995 0.95
55 Formation of stable crystalline enzyme-substrate intermediates at sub-zero temperatures. Nature 1976 0.93
56 The enzymic deacylation of esterified mono- and di-saccharides. IV. The products of esterase-catalyzed deacetylations. Can J Biochem 1969 0.93
57 Binding sites for substrate leaving groups and added nucleophiles in papain-catalyzed hydrolyses. Biochemistry 1969 0.92
58 Cryoenzymology. CRC Crit Rev Biochem 1981 0.92
59 X-ray cryoenzymology. Adv Enzymol Relat Areas Mol Biol 1981 0.92
60 Structural and functional similarity between Yersinia pestis capsular protein Caf1 and human interleukin-1 beta. Biochemistry 2001 0.91
61 Effect of salts on the stability and folding of staphylococcal nuclease. Biochemistry 2001 0.91
62 Fluorescence energy transfer indicates similar transient and equilibrium intermediates in staphylococcal nuclease folding. J Mol Biol 2000 0.91
63 Characterization of the unfolding of ribonuclease A in aqueous methanol solvents. Biochemistry 1987 0.90
64 Association-induced folding of globular proteins. Proc Natl Acad Sci U S A 1998 0.90
65 Cryoenzymology of staphylococcal beta-lactamase: trapping a serine-70-linked acyl-enzyme. Biochemistry 1990 0.89
66 Association of partially-folded intermediates of staphylococcal nuclease induces structure and stability. Protein Sci 1999 0.89
67 Effect of an engineered disulfide bond on the folding of T4 lysozyme at low temperatures. Biochemistry 1990 0.88
68 Accelerated fibrillation of alpha-synuclein induced by the combined action of macromolecular crowding and factors inducing partial folding. Curr Alzheimer Res 2009 0.88
69 Clavulanate inactivation of Staphylococcus aureus beta-lactamase. Biochem J 1989 0.88
70 Trapping the acyl-enzyme intermediate in beta-lactamase I catalysis. Biochem J 1989 0.87
71 Side-chain mobility of the beta-lactamase A state probed by electron spin resonance spectroscopy. Biochemistry 1993 0.87
72 Effect of dimethyl sulfoxide on the interaction of proflavine with alpha-chymotrypsin. Biochemistry 1974 0.87
73 Cryoenzymology: the study of enzyme catalysis at subzero temperatures. Methods Enzymol 1979 0.86
74 Three-state denaturation of DnaK induced by guanidine hydrochloride. Evidence for an expandable intermediate. Biochemistry 1993 0.86
75 Zn(2+)-mediated structure formation and compaction of the "natively unfolded" human prothymosin alpha. Biochem Biophys Res Commun 2000 0.86
76 The folding of staphylococcal nuclease in the presence of methanol or guanidine thiocyanate. J Biol Chem 1990 0.86
77 Methanol-stabilized intermediates in the thermal unfolding of ribonuclease A. Characterization by 1H nuclear magnetic resonance. J Mol Biol 1982 0.86
78 Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J 1992 0.85
79 Effect of prolyl isomerase on the folding reactions of staphylococcal nuclease. Biochemistry 1997 0.85
80 The -chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophan p-nitrophenyl ester in dimethyl sulfoxide at subzero temperatures. Biochemistry 1973 0.85
81 A point mutation leads to altered product specificity in beta-lactamase catalysis. Proc Natl Acad Sci U S A 1997 0.84
82 DnaK ATPase activity revisited. FEBS Lett 1993 0.84
83 Effects of cryoprotectants on enzyme structure. Cryobiology 1986 0.84
84 Acid-induced folding of heme proteins. Methods Enzymol 1994 0.83
85 Export and folding of signal-sequenceless Bacillus licheniformis beta-lactamase in Escherichia coli. Eur J Biochem 2000 0.83
86 Effects of site-specific mutagenesis of tyrosine 105 in a class A beta-lactamase. Biochem J 1994 0.83
87 Observation of intermediates in the folding of ribonuclease A at low temperature using proton nuclear magnetic resonance. Biochemistry 1982 0.82
88 The trypsin-catalyzed hydrolysis of N alpha-benzyloxycarbonyl-L-lysine p-nitrophenyl ester in dimethylsulfoxide at sub-zero temperatures. J Biol Chem 1974 0.82
89 Cryoenzymology of chymotrypsin: the detection of intermediates in the catalysis of a specific anilide substrate. Biochemistry 1976 0.82
90 The detection, accumulation and stabilization of a tetrahedral intermediate in trypsin catalysis. Biochem Biophys Res Commun 1980 0.82
91 The thermal denaturation of ribonuclease A in aqueous-methanol solvents. Biochim Biophys Acta 1992 0.82
92 Temperature-dependent change in the rate-limiting step of beta-glucosidase catalysis. J Biol Chem 1980 0.82
93 Conformational changes of an Hsp70 molecular chaperone induced by nucleotides, polypeptides, and N-ethylmaleimide. Biochemistry 1998 0.81
94 The beta-galactosidase-catalyzed hydrolysis of o-nitrophenol-beta-D-galactoside at subzero temperatures: evidence for a galactosyl-enzyme intermediate. Biochem Biophys Res Commun 1975 0.80
95 Papain-catalyzed reactions at subzero temperatures. Biochemistry 1976 0.80
96 Conformational changes in papain during catalysis and ligand binding. Biochemistry 1974 0.79
97 The isolation of N-acetyl-L-tryptophanyl- -chymotrypsin. Arch Biochem Biophys 1973 0.79
98 Cryoenzymology of porcine pepsin. Biochemistry 1984 0.79
99 Conformational change associated with the acylation of alpha-chymotrypsin by N-acetyl-L-phenylalanine methyl ester. J Biol Chem 1974 0.79
100 Intermediates in the refolding of ribonuclease at subzero temperatures. 1. Monitoring by nitrotyrosine absorbance. Biochemistry 1988 0.78
101 Low-temperature reactions of trypsin with p-nitroanilide substrates: tetrahedral intermediate formation or enzyme isomerization. Biochemistry 1984 0.78
102 Interaction of peptide boronic acids with elastase: circular dichroism studies. Proteins 1988 0.78
103 Enzyme-induced strain/distortion in the ground-state ES complex in beta-lactamase catalysis revealed by FTIR. Biochemistry 2000 0.78
104 Intermediates in the refolding of ribonuclease at subzero temperatures. 3. Multiple folding pathways. Biochemistry 1988 0.77
105 Preparation and properties of covalent compounds and intermediates of serine proteases. Methods Enzymol 1982 0.77
106 The effect of cryosolvents on the spectral and catalytic properties of liver alcohol dehydrogenase. J Biol Chem 1983 0.77
107 Detection and accumulation of tetrahedral intermediates in elastase catalysis. Proc Natl Acad Sci U S A 1979 0.77
108 Secondary structure formation precedes tertiary structure in the refolding of ribonuclease A. Biochim Biophys Acta 1992 0.77
109 Attenuated total reflectance Fourier transform infrared analysis of an acyl-enzyme intermediate of alpha-chymotrypsin. Anal Biochem 1990 0.77
110 Structural effect of association on protein molecules in partially folded intermediates. Biochemistry (Mosc) 1998 0.76
111 Protein folding in cryosolvents and at subzero temperatures. Methods Enzymol 1986 0.76
112 Physical interactions between members of the DnaK chaperone machinery: characterization of the DnaK.GrpE complex. Cell Stress Chaperones 1996 0.76
113 Structural properties of staphylococcal nuclease in oligomeric A-forms. Biochemistry (Mosc) 1998 0.76
114 Reinvestigation of the reaction of chymotrypsin with N-furylacryloyltryptophan derivatives at acidic pH. Biochem J 1979 0.75
115 Disaster preparation planning in industry. AAOHN J 1987 0.75
116 Intermediates in the refolding of ribonuclease at subzero temperatures. 2. Monitoring by inhibitor binding and catalytic activity. Biochemistry 1988 0.75
117 Evidence for a glucosyl-enzyme intermediate in the beta-glucosidase-catalyzed hydrolysis of p-nitrophenyl-beta-D-glucoside. Biochem Biophys Res Commun 1974 0.75
118 Resolution of the individual steps in the reaction of lysozyme with the trimer and hexamer of N-acetyl-D-glucosamine at subzero temperatures. Biochemistry 1980 0.75
119 The enzymic deacylation of esterified mono- and di-saccharides. I. The isolation and purification of an esterase from wheat germ lipase. Can J Biochem 1969 0.75
120 Cryoenzymology of human plasmin catalysis: comparison of cryosolvents and reactions with nitrophenyl ester and anilide substrates. Cryobiology 1987 0.75
121 The binding of NADH to horse liver alcohol dehydrogenase at subzero temperatures. A three-step reaction. J Biol Chem 1980 0.75
122 Effects of methanol cryosolvents on the structural and catalytic properties of bovine trypsin. J Biol Chem 1986 0.75